CO7020914A2 - Nievos derivados de morofolinilo útiles como inhibidores de mogat-2 - Google Patents
Nievos derivados de morofolinilo útiles como inhibidores de mogat-2Info
- Publication number
- CO7020914A2 CO7020914A2 CO14161421A CO14161421A CO7020914A2 CO 7020914 A2 CO7020914 A2 CO 7020914A2 CO 14161421 A CO14161421 A CO 14161421A CO 14161421 A CO14161421 A CO 14161421A CO 7020914 A2 CO7020914 A2 CO 7020914A2
- Authority
- CO
- Colombia
- Prior art keywords
- mogat
- snows
- morpholinyl
- inhibitors
- derived
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
- C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/145—Maleic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12382037 | 2012-01-31 | ||
| US201261617093P | 2012-03-29 | 2012-03-29 | |
| EP12382433 | 2012-11-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO7020914A2 true CO7020914A2 (es) | 2014-08-11 |
Family
ID=48905712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO14161421A CO7020914A2 (es) | 2012-01-31 | 2014-07-24 | Nievos derivados de morofolinilo útiles como inhibidores de mogat-2 |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8993568B2 (es) |
| EP (1) | EP2809661B1 (es) |
| JP (1) | JP5852269B2 (es) |
| KR (1) | KR20140107641A (es) |
| CN (1) | CN104080777B (es) |
| AP (1) | AP2014007793A0 (es) |
| AU (1) | AU2013215549B2 (es) |
| BR (1) | BR112014018712A8 (es) |
| CA (1) | CA2859992A1 (es) |
| CL (1) | CL2014001862A1 (es) |
| CO (1) | CO7020914A2 (es) |
| CR (1) | CR20140325A (es) |
| DO (1) | DOP2014000177A (es) |
| EA (1) | EA024182B1 (es) |
| ES (1) | ES2571577T3 (es) |
| GT (1) | GT201400169A (es) |
| HK (1) | HK1199024A1 (es) |
| IL (1) | IL233542A0 (es) |
| MX (1) | MX2014008604A (es) |
| PE (1) | PE20141789A1 (es) |
| PH (1) | PH12014501712B1 (es) |
| SG (1) | SG11201404508XA (es) |
| WO (1) | WO2013116065A1 (es) |
| ZA (1) | ZA201405227B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9073856B2 (en) | 2012-01-23 | 2015-07-07 | Eli Lilly And Company | Phenyl methanesulfonamide derivatives useful as MGAT-2 inhibitors |
| AR089771A1 (es) | 2012-01-31 | 2014-09-17 | Lilly Co Eli | Derivados de bencil sulfonamida utiles como inhibidores de mogat-2 |
| PE20141789A1 (es) | 2012-01-31 | 2014-11-19 | Lilly Co Eli | Nuevos derivados de morofolinilo utiles como inhibidores de mogat-2 |
| JP2016501844A (ja) | 2012-11-06 | 2016-01-21 | イーライ リリー アンド カンパニー | ＭｏＧＡＴ−２阻害剤として有用な新規のベンジルスルホンアミド化合物 |
| EP3395798A4 (en) | 2015-12-21 | 2019-07-17 | Shionogi & Co., Ltd | NON-AROMATIC HETEROCYCLIC DERIVATIVE HAVING MGAT2 INHIBITORY ACTIVITY |
| TWI782056B (zh) | 2017-07-14 | 2022-11-01 | 日商鹽野義製藥股份有限公司 | 具有ｍｇａｔ２抑制活性的縮合環衍生物 |
| US20220135577A1 (en) | 2019-01-11 | 2022-05-05 | Shionogi & Co., Ltd. | Dihydropyrazolopyrazinone derivative having mgat2 inhibitory activity |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5889006A (en) | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
| GB9702194D0 (en) | 1997-02-04 | 1997-03-26 | Lilly Co Eli | Sulphonide derivatives |
| WO2000006083A2 (en) | 1998-07-31 | 2000-02-10 | Eli Lilly And Company | Sulfonamide derivatives |
| AU5233999A (en) | 1998-07-31 | 2000-02-21 | Eli Lilly And Company | Alkenyl sulphonamide derivatives |
| GB0408777D0 (en) | 2004-04-20 | 2004-05-26 | Glaxo Group Ltd | Compounds |
| EP1659113A1 (en) | 2004-11-08 | 2006-05-24 | Evotec AG | Inhibitors of 11beta-hydroxy steroid dehydrogenase type 1 (11beta-HSD1) |
| EP1655283A1 (en) | 2004-11-08 | 2006-05-10 | Evotec OAI AG | 11beta-HSD1 Inhibitors |
| US8232282B2 (en) | 2006-09-28 | 2012-07-31 | Dainippon Sumitomo Pharma Co., Ltd. | Compound having bicyclic pyrimidine structure and pharmaceutical composition comprising the same |
| TW200831092A (en) * | 2006-12-21 | 2008-08-01 | Astrazeneca Ab | Therapeutic agents |
| MX2010006220A (es) * | 2007-12-05 | 2010-08-17 | Astrazeneca Ab | Derivados de morfolina como agentes antiobesidad. |
| EP2219646A4 (en) | 2007-12-21 | 2010-12-22 | Univ Rochester | METHOD FOR MODIFYING THE LIFETIME OF EUKARYOTIC ORGANISMS |
| US20110015198A1 (en) | 2008-03-28 | 2011-01-20 | Banyu Pharmaceutical Co., Inc. | Diarylmethylamide derivative having melanin-concentrating hormone receptor antagonism |
| CA2725949A1 (en) * | 2008-06-04 | 2009-12-10 | Astrazeneca Ab | New pyridine derivatives as leptin receptor modulator mimetics |
| WO2010095767A1 (en) | 2009-02-23 | 2010-08-26 | Banyu Pharmaceutical Co.,Ltd. | Pyrimidin-4(3h)-one derivatives |
| JP2014051434A (ja) | 2010-12-28 | 2014-03-20 | Dainippon Sumitomo Pharma Co Ltd | 二環性ピリミジン誘導体 |
| US9073856B2 (en) | 2012-01-23 | 2015-07-07 | Eli Lilly And Company | Phenyl methanesulfonamide derivatives useful as MGAT-2 inhibitors |
| AR089771A1 (es) | 2012-01-31 | 2014-09-17 | Lilly Co Eli | Derivados de bencil sulfonamida utiles como inhibidores de mogat-2 |
| PE20141789A1 (es) | 2012-01-31 | 2014-11-19 | Lilly Co Eli | Nuevos derivados de morofolinilo utiles como inhibidores de mogat-2 |
| JP2016501844A (ja) | 2012-11-06 | 2016-01-21 | イーライ リリー アンド カンパニー | ＭｏＧＡＴ−２阻害剤として有用な新規のベンジルスルホンアミド化合物 |
-
2013
- 2013-01-24 PE PE2014001194A patent/PE20141789A1/es not_active Application Discontinuation
- 2013-01-24 ES ES13702564T patent/ES2571577T3/es active Active
- 2013-01-24 BR BR112014018712A patent/BR112014018712A8/pt not_active IP Right Cessation
- 2013-01-24 EP EP13702564.9A patent/EP2809661B1/en active Active
- 2013-01-24 KR KR1020147021129A patent/KR20140107641A/ko active IP Right Grant
- 2013-01-24 MX MX2014008604A patent/MX2014008604A/es unknown
- 2013-01-24 EA EA201491227A patent/EA024182B1/ru not_active IP Right Cessation
- 2013-01-24 SG SG11201404508XA patent/SG11201404508XA/en unknown
- 2013-01-24 JP JP2014554806A patent/JP5852269B2/ja not_active Expired - Fee Related
- 2013-01-24 CA CA2859992A patent/CA2859992A1/en not_active Abandoned
- 2013-01-24 AP AP2014007793A patent/AP2014007793A0/xx unknown
- 2013-01-24 CN CN201380007113.8A patent/CN104080777B/zh not_active Expired - Fee Related
- 2013-01-24 WO PCT/US2013/022828 patent/WO2013116065A1/en active Application Filing
- 2013-01-24 US US14/372,833 patent/US8993568B2/en not_active Expired - Fee Related
- 2013-01-24 AU AU2013215549A patent/AU2013215549B2/en not_active Ceased
-
2014
- 2014-07-07 IL IL233542A patent/IL233542A0/en unknown
- 2014-07-08 CR CR20140325A patent/CR20140325A/es unknown
- 2014-07-15 CL CL2014001862A patent/CL2014001862A1/es unknown
- 2014-07-16 ZA ZA2014/05227A patent/ZA201405227B/en unknown
- 2014-07-24 CO CO14161421A patent/CO7020914A2/es unknown
- 2014-07-29 GT GT201400169A patent/GT201400169A/es unknown
- 2014-07-30 DO DO2014000177A patent/DOP2014000177A/es unknown
- 2014-07-30 PH PH12014501712A patent/PH12014501712B1/en unknown
- 2014-12-11 HK HK14112464.6A patent/HK1199024A1/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL233542A0 (en) | 2014-08-31 |
| DOP2014000177A (es) | 2014-08-31 |
| CN104080777B (zh) | 2015-12-09 |
| AU2013215549A1 (en) | 2014-07-17 |
| MX2014008604A (es) | 2014-08-22 |
| ZA201405227B (en) | 2016-05-25 |
| HK1199024A1 (zh) | 2015-06-19 |
| PH12014501712A1 (en) | 2014-10-13 |
| EP2809661B1 (en) | 2016-04-06 |
| EP2809661A1 (en) | 2014-12-10 |
| KR20140107641A (ko) | 2014-09-04 |
| EA024182B1 (ru) | 2016-08-31 |
| PE20141789A1 (es) | 2014-11-19 |
| CA2859992A1 (en) | 2013-08-08 |
| BR112014018712A2 (es) | 2017-06-20 |
| GT201400169A (es) | 2015-08-27 |
| CR20140325A (es) | 2014-08-25 |
| JP2015504917A (ja) | 2015-02-16 |
| US8993568B2 (en) | 2015-03-31 |
| JP5852269B2 (ja) | 2016-02-03 |
| SG11201404508XA (en) | 2014-10-30 |
| CL2014001862A1 (es) | 2014-11-14 |
| AP2014007793A0 (en) | 2014-07-31 |
| ES2571577T3 (es) | 2016-05-26 |
| EA201491227A1 (ru) | 2015-01-30 |
| PH12014501712B1 (en) | 2014-10-13 |
| AU2013215549B2 (en) | 2015-09-03 |
| US20150005305A1 (en) | 2015-01-01 |
| BR112014018712A8 (pt) | 2017-07-11 |
| CN104080777A (zh) | 2014-10-01 |
| WO2013116065A1 (en) | 2013-08-08 |
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