BR112015018738A8 - compostos de tetra-hidropirrolotiazina, seus usos, e composição farmacêutica - Google Patents
compostos de tetra-hidropirrolotiazina, seus usos, e composição farmacêuticaInfo
- Publication number
- BR112015018738A8 BR112015018738A8 BR112015018738A BR112015018738A BR112015018738A8 BR 112015018738 A8 BR112015018738 A8 BR 112015018738A8 BR 112015018738 A BR112015018738 A BR 112015018738A BR 112015018738 A BR112015018738 A BR 112015018738A BR 112015018738 A8 BR112015018738 A8 BR 112015018738A8
- Authority
- BR
- Brazil
- Prior art keywords
- pharmaceutical composition
- tetrahydropyrrolothiazine
- compounds
- tetrahydropyrrolothiazine compounds
- compound
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Abstract
resumo: patente de invenção: "compostos de tetra-hidropirrolotiazina.". a presente invenção fornece um composto de fórmula i: em que r é h ou f; e a é: ou um sal farmaceuticamente aceitável do mesmo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361776819P | 2013-03-12 | 2013-03-12 | |
| PCT/US2014/020070 WO2014143579A1 (en) | 2013-03-12 | 2014-03-04 | Tetrahydropyrrolothiazine compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112015018738A2 BR112015018738A2 (pt) | 2017-07-18 |
| BR112015018738A8 true BR112015018738A8 (pt) | 2018-01-23 |
Family
ID=50382615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015018738A BR112015018738A8 (pt) | 2013-03-12 | 2014-03-04 | compostos de tetra-hidropirrolotiazina, seus usos, e composição farmacêutica |
Country Status (38)
| Country | Link |
|---|---|
| US (3) | US8841293B1 (pt) |
| EP (1) | EP2970336B1 (pt) |
| JP (1) | JP6095844B2 (pt) |
| KR (1) | KR101688761B1 (pt) |
| CN (1) | CN105026404B (pt) |
| AP (1) | AP2015008713A0 (pt) |
| AR (1) | AR094918A1 (pt) |
| BR (1) | BR112015018738A8 (pt) |
| CA (1) | CA2898500C (pt) |
| CL (1) | CL2015002529A1 (pt) |
| CR (1) | CR20150418A (pt) |
| CY (1) | CY1119585T1 (pt) |
| DK (1) | DK2970336T3 (pt) |
| EA (1) | EA026006B1 (pt) |
| ES (1) | ES2653421T3 (pt) |
| HK (1) | HK1212694A1 (pt) |
| HR (1) | HRP20171851T1 (pt) |
| HU (1) | HUE037487T2 (pt) |
| IL (1) | IL240903B (pt) |
| JO (1) | JO3317B1 (pt) |
| LT (1) | LT2970336T (pt) |
| MA (1) | MA38390B1 (pt) |
| ME (1) | ME02910B (pt) |
| MX (1) | MX2015012628A (pt) |
| MY (1) | MY180083A (pt) |
| NO (1) | NO3039297T3 (pt) |
| NZ (1) | NZ712207A (pt) |
| PE (1) | PE20151542A1 (pt) |
| PH (1) | PH12015502031B1 (pt) |
| PL (1) | PL2970336T3 (pt) |
| PT (1) | PT2970336T (pt) |
| RS (1) | RS56645B1 (pt) |
| SG (1) | SG11201507499XA (pt) |
| SI (1) | SI2970336T1 (pt) |
| TN (1) | TN2015000340A1 (pt) |
| TW (1) | TWI593692B (pt) |
| UA (1) | UA112941C2 (pt) |
| WO (1) | WO2014143579A1 (pt) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2014DN09346A (pt) | 2012-06-13 | 2015-07-17 | Hoffmann La Roche | |
| EA036630B1 (ru) | 2012-09-25 | 2020-12-02 | Ф. Хоффманн-Ля Рош Аг | Бициклические производные |
| EP2912041B1 (en) | 2012-10-26 | 2016-12-14 | Eli Lilly and Company | Tetrahydropyrrolothiazine derivatives as bace inhibitors |
| AR095079A1 (es) | 2013-03-12 | 2015-09-16 | Hoffmann La Roche | Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo |
| PE20160845A1 (es) | 2013-11-26 | 2016-09-10 | Hoffmann La Roche | Nuevo octahidro-ciclobuta[1,2-c;3,4-c']dipirrol-2-ilo |
| TWI684452B (zh) | 2014-03-14 | 2020-02-11 | 美國禮來大藥廠 | 胺基噻嗪化合物 |
| ES2753549T3 (es) | 2014-03-26 | 2020-04-13 | Hoffmann La Roche | Compuestos bicíclicos como inhibidores de la producción de autotaxina (ATX) y ácido lisofosfatídico (LPA) |
| CA2935612A1 (en) | 2014-03-26 | 2015-10-01 | F. Hoffmann-La Roche Ag | Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors |
| TWI570127B (zh) * | 2014-09-15 | 2017-02-11 | 美國禮來大藥廠 | 結晶型N-[3-[(4aR,7aS)-2-胺基-6-(5-氟嘧啶-2-基)-4,4a,5,7-四氫吡咯并[3,4-d][1,3]噻嗪-7a-基]-4-氟-苯基]-5-甲氧基-吡嗪-2-甲醯胺、其用途及醫藥組合物 |
| TWI599358B (zh) | 2014-09-16 | 2017-09-21 | 美國禮來大藥廠 | 組合療法 |
| TWI574969B (zh) * | 2015-01-30 | 2017-03-21 | 美國禮來大藥廠 | 甲苯磺酸鹽 |
| AR103680A1 (es) | 2015-02-23 | 2017-05-24 | Lilly Co Eli | Inhibidores selectivos de bace1 |
| MA41898A (fr) | 2015-04-10 | 2018-02-13 | Hoffmann La Roche | Dérivés de quinazolinone bicyclique |
| AR104241A1 (es) | 2015-04-29 | 2017-07-05 | Lilly Co Eli | Derivados de tetrahidrofuro tiazina como inhibidores de bace1 selectivos |
| CA2992889A1 (en) | 2015-09-04 | 2017-03-09 | F. Hoffmann-La Roche Ag | Phenoxymethyl derivatives |
| BR112017026682A2 (pt) | 2015-09-24 | 2018-08-14 | Hoffmann La Roche | novos compostos bicíclicos como inibidores de dupla ação de atx/ca |
| MX2018001890A (es) | 2015-09-24 | 2018-06-20 | Hoffmann La Roche | Compuestos biciclicos como inhibidores de autotaxina (atx). |
| KR20180054830A (ko) | 2015-09-24 | 2018-05-24 | 에프. 호프만-라 로슈 아게 | 오토탁신(atx) 억제제로서의 이환형 화합물 |
| KR20180054634A (ko) | 2015-09-24 | 2018-05-24 | 에프. 호프만-라 로슈 아게 | 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 신규한 이환형 화합물 |
| TW201740954A (zh) * | 2016-03-16 | 2017-12-01 | 美國禮來大藥廠 | 組合療法 |
| TWI735600B (zh) | 2016-07-01 | 2021-08-11 | 美商美國禮來大藥廠 | 抗－N3pGlu類澱粉β肽抗體及其用途 |
| JP7149271B2 (ja) | 2016-12-15 | 2022-10-06 | アムジエン・インコーポレーテツド | β－セクレターゼ阻害剤としての１，４－チアジンジオキシドおよび１，２，４－チアジアジンジオキシド誘導体ならびに使用方法 |
| AU2017378316B2 (en) | 2016-12-15 | 2021-04-01 | Amgen Inc. | Cyclopropyl fused thiazine derivatives as beta-secretase inhibitors and methods of use |
| AU2017376441B2 (en) | 2016-12-15 | 2021-10-14 | Amgen Inc. | Oxazine derivatives as beta-secretase inhibitors and methods of use |
| MX2019007102A (es) | 2016-12-15 | 2019-12-16 | Amgen Inc | Derivados de tiazina como inhibidores de beta-secretasa y metodos de uso. |
| CA3047285A1 (en) | 2016-12-15 | 2018-06-21 | Amgen Inc. | Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use |
| KR20190129924A (ko) | 2017-03-16 | 2019-11-20 | 에프. 호프만-라 로슈 아게 | 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 유용한 헤테로환형 화합물 |
| WO2018167113A1 (en) | 2017-03-16 | 2018-09-20 | F. Hoffmann-La Roche Ag | New bicyclic compounds as atx inhibitors |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5284957A (en) * | 1992-09-03 | 1994-02-08 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| AU2003219955A1 (en) * | 2002-03-22 | 2003-10-13 | Eli Lilly And Company | Isoquinoline-3-carboxylic acid derivatives as excitatory amino acid receptor antagonists |
| TW201004961A (en) | 2005-06-14 | 2010-02-01 | Schering Corp | Aspartyl protease inhibitors |
| CN101346357B (zh) | 2005-10-25 | 2014-04-02 | 盐野义制药株式会社 | 氨基二氢噻嗪衍生物 |
| EP2151435A4 (en) | 2007-04-24 | 2011-09-14 | Shionogi & Co | PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE |
| PE20091438A1 (es) | 2008-01-18 | 2009-09-26 | Eisai Randd Man Co Ltd | Derivados fusionados de aminodihidrotiazina |
| EA201001532A1 (ru) * | 2008-04-22 | 2011-06-30 | Шеринг Корпорейшн | Соединения фенилзамещенного 2-имино-3-метилпирролопиримидинона в качестве ингибиторов bace-1, композиции и их применение |
| TWI431004B (zh) * | 2008-05-02 | 2014-03-21 | Lilly Co Eli | Ｂａｃｅ抑制劑 |
| CA2727859C (en) | 2008-06-13 | 2016-11-01 | Shionogi & Co., Ltd. | SULFUR-CONTAINING HETEROCYCLIC DERIVATIVE HAVING ß-SECRETASE-INHIBITING ACTIVITY |
| CA2738150A1 (en) | 2008-09-30 | 2010-04-08 | Eisai R&D Management Co., Ltd. | Novel fused aminodihydrothiazine derivative |
| AR077277A1 (es) | 2009-07-09 | 2011-08-17 | Lilly Co Eli | Compuestos de biciclo (1,3)tiazin-2-amina formulacion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para el tratamiento de la enfermedad de alzheimer |
| EP2511269A4 (en) | 2009-12-11 | 2013-04-24 | Shionogi & Co | FUSED HETEROCYCLIC COMPOUND HAVING AN AMINO GROUP |
| GB201100181D0 (en) | 2011-01-06 | 2011-02-23 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
| GB201101140D0 (en) | 2011-01-21 | 2011-03-09 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
| GB201101139D0 (en) * | 2011-01-21 | 2011-03-09 | Eisai Ltd | Fused aminodihydrothiazine derivatives |
| US9145426B2 (en) | 2011-04-07 | 2015-09-29 | Merck Sharp & Dohme Corp. | Pyrrolidine-fused thiadiazine dioxide compounds as BACE inhibitors, compositions, and their use |
| AR086539A1 (es) | 2011-05-24 | 2014-01-08 | Bristol Myers Squibb Co | COMPUESTOS PARA LA REDUCCION DE LA PRODUCCION DE b-AMILOIDE |
| JO3143B1 (ar) * | 2012-04-03 | 2017-09-20 | Lilly Co Eli | مركبات تتراهيدرو بيرولو ثيازين |
-
2014
- 2014-02-26 TW TW103106569A patent/TWI593692B/zh not_active IP Right Cessation
- 2014-02-27 AR ARP140100629A patent/AR094918A1/es unknown
- 2014-02-27 JO JOP/2014/0061A patent/JO3317B1/ar active
- 2014-03-04 MY MYPI2015703056A patent/MY180083A/en unknown
- 2014-03-04 PE PE2015001901A patent/PE20151542A1/es active IP Right Grant
- 2014-03-04 CA CA2898500A patent/CA2898500C/en not_active Expired - Fee Related
- 2014-03-04 WO PCT/US2014/020070 patent/WO2014143579A1/en active Application Filing
- 2014-03-04 US US14/195,897 patent/US8841293B1/en active Active
- 2014-03-04 BR BR112015018738A patent/BR112015018738A8/pt not_active Application Discontinuation
- 2014-03-04 RS RS20171243A patent/RS56645B1/sr unknown
- 2014-03-04 MA MA38390A patent/MA38390B1/fr unknown
- 2014-03-04 KR KR1020157024588A patent/KR101688761B1/ko active IP Right Grant
- 2014-03-04 SG SG11201507499XA patent/SG11201507499XA/en unknown
- 2014-03-04 ME MEP-2017-252A patent/ME02910B/me unknown
- 2014-03-04 MX MX2015012628A patent/MX2015012628A/es unknown
- 2014-03-04 LT LTEP14712875.5T patent/LT2970336T/lt unknown
- 2014-03-04 DK DK14712875.5T patent/DK2970336T3/da active
- 2014-03-04 ES ES14712875.5T patent/ES2653421T3/es active Active
- 2014-03-04 EA EA201591491A patent/EA026006B1/ru not_active IP Right Cessation
- 2014-03-04 CN CN201480014295.6A patent/CN105026404B/zh active Active
- 2014-03-04 HU HUE14712875A patent/HUE037487T2/hu unknown
- 2014-03-04 SI SI201430430T patent/SI2970336T1/sl unknown
- 2014-03-04 PL PL14712875T patent/PL2970336T3/pl unknown
- 2014-03-04 AP AP2015008713A patent/AP2015008713A0/xx unknown
- 2014-03-04 JP JP2016500566A patent/JP6095844B2/ja active Active
- 2014-03-04 NZ NZ71220714A patent/NZ712207A/en not_active IP Right Cessation
- 2014-03-04 PT PT147128755T patent/PT2970336T/pt unknown
- 2014-03-04 EP EP14712875.5A patent/EP2970336B1/en active Active
- 2014-04-03 UA UAA201508698A patent/UA112941C2/uk unknown
- 2014-08-07 US US14/453,855 patent/US8987254B2/en active Active
- 2014-08-12 NO NO14799063A patent/NO3039297T3/no unknown
-
2015
- 2015-02-19 US US14/626,320 patent/US20150157641A1/en not_active Abandoned
- 2015-08-10 TN TN2015000340A patent/TN2015000340A1/en unknown
- 2015-08-14 CR CR20150418A patent/CR20150418A/es unknown
- 2015-08-27 IL IL240903A patent/IL240903B/en not_active IP Right Cessation
- 2015-09-09 CL CL2015002529A patent/CL2015002529A1/es unknown
- 2015-09-10 PH PH12015502031A patent/PH12015502031B1/en unknown
-
2016
- 2016-01-21 HK HK16100629.1A patent/HK1212694A1/zh not_active IP Right Cessation
-
2017
- 2017-11-09 CY CY20171101177T patent/CY1119585T1/el unknown
- 2017-11-28 HR HRP20171851TT patent/HRP20171851T1/hr unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112015018738A8 (pt) | compostos de tetra-hidropirrolotiazina, seus usos, e composição farmacêutica | |
| BR112015021983A2 (pt) | compostos heterocíclicos e usos dos mesmos | |
| BR112015026967A8 (pt) | fenoxietil di-hidro-1h-isoquinolina, seus usos, e composição farmacêutica | |
| BR112015012693A2 (pt) | derivados de pirimidona e seu uso no tratamento, melhora ou prevenção de uma doença viral | |
| BR112016011755A2 (pt) | derivado de ureia ou sal farmacologicamente aceitável do mesmo | |
| BR112015009850A2 (pt) | compostos de piridila substituídos por heteroarila úteis como moduladores de quinase | |
| BR112015022077A2 (pt) | composto de pirazol-amida e usos medicinais do mesmo | |
| BR112015019276A2 (pt) | compostos de azabenzimidazol como inibidores de isoenzimas de pde4 para o tratamento de distúrbios do snc e outros distúrbios | |
| BR112015022643A2 (pt) | inibidores diidro-pirrolpiridinona | |
| BR112014026266A2 (pt) | derivado de quinazolidinadiona | |
| BR112015029348A2 (pt) | inibidores da bace | |
| BR112015024075A2 (pt) | compostos de piridinilpirazoloquinolina | |
| BR112016017317A2 (pt) | composto, antagonista de trpa1, medicamento, e, uso de um composto | |
| BR112014031616A2 (pt) | compostos de fenoxietil piperidina | |
| BR112014026305A2 (pt) | derivado de quinazolidinadiona | |
| BR112015020222A8 (pt) | composto de azetidiniloxifenilpirrolidina, seus usos, e composições farmacêuticas | |
| BR112015009032A2 (pt) | inibidores de agrecanase | |
| BR112015004523A2 (pt) | compostos de tetraciclina | |
| BR112014007078A2 (pt) | composição de controle de doença de plantas e seu uso | |
| BR112014026198A2 (pt) | compostos pirazol como inibidores de sglt1 | |
| BR112015014433A2 (pt) | compostos tricíclicos | |
| BR112018002127A2 (pt) | derivado de ureia, e, inibidor de receptor de domínio de discoidina 1 | |
| BR112015028876A2 (pt) | derivados de perhidroquinoxalina | |
| BR112019008415A2 (pt) | composto de piridona e inibidor de c-met, composição farmacêutica e uso dos mesmos | |
| BR112017021583A2 (pt) | métodos para o tratamento de transtornos inflamatórios |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] | ||
| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] |
Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI |
|
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements |