MX2023005983A - Nuevos agentes antivirales derivados de la espiropirrolidina. - Google Patents

Nuevos agentes antivirales derivados de la espiropirrolidina.

Info

Publication number
MX2023005983A
MX2023005983A MX2023005983A MX2023005983A MX2023005983A MX 2023005983 A MX2023005983 A MX 2023005983A MX 2023005983 A MX2023005983 A MX 2023005983A MX 2023005983 A MX2023005983 A MX 2023005983A MX 2023005983 A MX2023005983 A MX 2023005983A
Authority
MX
Mexico
Prior art keywords
spiropyrrolidine
novel
antiviral agents
formula
pharmaceutically acceptable
Prior art date
Application number
MX2023005983A
Other languages
English (en)
Inventor
Xiaowen Peng
Hui Cao
Yong He
Guoqiang Wang
Jun Ma
Xuechao Xing
Ruichao Shen
Xuri Gao
Yat Sun Or
Joseph D Panarese
Original Assignee
Enanta Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enanta Pharm Inc filed Critical Enanta Pharm Inc
Publication of MX2023005983A publication Critical patent/MX2023005983A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención describe compuestos de la Fórmula (I) y sales farmacéuticamente aceptables de los mismos: (ver fórmula) que inhiben la actividad de replicación del coronavirus. La invención se refiere además a composiciones farmacéuticas que comprenden un compuesto de Fórmula (I) o una sal farmacéuticamente aceptable del mismo, y métodos para tratar o prevenir una infección por coronavirus en un sujeto que lo necesite, que comprenden administrar al sujeto una cantidad terapéuticamente efectiva de un compuesto de Fórmula (I) o una sal farmacéuticamente aceptables del mismo.
MX2023005983A 2020-11-23 2021-11-22 Nuevos agentes antivirales derivados de la espiropirrolidina. MX2023005983A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063117184P 2020-11-23 2020-11-23
PCT/US2021/060243 WO2022109360A1 (en) 2020-11-23 2021-11-22 Novel spiropyrrolidine derived antiviral agents

Publications (1)

Publication Number Publication Date
MX2023005983A true MX2023005983A (es) 2023-08-15

Family

ID=81656811

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2023005983A MX2023005983A (es) 2020-11-23 2021-11-22 Nuevos agentes antivirales derivados de la espiropirrolidina.

Country Status (10)

Country Link
US (1) US11976084B2 (es)
EP (1) EP4247387A1 (es)
JP (1) JP2024500286A (es)
KR (1) KR20230124583A (es)
CN (1) CN116829571A (es)
AU (1) AU2021383832A1 (es)
CA (1) CA3202764A1 (es)
IL (1) IL302990A (es)
MX (1) MX2023005983A (es)
WO (1) WO2022109360A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11976084B2 (en) 2020-11-23 2024-05-07 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
US11970502B2 (en) 2021-05-04 2024-04-30 Enanta Pharmaceuticals, Inc. Macrocyclic antiviral agents
US11919910B2 (en) 2021-11-12 2024-03-05 Enanta Pharmaceuticals, Inc. Spiropyrrolidine derived antiviral agents
WO2023086350A1 (en) * 2021-11-12 2023-05-19 Enanta Pharmaceuticals, Inc. Alkyne-containing antiviral agents
WO2023086352A1 (en) 2021-11-12 2023-05-19 Enanta Pharmaceuticals, Inc. Novel spiropyrrolidine derived antiviral agents
US11993600B2 (en) 2021-12-08 2024-05-28 Enanta Pharmaceuticals, Inc. Saturated spirocyclics as antiviral agents
CN117751124A (zh) * 2021-12-17 2024-03-22 南京药石科技股份有限公司 螺环氧化吲哚类化合物及其用于制备抗病毒蛋白酶抑制剂药物的用途
US12006291B2 (en) 2022-01-11 2024-06-11 Enanta Pharmaceuticals, Inc. Processes for the preparation of 4,6,7-trifluoro-1H-indole-2-carboxylic acid
CN115894504A (zh) * 2022-10-21 2023-04-04 深圳信立泰药业股份有限公司 一种冠状病毒3cl蛋白酶抑制剂及其用途

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Publication number Publication date
AU2021383832A9 (en) 2024-06-27
EP4247387A1 (en) 2023-09-27
US11976084B2 (en) 2024-05-07
KR20230124583A (ko) 2023-08-25
US20220162231A1 (en) 2022-05-26
JP2024500286A (ja) 2024-01-09
WO2022109360A1 (en) 2022-05-27
IL302990A (en) 2023-07-01
CA3202764A1 (en) 2022-05-27
CN116829571A (zh) 2023-09-29
AU2021383832A1 (en) 2023-06-22

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