NO20052728D0 - Substituerte tricykliske gamma-karboliner som serotonin reseptor agonister og antagonister - Google Patents

Substituerte tricykliske gamma-karboliner som serotonin reseptor agonister og antagonister

Info

Publication number
NO20052728D0
NO20052728D0 NO20052728A NO20052728A NO20052728D0 NO 20052728 D0 NO20052728 D0 NO 20052728D0 NO 20052728 A NO20052728 A NO 20052728A NO 20052728 A NO20052728 A NO 20052728A NO 20052728 D0 NO20052728 D0 NO 20052728D0
Authority
NO
Norway
Prior art keywords
sup
antagonists
receptor agonists
serotonin receptor
novel compounds
Prior art date
Application number
NO20052728A
Other languages
English (en)
Other versions
NO20052728L (no
Inventor
Taekyu Lee
Wenting Chen
Wei Deng
Albert Robichaud
Ruth Wexler
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of NO20052728D0 publication Critical patent/NO20052728D0/no
Publication of NO20052728L publication Critical patent/NO20052728L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
NO20052728A 2002-12-19 2005-06-07 Substituerte tricykliske gamma-karboliner som serotonin reseptor agonister og antagonister NO20052728L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43476002P 2002-12-19 2002-12-19
PCT/US2003/041447 WO2004056324A2 (en) 2002-12-19 2003-12-19 Substituted tricyclic gamma-carbolines as serotonin receptor agonists and antagonists

Publications (2)

Publication Number Publication Date
NO20052728D0 true NO20052728D0 (no) 2005-06-07
NO20052728L NO20052728L (no) 2005-08-23

Family

ID=32682101

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20052728A NO20052728L (no) 2002-12-19 2005-06-07 Substituerte tricykliske gamma-karboliner som serotonin reseptor agonister og antagonister

Country Status (10)

Country Link
US (1) US7109339B2 (no)
EP (1) EP1581221B1 (no)
JP (1) JP4486505B2 (no)
AT (1) ATE509929T1 (no)
AU (1) AU2003303210A1 (no)
ES (1) ES2364046T3 (no)
IS (1) IS7891A (no)
NO (1) NO20052728L (no)
PL (1) PL377426A1 (no)
WO (1) WO2004056324A2 (no)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002250151B2 (en) * 2001-02-16 2007-08-16 Bristol-Myers Squibb Company Identification and cloning of a novel human gene, RET16, involved in the intracellular signaling cascade
SE0203712D0 (sv) 2002-12-13 2002-12-13 Astrazeneca Ab Novel compounds
JO2735B1 (en) * 2003-01-30 2013-09-15 هيلسين هيلث كير أس ايه. Liquid pharmaceutical formations of balloonosterone
US8598219B2 (en) 2003-01-30 2013-12-03 Helsinn Healthcare Sa Liquid pharmaceutical formulations of palonosetron
EP1756102A1 (en) * 2004-03-05 2007-02-28 Pharma C S.A. 8-PHENOXY-GammaCARBOLINE DERIVATIVES
US7592454B2 (en) 2004-04-14 2009-09-22 Bristol-Myers Squibb Company Substituted hexahydro-pyridoindole derivatives as serotonin receptor agonists and antagonists
US7572805B2 (en) * 2004-07-14 2009-08-11 Bristol-Myers Squibb Company Pyrrolo(oxo)isoquinolines as 5HT ligands
EP2400300A1 (en) 2004-08-25 2011-12-28 Takeda Pharmaceutical Company Limited Method of screening preventives/remedies for stress urinary incontinence
US8394765B2 (en) 2004-11-01 2013-03-12 Amylin Pharmaceuticals Llc Methods of treating obesity with two different anti-obesity agents
AU2005305036B2 (en) * 2004-11-01 2011-03-10 Amylin Pharmaceuticals, Llc Treatment of obesity and related disorders
EP1814590B2 (en) * 2004-11-01 2013-12-11 Amylin Pharmaceuticals, Inc. Treatment of obesity and related disorders
AR051946A1 (es) * 2004-11-05 2007-02-21 Wyeth Corp Formulaciones de derivados de [1,4] diazepina [6,7,1-ij] quinolina
TW200635926A (en) * 2004-11-05 2006-10-16 Wyeth Corp Metabolites of ceratin [1,4]diazepino[6,7,1-ij]quinoline derivatives and methods of preparation and use thereof
EP1910361A2 (en) * 2005-07-28 2008-04-16 Brystol-Myers Squibb Company Substituted tetrahydro-1h-pyrido[4,3,b]indoles as serotonin receptor agonists and antagonists
JP5073664B2 (ja) 2005-08-31 2012-11-14 エフ．ホフマン−ラ ロシュ アーゲー １１−βＨＳＤ１インヒビターとしてのピラゾロン誘導体
RU2338537C2 (ru) * 2006-01-25 2008-11-20 Сергей Олегович Бачурин СРЕДСТВО ДЛЯ ЛЕЧЕНИЯ ШИЗОФРЕНИИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b)ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ
WO2007132841A1 (ja) 2006-05-16 2007-11-22 Takeda Pharmaceutical Company Limited 縮合複素環化合物およびその用途
RU2329044C1 (ru) * 2006-11-16 2008-07-20 Андрей Александрович Иващенко Лиганды 5-ht6 рецепторов, фармацевтическая композиция, способ ее получения и лекарственное средство
JP5567349B2 (ja) 2007-03-12 2014-08-06 イントラ−セルラー・セラピーズ・インコーポレイテッド 置換ヘテロ環縮合ガンマ−カルボリンの合成
RU2338745C1 (ru) * 2007-03-21 2008-11-20 Андрей Александрович Иващенко ЗАМЕЩЕННЫЕ 2,3,4,5-ТЕТРАГИДРО-1Н-ПИРИДО[4,3-b]ИНДОЛЫ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ
KR20100024951A (ko) * 2007-05-25 2010-03-08 메디베이션 뉴롤로지 인코퍼레이티드 세포를 자극하기 위한 방법 및 조성물
RU2470023C2 (ru) 2007-06-26 2012-12-20 Астразенека Аб 1-цианоциклопропильные производные в качестве ингибиторов катепсина к
EP2194980A4 (en) * 2007-09-20 2012-01-18 D2E Llc PYRIDO FLUORINE DERIVATIVES [4,3-B] HYDROGENATED INDOLES HAVING NEUROPROTECTIVE AND COGNITIVE PROPERTIES, PREPARATION METHOD AND USE
EP2216023A4 (en) 2007-11-15 2013-03-13 Takeda Pharmaceutical CONDENSED PYRIDINE DERIVATIVE AND USE THEREOF
US8575186B2 (en) 2009-10-05 2013-11-05 Albany Molecular Research, Inc. Epiminocycloalkyl[b] indole derivatives as serotonin sub-type 6 (5-HT6) modulators and uses thereof
US20120253036A1 (en) 2009-12-11 2012-10-04 Yukinori Nagakura Agent for treating fibromyalgia
WO2011103485A1 (en) 2010-02-18 2011-08-25 Medivation Technologies, Inc. Fused tetracyclic pyrido[4,3-b]indole and pyrido[3,4-b]indole derivatives and methods of use
US9193728B2 (en) 2010-02-18 2015-11-24 Medivation Technologies, Inc. Fused tetracyclic pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use
US9034865B2 (en) 2010-02-18 2015-05-19 Medivation Technologies, Inc. Pyrido [4,3-B] indole and pyrido [3,4-B] indole derivatives and methods of use
EP2560676B8 (en) * 2010-04-22 2016-10-12 Intra-Cellular Therapies, Inc. Organic compounds
WO2012030953A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
US9067949B2 (en) 2011-01-19 2015-06-30 Albany Molecular Research, Inc. Benzofuro[3,2-c] pyridines and related analogs as serotonin sub-type 6 (5-HT6) modulators for the treatment of obesity, metabolic syndrome, cognition and schizophrenia
US9434747B2 (en) 2011-02-18 2016-09-06 Medivation Technologies, Inc. Methods of treating diabetes
WO2013155504A1 (en) 2012-04-14 2013-10-17 Intra-Cellular Therapies, Inc. Novel methods
US9708322B2 (en) 2013-03-15 2017-07-18 Intra-Cellular Therapies, Inc. Substituted pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxalines for inhibiting serotonin reuptake transporter activity
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
MX2016007219A (es) 2013-12-03 2016-09-16 Intra-Cellular Therapies Inc Metodos novedosos.
US10077267B2 (en) 2014-04-04 2018-09-18 Intra-Cellular Therapies, Inc. Organic compounds
US9745300B2 (en) 2014-04-04 2017-08-29 Intra-Cellular Therapies, Inc. Organic compounds
CN113786407A (zh) 2016-01-26 2021-12-14 细胞内治疗公司 有机化合物
KR20230003461A (ko) 2016-03-25 2023-01-05 인트라-셀룰라 써래피스, 인코퍼레이티드. 유기 화합물
US11014925B2 (en) 2016-03-28 2021-05-25 Intra-Cellular Therapies, Inc. Co-crystals of 1-(4-fluoro-phenyl)-4-((6bR,1OaS)-3-methyl-2,3,6b,9,10,10a-hexahydro-1H,7H- pyrido[3′,4′:4,51_pyrrolo [1,2,3-delqcuinoxalin-8-yl)-butan-1-one with nicotinamide or isonicotinamide
WO2017172795A1 (en) 2016-03-28 2017-10-05 Intra-Cellular Therapies, Inc. Novel compositions and methods
WO2017172784A1 (en) 2016-03-28 2017-10-05 Intra-Cellular Therapies, Inc. Novel salts and crystals
JP7013454B2 (ja) 2016-10-12 2022-02-15 イントラ－セルラー・セラピーズ・インコーポレイテッド アモルファス固体分散体
WO2018111805A1 (en) 2016-12-13 2018-06-21 St. Jude Children's Research Hospital Tetrahydroquinoline-based bromodomain inhibitors
US10961245B2 (en) 2016-12-29 2021-03-30 Intra-Cellular Therapies, Inc. Substituted heterocycle fused gamma-carbolines for treatment of central nervous system disorders
JP6987868B2 (ja) 2016-12-29 2022-01-05 イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. 有機化合物
MX2021013640A (es) 2017-03-24 2022-08-31 Intra Cellular Therapies Inc Composiciones novedosas y metodos.
US11207322B2 (en) 2017-04-28 2021-12-28 Board Of Regents, The University Of Texas System Method and composition related to combination therapy for addiction
BR112020001654A2 (pt) 2017-07-26 2020-07-21 Intra-Cellular Therapies, Inc. compostos orgânicos
IL272249B2 (en) 2017-07-26 2023-11-01 Intra Cellular Therapies Inc organic compounds
EP3733204A4 (en) 2017-12-27 2021-09-15 Takeda Pharmaceutical Company Limited THERAPEUTIC FOR EXERCISE INCONTINENCE AND STAIR INCONTINENCE
CN110831941A (zh) 2018-06-11 2020-02-21 细胞内治疗公司 取代的杂环稠合的γ-咔啉类化合物合成
CA3108558A1 (en) 2018-08-31 2020-03-05 Intra-Cellular Therapies, Inc. Novel methods
CN112584837A (zh) 2018-08-31 2021-03-30 细胞内治疗公司 新方法
WO2023288027A1 (en) * 2021-07-14 2023-01-19 Northeastern University Serotonin 5-ht2a, 5-ht2b, and 5-ht2c receptor inverse agonists
CN114105985B (zh) * 2021-12-13 2024-04-16 南方科技大学坪山生物医药研究院 不对称氢化构建卢美哌隆中间体的方法及卢美哌隆中间体

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4183936A (en) * 1972-06-19 1980-01-15 Endo Laboratories, Inc. Pyridopyrrolobenzheterocycles
US4013652A (en) * 1972-06-19 1977-03-22 Endo Laboratories, Inc. Pyridopyrrolobenzoxazine
US4115577A (en) * 1972-06-19 1978-09-19 Endo Laboratories, Inc. Pyridopyrrolobenzheterocycles
US3914421A (en) * 1972-06-19 1975-10-21 Endo Lab Pyridopyrrolobenzheterocycles for combatting depression
US4238607A (en) * 1972-06-19 1980-12-09 Endo Laboratories Inc. Pyridopyrrolo benzheterocycles
US4219550A (en) * 1978-11-09 1980-08-26 E. I. Du Pont De Nemours And Company Cis- and trans- octahydropyridopyrrolobenzheterocycles
HUT61548A (en) 1990-08-27 1993-01-28 Sandoz Ag Process for producing indolonaphthyridine derivatives and pharmaceutical compositions comprising such compounds
JP3108483B2 (ja) * 1991-09-30 2000-11-13 日清製粉株式会社 インドール誘導体およびこれを有効成分とする抗潰瘍薬
TW470745B (en) * 1996-05-23 2002-01-01 Janssen Pharmaceutica Nv Hexahydro-pyrido[4,3-b]indole derivatives
WO2000035922A1 (en) 1998-12-17 2000-06-22 American Home Products Corporation 2,3,4,4a-tetrahydro-1h-pyrazino(1,2-a)quinoxalin-5(6h)one derivates being 5ht2c agonists
IL145998A0 (en) 1999-06-15 2002-07-25 Du Pont Pharm Co Substituted heterocycle fused gamma-carbolines
EP1343791A2 (en) 2000-12-20 2003-09-17 Bristol-Myers Squibb Company Substituted tetracyclic pyridoindoles as serotonin agonists and antagonists
WO2003014118A1 (en) 2001-08-08 2003-02-20 Pharmacia & Upjohn Company THERAPEUTIC 1H-PYRIDO[4,3-b]INDOLES

Also Published As

Publication number Publication date
PL377426A1 (pl) 2006-02-06
WO2004056324A3 (en) 2004-09-02
EP1581221A4 (en) 2008-11-26
AU2003303210A1 (en) 2004-07-14
JP4486505B2 (ja) 2010-06-23
IS7891A (is) 2005-06-10
WO2004056324A2 (en) 2004-07-08
US7109339B2 (en) 2006-09-19
US20040180875A1 (en) 2004-09-16
EP1581221A2 (en) 2005-10-05
NO20052728L (no) 2005-08-23
ES2364046T3 (es) 2011-08-23
AU2003303210A8 (en) 2004-07-14
ATE509929T1 (de) 2011-06-15
JP2006511568A (ja) 2006-04-06
EP1581221B1 (en) 2011-05-18

Similar Documents

Publication Publication Date Title
NO20052728D0 (no) Substituerte tricykliske gamma-karboliner som serotonin reseptor agonister og antagonister
NO20032798D0 (no) Substituerte pyrrolokinoliner og pyridokinoliner som serotonin agonister ogantagonister
WO2002059129A3 (en) Substituted tetracyclic pyridoindoles as serotonin agonists and antagonists
WO2000077010A3 (en) Substituted heterocycle fused gamma-carbolines
NO20071660L (no) Nye pyridinonderivater og deres anvendelse som positive allosteriske modulatorer av MGLUR2-reseptorer
NO20080317L (no) Substituerte tetrahydro-1H-Pyrido[4,3-B]Indoler som serotonin reseptor-agonister og antagonister
MX2007012883A (es) Derivados de dihidrobenzofurano y usos de los mismos.
MX2007007220A (es) Compuestos de pirazolona como agonistas de receptor de glutamato metabotropico para el tratamiento de trastornos neurologicos y psiquiatricos.
BRPI0415657A (pt) derivados de alcanamina de diidrobenzofuranila como agonistas de 5ht2c
DE60231202D1 (de) Kondensierte heterozyklische verbindungen
MXPA05008212A (es) Nuevos compuestos de arilpiperazinilo.
NO20032795L (no) Substituerte pyrazinokinoksalinderivater som serotonin reseptor agonister og antagonister
GB0311349D0 (en) Therapeutic agents, compositions, preparations and uses
WO2004018482A8 (en) C6- and c9-substituted chromeno[4, 3-c]isoxazoline derivatives and their use as anti-depressants

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application