EA201171386A1 - ПРОИЗВОДНЫЕ ЦИКЛОПЕНТА[c]ПИРРОЛ-2-КАРБОКСИЛАТОВ, ИХ ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ В ТЕРАПИИ - Google Patents

ПРОИЗВОДНЫЕ ЦИКЛОПЕНТА[c]ПИРРОЛ-2-КАРБОКСИЛАТОВ, ИХ ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ В ТЕРАПИИ

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EA201171386A1
EA201171386A1 EA201171386A EA201171386A EA201171386A1 EA 201171386 A1 EA201171386 A1 EA 201171386A1 EA 201171386 A EA201171386 A EA 201171386A EA 201171386 A EA201171386 A EA 201171386A EA 201171386 A1 EA201171386 A1 EA 201171386A1
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therapy
alkylene
atom
pirrol
cyclopent
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EA201171386A
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English (en)
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Ахмед Абуабделла
Люк Эвен
Од Фэйоль
Жюльен Ваш
Филипп Иэш
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Санофи
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

Соединения, соответствующие общей формуле (I), в которой Rпредставляет собой атом водорода, фтора или гидроксигруппу, цианогруппу, трифторметил, C-алкил, C-алкоксигруппу, NRR; m, n, о и р независимо друг от друга представляют собой числа в интервале от 0 до 3; А представляет собой ковалентную связь, атом кислорода, C-алкилен или -O-C-алкилен, в котором концевой фрагмент, представляющий собой атом кислорода, связан с радикалом R, а концевой фрагмент, представляющий собой алкилен, связан с атомом углерода бицикла; Rпредставляет собой замещенный при необходимости арил или гетероарил; Rпредставляет собой атом водорода, фтора, C-алкил или трифторметил; Rпредставляет собой замещенный при необходимости пятичленный гетероцикл; в виде основания или кислотно-аддитивной соли. Применение в терапии.
EA201171386A 2009-05-12 2010-05-11 ПРОИЗВОДНЫЕ ЦИКЛОПЕНТА[c]ПИРРОЛ-2-КАРБОКСИЛАТОВ, ИХ ПОЛУЧЕНИЕ И ПРИМЕНЕНИЕ В ТЕРАПИИ EA201171386A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0902268A FR2945534B1 (fr) 2009-05-12 2009-05-12 DERIVES DE CYCLOPENTAL[c]PYRROLE-2-CARBOXYLATES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
PCT/FR2010/050913 WO2010130944A1 (fr) 2009-05-12 2010-05-11 Dérivés de cyclopenta[c]pyrrole-2-carboxylates, leur préparation et leur application en thérapeutique

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EA201171386A1 true EA201171386A1 (ru) 2012-07-30

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US (1) US8697883B2 (ru)
EP (1) EP2430006B1 (ru)
JP (1) JP5712204B2 (ru)
KR (1) KR20120016646A (ru)
CN (1) CN102459207B (ru)
AR (1) AR076562A1 (ru)
AU (1) AU2010247213B2 (ru)
BR (1) BRPI1012857A2 (ru)
CA (1) CA2761660C (ru)
CO (1) CO6400139A2 (ru)
EA (1) EA201171386A1 (ru)
FR (1) FR2945534B1 (ru)
IL (1) IL216226A0 (ru)
MA (1) MA33404B1 (ru)
MX (1) MX2011012059A (ru)
SG (1) SG176016A1 (ru)
TN (1) TN2011000569A1 (ru)
TW (1) TW201105664A (ru)
UY (1) UY32631A (ru)
WO (1) WO2010130944A1 (ru)

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AU2010247213B2 (en) 2015-07-16
FR2945534B1 (fr) 2012-11-16
JP5712204B2 (ja) 2015-05-07
JP2012526783A (ja) 2012-11-01
CA2761660C (fr) 2017-02-14
CO6400139A2 (es) 2012-03-15
SG176016A1 (en) 2011-12-29
US8697883B2 (en) 2014-04-15
EP2430006B1 (fr) 2014-11-26
US20120095040A1 (en) 2012-04-19
UY32631A (es) 2010-12-31
CN102459207B (zh) 2015-03-25
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CN102459207A (zh) 2012-05-16
IL216226A0 (en) 2012-01-31
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EP2430006A1 (fr) 2012-03-21
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