MX2015015755A - Derivados de perhidroquinoxalina utiles como analgesicos. - Google Patents

Derivados de perhidroquinoxalina utiles como analgesicos.

Info

Publication number
MX2015015755A
MX2015015755A MX2015015755A MX2015015755A MX2015015755A MX 2015015755 A MX2015015755 A MX 2015015755A MX 2015015755 A MX2015015755 A MX 2015015755A MX 2015015755 A MX2015015755 A MX 2015015755A MX 2015015755 A MX2015015755 A MX 2015015755A
Authority
MX
Mexico
Prior art keywords
analgesics
derivatives useful
perhydroquinoxaline
perhydroquinoxaline derivatives
antipruritic
Prior art date
Application number
MX2015015755A
Other languages
English (en)
Inventor
Michael Soeberdt
Christoph Abels
Ulrich Knie
Original Assignee
Wolff August Gmbh & Co Kg Arzneimittel Dr
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wolff August Gmbh & Co Kg Arzneimittel Dr filed Critical Wolff August Gmbh & Co Kg Arzneimittel Dr
Publication of MX2015015755A publication Critical patent/MX2015015755A/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/42—Benzopyrazines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
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    • A61P37/08—Antiallergic agents
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychiatry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Communicable Diseases (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)

Abstract

La presente invención se refiere a compuestos de perhidroquinoxalina según la fórmula general (1), su uso como un medicamento, en particular como analgésico, antiprurítico y agentes antiinflamatorios, y su preparación. (ver Fórmula).
MX2015015755A 2013-05-17 2014-05-16 Derivados de perhidroquinoxalina utiles como analgesicos. MX2015015755A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361824628P 2013-05-17 2013-05-17
EP13168208 2013-05-17
PCT/EP2014/060113 WO2014184355A1 (en) 2013-05-17 2014-05-16 Perhydroquinoxaline derivatives useful as analgesics

Publications (1)

Publication Number Publication Date
MX2015015755A true MX2015015755A (es) 2016-03-11

Family

ID=48428383

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015015755A MX2015015755A (es) 2013-05-17 2014-05-16 Derivados de perhidroquinoxalina utiles como analgesicos.

Country Status (13)

Country Link
US (1) US20160122307A1 (es)
EP (1) EP2997025A1 (es)
JP (1) JP2016518435A (es)
KR (1) KR20160008237A (es)
CN (1) CN105209459A (es)
AU (1) AU2014267225A1 (es)
BR (1) BR112015028876A2 (es)
CA (1) CA2908963A1 (es)
HK (1) HK1220443A1 (es)
MX (1) MX2015015755A (es)
RU (1) RU2015153827A (es)
SG (1) SG11201508483RA (es)
WO (1) WO2014184355A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016079109A1 (en) 2014-11-18 2016-05-26 Dr. August Wolff Gmbh & Co. Kg Arzneimittel Process for the preparation of perhydroquinoxaline derivatives
CN107805223A (zh) * 2017-10-30 2018-03-16 广东莱佛士制药技术有限公司 一种喹喔啉‑5‑磺酰氯的合成方法
EP3723751A4 (en) * 2017-12-08 2021-07-07 The Rockefeller University PYRANO [3,4-B] PYRAZIN-KAPPA-OPIOID RECEPTOR LIGANDS FOR THE TREATMENT OF ADDICTION, PRURITUS, PAIN AND INFLAMMATION
WO2019169165A1 (en) * 2018-02-28 2019-09-06 Novocine Therapeutics, Llc Ketamine and ketamine-related compounds for the treatment of neurological disorders
CN111487336B (zh) * 2020-04-13 2022-08-19 司法鉴定科学研究院 一种头发中37种芬太尼类新精神活性物质的分析方法
CN112244830A (zh) * 2020-11-16 2021-01-22 西北师范大学 一种用于心理教学的便携式人体反应时测量装置
CN114163439A (zh) * 2021-12-01 2022-03-11 哈尔滨工业大学（深圳） 一种催化加氢制备四氢叶酸的方法

Family Cites Families (5)

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Publication number Priority date Publication date Assignee Title
US5130432A (en) * 1990-12-21 1992-07-14 Syntex (U.S.A.) Inc. Process for preparing cyclic amines and intermediate products thereof
US5646151A (en) * 1996-03-08 1997-07-08 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
US5763445A (en) * 1996-03-08 1998-06-09 Adolor Corporation Kappa agonist compounds pharmaceutical formulations and method of prevention and treatment of pruritus therewith
US8906859B2 (en) 2006-11-10 2014-12-09 Cera Therapeutics, Inc. Uses of kappa opioid synthetic peptide amides
DE102007062550A1 (de) 2007-12-20 2009-06-25 Westfälische Wilhelms-Universität Münster Körperschaft des öffentlichen Rechts Perhydrochinoxalin-Derivate

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RU2015153827A (ru) 2017-06-21
HK1220443A1 (zh) 2017-05-05
BR112015028876A2 (pt) 2017-07-25
KR20160008237A (ko) 2016-01-21
WO2014184355A1 (en) 2014-11-20
JP2016518435A (ja) 2016-06-23
EP2997025A1 (en) 2016-03-23
CN105209459A (zh) 2015-12-30
SG11201508483RA (en) 2015-11-27
US20160122307A1 (en) 2016-05-05
AU2014267225A1 (en) 2015-11-05
CA2908963A1 (en) 2014-11-20

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