BRPI1007410A2 - piperidinas aroilamino- e heteroaroilamino-substituídas como inibidores de glyt-1 - Google Patents
piperidinas aroilamino- e heteroaroilamino-substituídas como inibidores de glyt-1Info
- Publication number
- BRPI1007410A2 BRPI1007410A2 BRPI1007410A BRPI1007410A BRPI1007410A2 BR PI1007410 A2 BRPI1007410 A2 BR PI1007410A2 BR PI1007410 A BRPI1007410 A BR PI1007410A BR PI1007410 A BRPI1007410 A BR PI1007410A BR PI1007410 A2 BRPI1007410 A2 BR PI1007410A2
- Authority
- BR
- Brazil
- Prior art keywords
- heteroaroylamino
- glyt
- aroylamino
- inhibitors
- substituted piperidines
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/20—Spiro-condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Psychology (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09151382 | 2009-01-27 | ||
| PCT/EP2010/050551 WO2010086251A1 (en) | 2009-01-27 | 2010-01-19 | Aroylamino - and heteroaroylamino-substituted piperidines as glyt-1 inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI1007410A2 true BRPI1007410A2 (pt) | 2016-02-16 |
Family
ID=41718529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI1007410A BRPI1007410A2 (pt) | 2009-01-27 | 2010-01-19 | piperidinas aroilamino- e heteroaroilamino-substituídas como inibidores de glyt-1 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US20100197715A1 (pt) |
| EP (1) | EP2391603B1 (pt) |
| JP (1) | JP5552494B2 (pt) |
| KR (1) | KR101289577B1 (pt) |
| CN (1) | CN102292320B (pt) |
| AR (1) | AR075160A1 (pt) |
| AU (1) | AU2010209816A1 (pt) |
| BR (1) | BRPI1007410A2 (pt) |
| CA (1) | CA2746967A1 (pt) |
| CO (1) | CO6341621A2 (pt) |
| CR (1) | CR20110348A (pt) |
| EC (1) | ECSP11011196A (pt) |
| ES (1) | ES2445143T3 (pt) |
| IL (1) | IL213672A0 (pt) |
| MA (1) | MA32947B1 (pt) |
| MX (1) | MX2011007272A (pt) |
| NZ (1) | NZ593279A (pt) |
| PE (1) | PE20120500A1 (pt) |
| RU (1) | RU2517701C2 (pt) |
| SG (1) | SG173116A1 (pt) |
| TW (1) | TWI403322B (pt) |
| UA (1) | UA104611C2 (pt) |
| WO (1) | WO2010086251A1 (pt) |
| ZA (1) | ZA201104237B (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI1007410A2 (pt) | 2009-01-27 | 2016-02-16 | Hoffmann La Roche | piperidinas aroilamino- e heteroaroilamino-substituídas como inibidores de glyt-1 |
| AU2010263641A1 (en) * | 2009-06-24 | 2012-01-19 | Sumitomo Dainippon Pharma Co., Ltd. | N-substituted-cyclic amino derivative |
| WO2013019621A1 (en) * | 2011-07-29 | 2013-02-07 | Tempero Pharmaceuticals, Inc. | Compounds and methods |
| US9012489B2 (en) | 2011-08-03 | 2015-04-21 | Boehringer Ingelheim International Gmbh | Phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones and the use thereof as medicament |
| EP2770987B1 (en) | 2011-10-27 | 2018-04-04 | Merck Sharp & Dohme Corp. | Novel compounds that are erk inhibitors |
| EP4054551A4 (en) * | 2019-11-07 | 2024-03-20 | Univ Illinois | INFLUENZA VIRAL ENTRY INHIBITORS |
| CN114478360B (zh) * | 2022-02-10 | 2023-08-15 | 江苏海洋大学 | 一种苯甲酰胺类衍生物及其制备方法和应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2600557A1 (de) * | 1976-01-09 | 1977-07-14 | Delmar Chem | 4-aryl-3/4-amino/hydroxy-piperidinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| WO2001081308A2 (en) | 2000-04-20 | 2001-11-01 | Nps Allelix Corp. | Aminopiperidines for use as glyt-1 inhibitors |
| WO2002080928A1 (en) * | 2001-04-03 | 2002-10-17 | Merck & Co., Inc. | N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists |
| RU2330842C2 (ru) * | 2003-02-17 | 2008-08-10 | Ф.Хоффманн-Ля Рош Аг | Производные пиперидинбензолсульфамида |
| FR2861074B1 (fr) * | 2003-10-17 | 2006-04-07 | Sanofi Synthelabo | Derives de n-[phenyl(piperidin-2-yl)methyl]benzamide, leur preparation et leur application en therapeutique |
| FR2861071B1 (fr) * | 2003-10-17 | 2006-01-06 | Sanofi Synthelabo | Derives de n-[phenyl(alkylpiperidin-2-yl) methyl]benzamide, leur prepartation et leur application en therapeutique |
| ES2297502T3 (es) | 2003-10-23 | 2008-05-01 | F. Hoffmann-La Roche Ag | Derivados de triaza-espiropiperidinas para uso como inhibidores de glyt-1 en el tratamiento de trastornos neurologicos y neuropsiquiatricos. |
| JPWO2008093737A1 (ja) * | 2007-01-31 | 2010-05-20 | 大日本住友製薬株式会社 | アミド誘導体 |
| UA41251U (ru) * | 2008-12-26 | 2009-05-12 | Яков Семенович Песиков | Способ лечения алкоголизма |
| BRPI1007410A2 (pt) | 2009-01-27 | 2016-02-16 | Hoffmann La Roche | piperidinas aroilamino- e heteroaroilamino-substituídas como inibidores de glyt-1 |
-
2010
- 2010-01-19 BR BRPI1007410A patent/BRPI1007410A2/pt not_active Application Discontinuation
- 2010-01-19 CN CN201080005279.2A patent/CN102292320B/zh not_active Expired - Fee Related
- 2010-01-19 RU RU2011134960/04A patent/RU2517701C2/ru not_active IP Right Cessation
- 2010-01-19 PE PE2011001308A patent/PE20120500A1/es not_active Application Discontinuation
- 2010-01-19 ES ES10700563.9T patent/ES2445143T3/es active Active
- 2010-01-19 JP JP2011546772A patent/JP5552494B2/ja not_active Expired - Fee Related
- 2010-01-19 NZ NZ593279A patent/NZ593279A/xx not_active IP Right Cessation
- 2010-01-19 AU AU2010209816A patent/AU2010209816A1/en not_active Abandoned
- 2010-01-19 WO PCT/EP2010/050551 patent/WO2010086251A1/en active Application Filing
- 2010-01-19 CA CA2746967A patent/CA2746967A1/en not_active Abandoned
- 2010-01-19 KR KR1020117019722A patent/KR101289577B1/ko not_active IP Right Cessation
- 2010-01-19 MA MA33992A patent/MA32947B1/fr unknown
- 2010-01-19 UA UAA201110177A patent/UA104611C2/ru unknown
- 2010-01-19 EP EP10700563.9A patent/EP2391603B1/en active Active
- 2010-01-19 MX MX2011007272A patent/MX2011007272A/es active IP Right Grant
- 2010-01-19 SG SG2011053360A patent/SG173116A1/en unknown
- 2010-01-20 US US12/690,128 patent/US20100197715A1/en not_active Abandoned
- 2010-01-25 TW TW099101973A patent/TWI403322B/zh not_active IP Right Cessation
- 2010-01-26 AR ARP100100160A patent/AR075160A1/es not_active Application Discontinuation
-
2011
- 2011-06-07 ZA ZA2011/04237A patent/ZA201104237B/en unknown
- 2011-06-10 CO CO11072655A patent/CO6341621A2/es active IP Right Grant
- 2011-06-20 IL IL213672A patent/IL213672A0/en unknown
- 2011-06-21 CR CR20110348A patent/CR20110348A/es unknown
- 2011-07-11 EC EC2011011196A patent/ECSP11011196A/es unknown
-
2013
- 2013-02-14 US US13/766,840 patent/US9067911B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| TW201032803A (en) | 2010-09-16 |
| CO6341621A2 (es) | 2011-11-21 |
| RU2517701C2 (ru) | 2014-05-27 |
| UA104611C2 (en) | 2014-02-25 |
| AU2010209816A1 (en) | 2011-08-11 |
| EP2391603A1 (en) | 2011-12-07 |
| NZ593279A (en) | 2013-03-28 |
| PE20120500A1 (es) | 2012-05-04 |
| US9067911B2 (en) | 2015-06-30 |
| RU2011134960A (ru) | 2013-03-10 |
| SG173116A1 (en) | 2011-08-29 |
| IL213672A0 (en) | 2011-07-31 |
| CR20110348A (es) | 2011-09-06 |
| US20130158050A1 (en) | 2013-06-20 |
| CA2746967A1 (en) | 2010-08-05 |
| CN102292320B (zh) | 2014-07-02 |
| TWI403322B (zh) | 2013-08-01 |
| ES2445143T3 (es) | 2014-02-28 |
| JP2012515744A (ja) | 2012-07-12 |
| US20100197715A1 (en) | 2010-08-05 |
| EP2391603B1 (en) | 2014-01-08 |
| AR075160A1 (es) | 2011-03-16 |
| KR20110107863A (ko) | 2011-10-04 |
| KR101289577B1 (ko) | 2013-07-24 |
| ZA201104237B (en) | 2012-02-29 |
| MX2011007272A (es) | 2011-08-08 |
| JP5552494B2 (ja) | 2014-07-16 |
| ECSP11011196A (es) | 2011-08-31 |
| WO2010086251A1 (en) | 2010-08-05 |
| CN102292320A (zh) | 2011-12-21 |
| MA32947B1 (fr) | 2012-01-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B11E | Dismissal acc. art. 34 of ipl - requirements for examination incomplete | ||
| B11T | Dismissal of application maintained [chapter 11.20 patent gazette] |