JO3148B1 - مركب مثبط لإشارات مسار notch - Google Patents

مركب مثبط لإشارات مسار notch

Info

Publication number
JO3148B1
JO3148B1 JOP/2012/0190A JOP20120190A JO3148B1 JO 3148 B1 JO3148 B1 JO 3148B1 JO P20120190 A JOP20120190 A JO P20120190A JO 3148 B1 JO3148 B1 JO 3148B1
Authority
JO
Jordan
Prior art keywords
notch pathway
inhibitor compound
signaling inhibitor
pathway signaling
compound
Prior art date
Application number
JOP/2012/0190A
Other languages
English (en)
Inventor
Alan Stephenson Gregory
Arthur Hipskind Philip
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of JO3148B1 publication Critical patent/JO3148B1/ar

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

يوفر الاختراع الحالي مركب، أو ملح أو هيدرات مقبولين صيدليًا، وتركيبة صيدلية تحتوي على المركب المذكور، أو ملح أو هيدرات مقبولين صيدليًا، ويكون مفيدًا كمثبِّط لإشارات مسار Notch لعلاج السرطان.
JOP/2012/0190A 2011-07-27 2012-07-10 مركب مثبط لإشارات مسار notch JO3148B1 (ar)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161512016P 2011-07-27 2011-07-27
US201161560486P 2011-11-16 2011-11-16

Publications (1)

Publication Number Publication Date
JO3148B1 true JO3148B1 (ar) 2017-09-20

Family

ID=46598983

Family Applications (1)

Application Number Title Priority Date Filing Date
JOP/2012/0190A JO3148B1 (ar) 2011-07-27 2012-07-10 مركب مثبط لإشارات مسار notch

Country Status (36)

Country Link
US (1) US8569286B2 (ar)
EP (1) EP2736920B1 (ar)
JP (1) JP6027110B2 (ar)
KR (1) KR101578309B1 (ar)
CN (1) CN103732612B (ar)
AP (1) AP4080A (ar)
AR (1) AR087107A1 (ar)
AU (1) AU2012287251B2 (ar)
BR (1) BR112014001600B1 (ar)
CA (1) CA2841178C (ar)
CL (1) CL2014000175A1 (ar)
CO (1) CO6862159A2 (ar)
CR (1) CR20140036A (ar)
CY (1) CY1116645T1 (ar)
DK (1) DK2736920T3 (ar)
DO (1) DOP2014000011A (ar)
EA (1) EA023044B1 (ar)
EC (1) ECSP14013179A (ar)
ES (1) ES2544937T3 (ar)
GT (1) GT201400012A (ar)
HR (1) HRP20150771T1 (ar)
HU (1) HUE027534T2 (ar)
IL (1) IL229988A (ar)
JO (1) JO3148B1 (ar)
MA (1) MA35611B1 (ar)
ME (1) ME02171B (ar)
MX (1) MX356536B (ar)
MY (1) MY184303A (ar)
PE (1) PE20141061A1 (ar)
PH (1) PH12014500215B1 (ar)
PL (1) PL2736920T3 (ar)
PT (1) PT2736920E (ar)
RS (1) RS54135B1 (ar)
SI (1) SI2736920T1 (ar)
TW (1) TWI568730B (ar)
WO (1) WO2013016081A1 (ar)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014110506A2 (en) * 2013-01-14 2014-07-17 The Trustees Of Columbia University In The City Of New York Methods of treating, preventing and diagnosing leukemia and other blood diseases and disorders
KR20160099081A (ko) 2013-07-26 2016-08-19 업데이트 파마 인코포레이트 비산트렌의 치료 효과 개선용 조합 방법
TWI704151B (zh) 2014-12-22 2020-09-11 美商美國禮來大藥廠 Ｅｒｋ抑制劑
TWI609687B (zh) 2015-04-14 2018-01-01 美國禮來大藥廠 平滑肌肉瘤之標靶性治療
JO3491B1 (ar) * 2015-07-07 2020-07-05 Audion Therapeutics مركبات مثبطة لإشارات مسار notch
CN118994191A (zh) 2016-02-05 2024-11-22 戴纳立制药公司 受体相互作用蛋白激酶1的抑制剂
CN120661674A (zh) 2016-03-15 2025-09-19 奥莱松基因组股份有限公司 用于治疗实体瘤的lsd1抑制剂的组合
WO2017180385A1 (en) * 2016-04-12 2017-10-19 Eli Lilly And Company Combination therapy with notch and pi3k/mtor inhibitors for use in treating cancer
ES2881801T3 (es) * 2016-04-12 2021-11-30 Lilly Co Eli Terapia de combinación con inhibidores de Notch y CDK4/6 para su uso en el tratamiento de cáncer de pulmón
CA3025024A1 (en) * 2016-05-20 2017-11-23 Eli Lilly And Company Combination therapy with notch and pd-1 or pd-l1 inhibitors
KR102512899B1 (ko) * 2016-08-31 2023-03-23 일라이 릴리 앤드 캄파니 고형 종양의 치료를 위한 투약 요법
US11376259B2 (en) 2016-10-12 2022-07-05 Eli Lilly And Company Targeted treatment of mature T-cell lymphoma
HRP20220636T1 (hr) 2016-12-09 2022-07-22 Denali Therapeutics Inc. Spojevi korisni kao inhibitori ripk1
WO2018151836A1 (en) 2017-02-17 2018-08-23 Fred Hutchinson Cancer Research Center Combination therapies for treatment of bcma-related cancers and autoimmune disorders
WO2019090003A1 (en) 2017-11-01 2019-05-09 Juno Therapeutics, Inc. Chimeric antigen receptors specific for b-cell maturation antigen (bcma)
SG11202003427XA (en) * 2017-11-06 2020-05-28 Juno Therapeutics Inc Combination of a cell therapy and a gamma secretase inhibitor
KR20210005714A (ko) * 2018-05-06 2021-01-14 아얄라 파마큐티컬즈 아이엔씨. 비스플루오로알킬-1,4-벤조디아제피논 화합물을 포함하는 조합 조성물 및 이의 사용 방법
US20220192984A1 (en) 2018-10-02 2022-06-23 Frequency Therapeutics, Inc. Pharmaceutical compositions comprising otic therapeutic agents and related methods
CA3136424A1 (en) 2019-04-08 2020-10-15 Frequency Therapeutics, Inc. Combination of chir99021 and valproic acid for treating hearing loss
AU2023206890A1 (en) 2022-01-12 2024-08-22 Denali Therapeutics Inc. Crystalline forms of (s)-5-benzyl-n-(5-methyl-4-oxo-2, 3,4,5- tetrahydropyrido [3,2-b] [l,4]oxazepin-3-yl)-4h-l,2,4-triazole-3-carboxamide

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3812952B2 (ja) * 1996-12-23 2006-08-23 エラン ファーマシューティカルズ，インコーポレイテッド シクロアルキル、ラクタム、ラクトンおよびその関連化合物およびその医薬組成物、並びに該化合物を用いたβ−アミロイドペプチドの放出および／またはその合成を阻害する方法
EP1089980A1 (en) * 1998-06-22 2001-04-11 Elan Pharmaceuticals, Inc. Compounds for inhibiting beta-amyloid peptide release and/or its synthesis
WO1999067219A1 (en) 1998-06-22 1999-12-29 Elan Pharmaceuticals, Inc. Compounds for inhibiting beta-amyloid peptide release and/or its synthesis
NZ541324A (en) 2003-02-04 2008-10-31 Hoffmann La Roche Malonamide derivatives as gamma-secretase inhibitors
DE602004020680D1 (de) 2003-09-09 2009-05-28 Hoffmann La Roche Die aktivität von gamma-secretase blockierende malonamidderivate
KR100867035B1 (ko) 2003-10-06 2008-11-04 에프. 호프만-라 로슈 아게 감마-세크레타제 저해제로서 유용한 치환된다이벤조-아제핀 및 벤조-다이아제핀 유도체
EP2018368B1 (en) 2006-03-27 2012-12-05 F. Hoffmann-La Roche AG Malonamide derivatives as gamma secretase inhibitors
BRPI0807341A2 (pt) * 2007-02-02 2014-05-20 Hoffmann La Roche Derivados de 6-oxo-6,7-di-hidro-5h-dibenzo[b,d]azepin-7-ila
BRPI0906831A2 (pt) 2008-01-11 2019-09-24 Hoffmann La Roche uso de um inibidor de gama-secretase para tratamento de câncer
WO2011060051A1 (en) * 2009-11-12 2011-05-19 University Of Massachusetts Methods for treating glioblastoma

Also Published As

Publication number Publication date
EP2736920B1 (en) 2015-07-01
JP6027110B2 (ja) 2016-11-16
US20130029972A1 (en) 2013-01-31
ME02171B (me) 2015-10-20
CL2014000175A1 (es) 2014-08-22
MX356536B (es) 2018-06-01
CA2841178C (en) 2016-12-20
RS54135B1 (sr) 2015-12-31
CN103732612B (zh) 2015-09-23
TWI568730B (zh) 2017-02-01
KR101578309B1 (ko) 2015-12-16
HUE027534T2 (en) 2016-11-28
BR112014001600A2 (pt) 2017-02-21
MA35611B1 (fr) 2014-11-01
IL229988A (en) 2017-07-31
CY1116645T1 (el) 2017-03-15
PL2736920T3 (pl) 2015-11-30
ECSP14013179A (es) 2014-03-31
BR112014001600B1 (pt) 2022-09-13
AP4080A (en) 2017-03-29
PE20141061A1 (es) 2014-09-06
PT2736920E (pt) 2015-09-16
NZ618891A (en) 2015-12-24
TW201315732A (zh) 2013-04-16
DK2736920T3 (en) 2015-07-20
CN103732612A (zh) 2014-04-16
AU2012287251B2 (en) 2015-05-14
HK1194086A1 (en) 2014-10-10
SI2736920T1 (sl) 2015-08-31
GT201400012A (es) 2014-07-16
KR20140026624A (ko) 2014-03-05
MX2014001084A (es) 2014-02-27
AR087107A1 (es) 2014-02-12
CA2841178A1 (en) 2013-01-31
EA023044B1 (ru) 2016-04-29
EA201490161A1 (ru) 2014-04-30
PH12014500215B1 (en) 2018-09-07
ES2544937T3 (es) 2015-09-07
CR20140036A (es) 2014-03-21
HRP20150771T1 (hr) 2015-08-28
PH12014500215A1 (en) 2014-03-17
EP2736920A1 (en) 2014-06-04
WO2013016081A1 (en) 2013-01-31
AP2014007362A0 (en) 2014-01-31
DOP2014000011A (es) 2014-07-31
MY184303A (en) 2021-03-31
AU2012287251A1 (en) 2014-01-30
CO6862159A2 (es) 2014-02-10
JP2014527042A (ja) 2014-10-09
US8569286B2 (en) 2013-10-29

Similar Documents

Publication Publication Date Title
JO3148B1 (ar) مركب مثبط لإشارات مسار notch
UA111382C2 (uk) Інгібітори протеїнкінази
SA515360469B1 (ar) مركبات حلقية غير متجانسة لتثبيط إنزيم جلوتاميناز والطرق الخاصة باستخدامها
IN2014DN10670A (ar)
EA201590224A1 (ru) Имидазотриазинкарбонитрилы, используемые в качестве ингибиторов киназы
PH12016500467A1 (en) Aminoheteroarlyl benzamides as kinase inhibitors
EA201391390A1 (ru) Циклопропиламины в качестве ингибиторов lsd
MX368703B (es) Un inhibidor de mdm2 derivado de acido benzoico para el tratamiento del cancer.
PH12015502031B1 (en) Tetrahydropyrrolothiazine compounds
MD4659B1 (ro) Polimorf al inhibitorilor SYK
EA201390085A1 (ru) Композиции ингибиторов киназ для лечения рака
AU2012214029A8 (en) Rorgammat inhibitors
MX2013011329A (es) Combinaciones de compuestos inhibidores de akt y erlotinib y metodos de uso.
MD4684B1 (ro) Formulări pe bază de imidazopirazine în calitate de inhibitori SYK
MX2013007336A (es) Compuestos de bi-heteroarilo como inhibidores de vps34.
MX2015010619A (es) Cis-morfolinona y otros compuestos como inhibidores de mdm2 para el tratamiento del cancer.
MX2016006667A (es) Derivados de pirrolo-pirrolona y su uso como inhibidores.
MX362879B (es) Usos novedosos.
EA201390499A1 (ru) Соединения, подходящие для ингибирования снк1
PH12014502492A1 (en) Pyrazole compounds as sglt1 inhibitors
JO3298B1 (ar) مشتقات جليكوبيرانوسيل-مستبدل و اندول-يوريا و استعمالاتهم كمثبطات sglt
UA110834C2 (uk) Сполука-інгібітор сигнального шляху notch
TN2013000515A1 (en) Notch pathway signaling inhibitor compound