AP2014007793A0 - Novel morpholinyl derivatives useful as mogat-2 inhibitors - Google Patents

Novel morpholinyl derivatives useful as mogat-2 inhibitors

Info

Publication number
AP2014007793A0
AP2014007793A0 AP2014007793A AP2014007793A AP2014007793A0 AP 2014007793 A0 AP2014007793 A0 AP 2014007793A0 AP 2014007793 A AP2014007793 A AP 2014007793A AP 2014007793 A AP2014007793 A AP 2014007793A AP 2014007793 A0 AP2014007793 A0 AP 2014007793A0
Authority
AP
ARIPO
Prior art keywords
mogat
inhibitors
derivatives useful
novel
morpholinyl derivatives
Prior art date
Application number
AP2014007793A
Other languages
English (en)
Inventor
Maria Rosario Gonzalez-Garcia
Maria Carmen Fernandez
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48905712&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AP2014007793(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AP2014007793A0 publication Critical patent/AP2014007793A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AP2014007793A 2012-01-31 2013-01-24 Novel morpholinyl derivatives useful as mogat-2 inhibitors AP2014007793A0 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP12382037 2012-01-31
US201261617093P 2012-03-29 2012-03-29
EP12382433 2012-11-06
PCT/US2013/022828 WO2013116065A1 (en) 2012-01-31 2013-01-24 Novel morpholinyl derivatives useful as mogat-2 inhibitors

Publications (1)

Publication Number Publication Date
AP2014007793A0 true AP2014007793A0 (en) 2014-07-31

Family

ID=48905712

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2014007793A AP2014007793A0 (en) 2012-01-31 2013-01-24 Novel morpholinyl derivatives useful as mogat-2 inhibitors

Country Status (24)

Country Link
US (1) US8993568B2 (es)
EP (1) EP2809661B1 (es)
JP (1) JP5852269B2 (es)
KR (1) KR20140107641A (es)
CN (1) CN104080777B (es)
AP (1) AP2014007793A0 (es)
AU (1) AU2013215549B2 (es)
BR (1) BR112014018712A8 (es)
CA (1) CA2859992A1 (es)
CL (1) CL2014001862A1 (es)
CO (1) CO7020914A2 (es)
CR (1) CR20140325A (es)
DO (1) DOP2014000177A (es)
EA (1) EA024182B1 (es)
ES (1) ES2571577T3 (es)
GT (1) GT201400169A (es)
HK (1) HK1199024A1 (es)
IL (1) IL233542A0 (es)
MX (1) MX2014008604A (es)
PE (1) PE20141789A1 (es)
PH (1) PH12014501712B1 (es)
SG (1) SG11201404508XA (es)
WO (1) WO2013116065A1 (es)
ZA (1) ZA201405227B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9073856B2 (en) 2012-01-23 2015-07-07 Eli Lilly And Company Phenyl methanesulfonamide derivatives useful as MGAT-2 inhibitors
CA2859992A1 (en) 2012-01-31 2013-08-08 Eli Lilly And Company Novel morpholinyl derivatives useful as mogat-2 inhibitors
AR089771A1 (es) 2012-01-31 2014-09-17 Lilly Co Eli Derivados de bencil sulfonamida utiles como inhibidores de mogat-2
KR20150063519A (ko) 2012-11-06 2015-06-09 일라이 릴리 앤드 캄파니 Mogat-2 억제제로서 유용한 신규 벤질 술폰아미드 화합물
WO2017110841A1 (ja) 2015-12-21 2017-06-29 塩野義製薬株式会社 Ｍｇａｔ２阻害活性を有する非芳香族複素環誘導体
TWI782056B (zh) 2017-07-14 2022-11-01 日商鹽野義製藥股份有限公司 具有ｍｇａｔ２抑制活性的縮合環衍生物
AU2020207716A1 (en) 2019-01-11 2021-07-15 Shionogi & Co., Ltd. Dihydropyrazolopyrazinone derivative having MGAT2 inhibitory activity

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5889006A (en) 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
GB9702194D0 (en) 1997-02-04 1997-03-26 Lilly Co Eli Sulphonide derivatives
AU5235699A (en) 1998-07-31 2000-02-21 Eli Lilly And Company Sulfonamide derivatives
AU5233999A (en) 1998-07-31 2000-02-21 Eli Lilly And Company Alkenyl sulphonamide derivatives
GB0408777D0 (en) 2004-04-20 2004-05-26 Glaxo Group Ltd Compounds
EP1655283A1 (en) 2004-11-08 2006-05-10 Evotec OAI AG 11beta-HSD1 Inhibitors
EP1659113A1 (en) 2004-11-08 2006-05-24 Evotec AG Inhibitors of 11beta-hydroxy steroid dehydrogenase type 1 (11beta-HSD1)
US8232282B2 (en) 2006-09-28 2012-07-31 Dainippon Sumitomo Pharma Co., Ltd. Compound having bicyclic pyrimidine structure and pharmaceutical composition comprising the same
TW200831092A (en) * 2006-12-21 2008-08-01 Astrazeneca Ab Therapeutic agents
KR20100097701A (ko) * 2007-12-05 2010-09-03 아스트라제네카 아베 비만 치료제로서의 모르폴린 유도체
US8642660B2 (en) 2007-12-21 2014-02-04 The University Of Rochester Method for altering the lifespan of eukaryotic organisms
JPWO2009119726A1 (ja) 2008-03-28 2011-07-28 Ｍｓｄ株式会社 メラニン凝集ホルモン受容体拮抗作用を有するジアリールメチルアミド誘導体
CA2725949A1 (en) 2008-06-04 2009-12-10 Astrazeneca Ab New pyridine derivatives as leptin receptor modulator mimetics
WO2010095767A1 (en) 2009-02-23 2010-08-26 Banyu Pharmaceutical Co.,Ltd. Pyrimidin-4(3h)-one derivatives
JP2014051434A (ja) 2010-12-28 2014-03-20 Dainippon Sumitomo Pharma Co Ltd 二環性ピリミジン誘導体
US9073856B2 (en) 2012-01-23 2015-07-07 Eli Lilly And Company Phenyl methanesulfonamide derivatives useful as MGAT-2 inhibitors
CA2859992A1 (en) 2012-01-31 2013-08-08 Eli Lilly And Company Novel morpholinyl derivatives useful as mogat-2 inhibitors
AR089771A1 (es) 2012-01-31 2014-09-17 Lilly Co Eli Derivados de bencil sulfonamida utiles como inhibidores de mogat-2
KR20150063519A (ko) 2012-11-06 2015-06-09 일라이 릴리 앤드 캄파니 Mogat-2 억제제로서 유용한 신규 벤질 술폰아미드 화합물

Also Published As

Publication number Publication date
US8993568B2 (en) 2015-03-31
BR112014018712A2 (es) 2017-06-20
CA2859992A1 (en) 2013-08-08
ES2571577T3 (es) 2016-05-26
CN104080777B (zh) 2015-12-09
CR20140325A (es) 2014-08-25
JP5852269B2 (ja) 2016-02-03
EP2809661B1 (en) 2016-04-06
ZA201405227B (en) 2016-05-25
HK1199024A1 (zh) 2015-06-19
PH12014501712A1 (en) 2014-10-13
SG11201404508XA (en) 2014-10-30
US20150005305A1 (en) 2015-01-01
EA024182B1 (ru) 2016-08-31
BR112014018712A8 (pt) 2017-07-11
CL2014001862A1 (es) 2014-11-14
PE20141789A1 (es) 2014-11-19
DOP2014000177A (es) 2014-08-31
AU2013215549B2 (en) 2015-09-03
CO7020914A2 (es) 2014-08-11
WO2013116065A1 (en) 2013-08-08
CN104080777A (zh) 2014-10-01
KR20140107641A (ko) 2014-09-04
GT201400169A (es) 2015-08-27
PH12014501712B1 (en) 2014-10-13
JP2015504917A (ja) 2015-02-16
EA201491227A1 (ru) 2015-01-30
EP2809661A1 (en) 2014-12-10
AU2013215549A1 (en) 2014-07-17
IL233542A0 (en) 2014-08-31
MX2014008604A (es) 2014-08-22

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