MA32057B1 - Derives d'imtoazo [1,2-a] pyridine-2-carboxamides,leur préparation et leur application en thérapeutique - Google Patents

Derives d'imtoazo [1,2-a] pyridine-2-carboxamides,leur préparation et leur application en thérapeutique

Info

Publication number
MA32057B1
MA32057B1 MA33055A MA33055A MA32057B1 MA 32057 B1 MA32057 B1 MA 32057B1 MA 33055 A MA33055 A MA 33055A MA 33055 A MA33055 A MA 33055A MA 32057 B1 MA32057 B1 MA 32057B1
Authority
MA
Morocco
Prior art keywords
group
alkyl
optionally substituted
alkoxy
atom
Prior art date
Application number
MA33055A
Other languages
Arabic (ar)
English (en)
Inventor
Jean-François Peyronel
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39739369&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA32057(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MA32057B1 publication Critical patent/MA32057B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

Composés de formule (i) dans laquelle: x et y forment avec l'atome d'azote qui les porte une aminé cyclique mono ou bicyclique saturée ou partiellement saturée, de 5 à 10 chainons comportant éventuellement 1 à 2 hétéroatomes supplémentaires choisis parmi o, s, n, éventuellement substituée par un atome d'halogène, un groupe (c1-c6)alkyle, un groupe (c1-c6)alcoxy, cyano, nrarb, coor8, les groupes (c1-c6)alkyle et (c1-c6)alcoxy étant éventuellement substitués par un ou plusieurs atomes d'halogène; r1 représente un atome d'hydrogène, un atome d'halogène, un groupe (c1-c6)alcoxy, un groupe (c1-c6)alkyle; r2 représente un atome d'hydrogène, un groupe (c1-c6)alkyle éventuellement substitué; un groupe (c1-c6)alcoxy éventuellement substitué; un groupe (c2-c6)alcényle, un groupe (c2-c6)alcynyle, un groupe -co-r5, un groupe -co-nr6r7, un groupe -co-o-r8, un groupe -nr9-co-r10, un groupe -n=ch-nrarb, un atome d'halogène, un groupe cyano, nitro, hydroxyiminoalkyle, alcoxyiminoalkyle, un groupe (c1-c6)alkylthio, un groupe (c1-c6)alkylsulfinyle, un groupe (c1-c6)alkylsulfonyle, un groupe (((c1-c6)alkyl)3)silyléthynyle, un groupe -so2-nr9r10, un groupe phényle éventuellement substitué, un groupe hétérocyclique éventuellement substituée; r3 représente un atome d'hydrogène, un groupe (c2-c6)alkyle, un groupe (c1-c6)alcoxy ou un atome d'halogène, r4 représente un atome d'hydrogène, un groupe (c1-c4)alkyle, un groupe (c1-c4)alcoxy ou un atome de fluor, à l'état de base ou de sel d'addition à un acide. Utilisation en thérapeutique.
MA33055A 2008-01-02 2010-08-02 Derives d'imtoazo [1,2-a] pyridine-2-carboxamides,leur préparation et leur application en thérapeutique MA32057B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0800004A FR2925902B1 (fr) 2008-01-02 2008-01-02 DERIVES D'IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
PCT/FR2008/001835 WO2009112651A1 (fr) 2008-01-02 2008-12-31 Dérivés d'mtoazo[1,2-a]pyridine-2-carboxamides, leur préparation et leur application en thérapeutique

Publications (1)

Publication Number Publication Date
MA32057B1 true MA32057B1 (fr) 2011-02-01

Family

ID=39739369

Family Applications (1)

Application Number Title Priority Date Filing Date
MA33055A MA32057B1 (fr) 2008-01-02 2010-08-02 Derives d'imtoazo [1,2-a] pyridine-2-carboxamides,leur préparation et leur application en thérapeutique

Country Status (21)

Country Link
US (1) US20100317656A1 (fr)
EP (1) EP2225244A1 (fr)
JP (1) JP2011508759A (fr)
KR (1) KR20100109941A (fr)
CN (1) CN101959886A (fr)
AR (1) AR070073A1 (fr)
AU (1) AU2008352728A1 (fr)
BR (1) BRPI0822223A2 (fr)
CA (1) CA2710797A1 (fr)
CL (1) CL2008003927A1 (fr)
CO (1) CO6331307A2 (fr)
EA (1) EA201070817A1 (fr)
FR (1) FR2925902B1 (fr)
IL (1) IL206673A0 (fr)
MA (1) MA32057B1 (fr)
MX (1) MX2010007351A (fr)
PA (1) PA8810101A1 (fr)
PE (1) PE20091182A1 (fr)
TW (1) TW200932746A (fr)
UY (1) UY31588A1 (fr)
WO (1) WO2009112651A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2925907B1 (fr) * 2008-01-02 2010-10-15 Sanofi Aventis DERIVES DE 2-HETEROAROYL-IMIDAZO°1,2-a!PYRIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
ES2573148T3 (es) * 2010-08-25 2016-06-06 Neopharm Co., Ltd. Compuestos y composición de 1H-benzo[d]imidazol-5-ilo para el tratamiento de enfermedades inflamatorias
US9981944B2 (en) 2015-02-20 2018-05-29 Rigel Pharmaceuticals, Inc GDF-8 inhibitors
NZ762985A (en) 2017-09-22 2024-03-22 Jubilant Epipad LLC Heterocyclic compounds as pad inhibitors
HUE061607T2 (hu) 2017-10-18 2023-07-28 Jubilant Epipad LLC Imidazopiridin vegyületek mint PAD inhibitorok
CN111386265A (zh) 2017-11-06 2020-07-07 朱比连特普罗德尔有限责任公司 作为pd1/pd-l1活化的抑制剂的嘧啶衍生物
CN107915752B (zh) * 2017-11-14 2018-09-18 牡丹江医学院 一种治疗白内障的药物及其制备方法
EP3704120B1 (fr) 2017-11-24 2024-03-06 Jubilant Episcribe LLC Composés hétérocycliques utilisés en tant qu'inhibiteurs de prmt5
BR112020018610A2 (pt) 2018-03-13 2020-12-29 Jubilant Prodel LLC Compostos de fórmula i, fórmula ii, fórmula iii, fórmula iv, fórmula v, fórmula vi, ou seus polimorfos, estereoisômeros, tautômeros, profármacos, solvatos e sais farmaceuticamente aceitáveis dos mesmos e uso dos mesmos; processo de preparação; composição farmacêutica; e método para o tratamento e/ou prevenção de várias doenças, que incluem câncer e doenças infecciosas

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8827189D0 (en) * 1988-11-21 1988-12-29 Fujisawa Pharmaceutical Co 2(1h)-quinolinone compounds processes for preparation thereof & pharmaceutical composition comprising same
US5716964A (en) * 1989-12-04 1998-02-10 G.D. Searle & Co. Tetrazolyl substituted imidazo 1,2-a!pyridinylalkyl compounds for treatment of neurotoxic injury
FR2696177B1 (fr) * 1992-09-28 1995-05-12 Synthelabo Dérivés de pipéridine, leur préparation et leur application en thérapeutique.
GB0420519D0 (en) * 2004-09-15 2004-10-20 Novartis Ag Organic compounds
AU2008287421A1 (en) * 2007-08-10 2009-02-19 Glaxosmithkline Llc Nitrogen containing bicyclic chemical entities for treating viral infections
EP2219646A4 (fr) * 2007-12-21 2010-12-22 Univ Rochester Procédé permettant de modifier la durée de vie d'organismes eucaryotes

Also Published As

Publication number Publication date
PE20091182A1 (es) 2009-08-31
JP2011508759A (ja) 2011-03-17
CO6331307A2 (es) 2011-10-20
UY31588A1 (es) 2009-08-03
CA2710797A1 (fr) 2009-09-17
AU2008352728A1 (en) 2009-09-17
CN101959886A (zh) 2011-01-26
US20100317656A1 (en) 2010-12-16
TW200932746A (en) 2009-08-01
FR2925902B1 (fr) 2011-01-07
CL2008003927A1 (es) 2010-02-12
EA201070817A1 (ru) 2011-02-28
IL206673A0 (en) 2010-12-30
WO2009112651A1 (fr) 2009-09-17
PA8810101A1 (es) 2009-08-26
EP2225244A1 (fr) 2010-09-08
AR070073A1 (es) 2010-03-10
MX2010007351A (es) 2010-10-05
BRPI0822223A2 (pt) 2015-06-23
KR20100109941A (ko) 2010-10-11
FR2925902A1 (fr) 2009-07-03

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