BR112018015410A2 - compostos, composições e métodos - Google Patents

compostos, composições e métodos

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Publication number
BR112018015410A2
BR112018015410A2 BR112018015410A BR112018015410A BR112018015410A2 BR 112018015410 A2 BR112018015410 A2 BR 112018015410A2 BR 112018015410 A BR112018015410 A BR 112018015410A BR 112018015410 A BR112018015410 A BR 112018015410A BR 112018015410 A2 BR112018015410 A2 BR 112018015410A2
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BR
Brazil
Prior art keywords
compositions
compounds
methods
present
relates generally
Prior art date
Application number
BR112018015410A
Other languages
English (en)
Other versions
BR112018015410B1 (pt
Inventor
Pozzan Alfonso
A Estrada Anthony
Fox Brian
Philip Leslie Colin
De Vicente Fidalgo Javier
A Feng Jianwen
P Lyssikatos Joseph
K Sweeney Zachary
Original Assignee
Denali Therapeutics Inc
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Publication date
Application filed by Denali Therapeutics Inc filed Critical Denali Therapeutics Inc
Publication of BR112018015410A2 publication Critical patent/BR112018015410A2/pt
Publication of BR112018015410B1 publication Critical patent/BR112018015410B1/pt

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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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  • Dermatology (AREA)
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Abstract

a presente invenção refere-se de modo geral a compostos e composições e seus usos como inibidores da quinase.
BR112018015410-5A 2016-02-05 2017-02-03 Compostos inibidores de quinase, composições que os compreendem, e usos dos mesmos BR112018015410B1 (pt)

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US201662292202P 2016-02-05 2016-02-05
US62/292,202 2016-02-05
US201662341019P 2016-05-24 2016-05-24
US62/341,019 2016-05-24
US201662363775P 2016-07-18 2016-07-18
US62/363,775 2016-07-18
US201662385217P 2016-09-08 2016-09-08
US62/385,217 2016-09-08
US201662417219P 2016-11-03 2016-11-03
US62/417,219 2016-11-03
PCT/US2017/016509 WO2017136727A2 (en) 2016-02-05 2017-02-03 Compounds, compositions and methods

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