MX2009006704A - Derivados de amina triciclicos como inhibidores de proteina de tirosina cinasa. - Google Patents

Derivados de amina triciclicos como inhibidores de proteina de tirosina cinasa.

Info

Publication number
MX2009006704A
MX2009006704A MX2009006704A MX2009006704A MX2009006704A MX 2009006704 A MX2009006704 A MX 2009006704A MX 2009006704 A MX2009006704 A MX 2009006704A MX 2009006704 A MX2009006704 A MX 2009006704A MX 2009006704 A MX2009006704 A MX 2009006704A
Authority
MX
Mexico
Prior art keywords
new compounds
compounds
cancer
diseases
treatment
Prior art date
Application number
MX2009006704A
Other languages
English (en)
Inventor
Miles Stuart Congreve
Valerio Berdini
Adrian Liam Gill
Gilbert Ebai Bensong
Maria Grazia Carr
Charlote Mary Griffiths-Jones
Andrew Madin
Christopher William Murray
Rajdeep Kaur Nijjar
Michael Alistair O'brien
Andrew Pike
Gordon Saxty
Emma Vickerstaffe
Richard David Taylor
Owen Callaghan
Original Assignee
Astex Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0625827A external-priority patent/GB0625827D0/en
Priority claimed from GB0719998A external-priority patent/GB0719998D0/en
Application filed by Astex Therapeutics Ltd filed Critical Astex Therapeutics Ltd
Publication of MX2009006704A publication Critical patent/MX2009006704A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Abstract

La invención se refiere a nuevos compuestos derivados heterocíclicos bicíclicos de la Fórmula (I), a composiciones farmacéuticas que comprenden los compuestos y al uso de los compuestos en el tratamiento de enfermedades, por ejemplo cáncer. Los compuestos de la Fórmula (I) son inhibidores de FGFR, VEGFR o PDGFR.
MX2009006704A 2006-12-22 2007-12-21 Derivados de amina triciclicos como inhibidores de proteina de tirosina cinasa. MX2009006704A (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US87153806P 2006-12-22 2006-12-22
GB0625827A GB0625827D0 (en) 2006-12-22 2006-12-22 New compounds
US97958207P 2007-10-12 2007-10-12
GB0719998A GB0719998D0 (en) 2007-10-12 2007-10-12 New compounds
PCT/GB2007/004960 WO2008078100A2 (en) 2006-12-22 2007-12-21 Tricyclic amine derivatives as protein tyrosine kinase inhibitors

Publications (1)

Publication Number Publication Date
MX2009006704A true MX2009006704A (es) 2009-06-30

Family

ID=39322759

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006704A MX2009006704A (es) 2006-12-22 2007-12-21 Derivados de amina triciclicos como inhibidores de proteina de tirosina cinasa.

Country Status (12)

Country Link
US (1) US8513276B2 (es)
EP (1) EP2121687B1 (es)
JP (1) JP5442449B2 (es)
CN (1) CN101679409B (es)
AU (1) AU2007337895C1 (es)
CA (1) CA2672213C (es)
CY (1) CY1117319T1 (es)
HR (1) HRP20151398T1 (es)
MX (1) MX2009006704A (es)
NO (1) NO342865B1 (es)
PL (1) PL2121687T3 (es)
WO (1) WO2008078100A2 (es)

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AU2007337895A1 (en) 2008-07-03
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EP2121687B1 (en) 2015-10-14
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JP5442449B2 (ja) 2014-03-12
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NO20092658L (no) 2009-09-17
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