JO3143B1 - مركبات تتراهيدرو بيرولو ثيازين - Google Patents

مركبات تتراهيدرو بيرولو ثيازين

Info

Publication number
JO3143B1
JO3143B1 JOP/2013/0080A JOP20130080A JO3143B1 JO 3143 B1 JO3143 B1 JO 3143B1 JO P20130080 A JOP20130080 A JO P20130080A JO 3143 B1 JO3143 B1 JO 3143B1
Authority
JO
Jordan
Prior art keywords
compounds
tetrahydropyrrolothiazine
tetrahydropyrrolothiazine compounds
ch2oh
och3
Prior art date
Application number
JOP/2013/0080A
Other languages
English (en)
Inventor
Michael Mathes Brian
Morgan Watson Brian
Peter Beck James
Eduardo Lopez Jose
James Mergott Dustin
Rankovic Zoran
James Green Steven
Larry Winneroski Leonard Jr
Jaye Porter Warren
Shi Yuan
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of JO3143B1 publication Critical patent/JO3143B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

يقدم الاختراع الحالي مركبات وفقًا للصيغة I: الصيغة I حيث يتم اختيار A من المجموعة المكونة من: ، ، و . R1 هي H أو F؛ R2 هي H، –CH2OH، C1-C3 ألكيل، و ؛ R3 هي H، F، أو CN؛ R4 هي H، F؛ أو CN؛ و R5 هي H، CH3-، أو OCH3-؛ أو ملح مقبول صيدليًا منها.
JOP/2013/0080A 2012-04-03 2013-03-21 مركبات تتراهيدرو بيرولو ثيازين JO3143B1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261619460P 2012-04-03 2012-04-03
US201261700960P 2012-09-14 2012-09-14
US201361758798P 2013-01-31 2013-01-31

Publications (1)

Publication Number Publication Date
JO3143B1 true JO3143B1 (ar) 2017-09-20

Family

ID=48083661

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2013/0080A JO3143B1 (ar) 2012-04-03 2013-03-21 مركبات تتراهيدرو بيرولو ثيازين

Country Status (19)

Country Link
US (3) US8629270B2 (ar)
EP (1) EP2836495B1 (ar)
JP (1) JP6067099B2 (ar)
CN (1) CN104185635B (ar)
AR (1) AR090474A1 (ar)
CA (1) CA2866201C (ar)
CY (1) CY1117688T1 (ar)
DK (1) DK2836495T3 (ar)
ES (1) ES2584827T3 (ar)
HR (1) HRP20160674T1 (ar)
HU (1) HUE030097T2 (ar)
JO (1) JO3143B1 (ar)
ME (1) ME02404B (ar)
PL (1) PL2836495T3 (ar)
PT (1) PT2836495T (ar)
RS (1) RS54899B1 (ar)
SI (1) SI2836495T1 (ar)
TW (1) TWI572610B (ar)
WO (1) WO2013151832A1 (ar)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0906962B8 (pt) 2008-01-18 2021-05-25 Eisai R&D Man Co Ltd composto de aminodiidrotiazina fundido
HUE031764T2 (en) * 2012-10-26 2017-07-28 Lilly Co Eli Tetrahydropyrrolothiazine derivatives as BACE inhibitors
TWI593692B (zh) * 2013-03-12 2017-08-01 美國禮來大藥廠 四氫吡咯并噻嗪化合物
TWI684452B (zh) * 2014-03-14 2020-02-11 美國禮來大藥廠 胺基噻嗪化合物
TWI570127B (zh) * 2014-09-15 2017-02-11 美國禮來大藥廠 結晶型N-[3-[(4aR,7aS)-2-胺基-6-(5-氟嘧啶-2-基)-4,4a,5,7-四氫吡咯并[3,4-d][1,3]噻嗪-7a-基]-4-氟-苯基]-5-甲氧基-吡嗪-2-甲醯胺、其用途及醫藥組合物
JP2019524788A (ja) * 2016-08-11 2019-09-05 イーライ リリー アンド カンパニー アミノチアジンおよびｂａｃｅ１阻害剤としてのそれらの使用
TWI726329B (zh) 2018-06-22 2021-05-01 美商美國禮來大藥廠 2,3-二氫呋喃并[2,3-b]吡啶化合物
CN111184725B (zh) * 2020-02-27 2020-12-01 慈溪市人民医院医疗健康集团(慈溪市人民医院) 一种防治脑梗塞的药物制剂及其制备方法
CN111675659B (zh) * 2020-06-16 2022-03-11 阿里生物新材料（常州）有限公司 一种（5-氟嘧啶-4-基）甲醇的合成方法
CN112263583B (zh) * 2020-11-23 2021-10-22 诸城市精神卫生中心 一种治疗帕金森疾病的药物及其制备方法
CN113666878A (zh) * 2021-08-27 2021-11-19 宁夏常晟药业有限公司 一种5-溴-2-氯嘧啶-4-羧酸甲酯的合成方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG162790A1 (en) * 2005-06-14 2010-07-29 Schering Corp Aspartyl protease inhibitors
JP5383483B2 (ja) * 2007-04-24 2014-01-08 塩野義製薬株式会社 アルツハイマー症治療用医薬組成物
BRPI0906962B8 (pt) * 2008-01-18 2021-05-25 Eisai R&D Man Co Ltd composto de aminodiidrotiazina fundido
AU2009239536C1 (en) 2008-04-22 2012-12-13 Merck Sharp & Dohme Corp. Phenyl-substituted 2-imino-3-methyl pyrrolo pyrimidinone compounds as BACE-1 inhibitors, compositions, and their use
WO2010038686A1 (ja) 2008-09-30 2010-04-08 エーザイ・アール・アンド・ディー・マネジメント株式会社 新規な縮合アミノジヒドロチアジン誘導体
AR077277A1 (es) 2009-07-09 2011-08-17 Lilly Co Eli Compuestos de biciclo (1,3)tiazin-2-amina formulacion farmaceutica que lo comprende y su uso para la manufactura de un medicamento util para el tratamiento de la enfermedad de alzheimer
GB0912778D0 (en) * 2009-07-22 2009-08-26 Eisai London Res Lab Ltd Fused aminodihydro-oxazine derivatives
US7964594B1 (en) * 2009-12-10 2011-06-21 Hoffmann-La Roche Inc. Amino oxazine derivatives
US20120245155A1 (en) 2009-12-11 2012-09-27 Shionogi & Co., Ltd. Fused heterocyclic compound having amino group
WO2012162334A1 (en) 2011-05-24 2012-11-29 Bristol-Myers Squibb Company Compounds for the reduction of beta-amyloid production
WO2013030713A1 (en) 2011-08-31 2013-03-07 Pfizer Inc. Hexahydropyrano [3,4-d][1,3] thiazin-2-amine compounds

Also Published As

Publication number Publication date
US20140094454A1 (en) 2014-04-03
EP2836495B1 (en) 2016-05-18
CA2866201C (en) 2016-09-20
CN104185635B (zh) 2016-03-09
AR090474A1 (es) 2014-11-12
PL2836495T3 (pl) 2016-11-30
CY1117688T1 (el) 2017-05-17
RS54899B1 (sr) 2016-10-31
PT2836495T (pt) 2016-07-18
ME02404B (me) 2016-09-20
US20140256933A1 (en) 2014-09-11
JP6067099B2 (ja) 2017-01-25
EP2836495A1 (en) 2015-02-18
CA2866201A1 (en) 2013-10-10
TW201400491A (zh) 2014-01-01
ES2584827T3 (es) 2016-09-29
HUE030097T2 (en) 2017-04-28
JP2015512445A (ja) 2015-04-27
WO2013151832A1 (en) 2013-10-10
US8889856B2 (en) 2014-11-18
SI2836495T1 (sl) 2016-06-30
US8629270B2 (en) 2014-01-14
TWI572610B (zh) 2017-03-01
US20130261111A1 (en) 2013-10-03
HRP20160674T1 (hr) 2016-07-15
CN104185635A (zh) 2014-12-03
US8772282B2 (en) 2014-07-08
DK2836495T3 (en) 2016-08-15

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