JO3148B1 - مركب مثبط لإشارات مسار notch - Google Patents
مركب مثبط لإشارات مسار notchInfo
- Publication number
- JO3148B1 JO3148B1 JOP/2012/0190A JOP20120190A JO3148B1 JO 3148 B1 JO3148 B1 JO 3148B1 JO P20120190 A JOP20120190 A JO P20120190A JO 3148 B1 JO3148 B1 JO 3148B1
- Authority
- JO
- Jordan
- Prior art keywords
- notch pathway
- inhibitor compound
- signaling inhibitor
- pathway signaling
- compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
يوفر الاختراع الحالي مركب، أو ملح أو هيدرات مقبولين صيدليًا، وتركيبة صيدلية تحتوي على المركب المذكور، أو ملح أو هيدرات مقبولين صيدليًا، ويكون مفيدًا كمثبِّط لإشارات مسار Notch لعلاج السرطان.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161512016P | 2011-07-27 | 2011-07-27 | |
| US201161560486P | 2011-11-16 | 2011-11-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| JO3148B1 true JO3148B1 (ar) | 2017-09-20 |
Family
ID=46598983
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JOP/2012/0190A JO3148B1 (ar) | 2011-07-27 | 2012-07-10 | مركب مثبط لإشارات مسار notch |
Country Status (36)
| Country | Link |
|---|---|
| US (1) | US8569286B2 (ar) |
| EP (1) | EP2736920B1 (ar) |
| JP (1) | JP6027110B2 (ar) |
| KR (1) | KR101578309B1 (ar) |
| CN (1) | CN103732612B (ar) |
| AP (1) | AP4080A (ar) |
| AR (1) | AR087107A1 (ar) |
| AU (1) | AU2012287251B2 (ar) |
| BR (1) | BR112014001600B1 (ar) |
| CA (1) | CA2841178C (ar) |
| CL (1) | CL2014000175A1 (ar) |
| CO (1) | CO6862159A2 (ar) |
| CR (1) | CR20140036A (ar) |
| CY (1) | CY1116645T1 (ar) |
| DK (1) | DK2736920T3 (ar) |
| DO (1) | DOP2014000011A (ar) |
| EA (1) | EA023044B1 (ar) |
| EC (1) | ECSP14013179A (ar) |
| ES (1) | ES2544937T3 (ar) |
| GT (1) | GT201400012A (ar) |
| HR (1) | HRP20150771T1 (ar) |
| HU (1) | HUE027534T2 (ar) |
| IL (1) | IL229988A (ar) |
| JO (1) | JO3148B1 (ar) |
| MA (1) | MA35611B1 (ar) |
| ME (1) | ME02171B (ar) |
| MX (1) | MX356536B (ar) |
| MY (1) | MY184303A (ar) |
| PE (1) | PE20141061A1 (ar) |
| PH (1) | PH12014500215B1 (ar) |
| PL (1) | PL2736920T3 (ar) |
| PT (1) | PT2736920E (ar) |
| RS (1) | RS54135B1 (ar) |
| SI (1) | SI2736920T1 (ar) |
| TW (1) | TWI568730B (ar) |
| WO (1) | WO2013016081A1 (ar) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014110506A2 (en) * | 2013-01-14 | 2014-07-17 | The Trustees Of Columbia University In The City Of New York | Methods of treating, preventing and diagnosing leukemia and other blood diseases and disorders |
| CA2928568A1 (en) | 2013-07-26 | 2015-01-29 | Update Pharma Inc. | Combinatorial methods to improve the therapeutic benefit of bisantrene |
| TWI704151B (zh) | 2014-12-22 | 2020-09-11 | 美商美國禮來大藥廠 | Ｅｒｋ抑制劑 |
| TWI609687B (zh) * | 2015-04-14 | 2018-01-01 | 美國禮來大藥廠 | 平滑肌肉瘤之標靶性治療 |
| JO3491B1 (ar) * | 2015-07-07 | 2020-07-05 | Audion Therapeutics | مركبات مثبطة لإشارات مسار notch |
| SG10201913587WA (en) | 2016-02-05 | 2020-02-27 | Denali Therapeutics Inc | Inhibitors of receptor-interacting protein kinase 1 |
| ES3057783T3 (en) | 2016-03-15 | 2026-03-04 | Oryzon Genomics Sa | Combinations of lsd1 inhibitors for use in the treatment of neoplastic diseases |
| KR102418765B1 (ko) * | 2016-04-12 | 2022-07-08 | 일라이 릴리 앤드 캄파니 | 암 치료를 위한 Notch 및 CDK4/6 억제제의 조합 요법 |
| KR102418766B1 (ko) * | 2016-04-12 | 2022-07-08 | 일라이 릴리 앤드 캄파니 | 암 치료에 사용하기 위한 Notch 및 PI3K/mTOR 억제제의 조합 요법 |
| US10688104B2 (en) | 2016-05-20 | 2020-06-23 | Eli Lilly And Company | Combination therapy with Notch and PD-1 or PD-L1 inhibitors |
| US20190209581A1 (en) * | 2016-08-31 | 2019-07-11 | Eli Lilly And Company | Dosage regimen for treatment of solid tumors |
| EP3525796A1 (en) | 2016-10-12 | 2019-08-21 | Eli Lilly and Company | Targeted treatment of mature t-cell lymphoma |
| DK3552017T3 (da) | 2016-12-09 | 2022-05-16 | Denali Therapeutics Inc | Forbindelser, der er anvendelige som ripk1-inhibitorer |
| JP2020507605A (ja) | 2017-02-17 | 2020-03-12 | フレッド ハッチンソン キャンサー リサーチ センター | Ｂｃｍａ関連癌および自己免疫疾患の治療のための併用療法 |
| MX2020004572A (es) | 2017-11-01 | 2020-10-07 | Juno Therapeutics Inc | Receptores de antigenos quimericos especificos para el antigeno de maduracion de celulas b y polinucleotidos que codifican los mismos. |
| EP3706754A1 (en) | 2017-11-06 | 2020-09-16 | Juno Therapeutics, Inc. | Combination of a cell therapy and a gamma secretase inhibitor |
| MX2020011826A (es) * | 2018-05-06 | 2021-01-15 | Ayala Pharmaceuticals Inc | Composiciones de combinacion que comprenden compuestos de bisfluoroalquil-1,4-benzodiazepinona y metodos de uso de las mismas. |
| MX2021003773A (es) | 2018-10-02 | 2021-07-16 | Frequency Therapeutics Inc | Composiciones farmacéuticas y métodos relacionados con los agentes terapéuticos óticos. |
| BR112021020141A2 (pt) | 2019-04-08 | 2021-12-21 | Frequency Therapeutics Inc | Combinação de chir99021 e ácido valpróico para tratamento de perda auditiva |
| WO2023137035A1 (en) | 2022-01-12 | 2023-07-20 | Denali Therapeutics Inc. | Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TR199901343T2 (xx) * | 1996-12-23 | 1999-09-21 | Elan Pharmaceuticals, Inc. | Sikloalkil, laktam, lakton ve ilgili bile�ikler, bunlar� i�eren farmas�tik bile�imler ve b�yle bile�ikler kullan�larak �-amiloid peptidinin sal�nmas�n� ve/veya sentezini inhibe etmek i�in y�ntemler. |
| AU4710199A (en) * | 1998-06-22 | 2000-01-10 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| WO1999067219A1 (en) | 1998-06-22 | 1999-12-29 | Elan Pharmaceuticals, Inc. | Compounds for inhibiting beta-amyloid peptide release and/or its synthesis |
| ATE402934T1 (de) | 2003-02-04 | 2008-08-15 | Hoffmann La Roche | Malonamidderivate als gamma-secretaseinhibitoren |
| AU2004270361B2 (en) | 2003-09-09 | 2009-06-25 | F. Hoffmann-La Roche Ag | Malonamide derivatives blocking the activity of gama-secretase |
| PT1673347E (pt) | 2003-10-06 | 2015-11-02 | Hoffmann La Roche | Derivados de dibenzo-azepina e benzo-diazepina substituídos, úteis como inibidores de secretase gama |
| KR101169628B1 (ko) | 2006-03-27 | 2012-07-30 | 에프. 호프만-라 로슈 아게 | 감마 세크레테아제 저해제로서의 말론아미드 유도체 |
| AU2008209861B2 (en) * | 2007-02-02 | 2012-08-09 | F. Hoffmann-La Roche Ag | 6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl derivatives |
| MA33076B1 (ar) | 2008-01-11 | 2012-03-01 | Hoffmann La Roche | استخدام مثبط غاما-سكريتيز لعلاج السرطان |
| US8637493B2 (en) * | 2009-11-12 | 2014-01-28 | University Of Massachusetts | Methods for treating glioblastoma |
-
2012
- 2012-07-10 AR ARP120102486A patent/AR087107A1/es not_active Application Discontinuation
- 2012-07-10 JO JOP/2012/0190A patent/JO3148B1/ar active
- 2012-07-13 TW TW101125459A patent/TWI568730B/zh active
- 2012-07-18 MX MX2014001084A patent/MX356536B/es active IP Right Grant
- 2012-07-18 SI SI201230246T patent/SI2736920T1/sl unknown
- 2012-07-18 AP AP2014007362A patent/AP4080A/en active
- 2012-07-18 US US13/551,681 patent/US8569286B2/en active Active
- 2012-07-18 PL PL12741192T patent/PL2736920T3/pl unknown
- 2012-07-18 CA CA2841178A patent/CA2841178C/en active Active
- 2012-07-18 ES ES12741192.4T patent/ES2544937T3/es active Active
- 2012-07-18 MY MYPI2014700183A patent/MY184303A/en unknown
- 2012-07-18 PH PH1/2014/500215A patent/PH12014500215B1/en unknown
- 2012-07-18 BR BR112014001600-3A patent/BR112014001600B1/pt active IP Right Grant
- 2012-07-18 HR HRP20150771TT patent/HRP20150771T1/hr unknown
- 2012-07-18 ME MEP-2015-105A patent/ME02171B/me unknown
- 2012-07-18 CN CN201280037471.9A patent/CN103732612B/zh active Active
- 2012-07-18 HU HUE12741192A patent/HUE027534T2/en unknown
- 2012-07-18 PT PT127411924T patent/PT2736920E/pt unknown
- 2012-07-18 EA EA201490161A patent/EA023044B1/ru not_active IP Right Cessation
- 2012-07-18 JP JP2014522877A patent/JP6027110B2/ja active Active
- 2012-07-18 WO PCT/US2012/047100 patent/WO2013016081A1/en not_active Ceased
- 2012-07-18 RS RS20150496A patent/RS54135B1/sr unknown
- 2012-07-18 EP EP12741192.4A patent/EP2736920B1/en active Active
- 2012-07-18 AU AU2012287251A patent/AU2012287251B2/en not_active Ceased
- 2012-07-18 KR KR1020147001731A patent/KR101578309B1/ko active Active
- 2012-07-18 PE PE2014000129A patent/PE20141061A1/es active IP Right Grant
- 2012-07-18 DK DK12741192.4T patent/DK2736920T3/en active
-
2013
- 2013-12-17 IL IL229988A patent/IL229988A/en active IP Right Grant
-
2014
- 2014-01-22 MA MA36712A patent/MA35611B1/fr unknown
- 2014-01-22 DO DO2014000011A patent/DOP2014000011A/es unknown
- 2014-01-23 CL CL2014000175A patent/CL2014000175A1/es unknown
- 2014-01-24 CO CO14014585A patent/CO6862159A2/es active IP Right Grant
- 2014-01-24 CR CR20140036A patent/CR20140036A/es unknown
- 2014-01-24 GT GT201400012A patent/GT201400012A/es unknown
- 2014-01-27 EC ECSP14013179 patent/ECSP14013179A/es unknown
-
2015
- 2015-08-25 CY CY20151100742T patent/CY1116645T1/el unknown
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