CO6331307A2 - Derivados de imidazo[1,2alfa]piridin-2-carboxamidas su preparacion y su aplicacion en terapeutica - Google Patents
Derivados de imidazo[1,2alfa]piridin-2-carboxamidas su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- CO6331307A2 CO6331307A2 CO10080876A CO10080876A CO6331307A2 CO 6331307 A2 CO6331307 A2 CO 6331307A2 CO 10080876 A CO10080876 A CO 10080876A CO 10080876 A CO10080876 A CO 10080876A CO 6331307 A2 CO6331307 A2 CO 6331307A2
- Authority
- CO
- Colombia
- Prior art keywords
- group
- alkoxy
- optionally substituted
- alkyl
- halogen atom
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Addiction (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
1.- Compuestos de fórmula (I):en la que:X e Y forman, con el átomo de nitrógeno al que están enlazados, una amina cíclica mono o bicíclica, saturada o parcialmente saturada, de 5 a 10 eslabones, que opcionalmente incluye 1 a 4 heteroátomos suplementarios escogidos entre O, S, N, opcionalmente sustituida por un átomo de halógeno, un grupo alquilo(C1-C6), un grupo alcoxi(C1-C6), ciano, NRaRb o COOR8, estando dichos grupos alquilo(C1-C6) y alcoxi(C1-C6) opcionalmente sustituidos por uno o varios átomos de halógeno;R1 representa un átomo de hidrógeno, un átomo de halógeno, un grupo alcoxi(C1-C6), un grupo alquilo(C1-C6) o NRcRd, pudiendo los grupos alquilo y alcoxi estar opcionalmente sustituidos por uno o varios átomos de halógeno, un grupo hidroxi, amino o alcoxi(:C1-C6);R2 representa uno de; los grupos siguientes: ° un grupo alquilo(C1-C6) opcionalmente sustituido por uno o varios grupos escogidos independientemente entre sí entre un gripo hidoxi, un átomo de halógeno, un grupo NRaRb, un grupo aIcoxi(C1-C6) o un grupo fenilo,° un grupo alcoxi(C1-C6) opcionalmente sustituido par uno o varios grupos escogidos independientemente entre sí entre un hidroxi, un átomo de halógeno, un grupo NRaRb,° un grupo alquenilo(C2-C6),° un grupo alquinilo (C2-C6),° un grupo -CO-R5,° un grupo -CO-NR6R7,° un grupo -CO-O-R8,° un grupo -NR9-CO-R10,° un grupo -N=CH-NRaRb,° un grupo NR11R12,° un átomo de halógeno, siendo R2, diferente de un átomo de cloro° un grupo ciano, nitro, hidroxiiminoalquilo, alcoxiiminoalquilo,° un grupo alquiltio(C1-C6),° un grupo alquilsulfinilo(C1-C6),° un grupo alquilsulfonilo(C1-C6), ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0800004A FR2925902B1 (fr) | 2008-01-02 | 2008-01-02 | DERIVES D'IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6331307A2 true CO6331307A2 (es) | 2011-10-20 |
Family
ID=39739369
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO10080876A CO6331307A2 (es) | 2008-01-02 | 2010-07-02 | Derivados de imidazo[1,2alfa]piridin-2-carboxamidas su preparacion y su aplicacion en terapeutica |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20100317656A1 (es) |
| EP (1) | EP2225244A1 (es) |
| JP (1) | JP2011508759A (es) |
| KR (1) | KR20100109941A (es) |
| CN (1) | CN101959886A (es) |
| AR (1) | AR070073A1 (es) |
| AU (1) | AU2008352728A1 (es) |
| BR (1) | BRPI0822223A2 (es) |
| CA (1) | CA2710797A1 (es) |
| CL (1) | CL2008003927A1 (es) |
| CO (1) | CO6331307A2 (es) |
| EA (1) | EA201070817A1 (es) |
| FR (1) | FR2925902B1 (es) |
| IL (1) | IL206673A0 (es) |
| MA (1) | MA32057B1 (es) |
| MX (1) | MX2010007351A (es) |
| PA (1) | PA8810101A1 (es) |
| PE (1) | PE20091182A1 (es) |
| TW (1) | TW200932746A (es) |
| UY (1) | UY31588A1 (es) |
| WO (1) | WO2009112651A1 (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2925907B1 (fr) * | 2008-01-02 | 2010-10-15 | Sanofi Aventis | DERIVES DE 2-HETEROAROYL-IMIDAZO°1,2-a!PYRIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
| ES2573148T3 (es) * | 2010-08-25 | 2016-06-06 | Neopharm Co., Ltd. | Compuestos y composición de 1H-benzo[d]imidazol-5-ilo para el tratamiento de enfermedades inflamatorias |
| WO2016133838A1 (en) | 2015-02-20 | 2016-08-25 | Rigel Pharmaceuticals, Inc. | Gdf-8 inhibitors |
| CN111108105B (zh) | 2017-09-22 | 2023-03-31 | 朱比兰特埃皮帕德有限公司 | 作为pad抑制剂的杂环化合物 |
| WO2019077631A1 (en) | 2017-10-18 | 2019-04-25 | Jubilant Biosys Limited | IMIDAZO-PYRIDINE COMPOUNDS FOR USE AS PAD INHIBITORS |
| KR20200085836A (ko) | 2017-11-06 | 2020-07-15 | 주빌런트 프로델 엘엘씨 | Pd1/pd-l1 활성화 억제제로서의 피리미딘 유도체 |
| CN107915752B (zh) * | 2017-11-14 | 2018-09-18 | 牡丹江医学院 | 一种治疗白内障的药物及其制备方法 |
| BR112020010322A2 (pt) | 2017-11-24 | 2020-11-17 | Jubilant Episcribe Llc | composto da fórmula i; composto da fórmula ia; composto da fórmula ib; processo de preparação de compostos da fórmula i; composição farmacêutica; método para o tratamento e/ou prevenção de várias doenças; uso dos compostos; método para o tratamento de câncer; e método para o tratamento e/ou prevenção de uma afecção mediada por prmt5 ou um distúrbio proliferativo ou câncer |
| WO2019175897A1 (en) | 2018-03-13 | 2019-09-19 | Jubilant Biosys Limited | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8827189D0 (en) * | 1988-11-21 | 1988-12-29 | Fujisawa Pharmaceutical Co | 2(1h)-quinolinone compounds processes for preparation thereof & pharmaceutical composition comprising same |
| US5716964A (en) * | 1989-12-04 | 1998-02-10 | G.D. Searle & Co. | Tetrazolyl substituted imidazo 1,2-a!pyridinylalkyl compounds for treatment of neurotoxic injury |
| FR2696177B1 (fr) * | 1992-09-28 | 1995-05-12 | Synthelabo | Dérivés de pipéridine, leur préparation et leur application en thérapeutique. |
| GB0420519D0 (en) * | 2004-09-15 | 2004-10-20 | Novartis Ag | Organic compounds |
| JP2010535773A (ja) * | 2007-08-10 | 2010-11-25 | グラクソスミスクライン エルエルシー | ウイルス感染を治療するための窒素含有二環式化学物質 |
| AU2008345225A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
-
2008
- 2008-01-02 FR FR0800004A patent/FR2925902B1/fr not_active Expired - Fee Related
- 2008-12-23 PA PA20088810101A patent/PA8810101A1/es unknown
- 2008-12-30 PE PE2008002195A patent/PE20091182A1/es not_active Application Discontinuation
- 2008-12-30 AR ARP080105778A patent/AR070073A1/es unknown
- 2008-12-30 UY UY31588A patent/UY31588A1/es not_active Application Discontinuation
- 2008-12-30 CL CL2008003927A patent/CL2008003927A1/es unknown
- 2008-12-31 MX MX2010007351A patent/MX2010007351A/es not_active Application Discontinuation
- 2008-12-31 KR KR1020107017147A patent/KR20100109941A/ko not_active Application Discontinuation
- 2008-12-31 CA CA2710797A patent/CA2710797A1/fr not_active Abandoned
- 2008-12-31 JP JP2010541084A patent/JP2011508759A/ja not_active Withdrawn
- 2008-12-31 CN CN2008801277688A patent/CN101959886A/zh active Pending
- 2008-12-31 AU AU2008352728A patent/AU2008352728A1/en not_active Abandoned
- 2008-12-31 WO PCT/FR2008/001835 patent/WO2009112651A1/fr active Application Filing
- 2008-12-31 EA EA201070817A patent/EA201070817A1/ru unknown
- 2008-12-31 BR BRPI0822223-1A patent/BRPI0822223A2/pt not_active IP Right Cessation
- 2008-12-31 TW TW097151675A patent/TW200932746A/zh unknown
- 2008-12-31 EP EP08873283A patent/EP2225244A1/fr not_active Ceased
-
2010
- 2010-06-28 IL IL206673A patent/IL206673A0/en unknown
- 2010-07-01 US US12/828,372 patent/US20100317656A1/en not_active Abandoned
- 2010-07-02 CO CO10080876A patent/CO6331307A2/es not_active Application Discontinuation
- 2010-08-02 MA MA33055A patent/MA32057B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PA8810101A1 (es) | 2009-08-26 |
| MX2010007351A (es) | 2010-10-05 |
| CN101959886A (zh) | 2011-01-26 |
| EA201070817A1 (ru) | 2011-02-28 |
| FR2925902B1 (fr) | 2011-01-07 |
| EP2225244A1 (fr) | 2010-09-08 |
| CA2710797A1 (fr) | 2009-09-17 |
| BRPI0822223A2 (pt) | 2015-06-23 |
| JP2011508759A (ja) | 2011-03-17 |
| TW200932746A (en) | 2009-08-01 |
| WO2009112651A1 (fr) | 2009-09-17 |
| KR20100109941A (ko) | 2010-10-11 |
| US20100317656A1 (en) | 2010-12-16 |
| PE20091182A1 (es) | 2009-08-31 |
| FR2925902A1 (fr) | 2009-07-03 |
| MA32057B1 (fr) | 2011-02-01 |
| AU2008352728A1 (en) | 2009-09-17 |
| UY31588A1 (es) | 2009-08-03 |
| CL2008003927A1 (es) | 2010-02-12 |
| IL206673A0 (en) | 2010-12-30 |
| AR070073A1 (es) | 2010-03-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Application withdrawn |