NO20091831L - Indoler - Google Patents
IndolerInfo
- Publication number
- NO20091831L NO20091831L NO20091831A NO20091831A NO20091831L NO 20091831 L NO20091831 L NO 20091831L NO 20091831 A NO20091831 A NO 20091831A NO 20091831 A NO20091831 A NO 20091831A NO 20091831 L NO20091831 L NO 20091831L
- Authority
- NO
- Norway
- Prior art keywords
- present
- relates
- compounds
- indoles
- anxiety
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
Foreliggende oppfinnelse angår nye indol-2-yl-karbonyl-piperidin-derivater som Vla-reseptorantagonister, fremstilling av dem, farmasøytiske preparater inneholdende dem og anvendelse av dem som medikamenter. De aktive forbindelser ifølge foreliggende oppfinnelse er anvendelige for forebygging og/eller behandling av angst og depressive lidelser og andre sykdommer. Foreliggende oppfinnelse angår forbindelser med den generelle formel (I), A: (a), (b), (c) hvor Rtil R, Rtil,', R', X og Y er som definert i beskrivelsen.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06125666 | 2006-12-08 | ||
PCT/EP2007/062983 WO2008068183A1 (en) | 2006-12-08 | 2007-11-29 | Indoles |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20091831L true NO20091831L (no) | 2009-07-07 |
Family
ID=39272414
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20091831A NO20091831L (no) | 2006-12-08 | 2009-05-11 | Indoler |
Country Status (19)
Country | Link |
---|---|
US (3) | US8026259B2 (no) |
EP (1) | EP2102186B1 (no) |
JP (1) | JP2010511659A (no) |
KR (2) | KR20090078367A (no) |
CN (1) | CN101547914A (no) |
AR (1) | AR064138A1 (no) |
AT (1) | ATE527249T1 (no) |
AU (1) | AU2007328993B2 (no) |
BR (1) | BRPI0720440A2 (no) |
CA (1) | CA2670139A1 (no) |
CL (1) | CL2007003504A1 (no) |
ES (1) | ES2371784T3 (no) |
IL (1) | IL198633A0 (no) |
MX (1) | MX2009005544A (no) |
NO (1) | NO20091831L (no) |
PE (1) | PE20081574A1 (no) |
RU (1) | RU2009120136A (no) |
TW (1) | TWI349667B (no) |
WO (1) | WO2008068183A1 (no) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8980924B2 (en) | 2010-11-24 | 2015-03-17 | The Trustees Of Columbia University In The City Of New York | Non-retinoid RBP4 antagonist for treatment of age-related macular degeneration and stargardt disease |
US9333202B2 (en) | 2012-05-01 | 2016-05-10 | The Trustees Of Columbia University In The City Of New York | Non-retinoid antagonists for treatment of age-related macular degeneration and stargardt disease |
US9944644B2 (en) | 2013-03-14 | 2018-04-17 | The Trustees Of Columbia University In The City Of New York | Octahydropyrrolopyrroles their preparation and use |
US10273243B2 (en) | 2013-03-14 | 2019-04-30 | The Trustees Of Columbia University In The City Of New York | 4-phenylpiperidines, their preparation and use |
ES2700541T3 (es) | 2013-03-14 | 2019-02-18 | Univ Columbia | Octahidrociclopentapirroles, su preparación y uso |
US9938291B2 (en) | 2013-03-14 | 2018-04-10 | The Trustess Of Columbia University In The City Of New York | N-alkyl-2-phenoxyethanamines, their preparation and use |
WO2015168286A1 (en) | 2014-04-30 | 2015-11-05 | The Trustees Of Columbia University In The City Of New York | Substituted 4-phenylpiperidines, their preparaiton and use |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CO5150201A1 (es) | 1998-09-07 | 2002-04-29 | Hoffmann La Roche | Derivados de piperidina |
HUP0302016A2 (hu) | 2000-05-12 | 2003-09-29 | Solvay Pharmaceuticals B.V. | Piperazin és piperidinvegyületek, ezeket tartalmazó gyógyászati készítmények, eljárás elżállításukra és alkalmazásuk |
HU227197B1 (en) * | 2000-10-24 | 2010-10-28 | Richter Gedeon Nyrt | Nmda receptor antagonist carboxylic acid amide derivatives and pharmaceutical compositions containing them |
CA2501539A1 (en) | 2002-10-17 | 2004-04-29 | Amgen Inc. | Benzimidazole derivatives and their use as vanilloid receptor ligands |
US20070197603A1 (en) * | 2003-07-04 | 2007-08-23 | Alessandra Consonni | Substituted indole ligands for the orl-1 receptor |
RU2422442C2 (ru) * | 2005-07-29 | 2011-06-27 | Ф. Хоффманн-Ля Рош Аг | Производные индол-3-ил-карбонил-пиперидина и пиперазина |
BRPI0720441A2 (pt) * | 2006-12-08 | 2014-01-07 | Hoffmann La Roche | Indóis que atuam como antagonistas de receptor v1a |
-
2007
- 2007-11-29 CA CA002670139A patent/CA2670139A1/en not_active Abandoned
- 2007-11-29 AT AT07847500T patent/ATE527249T1/de active
- 2007-11-29 AU AU2007328993A patent/AU2007328993B2/en not_active Expired - Fee Related
- 2007-11-29 EP EP07847500A patent/EP2102186B1/en not_active Not-in-force
- 2007-11-29 RU RU2009120136/04A patent/RU2009120136A/ru unknown
- 2007-11-29 ES ES07847500T patent/ES2371784T3/es active Active
- 2007-11-29 JP JP2009539705A patent/JP2010511659A/ja active Pending
- 2007-11-29 BR BRPI0720440-0A patent/BRPI0720440A2/pt not_active IP Right Cessation
- 2007-11-29 WO PCT/EP2007/062983 patent/WO2008068183A1/en active Application Filing
- 2007-11-29 KR KR1020097011626A patent/KR20090078367A/ko active IP Right Grant
- 2007-11-29 CN CNA2007800448800A patent/CN101547914A/zh active Pending
- 2007-11-29 MX MX2009005544A patent/MX2009005544A/es active IP Right Grant
- 2007-11-29 KR KR1020127007708A patent/KR20120055716A/ko not_active Application Discontinuation
- 2007-11-30 US US11/947,906 patent/US8026259B2/en not_active Expired - Fee Related
- 2007-11-30 US US11/947,877 patent/US20080139552A1/en not_active Abandoned
- 2007-11-30 US US11/947,851 patent/US8076360B2/en not_active Expired - Fee Related
- 2007-12-05 AR ARP070105429A patent/AR064138A1/es not_active Application Discontinuation
- 2007-12-05 CL CL200703504A patent/CL2007003504A1/es unknown
- 2007-12-06 TW TW096146546A patent/TWI349667B/zh not_active IP Right Cessation
- 2007-12-07 PE PE2007001747A patent/PE20081574A1/es not_active Application Discontinuation
-
2009
- 2009-05-07 IL IL198633A patent/IL198633A0/en unknown
- 2009-05-11 NO NO20091831A patent/NO20091831L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
RU2009120136A (ru) | 2011-01-20 |
MX2009005544A (es) | 2009-06-05 |
EP2102186B1 (en) | 2011-10-05 |
BRPI0720440A2 (pt) | 2014-01-07 |
AR064138A1 (es) | 2009-03-18 |
WO2008068183A1 (en) | 2008-06-12 |
CA2670139A1 (en) | 2008-06-12 |
US20080139550A1 (en) | 2008-06-12 |
JP2010511659A (ja) | 2010-04-15 |
CN101547914A (zh) | 2009-09-30 |
KR20090078367A (ko) | 2009-07-17 |
ES2371784T3 (es) | 2012-01-10 |
US8076360B2 (en) | 2011-12-13 |
US20080139552A1 (en) | 2008-06-12 |
AU2007328993A1 (en) | 2008-06-12 |
CL2007003504A1 (es) | 2008-07-04 |
US8026259B2 (en) | 2011-09-27 |
TW200831502A (en) | 2008-08-01 |
KR20120055716A (ko) | 2012-05-31 |
TWI349667B (en) | 2011-10-01 |
IL198633A0 (en) | 2010-02-17 |
EP2102186A1 (en) | 2009-09-23 |
PE20081574A1 (es) | 2008-11-22 |
AU2007328993B2 (en) | 2012-05-10 |
ATE527249T1 (de) | 2011-10-15 |
US20080139549A1 (en) | 2008-06-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |