ES2193875A1 - Derivados de benzoxazinona, su preparacion y su aplicacion como medicamentos. - Google Patents
Derivados de benzoxazinona, su preparacion y su aplicacion como medicamentos.Info
- Publication number
- ES2193875A1 ES2193875A1 ES200200813A ES200200813A ES2193875A1 ES 2193875 A1 ES2193875 A1 ES 2193875A1 ES 200200813 A ES200200813 A ES 200200813A ES 200200813 A ES200200813 A ES 200200813A ES 2193875 A1 ES2193875 A1 ES 2193875A1
- Authority
- ES
- Spain
- Prior art keywords
- medicaments
- preparation
- compounds
- general formula
- benzoxazinone derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title abstract 2
- HQQTZCPKNZVLFF-UHFFFAOYSA-N 4h-1,2-benzoxazin-3-one Chemical class C1=CC=C2ONC(=O)CC2=C1 HQQTZCPKNZVLFF-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/536—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Emergency Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Nutrition Science (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
Derivados de benzoxazinona, su preparación y su aplicación como medicamentos. La presente invención se refiere a nuevos compuestos de fórmula general (I), en la cual: R1 representa hidrógeno, halógeno, alcoxilo o un radical alquilo C1-C4; R2 representa hidrógeno, un radical alquilo C1-C4, un radical fenilo, un radical bencilo o junto con R3 puede formar parte de un heterociclo de cinco o seis miembros; R3 representa anillo bicíclico, anillo tricíclico, fenilo sustituido o fenilo sustituido por una cadena hidrocarbonada que junto con R2 forma parte de un heterociclo nitrogenado de cinco o seis miembros; A representa -CHR4- o -CHR4-CH2- R4 representa hidrógeno, un radical alquilo C1-C4 o un radical fenilo; o una de sus sales fisiológicamente aceptables; así como a sus sales fisiológicamente aceptables, a los procedimientos para su preparación, a su aplicación como medicamentos para la prevención o el tratamiento de varios trastornos del Sistema Nervioso Central, y en particular la obesidad, la ansiedad, la depresión, los trastornos cognitivos y otros trastornos mediados por el receptor NPY5 en mamíferos, y a las composiciones farmacéuticas que los contienen.
Priority Applications (40)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200200813A ES2193875B2 (es) | 2002-04-09 | 2002-04-09 | Derivados de benzoxazinona, su preparacion y su aplicacion como medicamentos. |
ARP030101184A AR039256A1 (es) | 2002-04-09 | 2003-04-04 | Derivados de benzoxazinona, su preparacion y su aplicacion como medicamentos |
US10/407,343 US7056914B2 (en) | 2002-04-09 | 2003-04-04 | Benzoxazinone-derived compounds, their preparation and use as medicaments |
BR0309083-3A BR0309083A (pt) | 2002-04-09 | 2003-04-08 | Compostos derivados de benzoxazinona, sua preparação e uso como medicamentos |
IL16444203A IL164442A0 (en) | 2002-04-09 | 2003-04-08 | Benzoxazinone-derived compounds, their preparationand use as medicaments |
AU2003222804A AU2003222804A1 (en) | 2002-04-09 | 2003-04-08 | Benzoxazinone-derived compounds, their preparation and use as medicaments |
RU2004133041/04A RU2004133041A (ru) | 2002-04-09 | 2003-04-08 | Производные бензоксазинона, их получение и применение в качестве лекарственных средств |
KR10-2004-7016130A KR20050008679A (ko) | 2002-04-09 | 2003-04-08 | 벤조옥사지논-유도 화합물, 그 제조방법 및 약제로서의 용도 |
CN038128853A CN1659164A (zh) | 2002-04-09 | 2003-04-08 | 苯并噁嗪酮衍生的化合物、它们的制备方法和作为药物的用途 |
PCT/EP2003/003629 WO2003084952A1 (en) | 2002-04-09 | 2003-04-08 | Benzoxazinone-derived compounds, their preparation und use as medicaments |
JP2003582149A JP2005529866A (ja) | 2002-04-09 | 2003-04-08 | ベンゾキサジノン誘導化合物、その調製および薬剤としての使用 |
MXPA04009889A MXPA04009889A (es) | 2002-04-09 | 2003-04-08 | Compuestos derivados de benzoxazinona, su preparacion y su aplicacion como medicamentos. |
US10/409,235 US7041665B2 (en) | 2002-04-09 | 2003-04-08 | Benzoxazinone derivatives, their preparation and use as medicaments |
AT03718741T ATE489382T1 (de) | 2002-04-09 | 2003-04-08 | Benzoxazinonderivate, deren herstellung und verwendung als arzneimittel |
ES03718741T ES2356815T3 (es) | 2002-04-09 | 2003-04-08 | Derivados de benzoxazinona, su preparación y su aplicación como medicamentos. |
PL03372537A PL372537A1 (en) | 2002-04-09 | 2003-04-08 | Benzoxazinone-derived compounds, their preparation und use as medicaments |
NZ536167A NZ536167A (en) | 2002-04-09 | 2003-04-08 | Benzoxazinone-derived compounds, their preparation and use as medicaments |
DE60335094T DE60335094D1 (de) | 2002-04-09 | 2003-04-08 | Benzoxazinonderivate, deren herstellung und verwendung als arzneimittel |
ARP030101235A AR048567A1 (es) | 2002-04-09 | 2003-04-08 | Derivados de benzoxazinona, su preparacion y composiciones farmaceuticas. |
CA002481701A CA2481701A1 (en) | 2002-04-09 | 2003-04-08 | Benzoxazinone-derived compounds, their preparation and use as medicaments |
EP03718741A EP1497285B1 (en) | 2002-04-09 | 2003-04-08 | Benzoxazinone-derived compounds, their preparation und use as medicaments |
DK03712152T DK1500654T3 (da) | 2002-04-09 | 2003-04-09 | Benzoxazinonderivater, fremstilling deraf og anvendelse deraf som lægemidler |
SI200330210T SI1500654T1 (sl) | 2002-04-09 | 2003-04-09 | Benzoksazinonski derivati, priprava in uporaba le-teh kot zdravila |
DE60303440T DE60303440T2 (de) | 2002-04-09 | 2003-04-09 | Benzoxazinonderivate, deren herstellung und deren verwendung als medikamente |
PT03712152T PT1500654E (pt) | 2002-04-09 | 2003-04-09 | Derivados de benzoxazinona, sua preparacao e utilizacao como medicamentos |
EP03712152A EP1500654B1 (en) | 2002-04-09 | 2003-04-09 | Benzoxazinone derivatives, the preparation and use thereof as medicaments |
PCT/ES2003/000162 WO2003084939A1 (es) | 2002-04-09 | 2003-04-09 | Derivados de benzoxazinona, su preparación y su aplicación como medicamentos |
AT03712152T ATE316966T1 (de) | 2002-04-09 | 2003-04-09 | Benzoxazinonderivate, deren herstellung und deren verwendung als medikamente |
AU2003216934A AU2003216934A1 (en) | 2002-04-09 | 2003-04-09 | Benzoxazinone derivatives, the preparation and use thereof as medicaments |
ES03712152T ES2258219T3 (es) | 2002-04-09 | 2003-04-09 | Derivados de benzoxazinona, su preparacion y su uso como medicamentos. |
UA20041109155A UA79460C2 (en) | 2002-04-09 | 2003-08-04 | Benzoxazinone derived compounds, method for their preparation, intermediate, medicaments containing these compounds |
HR20040919A HRP20040919A2 (en) | 2002-04-09 | 2004-10-05 | Benzoxazinone-derived compounds, their preparationund use as medicaments |
IS7491A IS7491A (is) | 2002-04-09 | 2004-10-06 | Benzoxazínon-afleidd efnasambönd, framleiðsla þeirra og notkun sem lyf |
EC2004005353A ECSP045353A (es) | 2002-04-09 | 2004-10-08 | Derivados de benzoxazinona, su preparación y aplicación como medicamentos |
MA27902A MA27692A1 (fr) | 2002-04-09 | 2004-10-08 | Composes derives de benzoxazinone, leur preparation et utilisation comme medicaments |
TNP2004000203A TNSN04203A1 (en) | 2002-04-09 | 2004-10-08 | Benzoxazinone-derived compounds, their preparation and use as medicaments |
NO20044322A NO20044322L (no) | 2002-04-09 | 2004-10-12 | Benzoksanon-avledede forbindelser, deres fremstilling og anvendelse som medikament |
ZA200408275A ZA200408275B (en) | 2002-04-09 | 2004-10-13 | Benzoxazinone-derived compounds their preparation and use as medicaments |
HK05102067.9A HK1069820A1 (en) | 2002-04-09 | 2005-03-09 | Benzoxazinone-derived compounds, their preparation und use as medicaments |
US11/338,363 US7514429B2 (en) | 2002-04-09 | 2006-01-24 | Benzoxazinone-derived compounds, their preparation and use as medicaments |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES200200813A ES2193875B2 (es) | 2002-04-09 | 2002-04-09 | Derivados de benzoxazinona, su preparacion y su aplicacion como medicamentos. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2193875A1 true ES2193875A1 (es) | 2003-11-01 |
ES2193875B2 ES2193875B2 (es) | 2005-03-01 |
Family
ID=28686085
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES200200813A Expired - Fee Related ES2193875B2 (es) | 2002-04-09 | 2002-04-09 | Derivados de benzoxazinona, su preparacion y su aplicacion como medicamentos. |
ES03718741T Expired - Lifetime ES2356815T3 (es) | 2002-04-09 | 2003-04-08 | Derivados de benzoxazinona, su preparación y su aplicación como medicamentos. |
ES03712152T Expired - Lifetime ES2258219T3 (es) | 2002-04-09 | 2003-04-09 | Derivados de benzoxazinona, su preparacion y su uso como medicamentos. |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES03718741T Expired - Lifetime ES2356815T3 (es) | 2002-04-09 | 2003-04-08 | Derivados de benzoxazinona, su preparación y su aplicación como medicamentos. |
ES03712152T Expired - Lifetime ES2258219T3 (es) | 2002-04-09 | 2003-04-09 | Derivados de benzoxazinona, su preparacion y su uso como medicamentos. |
Country Status (29)
Country | Link |
---|---|
US (3) | US7056914B2 (es) |
EP (2) | EP1497285B1 (es) |
JP (1) | JP2005529866A (es) |
KR (1) | KR20050008679A (es) |
CN (1) | CN1659164A (es) |
AR (2) | AR039256A1 (es) |
AT (2) | ATE489382T1 (es) |
AU (2) | AU2003222804A1 (es) |
BR (1) | BR0309083A (es) |
CA (1) | CA2481701A1 (es) |
DE (2) | DE60335094D1 (es) |
DK (1) | DK1500654T3 (es) |
EC (1) | ECSP045353A (es) |
ES (3) | ES2193875B2 (es) |
HK (1) | HK1069820A1 (es) |
HR (1) | HRP20040919A2 (es) |
IL (1) | IL164442A0 (es) |
IS (1) | IS7491A (es) |
MA (1) | MA27692A1 (es) |
MX (1) | MXPA04009889A (es) |
NO (1) | NO20044322L (es) |
NZ (1) | NZ536167A (es) |
PL (1) | PL372537A1 (es) |
PT (1) | PT1500654E (es) |
RU (1) | RU2004133041A (es) |
TN (1) | TNSN04203A1 (es) |
UA (1) | UA79460C2 (es) |
WO (2) | WO2003084952A1 (es) |
ZA (1) | ZA200408275B (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2193875B2 (es) * | 2002-04-09 | 2005-03-01 | Laboratorios Del Dr. Esteve, S.A. | Derivados de benzoxazinona, su preparacion y su aplicacion como medicamentos. |
ES2228268B1 (es) * | 2003-07-30 | 2006-07-01 | Laboratorios Del Dr. Esteve, S.A. | Combinacion de sustancias activas conteniendo al menos un compuesto con afinidad por el receptor del neuropeptido y (npy) y al menos un compuesto con afinidad por el receptor 5-ht6. |
ES2228267B1 (es) * | 2003-07-30 | 2006-07-01 | Laboratorios Del Dr. Esteve, S.A. | Combinacion de sustancias activas conteniendo al menos un compuesto con afinidad por el receptor del neuropeptido y (npy) y al menos un compuesto con afinidad por el receptor 5-ht6. |
ES2222833B1 (es) * | 2003-07-30 | 2006-03-01 | Laboratorios Del Dr. Esteve, S.A. | Compuestos piperidinicos 1,4-disustituidos, su preparacion y su uso como medicamentos. |
WO2005090340A1 (ja) * | 2004-03-22 | 2005-09-29 | Banyu Pharmaceutical Co., Ltd. | ピペリジン-1-カルボキサミド誘導体 |
US8147853B2 (en) | 2005-02-15 | 2012-04-03 | The Procter & Gamble Company | Personal care compositions containing hydrophobically modified non-platelet particles |
CA2590433C (en) * | 2005-03-21 | 2012-09-18 | The Procter & Gamble Company | Multi-phase personal care composition comprising visually distinct phases |
MX2007012898A (es) * | 2005-04-13 | 2007-12-10 | Procter & Gamble | Composicion de fases multiples estructurada para el cuidado personal que comprende surfactantes anionicos ramificados. |
US7820609B2 (en) | 2005-04-13 | 2010-10-26 | The Procter & Gamble Company | Mild, structured, multi-phase personal cleansing compositions comprising density modifiers |
ITMI20050909A1 (it) * | 2005-05-19 | 2006-11-20 | Acraf | Uso di un benzoil derivato dal 3-ammino-carbazolo per la produzione di un farmaco per il trattamento di un disturbo associato alla produzione di prostaglandina e2-pge2- |
US20120015009A9 (en) * | 2005-06-07 | 2012-01-19 | The Procter & Gamble Company | Multi-phased personal care composition comprising a blooming perfume composition |
ITMI20051523A1 (it) * | 2005-08-03 | 2007-02-04 | Acraf | Composto del 3-ammino-carbazolo composizione farmaceutica che lo contiene e metodo per prepararlo |
CN101326106A (zh) * | 2005-12-08 | 2008-12-17 | 宝洁公司 | 包括邻近表面形貌定位的模内标签的容器 |
US20070167338A1 (en) * | 2006-01-09 | 2007-07-19 | Mchugh Colin M | Multiphase personal care compositions comprising beads |
US8104616B2 (en) | 2006-02-11 | 2012-01-31 | The Procter & Gamble Company | Clamshell package for holding and displaying consumer products |
US8153144B2 (en) * | 2006-02-28 | 2012-04-10 | The Proctor & Gamble Company | Stable multiphase composition comprising alkylamphoacetate |
WO2008020455A2 (en) * | 2006-08-14 | 2008-02-21 | Council Of Scientific & Industrial Research | Pyrrolo[2,1-c][1,4]benzodiazepine hybrids and a process for the preparation thereof |
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