AR084913A1 - Derivados de aril-benzocicloalquil-amida - Google Patents
Derivados de aril-benzocicloalquil-amidaInfo
- Publication number
- AR084913A1 AR084913A1 ARP120100208A ARP120100208A AR084913A1 AR 084913 A1 AR084913 A1 AR 084913A1 AR P120100208 A ARP120100208 A AR P120100208A AR P120100208 A ARP120100208 A AR P120100208A AR 084913 A1 AR084913 A1 AR 084913A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cycloalkyl
- hydrogen
- alkoxy
- substituted
- Prior art date
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- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
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- Ophthalmology & Optometry (AREA)
Abstract
Composiciones que contienen estos compuestos y la utilización de dichos compuestos en el tratamiento de enfermedades renales. Se provee además, un método de preparación de los mismos.Reivindicación 1: Compuestos de la fórmula (1) en la que: R1 es alquilo, cicloalquilo, cicloalquilalquilo, alcoxi, alcoxialquilo, cicloalcoxi, cicloalcoxialquilo, haloalquilo, haloalcoxi, haloalcoxialquilo, halocicloalquilo, halocicloalquilalquilo, halocicloalcoxi, halocicloalcoxi-alquilo, alcoxicarbonilo, cicloalcoxicarbonilo, haloalcoxicarbonilo, halocicloalcoxicarbonilo, ciano, arilo, arilo sustituido, heteroarilo o heteroarilo sustituido, dichos arilo sustituido y heteroarilo sustituido están sustituidos de una a tres veces por sustituyentes elegidos con independencia entre alquilo, cicloalquilo, alquilcicloalquilo, cicloalquilalquilo, cicloalquilalcoxi, cicloalquilalcoxialquilo, cicloalcoxi, cicloalcoxialquilo, alquilcicloalquilalquilo, halocicloalquilo, halocicloalquilalquilo, halógeno, ciano, haloalquilo, alcoxi, alcoxialquilo, haloalcoxi, alcoxialcoxi, alcoxialcoxialquilo, amino y amino sustituido, dicho amino sustituido está sustituido por uno o dos sustituyentes elegidos con independencia entre alquilo, cicloalquilo, alquilcicloalquilo, cicloalquilalquilo, alquilcicloalquilalquilo, hidroxialquilo y alcoxialquilo; R2 es hidrógeno, alquilo, haloalquilo, alcoxi, cicloalquilo, ciano o halógeno; R3 es hidrógeno, alquilo, haloalquilo, alcoxi, cicloalquilo, ciano o halógeno; R4 es hidrógeno, alquilo, haloalquilo, alcoxi, cicloalquilo, ciano o halógeno; R5 es hidrógeno, alquilo, haloalquilo, alcoxi, cicloalquilo, ciano o halógeno; R6 es hidrógeno, alquilo, haloalquilo, alcoxi, cicloalquilo, ciano o halógeno; R7 es hidrógeno, alquilo o cicloalquilo; R8 es hidrógeno, alquilo o cicloalquilo; R9 es hidrógeno, alquilo o cicloalquilo; R10 es hidrógeno, alquilo o cicloalquilo; o R9 y R10 junto con el carbono, al que están unidos, forman un cicloalquilo o un heterocicloalquilo; R11 es hidrógeno, alquilo o cicloalquilo; R12 es hidrógeno, alquilo, cicloalquilo o -C(O)-R13; R13 es alquilo, cicloalquilo, cicloalquilalquilo, alcoxi, alcoxialcoxi, cicloalcoxi, halocicloalcoxi, alcoxialquilo, cicloalcoxialquilo, haloalquilo, haloalcoxialquilo, halocicloalquilo, halocicloalquilalquilo, halocicloalcoxialquilo, arilo, arilo sustituido, heteroarilo o heteroarilo sustituido, dichos arilo sustituido y heteroarilo sustituido están sustituidos de una a tres veces por sustituyentes elegidos con independencia entre alquilo, cicloalquilo, alquilcicloalquilo, cicloalquilalquilo, cicloalquilalcoxi, cicloalquilalcoxialquilo, cicloalcoxi, cicloalcoxialquilo, alquilcicloalquilalquilo, halocicloalquilo, halocicloalquilalquilo, halógeno, ciano, haloalquilo, hidroxi, hidroxialquilo, alcoxi, alcoxialquilo, haloalcoxi, hidroxialcoxi, alcoxialcoxi, alcoxialcoxialquilo, hidroxihaloalquilo, amino y amino sustituido, dicho amino sustituido está sustituido por uno o dos sustituyentes elegidos con independencia entre alquilo, cicloalquilo, alquilcicloalquilo, cicloalquilalquilo, alquilcicloalquilalquilo, hidroxialquilo y alcoxialquilo; R14 es hidrógeno, alquilo, alcoxi o cicloalquilo; R15 es hidrógeno, alquilo o cicloalquilo; R16 es hidrógeno, alquilo, haloalquilo, alcoxi, cicloalquilo, ciano o halógeno; A1 es CR14, O, NR15 o S; A2 es CR16 o N; n es el número 1, 2 ó 3; o sus sales farmacéuticamente aceptables.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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EP11151890 | 2011-01-24 |
Publications (1)
Publication Number | Publication Date |
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AR084913A1 true AR084913A1 (es) | 2013-07-10 |
Family
ID=45562281
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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ARP120100208A AR084913A1 (es) | 2011-01-24 | 2012-01-23 | Derivados de aril-benzocicloalquil-amida |
Country Status (13)
Country | Link |
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US (1) | US8592426B2 (es) |
EP (1) | EP2668155B1 (es) |
JP (1) | JP5986108B2 (es) |
KR (1) | KR20140005271A (es) |
CN (1) | CN103328436B (es) |
AR (1) | AR084913A1 (es) |
BR (1) | BR112013018732A2 (es) |
CA (1) | CA2823781A1 (es) |
ES (1) | ES2529509T3 (es) |
HK (1) | HK1187910A1 (es) |
MX (1) | MX343225B (es) |
RU (1) | RU2013136777A (es) |
WO (1) | WO2012101011A2 (es) |
Families Citing this family (13)
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US8912221B2 (en) * | 2010-12-27 | 2014-12-16 | Hoffmann-La Roche Inc. | Biaryl amide derivatives |
AU2015242219A1 (en) | 2014-03-29 | 2016-10-06 | Lupin Limited | Sulfonamide compounds as Voltage gated sodium channel modulators |
MX2017009445A (es) * | 2015-01-20 | 2017-11-08 | Merck Sharp & Dohme | Inhibidores del factor xia. |
WO2016168098A1 (en) * | 2015-04-16 | 2016-10-20 | Merck Sharp & Dohme Corp. | FACTOR XIa INHIBITORS |
EP3484859B1 (en) * | 2016-07-18 | 2021-09-15 | F. Hoffmann-La Roche AG | New difluoroketamide derivatives as htra1 inhibitors |
MA51620A (fr) * | 2018-01-19 | 2020-11-25 | Cytokinetics Inc | Analogues de dihydrobenzofurane et d'inden en tant qu'inhibiteurs de sarcomes cardiaques |
WO2020005887A1 (en) | 2018-06-26 | 2020-01-02 | Cytokinetics, Inc. | Cardiac sarcomere inhibitors |
AR116283A1 (es) | 2018-08-31 | 2021-04-21 | Cytokinetics Inc | Inhibidores del sarcómero cardíaco |
JP7413346B2 (ja) | 2019-03-06 | 2024-01-15 | 第一三共株式会社 | ピロロピラゾール誘導体 |
CN110256288A (zh) * | 2019-05-13 | 2019-09-20 | 苏州山青竹生物医药有限公司 | 一种制备(s)-1-氨基-2,3-二氢-1h-茚-4-甲腈的方法 |
JP2024501257A (ja) * | 2020-12-23 | 2024-01-11 | セルジーン コーポレーション | 神経変性疾患の治療のための、インダニルを含むカルボン酸化合物 |
JP2024508526A (ja) | 2021-03-04 | 2024-02-27 | サイトキネティックス, インコーポレイテッド | 心筋サルコメア阻害剤 |
CN114671747A (zh) * | 2022-04-08 | 2022-06-28 | 浙江永太科技股份有限公司 | 一种4-氯-2-氟苯甲醛的合成方法 |
Family Cites Families (10)
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WO2003065789A2 (en) * | 2002-02-08 | 2003-08-14 | Merck & Co., Inc. | N-biphenylmethyl aminocycloalkanecarboxamide derivatives |
TWI259079B (en) * | 2002-02-08 | 2006-08-01 | Merck & Co Inc | N-biphenyl(substituted methyl)aminocycloalkanecarboxamide derivatives |
ES2411655T3 (es) * | 2002-05-17 | 2013-07-08 | Pfizer Italia S.R.L. | Derivados de aminoindazol activos como inhibidores de quinasas, procedimiento para su preparación y composiciones farmacéuticas que los comprenden |
JP2005537323A (ja) * | 2002-08-29 | 2005-12-08 | メルク エンド カムパニー インコーポレーテッド | N−ビアリールメチルアミノシクロアルカンカルボキサミド誘導体 |
MXPA05013469A (es) * | 2003-06-20 | 2006-03-09 | Amgen Inc | Derivados de piperazina y metodos de uso. |
JP2007501790A (ja) * | 2003-08-07 | 2007-02-01 | メルク エンド カムパニー インコーポレーテッド | スルホニル置換n−(ビアリールメチル)アミノシクロプロパンカルボキサミド |
ZA200603912B (en) * | 2003-10-22 | 2007-11-28 | Amgen Inc | Antagonists of the Bradykinin B1 receptor |
CA2557858A1 (en) * | 2004-03-02 | 2005-09-15 | Merck & Co., Inc. | Amino cyclopropane carboxamide derivatives as bradykinin antagonists |
US20060217362A1 (en) * | 2004-12-29 | 2006-09-28 | Tung Jay S | Novel compounds useful for bradykinin B1 receptor antagonism |
WO2010097374A1 (de) | 2009-02-26 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Verbindungen als bradykinin-b1-antagonisten |
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2012
- 2012-01-17 US US13/351,253 patent/US8592426B2/en not_active Expired - Fee Related
- 2012-01-18 MX MX2013008312A patent/MX343225B/es active IP Right Grant
- 2012-01-18 JP JP2013550824A patent/JP5986108B2/ja not_active Expired - Fee Related
- 2012-01-18 RU RU2013136777/04A patent/RU2013136777A/ru not_active Application Discontinuation
- 2012-01-18 WO PCT/EP2012/050667 patent/WO2012101011A2/en active Application Filing
- 2012-01-18 CN CN201280006321.1A patent/CN103328436B/zh not_active Expired - Fee Related
- 2012-01-18 ES ES12702199.6T patent/ES2529509T3/es active Active
- 2012-01-18 CA CA2823781A patent/CA2823781A1/en not_active Abandoned
- 2012-01-18 KR KR1020137022122A patent/KR20140005271A/ko not_active Application Discontinuation
- 2012-01-18 EP EP12702199.6A patent/EP2668155B1/en not_active Not-in-force
- 2012-01-18 BR BR112013018732A patent/BR112013018732A2/pt active Search and Examination
- 2012-01-23 AR ARP120100208A patent/AR084913A1/es not_active Application Discontinuation
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2014
- 2014-01-30 HK HK14101020.6A patent/HK1187910A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
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CN103328436B (zh) | 2015-06-10 |
CN103328436A (zh) | 2013-09-25 |
US20130018055A1 (en) | 2013-01-17 |
EP2668155B1 (en) | 2014-11-26 |
MX2013008312A (es) | 2013-09-06 |
RU2013136777A (ru) | 2015-03-10 |
KR20140005271A (ko) | 2014-01-14 |
EP2668155A2 (en) | 2013-12-04 |
ES2529509T3 (es) | 2015-02-20 |
HK1187910A1 (en) | 2014-04-17 |
CA2823781A1 (en) | 2012-08-02 |
BR112013018732A2 (pt) | 2016-10-25 |
JP5986108B2 (ja) | 2016-09-06 |
MX343225B (es) | 2016-10-28 |
WO2012101011A3 (en) | 2012-09-20 |
WO2012101011A2 (en) | 2012-08-02 |
JP2014511359A (ja) | 2014-05-15 |
US8592426B2 (en) | 2013-11-26 |
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