MX2018002217A - Nuevos compuestos biciclicos como inhibidores de autotaxina (atx). - Google Patents

Nuevos compuestos biciclicos como inhibidores de autotaxina (atx).

Info

Publication number
MX2018002217A
MX2018002217A MX2018002217A MX2018002217A MX2018002217A MX 2018002217 A MX2018002217 A MX 2018002217A MX 2018002217 A MX2018002217 A MX 2018002217A MX 2018002217 A MX2018002217 A MX 2018002217A MX 2018002217 A MX2018002217 A MX 2018002217A
Authority
MX
Mexico
Prior art keywords
bicyclic compounds
atx inhibitors
compounds
atx
inhibitors
Prior art date
Application number
MX2018002217A
Other languages
English (en)
Inventor
Rudolph Markus
Hunziker Daniel
Hert Jérôme
Di Giorgio Patrick
Mattei Patrizio
Schmitz Petra
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2018002217A publication Critical patent/MX2018002217A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención proporciona nuevos compuestos que tienen la fórmula general (I): (ver Fórmula) en la que R1, R2, R9, Y, W, m, n, p y q tienen los significados aquí definidos, composiciones que contienen los compuestos y métodos de uso de tales compuestos.
MX2018002217A 2015-09-24 2016-09-20 Nuevos compuestos biciclicos como inhibidores de autotaxina (atx). MX2018002217A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15186645 2015-09-24
PCT/EP2016/072243 WO2017050732A1 (en) 2015-09-24 2016-09-20 Bicyclic compounds as atx inhibitors

Publications (1)

Publication Number Publication Date
MX2018002217A true MX2018002217A (es) 2018-03-23

Family

ID=54199041

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018002217A MX2018002217A (es) 2015-09-24 2016-09-20 Nuevos compuestos biciclicos como inhibidores de autotaxina (atx).

Country Status (20)

Country Link
US (2) US20180208602A1 (es)
EP (1) EP3353180B1 (es)
JP (1) JP6846414B2 (es)
KR (1) KR20180054830A (es)
CN (2) CN115124538A (es)
AR (1) AR106101A1 (es)
AU (1) AU2016328535A1 (es)
BR (1) BR112018006024A2 (es)
CA (1) CA2983782A1 (es)
CL (1) CL2018000596A1 (es)
CO (1) CO2017011151A2 (es)
HK (1) HK1246787A1 (es)
IL (1) IL255570A (es)
MA (1) MA42918A (es)
MX (1) MX2018002217A (es)
PE (1) PE20180461A1 (es)
PH (1) PH12018500408A1 (es)
RU (1) RU2018114289A (es)
TW (1) TW201720824A (es)
WO (1) WO2017050732A1 (es)

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EA032357B1 (ru) 2014-03-26 2019-05-31 Ф. Хоффманн-Ля Рош Аг Конденсированные [1,4]диазепиновые соединения в качестве ингибиторов продукции аутотаксина (atx) и лизофосфатидиловой кислоты (lpa)
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