EA201070817A1 - ПРОИЗВОДНЫЕ ИМИДАЗО[1,2-α]ПИРИДИН-2-КАРБОКСАМИДОВ, ИХ ПОЛУЧЕНИЕ И ИХ ПРИМЕНЕНИЕ В ТЕРАПИИ - Google Patents
ПРОИЗВОДНЫЕ ИМИДАЗО[1,2-α]ПИРИДИН-2-КАРБОКСАМИДОВ, ИХ ПОЛУЧЕНИЕ И ИХ ПРИМЕНЕНИЕ В ТЕРАПИИInfo
- Publication number
- EA201070817A1 EA201070817A1 EA201070817A EA201070817A EA201070817A1 EA 201070817 A1 EA201070817 A1 EA 201070817A1 EA 201070817 A EA201070817 A EA 201070817A EA 201070817 A EA201070817 A EA 201070817A EA 201070817 A1 EA201070817 A1 EA 201070817A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- group
- alkyl
- alkoxy
- atom
- hydrogen atom
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Соединения формулы (I), в которой Х и Y вместе с атомом азота, с которым они связаны, образуют 5-10-звенный моно- или бициклический амин, насыщенный или частично насыщенный, возможно содержащий 1-2 дополнительных гетероатома, выбранных из О, S, N, возможно замещенный атомом галогена, (C-С)алкильной группой, (C-C)алкоксигруппой, циано, NRaRb, COOR, (C-С)алкильной и (C-C)алкоксигруппами, возможно замещенными одним или несколькими атомами галогена; Rозначает атом водорода, атом галогена, (C-С)алкоксигруппу, (C-С)алкильную группу; Rозначает атом водорода, (C-С)алкильную группу, возможно замещенную; (C-С)алкоксигруппу, возможно замещенную; (С-С)алкенильную группу, (С-С)алкинильную группу, группу -CO-R, группу -CO-NRR, группу -CO-O-R, группу -NR-СО-R, группу -N=CH-NRaRb, атом галогена, группу циано, нитро, гидроксииминоалкильную, алкоксииминоалкильную группу, (C-С)алкилтиогруппу, (C-С)алкилсульфинильную группу, (C-С)алкилсульфонильную группу, (((C-C)алкил))силилэтинильную группу, группу -SO-NRR, фенильную группу, возможно замещенную, гетероциклическую группу, возможно замещенную; Rозначает атом водорода, (С-С)алкильную группу, (C-С)алкоксигруппу или атом галогена, Rозначает атом водорода, (C-C)алкильную группу, (C-C)алкоксигруппу или атом фтора, в состоянии основания или кислотно-аддитивной соли. Применение в терапии.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0800004A FR2925902B1 (fr) | 2008-01-02 | 2008-01-02 | DERIVES D'IMIDAZO°1,2-a!PYRIDINE-2-CARBOXAMIDES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
PCT/FR2008/001835 WO2009112651A1 (fr) | 2008-01-02 | 2008-12-31 | Dérivés d'mtoazo[1,2-a]pyridine-2-carboxamides, leur préparation et leur application en thérapeutique |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201070817A1 true EA201070817A1 (ru) | 2011-02-28 |
Family
ID=39739369
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201070817A EA201070817A1 (ru) | 2008-01-02 | 2008-12-31 | ПРОИЗВОДНЫЕ ИМИДАЗО[1,2-α]ПИРИДИН-2-КАРБОКСАМИДОВ, ИХ ПОЛУЧЕНИЕ И ИХ ПРИМЕНЕНИЕ В ТЕРАПИИ |
Country Status (21)
Country | Link |
---|---|
US (1) | US20100317656A1 (ru) |
EP (1) | EP2225244A1 (ru) |
JP (1) | JP2011508759A (ru) |
KR (1) | KR20100109941A (ru) |
CN (1) | CN101959886A (ru) |
AR (1) | AR070073A1 (ru) |
AU (1) | AU2008352728A1 (ru) |
BR (1) | BRPI0822223A2 (ru) |
CA (1) | CA2710797A1 (ru) |
CL (1) | CL2008003927A1 (ru) |
CO (1) | CO6331307A2 (ru) |
EA (1) | EA201070817A1 (ru) |
FR (1) | FR2925902B1 (ru) |
IL (1) | IL206673A0 (ru) |
MA (1) | MA32057B1 (ru) |
MX (1) | MX2010007351A (ru) |
PA (1) | PA8810101A1 (ru) |
PE (1) | PE20091182A1 (ru) |
TW (1) | TW200932746A (ru) |
UY (1) | UY31588A1 (ru) |
WO (1) | WO2009112651A1 (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2925907B1 (fr) * | 2008-01-02 | 2010-10-15 | Sanofi Aventis | DERIVES DE 2-HETEROAROYL-IMIDAZO°1,2-a!PYRIDINE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
WO2012026766A2 (ko) * | 2010-08-25 | 2012-03-01 | (주)네오팜 | 신규한 헤테로고리 화합물 및 이를 이용한 염증성 질환 치료용 조성물 |
US9981944B2 (en) | 2015-02-20 | 2018-05-29 | Rigel Pharmaceuticals, Inc | GDF-8 inhibitors |
RU2764243C2 (ru) | 2017-09-22 | 2022-01-14 | ДЖУБИЛАНТ ЭПИПЭД ЭлЭлСи | Гетероциклические соединения в качестве ингибиторов PAD |
CA3076476A1 (en) | 2017-10-18 | 2019-04-25 | Jubilant Epipad LLC | Imidazo-pyridine compounds as pad inhibitors |
CA3080677A1 (en) | 2017-11-06 | 2019-05-09 | Jubilant Prodel LLC | Pyrimidine derivatives as inhibitors of pd1/pd-l1 activation |
CN107915752B (zh) * | 2017-11-14 | 2018-09-18 | 牡丹江医学院 | 一种治疗白内障的药物及其制备方法 |
EP3704120B1 (en) | 2017-11-24 | 2024-03-06 | Jubilant Episcribe LLC | Heterocyclic compounds as prmt5 inhibitors |
CN112105610B (zh) | 2018-03-13 | 2024-01-26 | 朱比连特普罗德尔有限责任公司 | 作为pd1/pd-l1相互作用/活化的抑制剂的双环化合物 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8827189D0 (en) * | 1988-11-21 | 1988-12-29 | Fujisawa Pharmaceutical Co | 2(1h)-quinolinone compounds processes for preparation thereof & pharmaceutical composition comprising same |
US5716964A (en) * | 1989-12-04 | 1998-02-10 | G.D. Searle & Co. | Tetrazolyl substituted imidazo 1,2-a!pyridinylalkyl compounds for treatment of neurotoxic injury |
FR2696177B1 (fr) * | 1992-09-28 | 1995-05-12 | Synthelabo | Dérivés de pipéridine, leur préparation et leur application en thérapeutique. |
GB0420519D0 (en) * | 2004-09-15 | 2004-10-20 | Novartis Ag | Organic compounds |
EP2187883A2 (en) * | 2007-08-10 | 2010-05-26 | Genelabs Technologies, Inc. | Nitrogen containing bicyclic chemical entities for treating viral infections |
CA2709784A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
-
2008
- 2008-01-02 FR FR0800004A patent/FR2925902B1/fr not_active Expired - Fee Related
- 2008-12-23 PA PA20088810101A patent/PA8810101A1/es unknown
- 2008-12-30 AR ARP080105778A patent/AR070073A1/es unknown
- 2008-12-30 PE PE2008002195A patent/PE20091182A1/es not_active Application Discontinuation
- 2008-12-30 CL CL2008003927A patent/CL2008003927A1/es unknown
- 2008-12-30 UY UY31588A patent/UY31588A1/es not_active Application Discontinuation
- 2008-12-31 WO PCT/FR2008/001835 patent/WO2009112651A1/fr active Application Filing
- 2008-12-31 JP JP2010541084A patent/JP2011508759A/ja not_active Withdrawn
- 2008-12-31 CA CA2710797A patent/CA2710797A1/fr not_active Abandoned
- 2008-12-31 KR KR1020107017147A patent/KR20100109941A/ko not_active Application Discontinuation
- 2008-12-31 EA EA201070817A patent/EA201070817A1/ru unknown
- 2008-12-31 BR BRPI0822223-1A patent/BRPI0822223A2/pt not_active IP Right Cessation
- 2008-12-31 CN CN2008801277688A patent/CN101959886A/zh active Pending
- 2008-12-31 AU AU2008352728A patent/AU2008352728A1/en not_active Abandoned
- 2008-12-31 EP EP08873283A patent/EP2225244A1/fr not_active Ceased
- 2008-12-31 MX MX2010007351A patent/MX2010007351A/es not_active Application Discontinuation
- 2008-12-31 TW TW097151675A patent/TW200932746A/zh unknown
-
2010
- 2010-06-28 IL IL206673A patent/IL206673A0/en unknown
- 2010-07-01 US US12/828,372 patent/US20100317656A1/en not_active Abandoned
- 2010-07-02 CO CO10080876A patent/CO6331307A2/es not_active Application Discontinuation
- 2010-08-02 MA MA33055A patent/MA32057B1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
CN101959886A (zh) | 2011-01-26 |
UY31588A1 (es) | 2009-08-03 |
CL2008003927A1 (es) | 2010-02-12 |
MA32057B1 (fr) | 2011-02-01 |
WO2009112651A1 (fr) | 2009-09-17 |
AR070073A1 (es) | 2010-03-10 |
MX2010007351A (es) | 2010-10-05 |
US20100317656A1 (en) | 2010-12-16 |
PA8810101A1 (es) | 2009-08-26 |
KR20100109941A (ko) | 2010-10-11 |
BRPI0822223A2 (pt) | 2015-06-23 |
PE20091182A1 (es) | 2009-08-31 |
JP2011508759A (ja) | 2011-03-17 |
TW200932746A (en) | 2009-08-01 |
AU2008352728A1 (en) | 2009-09-17 |
CA2710797A1 (fr) | 2009-09-17 |
EP2225244A1 (fr) | 2010-09-08 |
FR2925902B1 (fr) | 2011-01-07 |
FR2925902A1 (fr) | 2009-07-03 |
IL206673A0 (en) | 2010-12-30 |
CO6331307A2 (es) | 2011-10-20 |
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