AU2001288432A1 - Materials and methods to potentiate cancer treatment - Google Patents
Materials and methods to potentiate cancer treatmentInfo
- Publication number
- AU2001288432A1 AU2001288432A1 AU2001288432A AU8843201A AU2001288432A1 AU 2001288432 A1 AU2001288432 A1 AU 2001288432A1 AU 2001288432 A AU2001288432 A AU 2001288432A AU 8843201 A AU8843201 A AU 8843201A AU 2001288432 A1 AU2001288432 A1 AU 2001288432A1
- Authority
- AU
- Australia
- Prior art keywords
- materials
- methods
- cancer treatment
- potentiate cancer
- potentiate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/40—Acylated substituent nitrogen atom
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61P35/00—Antineoplastic agents
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- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
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- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
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- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
- C07D311/30—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only not hydrogenated in the hetero ring, e.g. flavones
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- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
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- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/6533—Six-membered rings
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- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6578—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and sulfur atoms with or without oxygen atoms, as ring hetero atoms
- C07F9/65785—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and sulfur atoms with or without oxygen atoms, as ring hetero atoms the ring phosphorus atom and, at least, one ring sulfur atom being part of a thiophosphonic acid derivative
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Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1351946A2 (en) * | 2000-09-01 | 2003-10-15 | Icos Corporation | Materials and methods to potentiate cancer treatment |
EP1317442B1 (en) * | 2000-09-11 | 2005-11-16 | Chiron Corporation | Quinolinone derivatives as tyrosine kinase inhibitors |
US20030028018A1 (en) * | 2000-09-11 | 2003-02-06 | Chiron Coporation | Quinolinone derivatives |
US6875165B2 (en) * | 2001-02-22 | 2005-04-05 | Retinalabs, Inc. | Method of radiation delivery to the eye |
US8078262B2 (en) * | 2001-04-16 | 2011-12-13 | The Johns Hopkins University | Method for imaging and spectroscopy of tumors and determination of the efficacy of anti-tumor drug therapies |
GB0119865D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
GB0119863D0 (en) | 2001-08-14 | 2001-10-10 | Cancer Res Campaign Tech | DNA-PK inhibitors |
US7049313B2 (en) | 2002-02-25 | 2006-05-23 | Kudos Pharmaceuticals Ltd. | ATM inhibitors |
US7825132B2 (en) | 2002-08-23 | 2010-11-02 | Novartis Vaccines And Diagnostics, Inc. | Inhibition of FGFR3 and treatment of multiple myeloma |
CA2496164C (en) * | 2002-08-23 | 2010-11-09 | Chiron Corporation | Benzimidazole quinolinones and uses thereof |
US20060058313A1 (en) * | 2002-11-12 | 2006-03-16 | Hohneker John A | Treatment of mesothelioma |
KR20110108404A (en) * | 2002-11-13 | 2011-10-05 | 노바티스 백신즈 앤드 다이아그노스틱스 인코포레이티드 | Methods of treating cancer and related methods |
CA2523178C (en) * | 2003-03-24 | 2012-10-23 | Luitpold Pharmaceuticals, Inc. | Materials and methods to potentiate cancer treatment |
WO2004098523A2 (en) * | 2003-04-30 | 2004-11-18 | The Board Of Trustees At The University Of Illinois At Chicago | Intraocular brachytherapy device and method |
WO2004110418A2 (en) * | 2003-06-10 | 2004-12-23 | Kalypsys, Inc. | Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease |
US7271195B2 (en) | 2003-06-10 | 2007-09-18 | Kalypsys, Inc. | Carbonyl compounds as inhibitors of histone deacetylase for the treatment of disease |
TW200524924A (en) | 2003-08-13 | 2005-08-01 | Kudos Pharm Ltd | ATM inhibitors |
JP4890255B2 (en) * | 2003-11-07 | 2012-03-07 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | Pharmaceutically acceptable salts of quinolinone compounds with improved drug properties |
AU2005214040B2 (en) * | 2004-02-12 | 2011-03-31 | Neo Vista, Inc. | Methods and apparatus for intraocular brachytherapy |
JP5019884B2 (en) * | 2004-02-20 | 2012-09-05 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | Regulation of inflammatory and metastatic processes |
ES2358267T3 (en) * | 2004-03-15 | 2011-05-09 | Sunesis Pharmaceuticals, Inc. | PHARMACEUTICAL COMPOSITION INCLUDING SNS-595 AND ITS USES. |
BRPI0515498A (en) | 2004-09-20 | 2008-07-29 | Kudos Pharm Ltd | dna-pk inhibitors |
PL2301546T3 (en) * | 2005-01-27 | 2015-03-31 | Novartis Ag | Treatment of metastasized tumors |
CN101115747A (en) | 2005-02-09 | 2008-01-30 | 库多斯药物有限公司 | Atm inhibitors |
US20060234959A1 (en) * | 2005-04-14 | 2006-10-19 | Advanced Photodynamic Technologies, Inc. | Photodynamic therapy utilizing multiple duty cycle light modulation |
AR054438A1 (en) | 2005-04-15 | 2007-06-27 | Kudos Pharm Ltd | DNA INHIBITORS -PK |
WO2006117669A1 (en) * | 2005-05-03 | 2006-11-09 | Pfizer Inc. | Amide resorcinol compounds |
PT1885187E (en) | 2005-05-13 | 2013-12-16 | Novartis Ag | Methods for treating drug resistant cancer |
US8222413B2 (en) * | 2005-05-17 | 2012-07-17 | Novartis Ag | Methods for synthesizing heterocyclic compounds |
CA2609353C (en) | 2005-05-23 | 2015-04-28 | Novartis Ag | Crystalline and other forms of 4-amino-5-fluoro-3-[6-(4-methylpiperazin-1-yl)-1h-benzimidazol-2-yl]-1h-quinolin-2-one lactic acid salts |
US8580814B2 (en) | 2006-04-03 | 2013-11-12 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer |
UA96424C2 (en) | 2005-09-16 | 2011-11-10 | Янссен Фармацевтика Н.В. | Cyclopropyl amines as modulators of the histamine h3 receptor |
EP2407453A1 (en) | 2005-09-27 | 2012-01-18 | Shionogi & Co., Ltd. | PGD2 receptor antagonist |
JP2009515655A (en) * | 2005-11-15 | 2009-04-16 | ネオビスタ、インコーポレイテッド | Method and apparatus for intraocular brachytherapy |
AU2007212429A1 (en) | 2006-02-07 | 2007-08-16 | Wyeth | 11-beta HSD1 inhibitors |
US7834178B2 (en) | 2006-03-01 | 2010-11-16 | Bristol-Myers Squibb Company | Triazine 11-beta hydroxysteroid dehydrogenase type 1 inhibitors |
AU2007258280B2 (en) | 2006-06-12 | 2013-05-02 | Sunesis Pharmaceuticals, Inc. | Compounds and compositions for treatment of cancer |
AU2006233256B2 (en) * | 2006-10-30 | 2012-01-19 | Armaron Bio Pty Ltd | Improved flavonols |
RS55866B1 (en) | 2006-12-14 | 2017-08-31 | Janssen Pharmaceutica Nv | Process for the preparation of piperazinyl and diazepanyl benzamide derivatives |
US8093246B2 (en) * | 2006-12-14 | 2012-01-10 | Lexicon Pharmaceuticals, Inc. | O-linked pyrimidin-4-amine-based compounds, compositions comprising them, and methods of their use to treat cancer |
WO2008112164A2 (en) | 2007-03-08 | 2008-09-18 | The Board Of Trustees Of The Leland Stanford Junior University | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof |
WO2009008991A2 (en) * | 2007-07-06 | 2009-01-15 | Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health | Dna-pkcs modulates energy regulation and brain function |
EP3141250A1 (en) | 2007-10-22 | 2017-03-15 | Sunesis Pharmaceuticals, Inc. | Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid in combination therapy |
CA2704266A1 (en) * | 2007-11-02 | 2009-06-11 | Vertex Pharmaceuticals Incorporated | [1h- pyrazolo [3, 4-b] pyridine-4-yl] -phenyle or -pyridin-2-yle derivatives as protein kinase c-theta |
NZ586144A (en) | 2008-01-07 | 2012-11-30 | Salutaris Md | Curved cannula for delivery of radiation to the posterior portion of the eye |
US8608632B1 (en) | 2009-07-03 | 2013-12-17 | Salutaris Medical Devices, Inc. | Methods and devices for minimally-invasive extraocular delivery of radiation and/or pharmaceutics to the posterior portion of the eye |
JP2011522603A (en) | 2008-06-04 | 2011-08-04 | ネオビスタ、インコーポレイテッド | Handheld radiation delivery system for advancing a radiation source wire |
CN102209541B (en) | 2008-09-08 | 2016-05-18 | 小利兰·斯坦福大学托管委员会 | Modulators of aldehyde dehydrogenase activity and its using method |
US7825392B2 (en) * | 2008-10-08 | 2010-11-02 | Rodney Wayne Prosser | Cleaning process for radiopharmaceutical reusable pigs |
JP2012506856A (en) | 2008-10-28 | 2012-03-22 | ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティ | Modulator of aldehyde dehydrogenase and method of use thereof |
US8663210B2 (en) | 2009-05-13 | 2014-03-04 | Novian Health, Inc. | Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy |
US8269197B2 (en) | 2009-07-22 | 2012-09-18 | Intraop Medical Corporation | Method and system for electron beam applications |
NZ598685A (en) | 2009-09-11 | 2013-05-31 | Probiodrug Ag | Heterocylcic derivatives as inhibitors of glutaminyl cyclase |
WO2011109387A1 (en) * | 2010-03-01 | 2011-09-09 | Intraop Medical Corporation | Radiotherapy combined with hypoxic cell sensitizers |
AU2011229542A1 (en) * | 2010-03-16 | 2012-11-08 | Merck Patent Gmbh | Morpholinylquinazolines |
AU2011238421B2 (en) | 2010-04-06 | 2016-12-08 | Peter Maccallum Cancer Institute | Radioprotector compounds and methods |
US8642007B2 (en) | 2010-09-20 | 2014-02-04 | Yanping Kong | Method and compound for treatment of cancer using phosphorous-32 labeled DNA |
GB201106829D0 (en) | 2011-04-21 | 2011-06-01 | Proximagen Ltd | Heterocyclic compounds |
US10457659B2 (en) | 2011-04-29 | 2019-10-29 | The Board Of Trustees Of The Leland Stanford Junior University | Compositions and methods for increasing proliferation of adult salivary stem cells |
JO3115B1 (en) | 2011-08-22 | 2017-09-20 | Takeda Pharmaceuticals Co | Pyridazinone Compounds and Their Use as DAAO Inhibitors |
DE102011118830A1 (en) * | 2011-11-18 | 2013-05-23 | Merck Patent Gmbh | Morpholinylbenzotriazine |
EP3459942B1 (en) | 2012-04-24 | 2020-12-30 | Vertex Pharmaceuticals Incorporated | Dna-pk inhibitors |
SG11201507203RA (en) * | 2013-03-12 | 2015-10-29 | Vertex Pharma | Dna-pk inhibitors |
KR20150135332A (en) | 2013-03-14 | 2015-12-02 | 더 보드 오브 트러스티스 오브 더 리랜드 스탠포드 쥬니어 유니버시티 | Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof |
WO2014165816A1 (en) | 2013-04-05 | 2014-10-09 | North Carolina Central University | Compounds useful for the treatment of metabolic disorders and synthesis of the same |
EA024384B1 (en) * | 2013-06-27 | 2016-09-30 | Институт Нефтехимических Процессов Им. Академика Ю. Мамедалиева, Нан Азербайджана | Use of complex 2-morpholylmethyl-5-methylphenol salt as pesticide against oidium in grape fruits and leaves |
LT3057959T (en) * | 2013-10-17 | 2018-06-11 | Vertex Pharmaceuticals Incorporated | Dna-pk inhibitors |
CN108771681B (en) | 2013-10-17 | 2021-06-15 | 沃泰克斯药物股份有限公司 | Co-crystals of compounds and deuterated derivatives thereof as DNA-PK inhibitors |
WO2016009296A1 (en) | 2014-07-16 | 2016-01-21 | Pfizer Inc. | N-acylpiperidine ether tropomyosin-related kinase inhibitors |
CN105884827B (en) * | 2015-02-13 | 2018-03-13 | 山东轩竹医药科技有限公司 | Pyrimidine amide derivatives and its salt |
US11413255B2 (en) * | 2015-06-29 | 2022-08-16 | Montefiore Medical Center | Multifunctional cytoprotectant for treatment of pathogenic processes mediated by oxidative stress and toxic electrophiles |
CR20180413A (en) | 2016-02-05 | 2018-12-04 | Denali Therapeutics Inc | INHIBITORS OF PROTEIN QUINASA 1 THAT INTERACT WITH THE RECEIVER |
EP3484528B1 (en) | 2016-07-18 | 2020-11-25 | Janssen Pharmaceutica NV | Tau pet imaging ligands |
JP2019529475A (en) * | 2016-09-27 | 2019-10-17 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of a DNA damaging agent and a DNA-PK inhibitor |
CN110383066B (en) | 2016-12-09 | 2023-03-31 | 戴纳立制药公司 | Compounds, compositions and methods |
MA54758A (en) | 2019-01-18 | 2022-04-27 | Astrazeneca Ab | PCSK9 INHIBITORS AND METHODS OF USE THEREOF |
CN111978139B (en) * | 2020-09-04 | 2023-04-07 | 许昌学院 | Method for synthesizing phenol or derivatives thereof by photocatalysis in aqueous phase in one pot |
CN114933528B (en) * | 2022-05-30 | 2024-03-29 | 湖南大学 | New method for preparing aryl acyloxy alkyl iodide and conversion application method thereof |
Family Cites Families (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE630639A (en) * | 1962-04-12 | |||
FR8298M (en) * | 1967-07-20 | 1970-11-16 | ||
JPS5138245B2 (en) * | 1973-05-22 | 1976-10-20 | ||
US3904631A (en) * | 1973-05-29 | 1975-09-09 | Parke Davis & Co | Novel thioxanthenone compounds and means of producing the same |
US4003699A (en) * | 1974-11-22 | 1977-01-18 | Henkel & Cie G.M.B.H. | Oxidation hair dyes based upon tetraaminopyrimidine developers |
DE2737207A1 (en) | 1977-08-18 | 1979-03-01 | Basf Ag | COLOR PICTURES FOR COPYING |
DE2807761A1 (en) * | 1978-02-23 | 1979-08-30 | Basf Ag | CUMARIN DERIVATIVES |
JPS5544830A (en) | 1978-09-27 | 1980-03-29 | Hodogaya Chem Co Ltd | Pressure-sensitive copying paper |
DE2922488A1 (en) * | 1979-06-01 | 1980-12-11 | Thiemann Chem Pharm Fab | 2-Hydroxy-4-amino-6-methyl-isophthalic acid - and 2,6-di:acetyl-3-hydroxy-5-methylphenol derivs. with cardiovascular activity |
DE2950291A1 (en) | 1979-12-14 | 1981-06-19 | Basf Ag, 6700 Ludwigshafen | NEW CUMARINE COMPOUNDS AND METHOD FOR PRODUCING CUMARINE COMPOUNDS |
JPS5788455A (en) * | 1980-11-22 | 1982-06-02 | Canon Inc | Electrophotographic receptor |
DE3141970A1 (en) | 1981-10-22 | 1983-05-05 | Vsesojuznyj naučno-issledovatel'skij institut lekarstvennych rastenij, Vilar, Moskovskaja oblast' | MEDICINES FOR TREATING DISEASES GENERATED BY THE VIRUS OF THE HERPES GROUP |
US4426380A (en) * | 1981-10-28 | 1984-01-17 | Ciba-Geigy Corporation | Benzofuran-2-ones and pharmaceutical compositions |
EP0082109A3 (en) * | 1981-10-28 | 1985-04-17 | Ciba-Geigy Ag | Substituted 2-hydroxyphenylacetic acids and derivatives of them |
US4539412A (en) * | 1982-07-08 | 1985-09-03 | Rensselaer Polytechnic Institute | 7-Hydroxylucanthone, 7-hydroxhycanthone and their analogs |
EP0106800A1 (en) * | 1982-10-08 | 1984-04-25 | Ciba-Geigy Ag | Furans |
EP0107620A1 (en) * | 1982-10-13 | 1984-05-02 | Ciba-Geigy Ag | Phenol derivatives |
DE3800577A1 (en) * | 1988-01-12 | 1989-07-20 | Basf Ag | 3- (4-AMINO-2-HYDROXYPHENYL) -1-OXO-ISOINDOLENINE, METHOD FOR THE PRODUCTION THEREOF AND THEIR SAPONIFICATION OF 2- (4-AMINO-2-HYDROXYBENZOYL) -BENZOESAEUR |
EP0342665A3 (en) * | 1988-05-20 | 1990-08-16 | Takeda Chemical Industries, Ltd. | Physiologically active substance tan-931, its derivatives, their production and use |
WO1990014008A1 (en) | 1989-05-25 | 1990-11-29 | Sloan-Kettering Institute For Cancer Research | Methods and compositions for inhibiting tumor cell growth |
GB9018044D0 (en) | 1990-08-16 | 1990-10-03 | Ici Plc | Tricyclic heterocyclic derivatives |
EP0580609A1 (en) | 1991-03-22 | 1994-02-02 | Xenova Limited | Pharmaceutical xanthone derivatives |
EP0641789B1 (en) * | 1991-05-24 | 1997-12-03 | Taiho Pharmaceutical Company Limited | Benzothiadiazine derivative |
US5262549A (en) * | 1991-05-30 | 1993-11-16 | Polaroid Corporation | Benzpyrylium dyes, and processes for their preparation and use |
DE19502584C2 (en) * | 1994-01-28 | 1999-08-12 | Medigene Ag Ges Fuer Molekular | Method for determining the activity of a regulatory factor and use of this method |
DE4424712A1 (en) * | 1994-07-13 | 1996-01-18 | Basf Ag | Use of benzaldehydes to mark hydrocarbons |
US5558043A (en) * | 1994-10-06 | 1996-09-24 | Givens; Donovan J. | Lightweight, portable animal grooming stall |
AU4264396A (en) | 1994-11-25 | 1996-06-19 | Laboratoires De Biologie Vegetale Yves Rocher | Cosmetic or pharmaceutical compositions containing mangiferin or derivatives thereof |
DE19501303A1 (en) | 1995-01-18 | 1996-07-25 | Henkel Kgaa | Aryl ketones for dyeing keratin fibers |
AU6709596A (en) | 1995-08-22 | 1997-03-19 | Japan Tobacco Inc. | Amide compounds and use of the same |
WO1997031891A1 (en) * | 1996-03-01 | 1997-09-04 | Merck & Co., Inc. | Process for regioselective substitution of trifluorobenzoate or trifluorobenzonitrile |
CA2236867A1 (en) | 1996-09-27 | 1998-04-02 | Icos Corporation | Method to identify compounds for disrupting protein/protein interactions |
GB2326410A (en) * | 1997-06-18 | 1998-12-23 | Merck & Co Inc | Tocolytic Oxytocin Receptor Antagonists |
JPH11106371A (en) * | 1997-07-04 | 1999-04-20 | Nisshin Flour Milling Co Ltd | Acylhydrazone derivative |
SE9703377D0 (en) * | 1997-09-18 | 1997-09-18 | Astra Ab | New compounds |
JP4531149B2 (en) | 1997-10-17 | 2010-08-25 | 富山化学工業株式会社 | Nitrogen-containing tri- and tetracyclic compounds and antiviral agents containing the same |
AU1804299A (en) * | 1997-12-08 | 1999-06-28 | Glycomed Incorporated | Sialyl lewis x and sialyl lewis a glycomimetics |
TWI238841B (en) | 1998-01-30 | 2005-09-01 | Albemarle Corp | Photopolymerization compositions including maleimides and method thereof |
PL343419A1 (en) * | 1998-03-12 | 2001-08-13 | Microbial Chem Res Found | Benzofurylpyrone derivatives |
ES2288318T3 (en) * | 1998-06-30 | 2008-01-01 | Sloan-Kettering Institute For Cancer Research | USE OF DNA-PK. |
AU6055099A (en) * | 1998-09-21 | 2000-04-10 | Fox Chase Cancer Center | Assays and novel cellular targets for therapeutic agents to treat retroviral infection |
SK4172001A3 (en) * | 1998-09-28 | 2001-11-06 | Kimberly Clark Co | Chelates comprising chinoid groups as photoinitiators |
US6407092B1 (en) * | 1999-04-23 | 2002-06-18 | Pharmacia & Upjohn Company | Tetracyclic azepinoindole compounds |
US6297242B1 (en) * | 1999-08-12 | 2001-10-02 | Ortho-Mcneil Pharmaceutical, Inc. | N-substituted amidine and guanidine oxazolidinone antibacterials and methods of use thereof |
GB9920912D0 (en) | 1999-09-03 | 1999-11-10 | Indena Spa | Novel derivatives of flavones,xanthones and coumarins |
US6535593B1 (en) | 2000-02-28 | 2003-03-18 | Simplified Development Corp. | System and method for billing communications services provisioned on demand in converging telecommunications network |
JP2001247459A (en) * | 2000-03-03 | 2001-09-11 | Oakland Uniservices Ltd | Combination therapy for cancer |
EP1351946A2 (en) | 2000-09-01 | 2003-10-15 | Icos Corporation | Materials and methods to potentiate cancer treatment |
JP3968978B2 (en) | 2000-09-20 | 2007-08-29 | 三菱化学株式会社 | Organic electroluminescence device |
WO2003055479A1 (en) | 2001-12-21 | 2003-07-10 | Consejo Superior De Investigaciones Cientificas | Compounds and their therapeutic use related to the phosphorylating activity of the enzyme gsk-3 |
-
2001
- 2001-08-28 EP EP01968164A patent/EP1351946A2/en not_active Withdrawn
- 2001-08-28 AU AU2001288432A patent/AU2001288432A1/en not_active Abandoned
- 2001-08-28 WO PCT/US2001/026709 patent/WO2002020500A2/en active Application Filing
- 2001-08-28 US US09/941,897 patent/US7179912B2/en not_active Expired - Fee Related
-
2007
- 2007-02-16 US US11/708,163 patent/US8242115B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1351946A2 (en) | 2003-10-15 |
WO2002020500A3 (en) | 2003-07-31 |
US8242115B2 (en) | 2012-08-14 |
US20020165218A1 (en) | 2002-11-07 |
WO2002020500A2 (en) | 2002-03-14 |
US7179912B2 (en) | 2007-02-20 |
US20080090782A1 (en) | 2008-04-17 |
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