BR112012001157A2 - compostos de triazolopiridina, e ação do mesmo como inibidor de prolil hidroxilase e indutor de produção de eritropoetina - Google Patents

compostos de triazolopiridina, e ação do mesmo como inibidor de prolil hidroxilase e indutor de produção de eritropoetina

Info

Publication number
BR112012001157A2
BR112012001157A2 BR112012001157A BR112012001157A BR112012001157A2 BR 112012001157 A2 BR112012001157 A2 BR 112012001157A2 BR 112012001157 A BR112012001157 A BR 112012001157A BR 112012001157 A BR112012001157 A BR 112012001157A BR 112012001157 A2 BR112012001157 A2 BR 112012001157A2
Authority
BR
Brazil
Prior art keywords
inducer
action
prolyl hydroxylase
hydroxylase inhibitor
erythropoietin production
Prior art date
Application number
BR112012001157A
Other languages
English (en)
Inventor
Dai Motoda
Hiroyuki Abe
Ikuo Mitani
Kazuhito Ueyama
Masahiro Yokota
Masakazu Terashita
Takahiro Hotta
Takashi Ito
Takuya Matsui
Yosuke Ogoshi
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of BR112012001157A2 publication Critical patent/BR112012001157A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
BR112012001157A 2009-07-17 2010-07-16 compostos de triazolopiridina, e ação do mesmo como inibidor de prolil hidroxilase e indutor de produção de eritropoetina BR112012001157A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2009169565 2009-07-17
US27312709P 2009-07-30 2009-07-30
PCT/JP2010/062037 WO2011007856A1 (ja) 2009-07-17 2010-07-16 トリアゾロピリジン化合物、ならびにそのプロリル水酸化酵素阻害剤およびエリスロポエチン産生誘導剤としての作用

Publications (1)

Publication Number Publication Date
BR112012001157A2 true BR112012001157A2 (pt) 2016-02-23

Family

ID=43449466

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012001157A BR112012001157A2 (pt) 2009-07-17 2010-07-16 compostos de triazolopiridina, e ação do mesmo como inibidor de prolil hidroxilase e indutor de produção de eritropoetina

Country Status (29)

Country Link
US (3) US8283465B2 (pt)
EP (3) EP2455381B9 (pt)
JP (9) JP5021797B2 (pt)
KR (4) KR20180042443A (pt)
CN (1) CN102471337B (pt)
AR (1) AR077417A1 (pt)
AU (1) AU2010271732B2 (pt)
BR (1) BR112012001157A2 (pt)
CA (1) CA2768505C (pt)
CO (1) CO6430426A2 (pt)
DK (1) DK2455381T5 (pt)
ES (1) ES2477968T3 (pt)
HK (1) HK1168346A1 (pt)
HR (1) HRP20140705T1 (pt)
IL (1) IL217541A (pt)
ME (1) ME01858B (pt)
MX (1) MX2012000766A (pt)
MY (1) MY160814A (pt)
NZ (1) NZ598242A (pt)
PE (1) PE20120629A1 (pt)
PL (1) PL2455381T3 (pt)
PT (1) PT2455381E (pt)
RS (1) RS53499B1 (pt)
RU (1) RU2538963C2 (pt)
SG (1) SG178049A1 (pt)
SI (1) SI2455381T1 (pt)
SM (1) SMT201500122B (pt)
TW (1) TWI485150B (pt)
WO (1) WO2011007856A1 (pt)

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CA2896437C (en) * 2012-11-26 2021-01-19 Takaaki Abe Erythropoietin expression promoter
TWI598339B (zh) 2012-12-24 2017-09-11 卡地拉保健有限公司 新穎喹啉酮衍生物
ES2974273T3 (es) 2013-06-13 2024-06-26 Akebia Therapeutics Inc Composiciones y métodos para tratar la anemia
RU2534804C1 (ru) * 2013-08-05 2014-12-10 Общество С Ограниченной Ответственностью "Ньювак" (Ооо "Ньювак") ЗАМЕЩЕННЫЕ [1,2,4]ТРИАЗОЛО[4,3-a]ПИРИДИНЫ, ПРОЯВЛЯЮЩИЕ СВОЙСТВА АНТАГОНИСТОВ АДЕНОЗИНОВЫХ А2А РЕЦЕПТОРОВ, И ИХ ПРИМЕНЕНИЕ
SG11201602572YA (en) 2013-10-03 2016-04-28 Kura Oncology Inc Inhibitors of erk and methods of use
CN105384687B (zh) 2014-09-02 2018-05-01 广东东阳光药业有限公司 喹啉酮类化合物及其在药物中应用
JP2018039733A (ja) * 2014-12-22 2018-03-15 株式会社富士薬品 新規複素環誘導体
GB201504565D0 (en) * 2015-03-18 2015-05-06 Takeda Pharmaceutical Novel compounds
CN106146395B (zh) * 2015-03-27 2019-01-01 沈阳三生制药有限责任公司 3-羟基吡啶化合物、其制备方法及其制药用途
JP6814134B2 (ja) * 2015-05-28 2021-01-13 日本たばこ産業株式会社 糖尿病性腎症を治療又は予防する方法
MX2019006083A (es) * 2016-11-25 2019-07-10 Japan Tobacco Inc Metodo para la produccion de compuesto de triazolopiridina.
EP3613742B1 (en) 2017-05-09 2022-12-07 Kind Pharmaceutical Indolizine derivatives and application thereof in medicine
WO2019069973A1 (ja) * 2017-10-04 2019-04-11 日本たばこ産業株式会社 含窒素ヘテロアリール化合物およびその医薬用途
CN107739378A (zh) * 2017-11-14 2018-02-27 杭州安道药业有限公司 吲哚嗪衍生物及其在医药上的应用
US20210206765A1 (en) * 2018-09-13 2021-07-08 Kissei Pharmaceutical Co., Ltd. Imidazopyridinone compound
CN110105355B (zh) * 2019-05-24 2021-09-21 烟台大学 一种1,2,3-三唑-[1,5-a]并喹啉类化合物的制备方法
JPWO2021182490A1 (pt) * 2020-03-11 2021-09-16
JP7504822B2 (ja) 2020-03-12 2024-06-24 キッセイ薬品工業株式会社 イミダゾピリジノン化合物を含む医薬組成物
WO2021216530A1 (en) 2020-04-20 2021-10-28 Akebia Therapeutics, Inc. Treatment of viral infections, of organ injury, and of related conditions using a hif prolyl hydroxylase inhibitor or a hif-alpha stabilizer
WO2022150623A1 (en) 2021-01-08 2022-07-14 Akebia Therapeutics, Inc. Compounds and composition for the treatment of anemia
CN113387948B (zh) * 2021-02-06 2022-06-10 成都诺和晟泰生物科技有限公司 一种稠环杂芳基衍生物及其药物组合物和治疗方法及用途
EP4347022A1 (en) 2021-05-27 2024-04-10 Keryx Biopharmaceuticals, Inc. Pediatric formulations of ferric citrate
CN113582843A (zh) * 2021-09-09 2021-11-02 无锡捷化医药科技有限公司 一种5-氯-2-氟-3-羟基苯甲酸乙酯的制备方法
CN116496269A (zh) * 2021-12-02 2023-07-28 苏中药业集团股份有限公司 一种脯氨酰羟化酶抑制剂及其用途
CN114031619A (zh) * 2021-12-17 2022-02-11 山东汇海医药化工有限公司 一种图卡替尼中间体的制备方法
TW202412778A (zh) * 2022-09-19 2024-04-01 大陸商蘇中藥業集團股份有限公司 一種脯氨醯羥化酶抑制劑及其用途

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Also Published As

Publication number Publication date
SG178049A1 (en) 2012-03-29
KR20230165366A (ko) 2023-12-05
PL2455381T3 (pl) 2014-10-31
EP3594213A1 (en) 2020-01-15
PT2455381E (pt) 2014-06-24
ES2477968T9 (es) 2014-11-13
KR20180042443A (ko) 2018-04-25
SMT201500122B (it) 2015-07-09
JP2011037841A (ja) 2011-02-24
SI2455381T1 (sl) 2014-08-29
EP2455381B9 (en) 2014-10-22
CA2768505C (en) 2018-06-12
JP2024091878A (ja) 2024-07-05
EP2455381B1 (en) 2014-05-28
JP2016040321A (ja) 2016-03-24
PE20120629A1 (es) 2012-05-30
US8283465B2 (en) 2012-10-09
US20160145254A1 (en) 2016-05-26
JP6434575B2 (ja) 2018-12-05
ME01858B (me) 2014-12-20
KR20120051704A (ko) 2012-05-22
EP2746282A1 (en) 2014-06-25
RU2012105467A (ru) 2013-08-27
HK1168346A1 (en) 2012-12-28
US20110077267A1 (en) 2011-03-31
WO2011007856A1 (ja) 2011-01-20
AU2010271732B2 (en) 2016-08-25
JP2020111612A (ja) 2020-07-27
EP2455381A1 (en) 2012-05-23
IL217541A (en) 2014-07-31
RU2538963C2 (ru) 2015-01-10
MX2012000766A (es) 2012-02-08
JP2017214404A (ja) 2017-12-07
DK2455381T3 (da) 2014-07-21
JP2019019144A (ja) 2019-02-07
KR101850661B1 (ko) 2018-04-19
EP2455381A4 (en) 2012-12-12
AU2010271732A1 (en) 2012-03-08
KR20170018105A (ko) 2017-02-15
CN102471337B (zh) 2014-12-10
US20130096155A1 (en) 2013-04-18
KR101706803B1 (ko) 2017-02-14
HRP20140705T1 (hr) 2014-09-12
JP5021797B2 (ja) 2012-09-12
CO6430426A2 (es) 2012-04-30
ES2477968T3 (es) 2014-07-18
IL217541A0 (en) 2012-02-29
TWI485150B (zh) 2015-05-21
MY160814A (en) 2017-03-31
CA2768505A1 (en) 2011-01-20
JP2015003933A (ja) 2015-01-08
JP2012144571A (ja) 2012-08-02
TW201105671A (en) 2011-02-16
NZ598242A (en) 2013-09-27
RS53499B1 (en) 2015-02-27
DK2455381T5 (en) 2015-02-09
JP2022126843A (ja) 2022-08-30
AR077417A1 (es) 2011-08-24
CN102471337A (zh) 2012-05-23

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B25G Requested change of headquarter approved

Owner name: JAPAN TOBACCO INC. (JP)