MX2010008363A - Derivados de arilamida diazepinopirimidona sustituidos para el tratamiento de enfermedades neurodegenerativas causadas por la actividad anormal de gsk3-beta. - Google Patents

Derivados de arilamida diazepinopirimidona sustituidos para el tratamiento de enfermedades neurodegenerativas causadas por la actividad anormal de gsk3-beta.

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Publication number
MX2010008363A
MX2010008363A MX2010008363A MX2010008363A MX2010008363A MX 2010008363 A MX2010008363 A MX 2010008363A MX 2010008363 A MX2010008363 A MX 2010008363A MX 2010008363 A MX2010008363 A MX 2010008363A MX 2010008363 A MX2010008363 A MX 2010008363A
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Mexico
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group
alkyl group
atom
optionally substituted
hydrogen atom
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MX2010008363A
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English (en)
Inventor
Alistair Lochead
Mourad Saady
Philippe Yaiche
Julien Vache
Aude Fayol
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Sanofi Aventis
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Publication of MX2010008363A publication Critical patent/MX2010008363A/es

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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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Abstract

Un derivado de pirimidona representado por la fórmula (I) o una sal de éste, o un solvato de éste o un hidrato de éste: en la que: Y representa dos átomos de hidrógeno, un átomo de azufre, un átomo de oxígeno o un grupo alquilo C1-2 y un átomo de hidrógeno; Z representa un enlace, un átomo de oxigeno, un átomo de nitrógeno sustituido con un átomo de hidrógeno o un grupo alquilo C1-3, un átomo de azufre, un grupo metileno sustituido opcionalmente con uno o dos grupos seleccionados de un grupo alquilo C1-6, un grupo hidroxilo, un grupo alcoxi C1-6, un grupo alquilo C1-2 perhalogenado o un grupo amino; R1 representa un anillo de 2, 3 ó 4-piridina o un anillo de 2, 4 ó 5-pirimidina, el anillo que está sustituido opcionalmente con un grupo alquilo C1-6, un grupo alcoxi C1-6 o un átomo de halógeno; R2 representa un átomo de hidrógeno, un grupo alquilo C1-6 o un átomo de halógeno; R3 representa un anillo benceno o un anillo naftaleno; los anillos que están sustituidos opcionalmente; R4 representa un átomo de hidrógeno, un grupo alquilo C1-6, un grupo cicloalquilo C3-7, un grupo cicloalquil C3-7-alquilo C1-6, un grupo COO-(alquilo-C1-6), estos grupos que están sustituidos opcionalmente; R5 representa un átomo de hidrógeno o un grupo alquilo C1-6 y n representa de 0 a 3 y su uso terapéutico para el tratamiento de enfermedades causadas por la actividad anormal de GSKß.
MX2010008363A 2008-01-29 2009-01-27 Derivados de arilamida diazepinopirimidona sustituidos para el tratamiento de enfermedades neurodegenerativas causadas por la actividad anormal de gsk3-beta. MX2010008363A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08290074A EP2090578A1 (en) 2008-01-29 2008-01-29 Substituted arylamide diazepinopyrimidone derivatives for the treatment of neurodegenerative diseases caused by abnormal activity of GSK3-beta
PCT/IB2009/000324 WO2009095789A1 (en) 2008-01-29 2009-01-27 Substituted arylamide diazepinopyrimidone derivatives for the treatment of neurodegenerative diseases caused by abnormal activity of gsk3-beta

Publications (1)

Publication Number Publication Date
MX2010008363A true MX2010008363A (es) 2010-08-30

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MX2010008363A MX2010008363A (es) 2008-01-29 2009-01-27 Derivados de arilamida diazepinopirimidona sustituidos para el tratamiento de enfermedades neurodegenerativas causadas por la actividad anormal de gsk3-beta.

Country Status (16)

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US (1) US8507476B2 (es)
EP (2) EP2090578A1 (es)
JP (1) JP5611836B2 (es)
KR (1) KR20100116592A (es)
CN (1) CN101981032A (es)
AR (1) AR070274A1 (es)
AU (1) AU2009208728A1 (es)
BR (1) BRPI0906618A2 (es)
CA (1) CA2713256A1 (es)
EA (1) EA201070896A1 (es)
IL (1) IL207193A0 (es)
MX (1) MX2010008363A (es)
NZ (1) NZ587069A (es)
TW (1) TW200936589A (es)
WO (1) WO2009095789A1 (es)
ZA (1) ZA201005384B (es)

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EP2090579A1 (en) * 2008-01-29 2009-08-19 Sanofi-Aventis Substituted heteroarylamide diazepinopyrimidone derivatives
EP2085399A1 (en) * 2008-01-29 2009-08-05 Sanofi-Aventis substituted arylamide oxazepinopyrimidone derivatives
EP2085400A1 (en) * 2008-01-29 2009-08-05 Sanofi-Aventis Substituted heteroarylamide oxazepinopyrimidone derivatives
EP2138494A1 (en) * 2008-06-26 2009-12-30 Sanofi-Aventis Substituted alkyl pyrimidin-4-one derivatives
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EA201891620A1 (ru) 2016-02-05 2019-02-28 Денали Терапьютикс Инк. Ингибиторы взаимодействующей с рецептором протеинкиназы 1
HRP20220636T1 (hr) 2016-12-09 2022-07-22 Denali Therapeutics Inc. Spojevi korisni kao inhibitori ripk1
CN107987090A (zh) * 2017-12-19 2018-05-04 杨文思 一种用于治疗疟疾的恶性疟原虫糖原合成酶激酶-3抑制剂的合成方法
US11382889B2 (en) * 2018-04-19 2022-07-12 Institut D'investigació Biomèdica De Bellvitge (Idibell) NRF2 activators for the prevention and/or treatment of axonal degeneration
CN112516337B (zh) * 2020-12-11 2022-08-12 南京邮电大学 近红外二区有机共轭聚合物荧光探针的制备方法及其应用

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KR100868840B1 (ko) * 2001-09-21 2008-11-14 사노피-아벤티스 신경퇴행성 장애를 위한 치환된2-피리미디닐-6,7,8,9-테트라히드로피리미도[1,2-ａ]피리미딘-4-온 및7-피리미디닐-2,3-디히드로이미다조[1,2-ａ]피리미딘-5(1ｈ)온 유도체
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JP5611836B2 (ja) 2014-10-22
CA2713256A1 (en) 2009-08-06
NZ587069A (en) 2011-12-22
TW200936589A (en) 2009-09-01
IL207193A0 (en) 2010-12-30
EP2238141B1 (en) 2015-01-14
EP2238141A1 (en) 2010-10-13
AU2009208728A1 (en) 2009-08-06
ZA201005384B (en) 2011-10-26
AR070274A1 (es) 2010-03-25
EA201070896A1 (ru) 2011-02-28
EP2090578A1 (en) 2009-08-19
BRPI0906618A2 (pt) 2015-07-14
WO2009095789A1 (en) 2009-08-06
US8507476B2 (en) 2013-08-13
US20110039835A1 (en) 2011-02-17
KR20100116592A (ko) 2010-11-01
CN101981032A (zh) 2011-02-23
JP2011510970A (ja) 2011-04-07

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