GT201400169A - Nuevos derivados de morofolinilo utiles como inhibidores de mogat-2 - Google Patents

Nuevos derivados de morofolinilo utiles como inhibidores de mogat-2

Info

Publication number
GT201400169A
GT201400169A GT201400169A GT201400169A GT201400169A GT 201400169 A GT201400169 A GT 201400169A GT 201400169 A GT201400169 A GT 201400169A GT 201400169 A GT201400169 A GT 201400169A GT 201400169 A GT201400169 A GT 201400169A
Authority
GT
Guatemala
Prior art keywords
mogat
inhibitors
derivatives
morofolinyl
new useful
Prior art date
Application number
GT201400169A
Other languages
English (en)
Inventor
María Rosario Gonzalez Garcia
María Carmen Fernandez
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48905712&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GT201400169(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of GT201400169A publication Critical patent/GT201400169A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/03—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A NUEVOS DERIVADOS DE MORFOLINILO ÚTILES COMO INHIBIDORES DE MOGAT-2 LOS CUALES SON DE UTILIDAD PARA EL TRATAMIENTO DE HIPERTRIGLICERIDEMIA
GT201400169A 2012-01-31 2014-07-29 Nuevos derivados de morofolinilo utiles como inhibidores de mogat-2 GT201400169A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12382037 2012-01-31
US201261617093P 2012-03-29 2012-03-29
EP12382433 2012-11-06

Publications (1)

Publication Number Publication Date
GT201400169A true GT201400169A (es) 2015-08-27

Family

ID=48905712

Family Applications (1)

Application Number Title Priority Date Filing Date
GT201400169A GT201400169A (es) 2012-01-31 2014-07-29 Nuevos derivados de morofolinilo utiles como inhibidores de mogat-2

Country Status (24)

Country Link
US (1) US8993568B2 (es)
EP (1) EP2809661B1 (es)
JP (1) JP5852269B2 (es)
KR (1) KR20140107641A (es)
CN (1) CN104080777B (es)
AP (1) AP2014007793A0 (es)
AU (1) AU2013215549B2 (es)
BR (1) BR112014018712A8 (es)
CA (1) CA2859992A1 (es)
CL (1) CL2014001862A1 (es)
CO (1) CO7020914A2 (es)
CR (1) CR20140325A (es)
DO (1) DOP2014000177A (es)
EA (1) EA024182B1 (es)
ES (1) ES2571577T3 (es)
GT (1) GT201400169A (es)
HK (1) HK1199024A1 (es)
IL (1) IL233542A0 (es)
MX (1) MX2014008604A (es)
PE (1) PE20141789A1 (es)
PH (1) PH12014501712A1 (es)
SG (1) SG11201404508XA (es)
WO (1) WO2013116065A1 (es)
ZA (1) ZA201405227B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013112323A1 (en) 2012-01-23 2013-08-01 Eli Lilly And Company Phenyl methanesulfonamide derivatives useful as mgat - 2 inhibitors
TW201343629A (zh) 2012-01-31 2013-11-01 Lilly Co Eli 可作為ｍｏｇａｔ－２抑制劑之新穎芐磺醯胺衍生物
ES2571577T3 (es) 2012-01-31 2016-05-26 Lilly Co Eli Derivados novedosos de morfolinilo útiles como inhibidores de MOGAT-2
EA201590696A1 (ru) 2012-11-06 2015-08-31 Эли Лилли Энд Компани Новые бензилсульфонамидные соединения, подходящие в качестве ингибиторов mogat-2
US10335401B2 (en) 2015-12-21 2019-07-02 Shionogi & Co., Ltd. Non-aromatic heterocyclic derivative having MGAT2 inhibitory activity
TWI782056B (zh) 2017-07-14 2022-11-01 日商鹽野義製藥股份有限公司 具有ｍｇａｔ２抑制活性的縮合環衍生物
BR112021012428A2 (pt) 2019-01-11 2021-09-08 Shionogi & Co., Ltd. Derivado de dihidropirazolopirazinona tendo atividade inibitória de mgat2

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5889006A (en) 1995-02-23 1999-03-30 Schering Corporation Muscarinic antagonists
GB9702194D0 (en) 1997-02-04 1997-03-26 Lilly Co Eli Sulphonide derivatives
AU5233999A (en) 1998-07-31 2000-02-21 Eli Lilly And Company Alkenyl sulphonamide derivatives
CA2338994A1 (en) 1998-07-31 2000-02-10 Paul Leslie Ornstein Sulfonamide derivatives
GB0408777D0 (en) 2004-04-20 2004-05-26 Glaxo Group Ltd Compounds
EP1655283A1 (en) 2004-11-08 2006-05-10 Evotec OAI AG 11beta-HSD1 Inhibitors
EP1659113A1 (en) 2004-11-08 2006-05-24 Evotec AG Inhibitors of 11beta-hydroxy steroid dehydrogenase type 1 (11beta-HSD1)
EP2078719A4 (en) * 2006-09-28 2009-11-11 Dainippon Sumitomo Pharma Co COMPOUND WITH BICYCLIC PYRIMIDINE STRUCTURE AND THE COMPOUND CONTAINING PHARMACEUTICAL COMPOSITION
TW200831092A (en) * 2006-12-21 2008-08-01 Astrazeneca Ab Therapeutic agents
AU2008333111A1 (en) * 2007-12-05 2009-06-11 Astrazeneca Ab (Publ) Morpholine derivates as antiobesity agents
EP2219646A4 (en) 2007-12-21 2010-12-22 Univ Rochester METHOD FOR MODIFYING THE LIFETIME OF EUKARYOTIC ORGANISMS
CA2717384A1 (en) 2008-03-28 2009-10-01 Banyu Pharmaceutical Co., Ltd. Diarylmethylamide derivative having melanin-concentrating hormone receptor antagonism
AU2009254547A1 (en) 2008-06-04 2009-12-10 Astrazeneca Ab (Publ) New compounds V
EP2398800A4 (en) 2009-02-23 2012-07-25 Msd Kk Pyrimidin-4 (3H) -ONE DERIVATIVES
JP2014051434A (ja) 2010-12-28 2014-03-20 Dainippon Sumitomo Pharma Co Ltd 二環性ピリミジン誘導体
WO2013112323A1 (en) 2012-01-23 2013-08-01 Eli Lilly And Company Phenyl methanesulfonamide derivatives useful as mgat - 2 inhibitors
TW201343629A (zh) 2012-01-31 2013-11-01 Lilly Co Eli 可作為ｍｏｇａｔ－２抑制劑之新穎芐磺醯胺衍生物
ES2571577T3 (es) 2012-01-31 2016-05-26 Lilly Co Eli Derivados novedosos de morfolinilo útiles como inhibidores de MOGAT-2
EA201590696A1 (ru) 2012-11-06 2015-08-31 Эли Лилли Энд Компани Новые бензилсульфонамидные соединения, подходящие в качестве ингибиторов mogat-2

Also Published As

Publication number Publication date
EA024182B1 (ru) 2016-08-31
IL233542A0 (en) 2014-08-31
CO7020914A2 (es) 2014-08-11
PE20141789A1 (es) 2014-11-19
BR112014018712A8 (pt) 2017-07-11
HK1199024A1 (zh) 2015-06-19
BR112014018712A2 (es) 2017-06-20
DOP2014000177A (es) 2014-08-31
EP2809661A1 (en) 2014-12-10
WO2013116065A1 (en) 2013-08-08
CA2859992A1 (en) 2013-08-08
ZA201405227B (en) 2016-05-25
AU2013215549B2 (en) 2015-09-03
CL2014001862A1 (es) 2014-11-14
US8993568B2 (en) 2015-03-31
AU2013215549A1 (en) 2014-07-17
PH12014501712B1 (en) 2014-10-13
CN104080777A (zh) 2014-10-01
CR20140325A (es) 2014-08-25
EA201491227A1 (ru) 2015-01-30
CN104080777B (zh) 2015-12-09
AP2014007793A0 (en) 2014-07-31
MX2014008604A (es) 2014-08-22
JP2015504917A (ja) 2015-02-16
US20150005305A1 (en) 2015-01-01
EP2809661B1 (en) 2016-04-06
PH12014501712A1 (en) 2014-10-13
KR20140107641A (ko) 2014-09-04
JP5852269B2 (ja) 2016-02-03
ES2571577T3 (es) 2016-05-26
SG11201404508XA (en) 2014-10-30

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