MX343225B - Nuevos derivados de aril-benzocicloalquil-amida. - Google Patents

Nuevos derivados de aril-benzocicloalquil-amida.

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Publication number
MX343225B
MX343225B MX2013008312A MX2013008312A MX343225B MX 343225 B MX343225 B MX 343225B MX 2013008312 A MX2013008312 A MX 2013008312A MX 2013008312 A MX2013008312 A MX 2013008312A MX 343225 B MX343225 B MX 343225B
Authority
MX
Mexico
Prior art keywords
benzocycloalkyl
amide derivatives
new aryl
aryl
new
Prior art date
Application number
MX2013008312A
Other languages
English (en)
Other versions
MX2013008312A (es
Inventor
Aebi Johannes
Binggeli Alfred
Kuehne Holger
Wang Haiyan
Hertel Cornelia
P Maerki Hans
Kuhn Bernd
Ashok Konkar Anish
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2013008312A publication Critical patent/MX2013008312A/es
Publication of MX343225B publication Critical patent/MX343225B/es

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    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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Abstract

La invención proporciona nuevos compuestos que tienen la fórmula general (I) (Ver Formula) en la que R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, A1, A2 y n tienen los significados aquí descritos, composiciones que contienen estos compuestos y métodos para la utilización de los compuestos.
MX2013008312A 2011-01-24 2012-01-18 Nuevos derivados de aril-benzocicloalquil-amida. MX343225B (es)

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US10081617B2 (en) * 2015-04-16 2018-09-25 Merck Sharp & Dohme Corp. Factor XIa inhibitors
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BR112021003496A2 (pt) 2018-08-31 2021-05-18 Cytokinetics, Inc. composto, composição farmacêutica, e, métodos para tratar doença cardíaca, para tratar uma doença ou afecção associada à cardiomiopatia hipertrófica, ou afecção que está associada ao espessamento secundário da parede do ventrículo esquerdo, ou afecção que está associada à pequena cavidade do ventículo esquerdo e obliteração da cavidade, contração hiperdinâmica do ventrículo esquerdo, isquemia miocárdica ou fibrose cardíaca, ou afecção selecionada dentre distrofias musculares e doenças de armazenamento de glicogênio, para inibir o sarcômero cardíaco
WO2020179859A1 (ja) 2019-03-06 2020-09-10 第一三共株式会社 ピロロピラゾール誘導体
CN110256288A (zh) * 2019-05-13 2019-09-20 苏州山青竹生物医药有限公司 一种制备(s)-1-氨基-2,3-二氢-1h-茚-4-甲腈的方法
JP2024501257A (ja) * 2020-12-23 2024-01-11 セルジーン コーポレーション 神経変性疾患の治療のための、インダニルを含むカルボン酸化合物
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CN114671747A (zh) * 2022-04-08 2022-06-28 浙江永太科技股份有限公司 一种4-氯-2-氟苯甲醛的合成方法

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WO2012101011A3 (en) 2012-09-20
CA2823781A1 (en) 2012-08-02
ES2529509T3 (es) 2015-02-20
JP2014511359A (ja) 2014-05-15
EP2668155B1 (en) 2014-11-26
AR084913A1 (es) 2013-07-10
HK1187910A1 (en) 2014-04-17
CN103328436B (zh) 2015-06-10
EP2668155A2 (en) 2013-12-04
KR20140005271A (ko) 2014-01-14
BR112013018732A2 (pt) 2016-10-25
CN103328436A (zh) 2013-09-25
MX2013008312A (es) 2013-09-06
RU2013136777A (ru) 2015-03-10
WO2012101011A2 (en) 2012-08-02
US8592426B2 (en) 2013-11-26
US20130018055A1 (en) 2013-01-17
JP5986108B2 (ja) 2016-09-06

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