PE20120629A1 - Compuesto triazolopiridina y su accion como inhibidor de prolil hidroxilasa e inductor de la produccion de eritropoyetina - Google Patents

Compuesto triazolopiridina y su accion como inhibidor de prolil hidroxilasa e inductor de la produccion de eritropoyetina

Info

Publication number
PE20120629A1
PE20120629A1 PE2012000056A PE2012000056A PE20120629A1 PE 20120629 A1 PE20120629 A1 PE 20120629A1 PE 2012000056 A PE2012000056 A PE 2012000056A PE 2012000056 A PE2012000056 A PE 2012000056A PE 20120629 A1 PE20120629 A1 PE 20120629A1
Authority
PE
Peru
Prior art keywords
alkyl
erythropoyetin
production
triazolo
pyridin
Prior art date
Application number
PE2012000056A
Other languages
English (en)
Inventor
Ikuo Mitani
Yosuke Ogoshi
Takuya Matsui
Masahiro Yokota
Masakazu Terashita
Dai Motoda
Kazuhito Ueyama
Hiroyuki Abe
Takahiro Hotta
Takashi Ito
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of PE20120629A1 publication Critical patent/PE20120629A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)

Abstract

REFERIDA A UN DERIVADO DE TRIAZOLOPIRIDINA DE FORMULA (I), DONDE EL ANILLO DE 6 MIEMBROS UNIDO AL ANILLO (A) FORMAN LAS ESTRUCTURAS (a), (b), (c) O (d); R1 ES H, ALQUILO C1-C6, ARILO C6-C14, CICLOALQUILO C3-C8, ENTRE OTROS; R2 ES H, ALQUILO C1-C10, ARILO C6-C14, ENTRE OTROS; R3 ES H, HALOGENO, ALQUILO C1-C6, ARILO C6-C14, ENTRE OTROS; R4 Y R5 SON HALOGENO, ALQUILO C1-C6. SON COMPUESTOS PREFERIDOS: ACIDO {[5-(3-FLUORO-5-TRIFLUOROMETILFENIL)-7-HIDROXI[1,2,4]TRIAZOLO[1,5-a]PIRIDIN-8-CARBONIL]AMINO}ACETICO, ACIDO [(7-HIDROXI-5-PENTIL[1,2,4]TRIAZOLO[1,5-a]PIRIDIN-8-CARBONIL)AMINO]ACETICO, ACIDO {[5-(3-CICLOPROPIL-5-FLUOROFENIL)-7-HIDROXI[1,2,4]TRIAZOLO[1,5-a]PIRIDIN-8-CARBONIL]AMINO}ACETICO, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENEN ACTIVIDAD INHIBIDORA DE LA PROLIL HIDROXILASA (PHD) Y LA CAPACIDAD DE INDUCIR LA PRODUCCION DE ERITROPOYETINA (EPO) Y SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES CARDIACAS ISQUEMICAS, INSUFICIENCIAS RENALES CRONICAS, COMPLICACIONES DIABETICAS, ENTRE OTRAS
PE2012000056A 2009-07-17 2010-07-16 Compuesto triazolopiridina y su accion como inhibidor de prolil hidroxilasa e inductor de la produccion de eritropoyetina PE20120629A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2009169565 2009-07-17
US27312709P 2009-07-30 2009-07-30

Publications (1)

Publication Number Publication Date
PE20120629A1 true PE20120629A1 (es) 2012-05-30

Family

ID=43449466

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2012000056A PE20120629A1 (es) 2009-07-17 2010-07-16 Compuesto triazolopiridina y su accion como inhibidor de prolil hidroxilasa e inductor de la produccion de eritropoyetina

Country Status (29)

Country Link
US (3) US8283465B2 (es)
EP (3) EP2455381B9 (es)
JP (8) JP5021797B2 (es)
KR (4) KR20180042443A (es)
CN (1) CN102471337B (es)
AR (1) AR077417A1 (es)
AU (1) AU2010271732B2 (es)
BR (1) BR112012001157A2 (es)
CA (1) CA2768505C (es)
CO (1) CO6430426A2 (es)
DK (1) DK2455381T5 (es)
ES (1) ES2477968T3 (es)
HK (1) HK1168346A1 (es)
HR (1) HRP20140705T1 (es)
IL (1) IL217541A (es)
ME (1) ME01858B (es)
MX (1) MX2012000766A (es)
MY (1) MY160814A (es)
NZ (1) NZ598242A (es)
PE (1) PE20120629A1 (es)
PL (1) PL2455381T3 (es)
PT (1) PT2455381E (es)
RS (1) RS53499B1 (es)
RU (1) RU2538963C2 (es)
SG (1) SG178049A1 (es)
SI (1) SI2455381T1 (es)
SM (1) SMT201500122B (es)
TW (1) TWI485150B (es)
WO (1) WO2011007856A1 (es)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2768505C (en) * 2009-07-17 2018-06-12 Japan Tobacco Inc. Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor and erythropoietin production inducer
JP2011168582A (ja) * 2010-01-21 2011-09-01 Ishihara Sangyo Kaisha Ltd トリアゾロピリジン誘導体又はその塩、それらの製造方法及びそれらを含有する有害生物防除剤
WO2012065297A1 (en) * 2010-11-16 2012-05-24 Impact Therapeutics, Inc. 3-ARYL-6-ARYL-[1,2,4]TRIAZOLO[4,3-a]PYRIDINES AS INHIBITORS OF CELL PROLIFERATION AND THE USE THEREOF
US10004718B2 (en) 2012-11-26 2018-06-26 Tohoku University Erythropoietin expression promoter
WO2014102818A1 (en) 2012-12-24 2014-07-03 Cadila Healthcare Limited Novel quinolone derivatives
RS65341B1 (sr) 2013-06-13 2024-04-30 Akebia Therapeutics Inc Kompozicije i postupci za lečenje anemije
RU2534804C1 (ru) * 2013-08-05 2014-12-10 Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") ЗАМЕЩЕННЫЕ [1,2,4]ТРИАЗОЛО[4,3-a]ПИРИДИНЫ, ПРОЯВЛЯЮЩИЕ СВОЙСТВА АНТАГОНИСТОВ АДЕНОЗИНОВЫХ А2А РЕЦЕПТОРОВ, И ИХ ПРИМЕНЕНИЕ
RS57058B1 (sr) * 2013-10-03 2018-05-31 Kura Oncology Inc Ekr inhibitori i postupci primene
EP3190104B1 (en) 2014-09-02 2021-10-27 Sunshine Lake Pharma Co., Ltd. Quinolinone compound and use thereof
JP2018039733A (ja) * 2014-12-22 2018-03-15 株式会社富士薬品 新規複素環誘導体
GB201504565D0 (en) * 2015-03-18 2015-05-06 Takeda Pharmaceutical Novel compounds
CN106146395B (zh) * 2015-03-27 2019-01-01 沈阳三生制药有限责任公司 3-羟基吡啶化合物、其制备方法及其制药用途
JP6814134B2 (ja) * 2015-05-28 2021-01-13 日本たばこ産業株式会社 糖尿病性腎症を治療又は予防する方法
AU2017364725B2 (en) 2016-11-25 2021-04-01 Japan Tobacco Inc. Method for producing triazolopyridine compound
WO2018205928A1 (zh) 2017-05-09 2018-11-15 杭州安道药业有限公司 吲哚嗪衍生物及其在医药上的应用
AU2018345221A1 (en) * 2017-10-04 2020-05-07 Japan Tobacco Inc. Nitrogen-containing heteroaryl compound, and pharmaceutical use thereof
CN107739378A (zh) * 2017-11-14 2018-02-27 杭州安道药业有限公司 吲哚嗪衍生物及其在医药上的应用
AU2019340173B2 (en) * 2018-09-13 2024-02-08 Kissei Pharmaceutical Co., Ltd. Imidazopyridinone compound
CN110105355B (zh) * 2019-05-24 2021-09-21 烟台大学 一种1,2,3-三唑-[1,5-a]并喹啉类化合物的制备方法
CA3169000A1 (en) * 2020-03-11 2021-09-16 Hideki Takeuchi Crystal of imidazopyridinone compound or salt thereof
JP7504822B2 (ja) 2020-03-12 2024-06-24 キッセイ薬品工業株式会社 イミダゾピリジノン化合物を含む医薬組成物
US20230218592A1 (en) 2020-04-20 2023-07-13 Akebia Therapeutics, Inc. Treatment of viral infections, of organ injury, and of related conditions using a hif prolyl hydroxylase inhibitor or a hif-alpha stabilizer
WO2022150623A1 (en) 2021-01-08 2022-07-14 Akebia Therapeutics, Inc. Compounds and composition for the treatment of anemia
CN113387948B (zh) * 2021-02-06 2022-06-10 成都诺和晟泰生物科技有限公司 一种稠环杂芳基衍生物及其药物组合物和治疗方法及用途
TW202313072A (zh) 2021-05-27 2023-04-01 美商凱立克斯生物製藥股份有限公司 檸檬酸鐵之兒科調配物
CN113582843A (zh) * 2021-09-09 2021-11-02 无锡捷化医药科技有限公司 一种5-氯-2-氟-3-羟基苯甲酸乙酯的制备方法
CN116496269A (zh) * 2021-12-02 2023-07-28 苏中药业集团股份有限公司 一种脯氨酰羟化酶抑制剂及其用途
CN114031619A (zh) * 2021-12-17 2022-02-11 山东汇海医药化工有限公司 一种图卡替尼中间体的制备方法
WO2024061172A1 (zh) * 2022-09-19 2024-03-28 苏中药业集团股份有限公司 一种脯氨酰羟化酶抑制剂及其用途

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19746287A1 (de) * 1997-10-20 1999-04-22 Hoechst Marion Roussel De Gmbh Substituierte Isochinolin-2-Carbonsäureamide, ihre Herstellung und ihre Verwendung als Arzneimittel
US6355653B1 (en) * 1999-09-06 2002-03-12 Hoffmann-La Roche Inc. Amino-triazolopyridine derivatives
US6514989B1 (en) * 2001-07-20 2003-02-04 Hoffmann-La Roche Inc. Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives
BR0213172A (pt) * 2001-10-08 2004-09-14 Hoffmann La Roche Amida do ácido 8-amino-[1,2,4]triazolo[1,5-a]piridina-6-carboxìlico
CA2531796A1 (en) 2003-08-08 2005-02-17 Transtech Pharma, Inc. Aryl and heteroaryl compounds, compositions, and methods of use
WO2006013048A1 (en) * 2004-08-05 2006-02-09 F.Hoffmann-La Roche Ag Indole, indazole or indoline derivatives
FR2889383A1 (fr) * 2005-08-01 2007-02-02 France Telecom Procede et dispositif de detection pour systeme mimo, systeme mimo, programme et support d'information
PE20071020A1 (es) 2006-03-07 2007-12-11 Smithkline Beecham Corp Compuestos derivados de glicina n-sustituidos como inhibidores de prolil hidroxilasa
US20090176825A1 (en) 2006-05-16 2009-07-09 Fitch Duke M Prolyl hydroxylase inhibitors
JO2934B1 (en) 2006-06-23 2015-09-15 سميث كلاين بيتشام كوربوريشن Prolyl hydroxylase inhibitors
JP5113838B2 (ja) * 2006-06-26 2013-01-09 アケビア セラピューティックス， インコーポレイテッド プロリルヒドロキシラーゼ阻害剤および使用方法
AU2007272009A1 (en) 2006-07-12 2008-01-17 Syngenta Limited Triazolopyridine derivatives as herbicides
CL2008000066A1 (es) 2007-01-12 2008-08-01 Smithkline Beecham Corp Compuestos derivados de (5-hidroxi-3-oxo-2,3-dihidropiridazina-4-carbonil)glicina, inhibidores de hif prolil hidroxilasas; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso en el tratamiento de la anem
JP2010524942A (ja) 2007-04-18 2010-07-22 アムジエン・インコーポレーテツド プロリルヒドロキシラーゼを阻害するキノロン及びアザキノロン
CA2685219C (en) 2007-05-04 2012-06-19 Amgen Inc. Diazaquinolones that inhibit prolyl hydroxylase activity
US20110028463A1 (en) 2007-07-03 2011-02-03 Astellas Pharma Inc. Amide compounds
AU2008331480A1 (en) * 2007-11-30 2009-06-11 Glaxosmithkline Llc Prolyl hydroxylase inhibitors
EP2224926A4 (en) * 2007-11-30 2010-12-01 Glaxosmithkline Llc INHIBITORS OF PROLYL HYDROXYLASES
US8324241B2 (en) * 2008-04-11 2012-12-04 Bristol-Myers Squibb Company Triazolo compounds useful as DGAT1 inhibitors
EP2273879A4 (en) * 2008-04-30 2012-03-21 Glaxosmithkline Llc PROLYLHYDROXYLASEHEMMER
MX2010012961A (es) 2008-05-29 2011-03-03 Sirtris Pharmaceuticals Inc Star Imidazopiridina y analogos relacionados como moduladores de sirtuina.
PL2379548T3 (pl) 2008-12-19 2016-08-31 Leo Pharma As Triazolopirydyny jako inhibitory fosfodiesterazy do leczenia chorób skórnych
CA2768505C (en) * 2009-07-17 2018-06-12 Japan Tobacco Inc. Triazolopyridine compound, and action thereof as prolyl hydroxylase inhibitor and erythropoietin production inducer

Also Published As

Publication number Publication date
MX2012000766A (es) 2012-02-08
JP2019019144A (ja) 2019-02-07
CO6430426A2 (es) 2012-04-30
US20130096155A1 (en) 2013-04-18
CA2768505C (en) 2018-06-12
EP2746282A1 (en) 2014-06-25
IL217541A (en) 2014-07-31
KR101850661B1 (ko) 2018-04-19
TW201105671A (en) 2011-02-16
AU2010271732A1 (en) 2012-03-08
JP2017214404A (ja) 2017-12-07
SI2455381T1 (sl) 2014-08-29
KR20180042443A (ko) 2018-04-25
DK2455381T3 (da) 2014-07-21
RU2012105467A (ru) 2013-08-27
ES2477968T3 (es) 2014-07-18
IL217541A0 (en) 2012-02-29
JP5021797B2 (ja) 2012-09-12
EP2455381B9 (en) 2014-10-22
AU2010271732B2 (en) 2016-08-25
US20160145254A1 (en) 2016-05-26
NZ598242A (en) 2013-09-27
CN102471337B (zh) 2014-12-10
KR20120051704A (ko) 2012-05-22
EP2455381A4 (en) 2012-12-12
ME01858B (me) 2014-12-20
ES2477968T9 (es) 2014-11-13
EP2455381B1 (en) 2014-05-28
SG178049A1 (en) 2012-03-29
US20110077267A1 (en) 2011-03-31
HK1168346A1 (en) 2012-12-28
WO2011007856A1 (ja) 2011-01-20
EP3594213A1 (en) 2020-01-15
KR101706803B1 (ko) 2017-02-14
TWI485150B (zh) 2015-05-21
PT2455381E (pt) 2014-06-24
JP2012144571A (ja) 2012-08-02
AR077417A1 (es) 2011-08-24
JP2011037841A (ja) 2011-02-24
JP6434575B2 (ja) 2018-12-05
EP2455381A1 (en) 2012-05-23
BR112012001157A2 (pt) 2016-02-23
HRP20140705T1 (hr) 2014-09-12
RU2538963C2 (ru) 2015-01-10
CN102471337A (zh) 2012-05-23
JP2015003933A (ja) 2015-01-08
CA2768505A1 (en) 2011-01-20
MY160814A (en) 2017-03-31
JP2016040321A (ja) 2016-03-24
PL2455381T3 (pl) 2014-10-31
SMT201500122B (it) 2015-07-09
DK2455381T5 (en) 2015-02-09
RS53499B1 (en) 2015-02-27
JP2022126843A (ja) 2022-08-30
KR20170018105A (ko) 2017-02-15
US8283465B2 (en) 2012-10-09
JP2020111612A (ja) 2020-07-27
KR20230165366A (ko) 2023-12-05

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