AR084606A1 - Derivados de biaril-amida - Google Patents
Derivados de biaril-amidaInfo
- Publication number
- AR084606A1 AR084606A1 ARP110104949A ARP110104949A AR084606A1 AR 084606 A1 AR084606 A1 AR 084606A1 AR P110104949 A ARP110104949 A AR P110104949A AR P110104949 A ARP110104949 A AR P110104949A AR 084606 A1 AR084606 A1 AR 084606A1
- Authority
- AR
- Argentina
- Prior art keywords
- cycloalkyl
- alkyl
- hydrogen
- substituted
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D305/04—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D305/08—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
Abstract
Procedimiento para obtener el compuesto divulgado.Reivindicación 1: Compuestos de la fórmula (1) en la que: R1 es alquilo, cicloalquilo, cicloalquilalquilo, alcoxialquilo, cicloalcoxialquilo, haloalquilo, haloalcoxialquilo, halocicloalquilo, halocicloalquilalquilo, halocicloalcoxialquilo, arilo, arilo sustituido, heteroarilo o heteroarilo sustituido, dichos arilo y heteroarilo sustituidos están sustituidos de una a tres veces por sustituyentes elegidos con independencia entre alquilo, cicloalquilo, alquilcicloalquilo, cicloalquilalquilo, cicloalquilalcoxi, cicloalquilalcoxialquilo, cicloalcoxi, cicloalcoxialquilo, alquilcicloalquilalquilo, halocicloalquilo, halocicloalquilalquilo, halógeno, haloalquilo, hidroxi, hidroxialquilo, alcoxi, alcoxialquilo, haloalcoxi, hidroxialcoxi, alcoxialcoxi, alcoxialcoxialquilo, hidroxihaloalquilo, amino y amino sustituido, dicho amino sustituido está sustituido por uno o dos sustituyentes elegidos con independencia entre alquilo, cicloalquilo, alquilcicloalquilo, cicloalquilalquilo, alquilcicloalquilalquilo, hidroxialquilo y alcoxialquilo; R2 es hidrógeno, alquilo o cicloalquilo; R3 es hidrogeno, alquilo o cicloalquilo; R4 es hidrógeno, alquilo o cicloalquilo; R5 es hidrógeno, alquilo o cicloalquilo; o R4 y R5 junto con el átomo de carbono al que están unidos forman un cicloalquilo; R6 es hidrógeno, alquilo, alcoxi, cicloalquilo, halógeno o ciano; R7 es hidrógeno, alquilo, alcoxi, cicloalquilo, halógeno o ciano; R8 es alquilo, cicloalquilo, cicloalquilalquilo, alcoxi, alcoxialquilo, cicloalcoxi, cicloalcoxialquilo, haloalquilo, haloalcoxi, haloalcoxialquilo, halocicloalquilo, halocicloalquilalquilo, halocicloalcoxi, halocicloalcoxialquilo, alcoxicarbonilo, cicloalcoxicarbonilo, haloalcoxicarbonilo, halocicloalcoxicarbonilo, arilo, arilo sustituido, heteroarilo o heteroarilo sustituido, dichos arilo y heteroarilo sustituidos están sustituidos de una a tres veces por sustituyentes elegidos con independencia entre alquilo, cicloalquilo, alquilcicloalquilo, cicloalquilalquilo, cicloalquilalcoxi, cicloalquilalcoxialquilo, cicloalcoxi, cicloalcoxialquilo, alquilcicloalquilalquilo, halocicloalquilo, halocicloalquilalquilo, halógeno, haloalquilo, alcoxi, alcoxialquilo, haloalcoxi, alcoxialcoxi, alcoxialcoxialquilo, amino y amino sustituido, dicho amino sustituido está sustituido por uno o dos sustituyentes elegidos con independencia entre alquilo, cicloalquilo, alquilcicloalquilo, cicloalquilalquilo, alquilcicloalquilalquilo, hidroxialquilo y alcoxialquilo; R9 es hidrógeno, alquilo, alcoxi, cicloalquilo, halógeno o ciano; R10 es hidrógeno, alquilo, alcoxi, cicloalquilo, halógeno o ciano; R11 es hidrógeno, alquilo, alcoxi, cicloalquilo, halógeno o ciano; R12 es hidrógeno, alquilo, alcoxi, cicloalquilo, halógeno o ciano; R13 es hidrógeno, alquilo, alcoxi, cicloalquilo, halógeno o ciano; A es CR13 o N; o sus sales farmacéuticamente aceptables. Reivindicación 20: El uso de un compuesto según una cualquiera de las reivindicaciones de 1 a 14 para la fabricación de un medicamento destinado al tratamiento o profilaxis de la glomerulonefritis, la nefropatía púrpura de Henoch-Schönlein, la nefropatía creciente asociada con el ANCA, la nefritis por lupus y la nefritis por IgA. Reivindicación 22: Un método de tratamiento o profilaxis de la glomerulonefritis, la nefropatía púrpura de Henoch-Schönlein, la nefropatía creciente asociada con el ANCA, la nefritis por lupus y la nefritis por IgA, dicho método consiste en administrar una cantidad eficaz de un compuesto según una cualquiera de las reivindicaciones de 1 a 14.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10197030 | 2010-12-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR084606A1 true AR084606A1 (es) | 2013-05-29 |
Family
ID=45401081
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110104949A AR084606A1 (es) | 2010-12-27 | 2011-12-27 | Derivados de biaril-amida |
Country Status (12)
Country | Link |
---|---|
US (2) | US8912221B2 (es) |
EP (1) | EP2658848A1 (es) |
JP (1) | JP2014501266A (es) |
KR (1) | KR20140014114A (es) |
CN (1) | CN103249727B (es) |
AR (1) | AR084606A1 (es) |
BR (1) | BR112013016431A2 (es) |
CA (1) | CA2822188A1 (es) |
HK (1) | HK1186464A1 (es) |
MX (1) | MX2013005753A (es) |
RU (1) | RU2013133280A (es) |
WO (1) | WO2012089601A1 (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8912221B2 (en) * | 2010-12-27 | 2014-12-16 | Hoffmann-La Roche Inc. | Biaryl amide derivatives |
CN105294520A (zh) * | 2015-11-23 | 2016-02-03 | 大连九信生物化工科技有限公司 | 一种2-(2’,2’-二氟乙氧基)-6-三氟甲基苯基丙基硫醚的合成工艺 |
TW202120479A (zh) | 2019-11-27 | 2021-06-01 | 瑞士商先正達農作物保護公司 | 用於製備具有3-含硫取代基的5-氯-吡啶-2-羧酸及羧酸酯之方法 |
TW202134214A (zh) | 2020-03-04 | 2021-09-16 | 瑞士商先正達農作物保護公司 | 用於製備具有3-含硫取代基的5-氯-吡啶-2-甲酸醯胺以及甲酸鹽之方法 |
TW202229238A (zh) | 2020-10-09 | 2022-08-01 | 瑞士商先正達農作物保護公司 | 用於製備5-(1-氰基環丙基)-吡啶-2-甲酸、酯、醯胺和腈之方法 |
CN114671747A (zh) * | 2022-04-08 | 2022-06-28 | 浙江永太科技股份有限公司 | 一种4-氯-2-氟苯甲醛的合成方法 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI259079B (en) * | 2002-02-08 | 2006-08-01 | Merck & Co Inc | N-biphenyl(substituted methyl)aminocycloalkanecarboxamide derivatives |
EP1545538A2 (en) * | 2002-08-29 | 2005-06-29 | Merck & Co., Inc. | N-biarylmethyl aminocycloalkanecarboxamide derivatives |
CN1832922A (zh) * | 2003-08-07 | 2006-09-13 | 默克公司 | 磺酰基取代的n-(联芳基甲基)氨基环丙烷甲酰胺类 |
EP1723143B1 (en) * | 2004-03-02 | 2009-02-18 | Merck & Co., Inc. | Amino cyclopropane carboxamide derivatives as bradykinin antagonists |
KR20070012552A (ko) * | 2004-05-13 | 2007-01-25 | 베링거 인겔하임 인터내셔날 게엠베하 | 신규한 치환된 티오펜카복스아미드, 이의 제조방법 및약제로서의 이의 용도 |
DE102004047840A1 (de) * | 2004-09-29 | 2006-03-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue substituierte Thiophencarbonsäureamide, deren Herstellung und deren Verwendung als Arzneimittel |
HUP0600808A3 (en) * | 2006-10-27 | 2008-09-29 | Richter Gedeon Nyrt | New benzamide derivatives as bradykinin antagonists, process for their preparation and pharmaceutical compositions containing them |
ES2525237T3 (es) * | 2007-11-29 | 2014-12-19 | Boehringer Ingelheim International Gmbh | Derivados de amidas del ácido 6,7-dihidro-5H-imidazo[1,2-a]imidazol-3-carboxílico |
WO2010097374A1 (de) | 2009-02-26 | 2010-09-02 | Boehringer Ingelheim International Gmbh | Verbindungen als bradykinin-b1-antagonisten |
AU2010217606C1 (en) * | 2009-02-26 | 2017-01-19 | Boehringer Ingelheim International Gmbh | Compounds as bradykinin B1 antagonists |
US8470820B2 (en) * | 2010-01-22 | 2013-06-25 | Hoffman-La Roche Inc. | Nitrogen-containing heteroaryl derivatives |
EP3431489B1 (en) * | 2010-11-15 | 2020-12-23 | Ramot at Tel-Aviv University Ltd. | Dipeptide analogs for treating conditions associated with amyloid fibril formation |
AR084070A1 (es) * | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
US8912221B2 (en) * | 2010-12-27 | 2014-12-16 | Hoffmann-La Roche Inc. | Biaryl amide derivatives |
US8592426B2 (en) * | 2011-01-24 | 2013-11-26 | Hoffmann—La Roche Inc. | Aryl-benzocycloalkyl amide derivatives |
RU2586885C2 (ru) * | 2011-11-17 | 2016-06-10 | Пфайзер Инк. | Цитотоксические пептиды и их конъюгаты антитело-лекарственное средство |
US9326973B2 (en) * | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
-
2011
- 2011-12-19 US US13/329,349 patent/US8912221B2/en not_active Expired - Fee Related
- 2011-12-22 WO PCT/EP2011/073717 patent/WO2012089601A1/en active Application Filing
- 2011-12-22 BR BR112013016431A patent/BR112013016431A2/pt not_active IP Right Cessation
- 2011-12-22 JP JP2013546672A patent/JP2014501266A/ja active Pending
- 2011-12-22 EP EP11799718.9A patent/EP2658848A1/en not_active Withdrawn
- 2011-12-22 MX MX2013005753A patent/MX2013005753A/es unknown
- 2011-12-22 RU RU2013133280/04A patent/RU2013133280A/ru not_active Application Discontinuation
- 2011-12-22 CA CA2822188A patent/CA2822188A1/en not_active Abandoned
- 2011-12-22 KR KR1020137018955A patent/KR20140014114A/ko not_active Application Discontinuation
- 2011-12-22 CN CN201180059302.0A patent/CN103249727B/zh not_active Expired - Fee Related
- 2011-12-27 AR ARP110104949A patent/AR084606A1/es not_active Application Discontinuation
-
2013
- 2013-12-12 HK HK13113842.8A patent/HK1186464A1/zh not_active IP Right Cessation
-
2014
- 2014-10-29 US US14/527,299 patent/US20150065516A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
MX2013005753A (es) | 2013-08-01 |
HK1186464A1 (zh) | 2014-03-14 |
US20150065516A1 (en) | 2015-03-05 |
US8912221B2 (en) | 2014-12-16 |
RU2013133280A (ru) | 2015-02-10 |
WO2012089601A1 (en) | 2012-07-05 |
CN103249727A (zh) | 2013-08-14 |
CA2822188A1 (en) | 2012-07-05 |
US20120165338A1 (en) | 2012-06-28 |
JP2014501266A (ja) | 2014-01-20 |
CN103249727B (zh) | 2016-08-10 |
KR20140014114A (ko) | 2014-02-05 |
EP2658848A1 (en) | 2013-11-06 |
BR112013016431A2 (pt) | 2016-10-04 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA | Abandonment or withdrawal |