BR112013008886A2 - pirrolidinonas como inibidores de metap-2 - Google Patents

pirrolidinonas como inibidores de metap-2

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Publication number
BR112013008886A2
BR112013008886A2 BR112013008886A BR112013008886A BR112013008886A2 BR 112013008886 A2 BR112013008886 A2 BR 112013008886A2 BR 112013008886 A BR112013008886 A BR 112013008886A BR 112013008886 A BR112013008886 A BR 112013008886A BR 112013008886 A2 BR112013008886 A2 BR 112013008886A2
Authority
BR
Brazil
Prior art keywords
metap
pyrrolidinones
inhibitors
Prior art date
Application number
BR112013008886A
Other languages
English (en)
Other versions
BR112013008886B1 (pt
Inventor
Djordje Musil
Frank Zenke
Michel Calderini
Timo Henrich
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of BR112013008886A2 publication Critical patent/BR112013008886A2/pt
Publication of BR112013008886B1 publication Critical patent/BR112013008886B1/pt

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
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    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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BR112018076812A2 (pt) * 2016-06-21 2021-09-28 The University Of Melbourne Ativadores da latência de hiv
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CN108409630B (zh) * 2018-02-07 2021-01-15 宁波大学 一种水相中3-羟基-2-吲哚酮衍生物的制备方法
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CN112480100B (zh) * 2019-09-11 2022-10-14 康威(广州)生物科技有限公司 吡咯烷酮衍生物
CN110759843A (zh) * 2019-09-30 2020-02-07 东北师范大学 一种氟叠氮取代的四元杂环化合物的制备和应用
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CN117412952A (zh) * 2021-03-28 2024-01-16 康崴新药有限公司 Metap-2抑制剂、药物组合物及其治疗方法
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