BR112015022077A2 - composto de pirazol-amida e usos medicinais do mesmo - Google Patents

composto de pirazol-amida e usos medicinais do mesmo

Info

Publication number
BR112015022077A2
BR112015022077A2 BR112015022077A BR112015022077A BR112015022077A2 BR 112015022077 A2 BR112015022077 A2 BR 112015022077A2 BR 112015022077 A BR112015022077 A BR 112015022077A BR 112015022077 A BR112015022077 A BR 112015022077A BR 112015022077 A2 BR112015022077 A2 BR 112015022077A2
Authority
BR
Brazil
Prior art keywords
medicinal uses
formula
pyrazol
amide
pyrazol amide
Prior art date
Application number
BR112015022077A
Other languages
English (en)
Inventor
Shomi Gakujun
Motomura Takahisa
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51536938&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112015022077(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of BR112015022077A2 publication Critical patent/BR112015022077A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C39/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring
    • C07C39/23—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring polycyclic, containing six-membered aromatic rings and other rings, with unsaturation outside the aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/78—Benzoic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

resumo patente de invenção: "composto de pirazol-amida e usos medicinais do mesmo". é fornecido um composto representado pela fórmula [l] [em que n indica 1 ou 2], fórmula [ll] ou fórmula [llh] ou fórmula [lll], ou um sal farmaceuticamente aceitável do mesmo. também são fornecidos usos medicinais para os compostos ou sais dos mesmos.
BR112015022077A 2013-03-15 2014-03-14 composto de pirazol-amida e usos medicinais do mesmo BR112015022077A2 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361791164P 2013-03-15 2013-03-15
JP2013053195 2013-03-15
JP2013127318 2013-06-18
PCT/JP2014/056825 WO2014142290A1 (ja) 2013-03-15 2014-03-14 ピラゾール－アミド化合物およびその医薬用途

Publications (1)

Publication Number Publication Date
BR112015022077A2 true BR112015022077A2 (pt) 2017-07-18

Family

ID=51536938

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015022077A BR112015022077A2 (pt) 2013-03-15 2014-03-14 composto de pirazol-amida e usos medicinais do mesmo

Country Status (31)

Country Link
US (4) US9040717B2 (pt)
EP (3) EP2975028B1 (pt)
JP (6) JP6208603B2 (pt)
KR (1) KR102226096B1 (pt)
CN (1) CN105051015B (pt)
AU (1) AU2014230569B2 (pt)
BR (1) BR112015022077A2 (pt)
CA (1) CA2904985C (pt)
CL (1) CL2015002608A1 (pt)
CY (1) CY1120173T1 (pt)
DK (1) DK2975028T3 (pt)
ES (1) ES2663789T3 (pt)
HK (1) HK1215808A1 (pt)
HR (1) HRP20180635T1 (pt)
HU (1) HUE036672T2 (pt)
IL (1) IL241355B (pt)
LT (1) LT2975028T (pt)
ME (1) ME03090B (pt)
MX (1) MX2015012743A (pt)
MY (1) MY182884A (pt)
NO (1) NO2975028T3 (pt)
PE (1) PE20151595A1 (pt)
PH (1) PH12015501993A1 (pt)
PL (1) PL2975028T3 (pt)
PT (1) PT2975028T (pt)
RS (1) RS57188B1 (pt)
RU (1) RU2664532C2 (pt)
SG (1) SG11201507327TA (pt)
SI (1) SI2975028T1 (pt)
TW (1) TWI633885B (pt)
WO (1) WO2014142290A1 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2649156T3 (es) 2013-01-14 2018-01-10 Incyte Holdings Corporation Compuestos bicíclicos de carboxamida aromática útiles como inhibidores de quinasas Pim
BR112015016793B1 (pt) 2013-01-15 2021-12-28 Incyte Holdings Corporation Compostos de tiazolacarboxamidas e piridinacarboxamida, composição compreendendo os mesmos, método de inibição da enzima pim1, pim2, ou pim3, e usos dos referidos compostos
SI2975028T1 (en) * 2013-03-15 2018-07-31 Japan Tobacco, Inc. PIRAZOL-AMIDIC COMPOUNDS AND MEDICINAL USE FORM
US9556197B2 (en) 2013-08-23 2017-01-31 Incyte Corporation Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
US9822124B2 (en) 2014-07-14 2017-11-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors
US9540347B2 (en) 2015-05-29 2017-01-10 Incyte Corporation Pyridineamine compounds useful as Pim kinase inhibitors
AR105967A1 (es) 2015-09-09 2017-11-29 Incyte Corp Sales de un inhibidor de pim quinasa
WO2017059251A1 (en) 2015-10-02 2017-04-06 Incyte Corporation Heterocyclic compounds useful as pim kinase inhibitors
RU2736722C2 (ru) * 2016-07-29 2020-11-19 Джапан Тобакко Инк. Способ получения соединения пиразоламида
TW201924683A (zh) 2017-12-08 2019-07-01 美商英塞特公司 用於治療骨髓增生性贅瘤的低劑量組合療法
TWI803570B (zh) * 2018-02-01 2023-06-01 日商日本香煙產業股份有限公司 含氮雜環醯胺化合物以及其醫藥用途
JPWO2020054734A1 (ja) * 2018-09-11 2021-08-30 日本たばこ産業株式会社 ピラゾール−アミド化合物を含有する慢性腎臓病の治療又は予防剤
US20220409548A1 (en) 2019-03-04 2022-12-29 Japan Tobacco Inc. Amorphous solid dispersion of pyrazole-amide compound
JP2022007994A (ja) * 2020-03-04 2022-01-13 日本たばこ産業株式会社 縮合三環性化合物及びその医薬用途
CA3228249A1 (en) * 2021-09-01 2023-03-09 Maki YAMAKAWA Nitrogen-containing tricyclic compound and pharmaceutical use thereof
KR20240045387A (ko) * 2022-09-28 2024-04-08 (주)제이디바이오사이언스 신규한 플루오렌 유도체 및 이의 용도

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RU2007147844A (ru) * 2005-05-23 2009-06-27 Джапан Тобакко Инк. (Jp) Пиразольное соединение и содержащее его терапевтическое средство для лечения сахарного диабета
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JP2014198712A (ja) 2013-03-15 2014-10-23 日本たばこ産業株式会社 フルオレン化合物の水和物、およびその結晶
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Also Published As

Publication number Publication date
HUE036672T2 (hu) 2018-07-30
EP3805205A1 (en) 2021-04-14
AU2014230569B2 (en) 2017-11-23
KR102226096B1 (ko) 2021-03-09
HRP20180635T1 (hr) 2018-06-01
PH12015501993B1 (en) 2016-01-11
CY1120173T1 (el) 2018-12-12
CA2904985A1 (en) 2014-09-18
DK2975028T3 (en) 2018-03-12
ES2663789T3 (es) 2018-04-17
ME03090B (me) 2019-01-20
CN105051015B (zh) 2018-09-25
PT2975028T (pt) 2018-03-29
AU2014230569A1 (en) 2015-10-08
SG11201507327TA (en) 2015-10-29
TWI633885B (zh) 2018-09-01
SI2975028T1 (en) 2018-07-31
US20140296315A1 (en) 2014-10-02
WO2014142290A1 (ja) 2014-09-18
JP2015024984A (ja) 2015-02-05
EP2975028A1 (en) 2016-01-20
JP2018188449A (ja) 2018-11-29
PL2975028T3 (pl) 2018-10-31
EP2975028A4 (en) 2016-08-17
MX2015012743A (es) 2016-02-19
JP6208603B2 (ja) 2017-10-04
RU2664532C2 (ru) 2018-08-20
HK1215808A1 (zh) 2016-09-15
EP3348545A1 (en) 2018-07-18
US9040717B2 (en) 2015-05-26
TW201501711A (zh) 2015-01-16
IL241355A0 (en) 2015-11-30
US20160074364A1 (en) 2016-03-17
KR20150131221A (ko) 2015-11-24
JP2020189855A (ja) 2020-11-26
CN105051015A (zh) 2015-11-11
US20180256547A1 (en) 2018-09-13
JP2018021061A (ja) 2018-02-08
PE20151595A1 (es) 2015-11-24
RU2015144182A3 (pt) 2018-03-06
IL241355B (en) 2019-03-31
JP2019194197A (ja) 2019-11-07
LT2975028T (lt) 2018-04-10
CL2015002608A1 (es) 2016-03-04
US20200163937A1 (en) 2020-05-28
PH12015501993A1 (en) 2016-01-11
MY182884A (en) 2021-02-05
NO2975028T3 (pt) 2018-07-21
EP2975028B1 (en) 2018-02-21
RU2015144182A (ru) 2017-04-24
RS57188B1 (sr) 2018-07-31
JP2022000453A (ja) 2022-01-04
CA2904985C (en) 2021-07-20

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B25G Requested change of headquarter approved

Owner name: JAPAN TOBACCO INC. (JP)

B06G Technical and formal requirements: other requirements [chapter 6.7 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL.