SMT201700065B - Derivato piridonico - Google Patents

Derivato piridonico

Info

Publication number
SMT201700065B
SMT201700065B SM201700065T SM201700065T SMT201700065B SM T201700065 B SMT201700065 B SM T201700065B SM 201700065 T SM201700065 T SM 201700065T SM 201700065 T SM201700065 T SM 201700065T SM T201700065 B SMT201700065 B SM T201700065B
Authority
SM
San Marino
Prior art keywords
pyridonic
derivative
pyridonic derivative
Prior art date
Application number
SM201700065T
Other languages
English (en)
Inventor
Hitoshi Ohki
Masahiro Ota
Kosuke Takeuchi
Hideaki Watanabe
Akitake Yamaguchi
Yoshihiro Shibata
Yuichi Tominaga
Takeshi Jimbo
Keijiro Kobayashi
Katsuhiro Kobayashi
Daisuke Fukatsu
Original Assignee
Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of SMT201700065B publication Critical patent/SMT201700065B/it

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • C07D213/82Amides; Imides in position 3
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SM201700065T 2012-01-31 2017-01-30 Derivato piridonico SMT201700065B (it)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2012017971 2012-01-31
US201261746039P 2012-12-26 2012-12-26
PCT/JP2013/052111 WO2013115280A1 (ja) 2012-01-31 2013-01-30 ピリドン誘導体

Publications (1)

Publication Number Publication Date
SMT201700065B true SMT201700065B (it) 2017-03-08

Family

ID=48905312

Family Applications (2)

Application Number Title Priority Date Filing Date
SM20170065T SMT201700065T1 (it) 2012-01-31 2013-01-30 Derivato piridonico
SM201700065T SMT201700065B (it) 2012-01-31 2017-01-30 Derivato piridonico

Family Applications Before (1)

Application Number Title Priority Date Filing Date
SM20170065T SMT201700065T1 (it) 2012-01-31 2013-01-30 Derivato piridonico

Country Status (30)

Country Link
US (1) US8933103B2 (it)
EP (1) EP2810937B1 (it)
JP (1) JP6006241B2 (it)
KR (1) KR102078530B1 (it)
CN (1) CN104185627B (it)
AU (1) AU2013216006B2 (it)
BR (1) BR112014018702B1 (it)
CA (1) CA2863515C (it)
CO (1) CO7071126A2 (it)
CY (1) CY1118656T1 (it)
DK (1) DK2810937T3 (it)
ES (1) ES2617484T3 (it)
HR (1) HRP20170303T1 (it)
HU (1) HUE031624T2 (it)
IL (1) IL233863A (it)
LT (1) LT2810937T (it)
MX (1) MX351812B (it)
MY (1) MY165215A (it)
NZ (1) NZ627586A (it)
PH (1) PH12014501719B1 (it)
PL (1) PL2810937T3 (it)
PT (1) PT2810937T (it)
RS (1) RS55728B1 (it)
RU (1) RU2632885C2 (it)
SG (1) SG11201404505PA (it)
SI (1) SI2810937T1 (it)
SM (2) SMT201700065T1 (it)
TW (1) TWI537259B (it)
WO (1) WO2013115280A1 (it)
ZA (1) ZA201405486B (it)

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TWI903299B (zh) 2018-03-08 2025-11-01 美商英塞特公司 作為PI3K-γ抑制劑之胺基吡嗪二醇化合物
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TWI840378B (zh) * 2018-07-04 2024-05-01 日商第一三共股份有限公司 二芳基吡啶衍生物之製造方法
CN110857293B (zh) * 2018-08-24 2023-01-10 药捷安康(南京)科技股份有限公司 一种新型的喹啉衍生物抑制剂
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CN112625026B (zh) * 2019-09-24 2022-09-09 药捷安康(南京)科技股份有限公司 Tam家族激酶抑制剂的喹啉衍生物
IL291665B2 (en) 2019-09-27 2025-07-01 Univ Texas Inhibitors of receptor interacting protein kinase i for the treatment of disease
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Also Published As

Publication number Publication date
PH12014501719B1 (en) 2019-07-17
IL233863A0 (en) 2014-09-30
SG11201404505PA (en) 2014-10-30
DK2810937T3 (en) 2017-03-13
HRP20170303T1 (hr) 2017-04-21
HUE031624T2 (en) 2017-07-28
ZA201405486B (en) 2015-11-25
EP2810937A4 (en) 2015-07-22
RS55728B1 (sr) 2017-07-31
AU2013216006A1 (en) 2014-08-28
WO2013115280A1 (ja) 2013-08-08
SI2810937T1 (sl) 2017-01-31
JP6006241B2 (ja) 2016-10-12
US8933103B2 (en) 2015-01-13
MX351812B (es) 2017-10-27
CN104185627A (zh) 2014-12-03
SMT201700065T1 (it) 2017-03-08
PH12014501719A1 (en) 2014-11-10
BR112014018702B1 (pt) 2021-12-14
KR102078530B1 (ko) 2020-02-18
CY1118656T1 (el) 2017-07-12
CN104185627B (zh) 2018-01-12
EP2810937B1 (en) 2016-11-30
US20130281428A1 (en) 2013-10-24
CO7071126A2 (es) 2014-09-30
IL233863A (en) 2017-08-31
PT2810937T (pt) 2017-03-03
BR112014018702A8 (pt) 2017-07-11
KR20140117439A (ko) 2014-10-07
MY165215A (en) 2018-03-09
AU2013216006B2 (en) 2017-06-08
BR112014018702A2 (it) 2017-06-20
TW201335148A (zh) 2013-09-01
PL2810937T3 (pl) 2017-07-31
ES2617484T3 (es) 2017-06-19
NZ627586A (en) 2016-08-26
CA2863515A1 (en) 2013-08-08
MX2014009246A (es) 2014-10-14
EP2810937A1 (en) 2014-12-10
LT2810937T (lt) 2017-02-10
TWI537259B (zh) 2016-06-11
CA2863515C (en) 2018-02-27
HK1203504A1 (en) 2015-10-30
JPWO2013115280A1 (ja) 2015-05-11
RU2632885C2 (ru) 2017-10-11
RU2014135401A (ru) 2016-03-20

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