MX343077B - Nuevo derivado de octahidrotienoquinolina, composicion farmaceutica que comprende el derivado, y uso de los mismos. - Google Patents
Nuevo derivado de octahidrotienoquinolina, composicion farmaceutica que comprende el derivado, y uso de los mismos.Info
- Publication number
- MX343077B MX343077B MX2013010587A MX2013010587A MX343077B MX 343077 B MX343077 B MX 343077B MX 2013010587 A MX2013010587 A MX 2013010587A MX 2013010587 A MX2013010587 A MX 2013010587A MX 343077 B MX343077 B MX 343077B
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- derivative
- pharmaceutical composition
- cycloalkyl
- novel
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 6
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229960003638 dopamine Drugs 0.000 abstract 1
- 150000002431 hydrogen Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La presente invención proporciona un compuesto representado por la fórmula general (I), (Ver Formula) donde R1 es ciano o similares; R2 y R3 son hidrógeno o similares; R4 es alquilo de 1 a 6 átomos de carbono o similares; R5 es alquilo de 1 a 6 átomos de carbono, halo-alquilo de 1 a 6 átomos de carbono, cicloalquilo, cicloalquil-alquilo de 1 a 6 átomos de carbono, aralquilo o similares; R6 y R7 son cada uno hidrógeno o un alquilo de 1 a 6 átomos de carbono, halo-alquilo de 1 a 6 átomos de carbono, cicloalquilo, alcoxi de 1 a 6 átomos de carbono-alquilo de 1 a 6 átomos de carbono, R12R13N-alquilo de 1 a 6 átomos de carbono o similares, que tiene una potente actividad estimulante del receptor de dopamina D2, o una sal farmacéuticamente aceptable del mismo, una composición farmacéutica que comprende el derivado o la sal del mismo, y usos del mismo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011055154 | 2011-03-14 | ||
| PCT/JP2012/056252 WO2012124649A1 (ja) | 2011-03-14 | 2012-03-12 | 新規なオクタヒドロチエノキノリン誘導体、それを含有する医薬組成物およびそれらの用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2013010587A MX2013010587A (es) | 2013-10-07 |
| MX343077B true MX343077B (es) | 2016-10-24 |
Family
ID=46830720
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2013010587A MX343077B (es) | 2011-03-14 | 2012-03-12 | Nuevo derivado de octahidrotienoquinolina, composicion farmaceutica que comprende el derivado, y uso de los mismos. |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US9138434B2 (es) |
| EP (1) | EP2687532B1 (es) |
| JP (1) | JP5563716B2 (es) |
| KR (1) | KR101618624B1 (es) |
| CN (2) | CN104829628B (es) |
| AU (1) | AU2012227428B2 (es) |
| BR (1) | BR112013023575B1 (es) |
| CA (1) | CA2827629C (es) |
| DK (1) | DK2687532T3 (es) |
| ES (1) | ES2613658T3 (es) |
| HU (1) | HUE033449T2 (es) |
| IL (1) | IL228318A (es) |
| MX (1) | MX343077B (es) |
| MY (1) | MY183288A (es) |
| PH (1) | PH12013501856A1 (es) |
| PL (1) | PL2687532T3 (es) |
| PT (1) | PT2687532T (es) |
| RU (1) | RU2573399C2 (es) |
| SG (1) | SG193400A1 (es) |
| TW (1) | TWI537274B (es) |
| WO (1) | WO2012124649A1 (es) |
| ZA (1) | ZA201306905B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6166990B2 (ja) * | 2012-09-12 | 2017-07-19 | キッセイ薬品工業株式会社 | オクタヒドロチエノキノリン誘導体の製造方法及びその製造中間体 |
| US9585885B2 (en) | 2012-12-10 | 2017-03-07 | Kissei Pharmaceutical Co., Ltd. | Substituted pyrido[2,3-g]quinazolines as dopamine D2 receptor agonists |
| WO2014112492A1 (ja) * | 2013-01-17 | 2014-07-24 | キッセイ薬品工業株式会社 | 新規なオクタヒドロキノリン誘導体、それを含有する医薬組成物およびそれらの用途 |
| KR102169337B1 (ko) | 2018-08-22 | 2020-10-23 | 주식회사 도원엔바이로 | 질소와 인의 흡착형 세라믹 미생물 담체 및 이의 제조방법 |
| EP4177257B1 (en) * | 2020-07-06 | 2025-12-10 | Kissei Pharmaceutical Co., Ltd. | Succinate of octahydrothienoquinoline compound, and crystals thereof |
| JP7773687B2 (ja) * | 2020-10-07 | 2025-11-20 | キッセイ薬品工業株式会社 | オクタヒドロチエノキノリン化合物の製造方法及びその製造中間体 |
| TW202541802A (zh) * | 2023-12-28 | 2025-11-01 | 日商橘生藥品工業股份有限公司 | 神經退化性疾病治療劑 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH507249A (de) | 1968-05-31 | 1971-05-15 | Sandoz Ag | Verfahren zur Herstellung von 2-Brom-a-ergokryptin |
| BG17968A3 (bg) | 1970-08-14 | 1974-03-05 | Dr. Karl Thomae Gmbh | Метод за получаване на производни на азепина |
| US4166182A (en) | 1978-02-08 | 1979-08-28 | Eli Lilly And Company | 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds |
| CA1131227A (en) * | 1979-01-22 | 1982-09-07 | Nicholas J. Bach | Octahydro-2h-pyrrolo (3,4,-g) quinolines |
| US4526892A (en) * | 1981-03-03 | 1985-07-02 | Farmitalia Carlo Erba, S.P.A. | Dimethylaminoalkyl-3-(ergoline-8'βcarbonyl)-ureas |
| US4452808A (en) | 1982-12-07 | 1984-06-05 | Smithkline Beckman Corporation | 4-Aminoalkyl-2(3H)-indolones |
| US4501890A (en) * | 1983-09-26 | 1985-02-26 | Eli Lilly And Company | Trans-(±)-2,4,6-substituted-5,5a,6,7,8,9,9a,10-octahydro-pyrimido[4,5-g]quinolines |
| US4537893A (en) * | 1984-04-27 | 1985-08-27 | Eli Lilly And Company | Octahydrothiazolo[4,5-g]quinolines and use as prolactin secretion inhibitors |
| DE3572485D1 (en) | 1984-12-22 | 1989-09-28 | Thomae Gmbh Dr K | Tetrahydro-benzothiazoles, their production and their use as intermediates or drugs |
| US4826986A (en) | 1986-06-16 | 1989-05-02 | Eli Lilly And Company | 6-Oxo-trans-octa- and decahydroquinolines |
| US5057515A (en) * | 1989-07-24 | 1991-10-15 | Eli Lilly And Company | Method for agonizing a dopamine receptor |
| US7026484B2 (en) * | 2001-02-23 | 2006-04-11 | Ligand Pharmaceuticals Incorporated | Tricyclic androgen receptor modulator compounds and methods |
| JP2005129430A (ja) | 2003-10-27 | 2005-05-19 | Konica Minolta Holdings Inc | 光電変換材料用半導体、光電変換素子及び太陽電池 |
-
2012
- 2012-03-09 TW TW101108043A patent/TWI537274B/zh active
- 2012-03-12 PL PL12758328T patent/PL2687532T3/pl unknown
- 2012-03-12 CA CA2827629A patent/CA2827629C/en active Active
- 2012-03-12 MY MYPI2013701637A patent/MY183288A/en unknown
- 2012-03-12 BR BR112013023575-6A patent/BR112013023575B1/pt active IP Right Grant
- 2012-03-12 CN CN201510116497.8A patent/CN104829628B/zh active Active
- 2012-03-12 PH PH1/2013/501856A patent/PH12013501856A1/en unknown
- 2012-03-12 JP JP2013504717A patent/JP5563716B2/ja active Active
- 2012-03-12 US US14/002,533 patent/US9138434B2/en active Active
- 2012-03-12 RU RU2013145799/04A patent/RU2573399C2/ru active
- 2012-03-12 PT PT127583284T patent/PT2687532T/pt unknown
- 2012-03-12 SG SG2013068242A patent/SG193400A1/en unknown
- 2012-03-12 EP EP12758328.4A patent/EP2687532B1/en active Active
- 2012-03-12 HU HUE12758328A patent/HUE033449T2/en unknown
- 2012-03-12 DK DK12758328.4T patent/DK2687532T3/en active
- 2012-03-12 AU AU2012227428A patent/AU2012227428B2/en active Active
- 2012-03-12 CN CN201280013522.4A patent/CN103443106B/zh active Active
- 2012-03-12 MX MX2013010587A patent/MX343077B/es active IP Right Grant
- 2012-03-12 ES ES12758328.4T patent/ES2613658T3/es active Active
- 2012-03-12 KR KR1020137026327A patent/KR101618624B1/ko active Active
- 2012-03-12 WO PCT/JP2012/056252 patent/WO2012124649A1/ja not_active Ceased
-
2013
- 2013-09-09 IL IL228318A patent/IL228318A/en active IP Right Grant
- 2013-09-13 ZA ZA2013/06905A patent/ZA201306905B/en unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |