BR112014018702A8 - Composto, cristal, inibidor, medicamento, composição farmacêutica, e, uso de um composto ou sal - Google Patents
Composto, cristal, inibidor, medicamento, composição farmacêutica, e, uso de um composto ou salInfo
- Publication number
- BR112014018702A8 BR112014018702A8 BR112014018702A BR112014018702A BR112014018702A8 BR 112014018702 A8 BR112014018702 A8 BR 112014018702A8 BR 112014018702 A BR112014018702 A BR 112014018702A BR 112014018702 A BR112014018702 A BR 112014018702A BR 112014018702 A8 BR112014018702 A8 BR 112014018702A8
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- drug
- inhibitor
- salt
- crystal
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
Abstract
COMPOSTO, CRISTAL, INIBIDOR, MEDICAMENTO, COMPOSIÇÃO FARMACÊUTICA, MÉTODOS PARA O TRATAMENTO DE UMA DOENÇA, PARA A PREVENÇÃO DE METÁSTASES DO CÂNCER, E PARA SUPERAR A RESISTÊNCIA À DROGA, E, USO DE UM COMPOSTO OU SAL. São fornecidos novos compostos ou sais dos mesmos, ou cristais dos mesmos, que inibem Axl e são úteis para o tratamento de doenças causadas por hiperfunção de Axl, doenças associadas com hiperfunção de Axl e/ou doenças acompanhadas por hiperfunção de Axl. São fornecidos derivados de piridona representados pela fórmula (I) tendo vários substituintes ou sais dos mesmos, ou cristais dos mesmos (em que R1, R2, R3, R5, R6, A, W, X e n na fórmula (I) são como definidos no relatório descritivo, respectivamente).
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012017971 | 2012-01-31 | ||
JP2012-017971 | 2012-01-31 | ||
US201261746039P | 2012-12-26 | 2012-12-26 | |
US61/746039 | 2012-12-26 | ||
PCT/JP2013/052111 WO2013115280A1 (ja) | 2012-01-31 | 2013-01-30 | ピリドン誘導体 |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112014018702A2 BR112014018702A2 (pt) | 2017-06-20 |
BR112014018702A8 true BR112014018702A8 (pt) | 2017-07-11 |
BR112014018702B1 BR112014018702B1 (pt) | 2021-12-14 |
Family
ID=48905312
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014018702-9A BR112014018702B1 (pt) | 2012-01-31 | 2013-01-30 | Composto, cristal, inibidor, medicamento, composição farmacêutica, e, uso de um composto ou sal |
Country Status (31)
Country | Link |
---|---|
US (1) | US8933103B2 (pt) |
EP (1) | EP2810937B1 (pt) |
JP (1) | JP6006241B2 (pt) |
KR (1) | KR102078530B1 (pt) |
CN (1) | CN104185627B (pt) |
AU (1) | AU2013216006B2 (pt) |
BR (1) | BR112014018702B1 (pt) |
CA (1) | CA2863515C (pt) |
CO (1) | CO7071126A2 (pt) |
CY (1) | CY1118656T1 (pt) |
DK (1) | DK2810937T3 (pt) |
ES (1) | ES2617484T3 (pt) |
HK (1) | HK1203504A1 (pt) |
HR (1) | HRP20170303T1 (pt) |
HU (1) | HUE031624T2 (pt) |
IL (1) | IL233863A (pt) |
LT (1) | LT2810937T (pt) |
MX (1) | MX351812B (pt) |
MY (1) | MY165215A (pt) |
NZ (1) | NZ627586A (pt) |
PH (1) | PH12014501719A1 (pt) |
PL (1) | PL2810937T3 (pt) |
PT (1) | PT2810937T (pt) |
RS (1) | RS55728B1 (pt) |
RU (1) | RU2632885C2 (pt) |
SG (1) | SG11201404505PA (pt) |
SI (1) | SI2810937T1 (pt) |
SM (1) | SMT201700065B (pt) |
TW (1) | TWI537259B (pt) |
WO (1) | WO2013115280A1 (pt) |
ZA (1) | ZA201405486B (pt) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2013162061A1 (ja) * | 2012-04-26 | 2013-10-31 | 第一三共株式会社 | 二環性ピリミジン化合物 |
WO2015068767A1 (ja) * | 2013-11-08 | 2015-05-14 | 小野薬品工業株式会社 | ピロロピリミジン誘導体 |
AU2014353006B2 (en) | 2013-11-20 | 2019-04-04 | Signalchem Life Sciences Corp. | Quinazoline derivatives as TAM family kinase inhibitors |
MX2016006815A (es) | 2013-11-27 | 2016-12-02 | Signalchem Lifesciences Corp | Derivados de aminopiridina como inhibidores de cinasas de la familia de tyro3, axl y mer (tam). |
CN106659765B (zh) | 2014-04-04 | 2021-08-13 | 德玛医药 | 二脱水半乳糖醇及其类似物或衍生物用于治疗非小细胞肺癌和卵巢癌的用途 |
TWI723572B (zh) * | 2014-07-07 | 2021-04-01 | 日商第一三共股份有限公司 | 具有四氫吡喃基甲基之吡啶酮衍生物及其用途 |
WO2016183071A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Hetero-tricyclic compounds and their use for the treatment of cancer |
WO2017027717A1 (en) | 2015-08-12 | 2017-02-16 | Incyte Corporation | Bicyclic fused pyrimidine compounds as tam inhibitors |
WO2017035366A1 (en) | 2015-08-26 | 2017-03-02 | Incyte Corporation | Pyrrolopyrimidine derivatives as tam inhibitors |
ES2896079T3 (es) | 2016-02-26 | 2022-02-23 | Ono Pharmaceutical Co | Fármaco para la terapia del cáncer, caracterizado por la administración de la combinación entre un inhibidor de Axl y un inhibidor del punto de control inmunitario |
KR102558066B1 (ko) | 2016-03-28 | 2023-07-25 | 인사이트 코포레이션 | Tam 억제제로서 피롤로트리아진 화합물 |
CN108250200A (zh) * | 2016-12-28 | 2018-07-06 | 中国科学院上海药物研究所 | 一种具有Axl抑制活性的化合物及其制备和应用 |
JP7156287B2 (ja) | 2017-08-23 | 2022-10-19 | 小野薬品工業株式会社 | Axl阻害剤を有効成分として含むがん治療剤 |
KR20200088308A (ko) | 2017-09-27 | 2020-07-22 | 인사이트 코포레이션 | Tam 억제제로서 유용한 피롤로트리아진 유도체의 염 |
JP7223998B2 (ja) | 2017-10-13 | 2023-02-17 | 小野薬品工業株式会社 | Axl阻害剤を有効成分として含む固形がん治療剤 |
MX2020007956A (es) * | 2018-01-29 | 2021-01-08 | Capulus Therapeutics Llc | Inhibidores de la proteína de unión al elemento regulador de esterol (srebp) que comprenden un anillo central de 6 miembros. |
IL277071B1 (en) | 2018-03-08 | 2024-03-01 | Incyte Corp | Aminopyrizine diol compounds as PI3K–y inhibitors |
MA53010A (fr) | 2018-06-29 | 2021-05-05 | Incyte Corp | Formulations d'un inhibiteur de axl/mer |
US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
IL279070B1 (en) * | 2018-07-04 | 2024-01-01 | Daiichi Sankyo Co Ltd | A method for the production of diarylpyridine derivatives |
US20220143049A1 (en) | 2019-03-21 | 2022-05-12 | Onxeo | A dbait molecule in combination with kinase inhibitor for the treatment of cancer |
US11718612B2 (en) | 2019-09-06 | 2023-08-08 | Board Of Regents, The University Of Texas System | Inhibitors of receptor interacting protein kinase I for the treatment of disease |
CN112625026B (zh) * | 2019-09-24 | 2022-09-09 | 药捷安康(南京)科技股份有限公司 | Tam家族激酶抑制剂的喹啉衍生物 |
AU2020353663A1 (en) | 2019-09-27 | 2022-04-07 | Board Of Regents, The University Of Texas System | Inhibitors of Receptor Interacting Protein Kinase I for the treatment of disease |
JP2023500906A (ja) | 2019-11-08 | 2023-01-11 | インサーム(インスティテュ ナシオナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシェ メディカル) | キナーゼ阻害剤に対する獲得抵抗性を有するがんの処置方法 |
AU2020391425A1 (en) * | 2019-11-26 | 2022-06-16 | Board Of Regents, The University Of Texas System | Inhibitors of Receptor Interacting Protein Kinase 1 for the treatment of disease |
WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
WO2022220227A1 (ja) * | 2021-04-14 | 2022-10-20 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | テトラヒドロピリドピリミジン化合物 |
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DK2235002T3 (da) | 2008-01-23 | 2013-03-11 | Bristol Myers Squibb Co | 4-pyridinonforbindelser og anvendelse heraf til behandling af cancer |
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2013
- 2013-01-30 PT PT137439857T patent/PT2810937T/pt unknown
- 2013-01-30 JP JP2013556479A patent/JP6006241B2/ja active Active
- 2013-01-30 NZ NZ627586A patent/NZ627586A/en unknown
- 2013-01-30 WO PCT/JP2013/052111 patent/WO2013115280A1/ja active Application Filing
- 2013-01-30 EP EP13743985.7A patent/EP2810937B1/en active Active
- 2013-01-30 LT LTEP13743985.7T patent/LT2810937T/lt unknown
- 2013-01-30 CA CA2863515A patent/CA2863515C/en active Active
- 2013-01-30 SI SI201330421A patent/SI2810937T1/sl unknown
- 2013-01-30 AU AU2013216006A patent/AU2013216006B2/en active Active
- 2013-01-30 SG SG11201404505PA patent/SG11201404505PA/en unknown
- 2013-01-30 TW TW102103411A patent/TWI537259B/zh active
- 2013-01-30 MX MX2014009246A patent/MX351812B/es active IP Right Grant
- 2013-01-30 DK DK13743985.7T patent/DK2810937T3/en active
- 2013-01-30 RS RS20170211A patent/RS55728B1/sr unknown
- 2013-01-30 BR BR112014018702-9A patent/BR112014018702B1/pt active IP Right Grant
- 2013-01-30 MY MYPI2014002198A patent/MY165215A/en unknown
- 2013-01-30 RU RU2014135401A patent/RU2632885C2/ru active
- 2013-01-30 ES ES13743985.7T patent/ES2617484T3/es active Active
- 2013-01-30 KR KR1020147020852A patent/KR102078530B1/ko active IP Right Grant
- 2013-01-30 US US13/753,926 patent/US8933103B2/en active Active
- 2013-01-30 CN CN201380017353.6A patent/CN104185627B/zh active Active
- 2013-01-30 HU HUE13743985A patent/HUE031624T2/en unknown
- 2013-01-30 PL PL13743985T patent/PL2810937T3/pl unknown
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2014
- 2014-07-24 ZA ZA2014/05486A patent/ZA201405486B/en unknown
- 2014-07-30 IL IL233863A patent/IL233863A/en active IP Right Grant
- 2014-07-30 PH PH12014501719A patent/PH12014501719A1/en unknown
- 2014-08-28 CO CO14189810A patent/CO7071126A2/es unknown
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2015
- 2015-04-28 HK HK15104103.9A patent/HK1203504A1/xx unknown
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2017
- 2017-01-30 SM SM201700065T patent/SMT201700065B/it unknown
- 2017-02-23 HR HRP20170303TT patent/HRP20170303T1/hr unknown
- 2017-02-23 CY CY20171100251T patent/CY1118656T1/el unknown
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