NO20072978L - Nye betuinderivater, preparat derav og anvendelse derav - Google Patents

Nye betuinderivater, preparat derav og anvendelse derav

Info

Publication number
NO20072978L
NO20072978L NO20072978A NO20072978A NO20072978L NO 20072978 L NO20072978 L NO 20072978L NO 20072978 A NO20072978 A NO 20072978A NO 20072978 A NO20072978 A NO 20072978A NO 20072978 L NO20072978 L NO 20072978L
Authority
NO
Norway
Prior art keywords
derivatives
betuene
preparation
new
relates
Prior art date
Application number
NO20072978A
Other languages
English (en)
Inventor
Thomas Stephen Coulter
Carl T Wild
Gary N Robinson
Mark Ashton
Thomas Russell
Christian Montalbetti
Filippo Magaraci
Robert James Townsend
Theodore John Nitz
Original Assignee
Panacos Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Panacos Pharmaceuticals Inc filed Critical Panacos Pharmaceuticals Inc
Publication of NO20072978L publication Critical patent/NO20072978L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J53/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by condensation with a carbocyclic rings or by formation of an additional ring by means of a direct link between two ring carbon atoms, including carboxyclic rings fused to the cyclopenta(a)hydrophenanthrene skeleton are included in this class

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Foreliggende oppfinnelse angår nye, syntetiske derivater av betulin og anvendelse av slike derivater som farmasøytiske midler. Foreliggende oppfinnelse angår nye forbindelser med formel (I) eller et farmasøytisk akseptabelt salt eller prodrug derav.
NO20072978A 2004-11-12 2007-06-11 Nye betuinderivater, preparat derav og anvendelse derav NO20072978L (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62688604P 2004-11-12 2004-11-12
US65308005P 2005-02-16 2005-02-16
PCT/US2005/041043 WO2006053255A2 (en) 2004-11-12 2005-11-14 Novel betulin derivatives, preparation thereof and use thereof

Publications (1)

Publication Number Publication Date
NO20072978L true NO20072978L (no) 2007-06-27

Family

ID=36337281

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20072978A NO20072978L (no) 2004-11-12 2007-06-11 Nye betuinderivater, preparat derav og anvendelse derav

Country Status (14)

Country Link
US (1) US20060205697A1 (no)
EP (1) EP1828223A4 (no)
JP (1) JP2008519857A (no)
KR (1) KR20070101851A (no)
AR (1) AR051768A1 (no)
AU (1) AU2005304323A1 (no)
BR (1) BRPI0517343A (no)
CA (1) CA2587498A1 (no)
IL (1) IL183102A0 (no)
MX (1) MX2007005694A (no)
NO (1) NO20072978L (no)
RU (1) RU2007121729A (no)
TW (1) TW200628161A (no)
WO (1) WO2006053255A2 (no)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090023698A1 (en) * 2005-03-29 2009-01-22 Krasutsky Pavel A Methods of manufacturing bioactive 3-esters of betulinic aldehyde and betulinic acid
BRPI0610668A2 (pt) * 2005-04-12 2010-07-13 Panacos Pharmaceuticals Inc polimorfas de di-n-metil-d-glucamina do ácido 3-o-(3',3'-dimetilsuccinil) betulìnico
KR20080017334A (ko) * 2005-06-22 2008-02-26 미리어드 제네틱스, 인크. 항바이러스 화합물
FI121468B (fi) * 2006-06-07 2010-11-30 Valtion Teknillinen Betuliiniperäiset yhdisteet antimikrobisina aineina
US20080039428A1 (en) * 2006-06-29 2008-02-14 Panacos Pharmaceuticals, Inc. Antiretroviral combination therapy
WO2008097341A2 (en) * 2006-07-26 2008-08-14 Myriad Genetics, Inc. Antiviral compounds and use thereof
CZ300722B6 (cs) * 2006-09-27 2009-07-22 Univerzita Karlova v Praze, Prírodovedecká fakulta Zpusob prípravy inkluzního komplexu pentacyklických a tetracyklických terpenoidu a farmaceutického prostredku obsahujícího tento inkluzní komplex, inkluzní komplex pentacyklického nebo tetracyklického terpenoidu a farmaceutický prostredek obsahující
WO2008127364A2 (en) * 2006-10-13 2008-10-23 Myriad Genetics, Inc. Antiviral compounds and use thereof
US20090105203A1 (en) * 2006-10-16 2009-04-23 Myriad Genetics, Incorporated Compounds for treating viral infections
US9505800B2 (en) 2006-11-03 2016-11-29 Myrexis, Inc. Extended triterpene derivatives
US20110152229A1 (en) * 2006-11-22 2011-06-23 Duke University Betulinic acid derivatives as anti-hiv agents
EP2231163A4 (en) * 2007-12-04 2012-10-31 Myriad Pharmaceuticals Inc COMPOUNDS AND THEIR THERAPEUTIC USE
JP2011508748A (ja) * 2008-01-03 2011-03-17 バイロケム ファーマ インコーポレイテッド 新規のルパン誘導体
US8269026B2 (en) * 2008-01-03 2012-09-18 Vertex Pharmaceuticals Incorporated Lupane derivatives useful for treating HIV
WO2009100532A1 (en) * 2008-02-14 2009-08-20 Virochem Pharma Inc. NOVEL 17ß LUPANE DERIVATIVES
MD4009C2 (ro) * 2008-07-15 2010-08-31 Институт Химии Академии Наук Молдовы Utilizarea 1-metil-4-(N-metilaminobutil-4)-β-carbolinei în calitate de remediu antituberculos
KR101027217B1 (ko) * 2009-03-11 2011-04-06 주식회사 바이오폴리메드 신규한 수용성 베툴린 유도체, 이의 제조방법 및 이를 포함하는 주름 개선용 화장료 조성물
KR101061911B1 (ko) * 2009-04-01 2011-09-02 주식회사 페라온 페길레이션된 베튤린 유도체 및 그를 포함하는 화장료 조성물
WO2010132334A1 (en) * 2009-05-15 2010-11-18 The University Of North Carolina At Chapel Hill 3,28-disubstituted betulinic acid derivatives as anti-hiv agents
US9067966B2 (en) * 2009-07-14 2015-06-30 Hetero Research Foundation, Hetero Drugs Ltd. Lupeol-type triterpene derivatives as antivirals
US8802727B2 (en) * 2009-07-14 2014-08-12 Hetero Research Foundation, Hetero Drugs Limited Pharmaceutically acceptable salts of betulinic acid derivatives
KR20120138761A (ko) * 2010-02-11 2012-12-26 글락소스미스클라인 엘엘씨 베툴린의 유도체
RS54239B1 (en) * 2010-06-04 2015-12-31 Bristol-Myers Squibb Company C-28 MODIFIED C-3 BETULINIC ACID DERIVATIVES AS INHIBITORS OF HIV AGING
ES2612452T3 (es) * 2010-06-04 2017-05-17 VIIV Healthcare UK (No.5) Limited Derivados de ácido betulínico C-3 modificados como inhibidores de la maduración del VIH
RU2448115C1 (ru) * 2010-12-20 2012-04-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Новосибирский национальный исследовательский государственный университет" (Новосибирский государственный университет (НГУ) Гидрированная бетулоновая кислота и ее амиды как противоопухолевые средства тритерпеновой природы
US8846647B2 (en) * 2011-01-31 2014-09-30 Bristol-Myers Squibb Company C-17 and C-3 modified triterpenoids with HIV maturation inhibitory activity
EP2670764B1 (en) 2011-01-31 2015-09-02 Bristol-Myers Squibb Company C-28 amines of c-3 modified betulinic acid derivatives as hiv maturation inhibitors
ES2553900T3 (es) * 2011-09-12 2015-12-14 Centre National De La Recherche Scientifique (Cnrs) Derivados del ácido 3-O-(3',3'-dimetilsuccinil)-betulínico
WO2013043778A1 (en) 2011-09-21 2013-03-28 Bristol-Myers Squibb Company Novel betulinic acid derivatives with antiviral activity
US9340513B2 (en) 2011-12-14 2016-05-17 Glaxosmithkline Llc Propenoate derivatives of betulin
JO3387B1 (ar) 2011-12-16 2019-03-13 Glaxosmithkline Llc مشتقات بيتولين
US8906889B2 (en) 2012-02-15 2014-12-09 Bristol-Myers Squibb Company C-3 cycloalkenyl triterpenoids with HIV maturation inhibitory activity
US8889854B2 (en) * 2012-05-07 2014-11-18 Bristol-Myers Squibb Company C-17 bicyclic amines of triterpenoids with HIV maturation inhibitory activity
CA2893959A1 (en) 2012-12-14 2014-06-19 Shenshen Cai Pharmaceutical compositions
US9637516B2 (en) 2012-12-31 2017-05-02 Hetero Research Foundation Betulinic acid proline derivatives as HIV inhibitors
CN105121454A (zh) 2013-02-06 2015-12-02 百时美施贵宝公司 具有hiv成熟抑制活性的c-19经修饰的三萜类化合物
US9249180B2 (en) 2013-02-25 2016-02-02 Bristol-Myers Squibb Company C-3 alkyl and alkenyl modified betulinic acid derivatives
UA120927C2 (uk) 2014-04-11 2020-03-10 Віів Гелскер Юк (Но.4) Лімітед Тритерпеноїди, заміщені в положенні 3 неароматичним кільцем, яке несе галогеналкільний замісник, з інгібуючою активністю щодо дозрівання віл
WO2015195776A1 (en) 2014-06-19 2015-12-23 Bristol-Myers Squibb Company Betulinic acid derivatives with hiv maturation inhibitory activity
US20170129916A1 (en) * 2014-06-26 2017-05-11 Hetero Research Foundation Novel betulinic proline imidazole derivatives as hiv inhibitors
WO2015198263A2 (en) * 2014-06-26 2015-12-30 Hetero Research Foundation Novel betulinic proline substituted derivatives as hiv inhibitors
KR20170056702A (ko) 2014-09-26 2017-05-23 글락소스미스클라인 인털렉츄얼 프로퍼티 (넘버 2) 리미티드 지효성 약제학적 조성물
JP2017533937A (ja) 2014-11-14 2017-11-16 ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド オキソルペン誘導体
WO2016077569A1 (en) 2014-11-14 2016-05-19 Bristol-Myers Squibb Company C17-aryl substituted betulinic acid analogs
US10301452B2 (en) * 2014-11-24 2019-05-28 Basf Se Mono-azide compound for photo-induced cross-linking polymer strands
MA40886B1 (fr) 2015-02-09 2020-03-31 Hetero Research Foundation Nouveau triterpénone en c-3 avec des dérivés d'amide inverse en c-28 en tant qu'inhibiteurs du vih
US10370405B2 (en) 2015-03-16 2019-08-06 Hetero Labs Limited C-3 novel triterpenone with C-28 amide derivatives as HIV inhibitors
WO2017017630A1 (en) * 2015-07-28 2017-02-02 Hetero Research Foundation Novel betulinic substituted amide derivatives as hiv inhibitors
WO2017064628A1 (en) * 2015-10-13 2017-04-20 Hetero Research Foundation C-3 novel triterpenone with c-28 urea derivatives as hiv inhibitors
AR107512A1 (es) 2016-02-04 2018-05-09 VIIV HEALTHCARE UK Nº 5 LTD Triterpenoides modificados en c-3 y c-17 como inhibidores del vih-1
PT3924361T (pt) 2019-02-11 2023-12-12 Hetero Labs Ltd Novos derivados de triterpeno como inibidores do vih

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6448392B1 (en) * 1985-03-06 2002-09-10 Chimerix, Inc. Lipid derivatives of antiviral nucleosides: liposomal incorporation and method of use
US6599887B2 (en) * 1988-07-07 2003-07-29 Chimerix, Inc. Methods of treating viral infections using antiviral liponucleotides
FR2683531B1 (fr) * 1991-11-13 1993-12-31 Rhone Poulenc Rorer Sa Nouveaux derives du lupane, leur preparation et les compositions pharmaceutiques qui les contiennent.
US5643884A (en) * 1993-08-09 1997-07-01 Glycomed Incorporated Lupane triterpenoid derivatives
US6787527B1 (en) * 1994-11-10 2004-09-07 Duke University Methods of preventing and treating HIV infection
US5696277A (en) * 1994-11-15 1997-12-09 Karl Y. Hostetler Antiviral prodrugs
US5679828A (en) * 1995-06-05 1997-10-21 Biotech Research Labs, Inc. Betulinic acid and dihydrobetulinic acid derivatives and uses therefor
US6730679B1 (en) * 1996-03-22 2004-05-04 Smithkline Beecham Corporation Pharmaceutical formulations
WO1998055497A1 (en) * 1997-06-04 1998-12-10 Cornell Research Foundation, Inc. Betulinol derivatives
EP1068219B1 (en) * 1998-03-02 2006-12-20 The University of North Carolina at Chapel Hill Acylated betulin and dihydrobetulin derivatives, preparation thereof and use thereof
AU2001294959A1 (en) * 2000-09-29 2002-04-08 Robert M. Carlson Triterpenes having antibacterial activity
ATE420099T1 (de) * 2003-02-11 2009-01-15 Novelix Pharmaceuticals Inc Medikament zur wachstumsinhibierung von tumoren
US7026305B2 (en) * 2003-04-14 2006-04-11 Meharry Medical College Anti-HIV agents with dual sites of action
US20090023698A1 (en) * 2005-03-29 2009-01-22 Krasutsky Pavel A Methods of manufacturing bioactive 3-esters of betulinic aldehyde and betulinic acid

Also Published As

Publication number Publication date
EP1828223A2 (en) 2007-09-05
RU2007121729A (ru) 2008-12-20
TW200628161A (en) 2006-08-16
EP1828223A4 (en) 2009-03-11
WO2006053255A2 (en) 2006-05-18
CA2587498A1 (en) 2006-05-18
US20060205697A1 (en) 2006-09-14
AU2005304323A1 (en) 2006-05-18
BRPI0517343A (pt) 2008-10-07
AR051768A1 (es) 2007-02-07
IL183102A0 (en) 2007-09-20
MX2007005694A (es) 2007-07-09
WO2006053255A3 (en) 2007-01-18
KR20070101851A (ko) 2007-10-17
JP2008519857A (ja) 2008-06-12

Similar Documents

Publication Publication Date Title
NO20072978L (no) Nye betuinderivater, preparat derav og anvendelse derav
NO20070224L (no) 2-karbamid-4-fenyltiazolderivater, fremstilling og terapeutisk anvendelse derav
NO20090835L (no) Nye HIV-reverstranskriptaseinhibitorer
NO20080865L (no) Spirokromanonderivater som acetyl-koenzym-A-karboksylase(ACC)inhibitorer
NO20055568L (no) Substituerte 1,4-diazepiner og anvendelser derav
NO20083434L (no) Benzamid- og heteroarenderivater
NO20072371L (no) Kinuklidinderivater og deres anvendelse som muskarine M3-reseptorantagonister
NO20062021L (no) Omleirede pentanoler, fremgangsmpte for fremstilling av dette, og deres anvendelse som antiflogistika
DE602004008098D1 (de) Substituierte 2h-ä1,2,4ütriazoloä4,3-aüpyrazine als gsk-3-inhibitoren
EA201390908A1 (ru) Производные бицикло[3.2.1]октиламида и их применение
EA200970585A1 (ru) Бензамидные производные как агонисты ер-рецепторов
NO20074592L (no) Acetylenyl-pyrazolo-pyrimidinderivater som mGluR2-antagonister
NO20091553L (no) Fenylderivater og deres anvendelse som immunmodulatorer
NO20060195L (no) Kinolylamidderivater som CCR-5-antagonister
WO2007135527A3 (en) Benzimidazolyl compounds
NO20073876L (no) Pyrazolopyrimidinderivater som mGluR2-antagonister
NO20092033L (no) Nye forbindelser
EA201001669A1 (ru) Замещенные пиримидин-5-карбоксамиды 281
NO20076648L (no) Novel thiophene derivatives
NO20081970L (no) Sulfonamidderivat med PGD2-reseptorantagonistaktivitet
SE0302760D0 (sv) New compounds
SE0400284D0 (sv) Novel compounds
MA32812B1 (fr) Composition pharmaceutique d'un inhibiteur puissant du vhc pour une administration orale
WO2007017728A3 (en) Novel heterocyclic compounds
NO20083708L (no) 4-Fenyl-tiazol-5-karboksylsyre og 4-fenyl-tiazol-5-karboksylmider som PLK1-inhibitorer

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application