NO20071660L - Nye pyridinonderivater og deres anvendelse som positive allosteriske modulatorer av MGLUR2-reseptorer - Google Patents

Nye pyridinonderivater og deres anvendelse som positive allosteriske modulatorer av MGLUR2-reseptorer

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Publication number
NO20071660L
NO20071660L NO20071660A NO20071660A NO20071660L NO 20071660 L NO20071660 L NO 20071660L NO 20071660 A NO20071660 A NO 20071660A NO 20071660 A NO20071660 A NO 20071660A NO 20071660 L NO20071660 L NO 20071660L
Authority
NO
Norway
Prior art keywords
mglur2
compounds
positive allosteric
allosteric modulators
diseases
Prior art date
Application number
NO20071660A
Other languages
English (en)
Inventor
Christelle Bolea
Jean-Philippe Rocher
Hassan Julien Imogai
Jose Maria Cid-Nunez
Guillaume Albert Jacques Duvey
Vanthea Nhem
Terry Patrick Finn
Emmanuel Christian Le Poul
Robert Johannes Luetjens
Original Assignee
Addex Pharmaceuticals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Addex Pharmaceuticals Sa filed Critical Addex Pharmaceuticals Sa
Publication of NO20071660L publication Critical patent/NO20071660L/no

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
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Abstract

Foreliggende oppfinnelse angår nye forbindelser, spesielt nye pyridinonderivater i henhold til Formel (I) (I) hvor alle rester er definert i søknaden. Forbindelsene ifølge oppfinnelsen er positive allosteriske modulatorer av metabotrope reseptorer - undertype 2 ("mGluR2") som er anvendelige for behandling eller forebygging av nevrologiske og psykiatriske lidelser forbundet med glutamat dysfunksjon og sykdommer hvor mGluR2 undertypen av metabotrope reseptorer er involvert. Spesielt, er slike sykdommer sentralnervesystemlidelser valgt fra gruppen angst, schizofreni, migrene, depresjon og epilepsi. Oppfinnelsen angår også farmasøytiske preparater og fremgangsmåter for å fremstille slike forbindelser og preparater, så vel som anvendelse av slike forbindelser for forebygging og behandling av slike sykdommer hvor mGluR2 er involvert.
NO20071660A 2004-09-17 2007-03-29 Nye pyridinonderivater og deres anvendelse som positive allosteriske modulatorer av MGLUR2-reseptorer NO20071660L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0420722A GB0420722D0 (en) 2004-09-17 2004-09-17 Novel allosteric modulators
PCT/EP2005/054636 WO2006030032A1 (en) 2004-09-17 2005-09-16 Novel pyridinone derivatives and their use as positive allosteric modulators of mglur2-receptors

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Publication Number Publication Date
NO20071660L true NO20071660L (no) 2007-06-15

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NO20071660A NO20071660L (no) 2004-09-17 2007-03-29 Nye pyridinonderivater og deres anvendelse som positive allosteriske modulatorer av MGLUR2-reseptorer

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US (2) US8399493B2 (no)
EP (1) EP1799646B1 (no)
JP (2) JP5179873B2 (no)
KR (1) KR20070085262A (no)
CN (1) CN101061098B (no)
AU (1) AU2005284098B2 (no)
BR (1) BRPI0515412A (no)
CA (1) CA2581144C (no)
EA (1) EA013740B1 (no)
ES (1) ES2527418T3 (no)
GB (1) GB0420722D0 (no)
IL (1) IL181742A0 (no)
MX (1) MX2007003006A (no)
NO (1) NO20071660L (no)
NZ (1) NZ554041A (no)
SG (1) SG155938A1 (no)
TW (1) TW200633982A (no)
UA (1) UA98098C2 (no)
WO (1) WO2006030032A1 (no)
ZA (1) ZA200703088B (no)

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SE0302486D0 (sv) 2003-09-18 2003-09-18 Astrazeneca Ab Novel compounds
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