EA201891620A1 - Ингибиторы взаимодействующей с рецептором протеинкиназы 1 - Google Patents
Ингибиторы взаимодействующей с рецептором протеинкиназы 1Info
- Publication number
- EA201891620A1 EA201891620A1 EA201891620A EA201891620A EA201891620A1 EA 201891620 A1 EA201891620 A1 EA 201891620A1 EA 201891620 A EA201891620 A EA 201891620A EA 201891620 A EA201891620 A EA 201891620A EA 201891620 A1 EA201891620 A1 EA 201891620A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- inhibitors
- receptor
- interactivating
- proteinkinase
- azepinylcarboxamide
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 101001031598 Dictyostelium discoideum Probable serine/threonine-protein kinase fhkC Proteins 0.000 title 1
- 101001109145 Homo sapiens Receptor-interacting serine/threonine-protein kinase 1 Proteins 0.000 abstract 1
- 206010061218 Inflammation Diseases 0.000 abstract 1
- 102100022501 Receptor-interacting serine/threonine-protein kinase 1 Human genes 0.000 abstract 1
- 230000006907 apoptotic process Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- SERDDNFMZBCVEJ-UHFFFAOYSA-N n-(1h-azepin-2-yl)formamide Chemical class O=CNC1=CC=CC=CN1 SERDDNFMZBCVEJ-UHFFFAOYSA-N 0.000 abstract 1
- 230000021597 necroptosis Effects 0.000 abstract 1
Classifications
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- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
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- Endocrinology (AREA)
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Abstract
Настоящее изобретение в целом относится к производным N-азепинилкарбоксамида и их композициям, а также к их применению в качестве ингибиторов взаимодействующей с рецептором протеинкиназы 1, которая является ключевым регулятором воспаления, апоптоза и некроптоза.
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