PE20091182A1 - DERIVADOS DE IMIDAZO[1,2-a]PIRIDIN-2-CARBOXAMIDAS, SU PREPARACION Y SU APLICACION EN TERAPEUTICA - Google Patents

DERIVADOS DE IMIDAZO[1,2-a]PIRIDIN-2-CARBOXAMIDAS, SU PREPARACION Y SU APLICACION EN TERAPEUTICA

Info

Publication number
PE20091182A1
PE20091182A1 PE2008002195A PE2008002195A PE20091182A1 PE 20091182 A1 PE20091182 A1 PE 20091182A1 PE 2008002195 A PE2008002195 A PE 2008002195A PE 2008002195 A PE2008002195 A PE 2008002195A PE 20091182 A1 PE20091182 A1 PE 20091182A1
Authority
PE
Peru
Prior art keywords
imidazo
pyridin
alkyl
alcoxy
derivatives
Prior art date
Application number
PE2008002195A
Other languages
English (en)
Inventor
Jean-Francois Peyronel
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39739369&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20091182(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of PE20091182A1 publication Critical patent/PE20091182A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

SE REFIERE A DERIVADOS DE IMIDAZO[1,2-a]PIRIDIN-2-CARBOXAMIDAS DE FORMULA (I), DONDE X E Y FORMAN CON EL N AL QUE ESTAN ENLAZADOS UNA AMINA CICLICA MONO O BICICLICA SUSTITUIDO O NO; R1 ES H, HALOGENO, ALCOXI C1-C6, ALQUILO C1-C6, ENTRE OTROS; R2 ES H, ALQUILO C1-C6, ALCOXI C1-C6, ALQUENILO C2-C6, ENTRE OTROS; R3 ES H, ALQUILO C2-C6, ALCOXI C1-C6, HALOGENO; R4 ES H, ALQUILO C1-C4, ALCOXI C1-C4, F. SON COMPUESTOS PREFERIDOS: {3-[2-PIPERIDIN-1-ILCARBONIL)IMIDAZO[1,2-a]PIRIDIN-6-IL]FENIL}METANOL; {3-[2-(2,3-DIHIDRO-4H-1,4-BENZOXAZIN-4-ILCARBONIL)IMIDAZO[1,2-a]PIRIDIN-6-IL]FENIL}METANOL; {3-[2-(MORFOLIN-4-ILCARBONIL)IMIDAZO[1,2-a]PIRIDIN-6-IL]FENIL}METANOL; ENTRE OTROS. TAMBIEN SE REFIERE A UN METODO DE PREPARACION Y UNA COMPOSICION FARMACEUTICA. DICHO COMPUESTO TIENE ACTIVIDAD SOBRE EL RECEPTOR NUCLEAR NURR-1, SIENDO DE UTILIDAD EN EL TRATAMIENTO DE ENFERMEDADES NEURODEGERATIVAS
PE2008002195A 2008-01-02 2008-12-30 DERIVADOS DE IMIDAZO[1,2-a]PIRIDIN-2-CARBOXAMIDAS, SU PREPARACION Y SU APLICACION EN TERAPEUTICA PE20091182A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0800004A FR2925902B1 (fr) 2008-01-02 2008-01-02 DERIVES D'IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Publications (1)

Publication Number Publication Date
PE20091182A1 true PE20091182A1 (es) 2009-08-31

Family

ID=39739369

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008002195A PE20091182A1 (es) 2008-01-02 2008-12-30 DERIVADOS DE IMIDAZO[1,2-a]PIRIDIN-2-CARBOXAMIDAS, SU PREPARACION Y SU APLICACION EN TERAPEUTICA

Country Status (21)

Country Link
US (1) US20100317656A1 (es)
EP (1) EP2225244A1 (es)
JP (1) JP2011508759A (es)
KR (1) KR20100109941A (es)
CN (1) CN101959886A (es)
AR (1) AR070073A1 (es)
AU (1) AU2008352728A1 (es)
BR (1) BRPI0822223A2 (es)
CA (1) CA2710797A1 (es)
CL (1) CL2008003927A1 (es)
CO (1) CO6331307A2 (es)
EA (1) EA201070817A1 (es)
FR (1) FR2925902B1 (es)
IL (1) IL206673A0 (es)
MA (1) MA32057B1 (es)
MX (1) MX2010007351A (es)
PA (1) PA8810101A1 (es)
PE (1) PE20091182A1 (es)
TW (1) TW200932746A (es)
UY (1) UY31588A1 (es)
WO (1) WO2009112651A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2925907B1 (fr) * 2008-01-02 2010-10-15 Sanofi Aventis DERIVES DE 2-HETEROAROYL-IMIDAZO°1,2-a!PYRIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
WO2012026766A2 (ko) * 2010-08-25 2012-03-01 (주)네오팜 신규한 헤테로고리 화합물 및 이를 이용한 염증성 질환 치료용 조성물
US9981944B2 (en) 2015-02-20 2018-05-29 Rigel Pharmaceuticals, Inc GDF-8 inhibitors
RU2764243C2 (ru) 2017-09-22 2022-01-14 ДЖУБИЛАНТ ЭПИПЭД ЭлЭлСи Гетероциклические соединения в качестве ингибиторов PAD
CA3076476A1 (en) 2017-10-18 2019-04-25 Jubilant Epipad LLC Imidazo-pyridine compounds as pad inhibitors
CA3080677A1 (en) 2017-11-06 2019-05-09 Jubilant Prodel LLC Pyrimidine derivatives as inhibitors of pd1/pd-l1 activation
CN107915752B (zh) * 2017-11-14 2018-09-18 牡丹江医学院 一种治疗白内障的药物及其制备方法
EP3704120B1 (en) 2017-11-24 2024-03-06 Jubilant Episcribe LLC Heterocyclic compounds as prmt5 inhibitors
CN112105610B (zh) 2018-03-13 2024-01-26 朱比连特普罗德尔有限责任公司 作为pd1/pd-l1相互作用/活化的抑制剂的双环化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8827189D0 (en) * 1988-11-21 1988-12-29 Fujisawa Pharmaceutical Co 2(1h)-quinolinone compounds processes for preparation thereof & pharmaceutical composition comprising same
US5716964A (en) * 1989-12-04 1998-02-10 G.D. Searle & Co. Tetrazolyl substituted imidazo 1,2-a!pyridinylalkyl compounds for treatment of neurotoxic injury
FR2696177B1 (fr) * 1992-09-28 1995-05-12 Synthelabo Dérivés de pipéridine, leur préparation et leur application en thérapeutique.
GB0420519D0 (en) * 2004-09-15 2004-10-20 Novartis Ag Organic compounds
EP2187883A2 (en) * 2007-08-10 2010-05-26 Genelabs Technologies, Inc. Nitrogen containing bicyclic chemical entities for treating viral infections
CA2709784A1 (en) * 2007-12-21 2009-07-09 University Of Rochester Method for altering the lifespan of eukaryotic organisms

Also Published As

Publication number Publication date
CN101959886A (zh) 2011-01-26
UY31588A1 (es) 2009-08-03
CL2008003927A1 (es) 2010-02-12
MA32057B1 (fr) 2011-02-01
WO2009112651A1 (fr) 2009-09-17
AR070073A1 (es) 2010-03-10
MX2010007351A (es) 2010-10-05
US20100317656A1 (en) 2010-12-16
PA8810101A1 (es) 2009-08-26
KR20100109941A (ko) 2010-10-11
BRPI0822223A2 (pt) 2015-06-23
JP2011508759A (ja) 2011-03-17
TW200932746A (en) 2009-08-01
AU2008352728A1 (en) 2009-09-17
CA2710797A1 (fr) 2009-09-17
EP2225244A1 (fr) 2010-09-08
FR2925902B1 (fr) 2011-01-07
EA201070817A1 (ru) 2011-02-28
FR2925902A1 (fr) 2009-07-03
IL206673A0 (en) 2010-12-30
CO6331307A2 (es) 2011-10-20

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