AR052227A1 - Metabolitos derivados de [1,4] diazepin [ 6,7,1-ij] quinolina, metodos de preparacion y usos de los mismos - Google Patents

Metabolitos derivados de [1,4] diazepin [ 6,7,1-ij] quinolina, metodos de preparacion y usos de los mismos

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Publication number
AR052227A1
AR052227A1 ARP050104611A ARP050104611A AR052227A1 AR 052227 A1 AR052227 A1 AR 052227A1 AR P050104611 A ARP050104611 A AR P050104611A AR P050104611 A ARP050104611 A AR P050104611A AR 052227 A1 AR052227 A1 AR 052227A1
Authority
AR
Argentina
Prior art keywords
hydrogen
oso3h
hydroxy
compounds
diazepin
Prior art date
Application number
ARP050104611A
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English (en)
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Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of AR052227A1 publication Critical patent/AR052227A1/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61P25/36—Opioid-abuse
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/02—Heterocyclic radicals containing only nitrogen as ring hetero atoms
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    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/22—Pteridine radicals

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  • Obesity (AREA)
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Abstract

La presente se relaciona con los compuestos de formula (1), donde: para cada Rn y Rn', donde n es 1 hasta 8; Rn es independientemente hidrogeno, hidroxi, CH3C(O)-O, -OSO3H, o -O-G; o Rn y el correspondiente Rn', donde n 2, 3, 4, 5, 6, 7 o 8, tomados en conjunto con el carbono al cual están unidos, forman C=O; o Rn junto con el correspondiente Rn+1, donde n es 1, 2, 3, 4, 5, o 7, tomados en conjunto forman un doble enlace entre los carbonos a los cuales están unidos, y cada uno que corresponda a Rn' y R(n+1)' es independientemente hidrogeno, hidroxi, CH3C(O)-O, -OSO3H, o -O-G; G tiene la formula (2), donde el nitrogeno designado con el símbolo * puede opcionalmente formar un N-oxido; X-Y- es CH=N, CH=N(O), CH2N(O), C(O)NH o CR9HNR10; R9 es hidrogeno, hidroxilo, o -OSO3H; R10 es hidrogeno, acetilo, -SO3H, -G, o -C(O)-OG; Z es hidrogeno, hidroxi, -OSO3H, o -O-G; con la condicion que cuando Z es hidroxi, entonces uno cualquiera a) de R1, R2, R3, R4, R5, R6, R7, R8, R9, y R10 no sea hidrogeno, o b) X-Y no sea CR9NHR10; y con la condicion adicional que cuando X-Y es CHR9NR10, entonces al menos de Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, y R10 no sea H. La presente también proporciona composiciones farmacéuticas que incluyen compuestos de formula (1), los métodos de hacer tales compuestos, y métodos para utilizar tales compuestos.
ARP050104611A 2004-11-05 2005-11-03 Metabolitos derivados de [1,4] diazepin [ 6,7,1-ij] quinolina, metodos de preparacion y usos de los mismos AR052227A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US62533504P 2004-11-05 2004-11-05

Publications (1)

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AR052227A1 true AR052227A1 (es) 2007-03-07

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ID=36002462

Family Applications (1)

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ARP050104611A AR052227A1 (es) 2004-11-05 2005-11-03 Metabolitos derivados de [1,4] diazepin [ 6,7,1-ij] quinolina, metodos de preparacion y usos de los mismos

Country Status (18)

Country Link
US (1) US20060111305A1 (es)
EP (1) EP1812436A1 (es)
JP (1) JP2008519056A (es)
KR (1) KR20070084009A (es)
CN (1) CN101124225A (es)
AR (1) AR052227A1 (es)
AU (1) AU2005304757A1 (es)
BR (1) BRPI0517100A (es)
CA (1) CA2586122A1 (es)
CR (1) CR9092A (es)
GT (1) GT200500319A (es)
IL (1) IL182755A0 (es)
MX (1) MX2007005475A (es)
NO (1) NO20072165L (es)
PE (1) PE20060939A1 (es)
RU (1) RU2007116264A (es)
TW (1) TW200635926A (es)
WO (1) WO2006052886A1 (es)

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CA2586122A1 (en) 2006-05-18
NO20072165L (no) 2007-07-25
IL182755A0 (en) 2007-07-24
WO2006052886A8 (en) 2007-06-14
MX2007005475A (es) 2007-05-24
GT200500319A (es) 2006-06-02
KR20070084009A (ko) 2007-08-24
TW200635926A (en) 2006-10-16
PE20060939A1 (es) 2006-11-10
BRPI0517100A (pt) 2008-09-30
US20060111305A1 (en) 2006-05-25
JP2008519056A (ja) 2008-06-05
CR9092A (es) 2007-10-23
EP1812436A1 (en) 2007-08-01
AU2005304757A1 (en) 2006-05-18
RU2007116264A (ru) 2008-12-10
CN101124225A (zh) 2008-02-13
WO2006052886A1 (en) 2006-05-18

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