EA202090183A1 - Композиции, способы и получение дейтерированного домперидона - Google Patents
Композиции, способы и получение дейтерированного домперидонаInfo
- Publication number
- EA202090183A1 EA202090183A1 EA202090183A EA202090183A EA202090183A1 EA 202090183 A1 EA202090183 A1 EA 202090183A1 EA 202090183 A EA202090183 A EA 202090183A EA 202090183 A EA202090183 A EA 202090183A EA 202090183 A1 EA202090183 A1 EA 202090183A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- methods
- compositions
- domperidone
- deutered
- obtaining
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- FGXWKSZFVQUSTL-UHFFFAOYSA-N domperidone Chemical compound C12=CC=CC=C2NC(=O)N1CCCN(CC1)CCC1N1C2=CC=C(Cl)C=C2NC1=O FGXWKSZFVQUSTL-UHFFFAOYSA-N 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 title abstract 2
- 229960001253 domperidone Drugs 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 230000001151 other effect Effects 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Hospice & Palliative Care (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Zoology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Композиции дейтерированного домперидона, способы синтеза, способы применения и лекарственные формы, обеспечивающие благоприятную безопасность и другие эффекты.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662291198P | 2016-02-04 | 2016-02-04 | |
US15/639,431 US10266516B2 (en) | 2016-02-04 | 2017-06-30 | Deuterated domperidone compositions, methods, and preparation |
PCT/US2018/039928 WO2019006078A1 (en) | 2016-02-04 | 2018-06-28 | DETERERATED DOMPERIDONE COMPOSITIONS, METHODS AND PREPARATION |
Publications (1)
Publication Number | Publication Date |
---|---|
EA202090183A1 true EA202090183A1 (ru) | 2020-04-15 |
Family
ID=59501077
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201891727A EA035515B1 (ru) | 2016-02-04 | 2017-02-03 | Композиции на основе дейтерированного домперидона и способы терапии расстройств |
EA202090183A EA202090183A1 (ru) | 2016-02-04 | 2018-06-28 | Композиции, способы и получение дейтерированного домперидона |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201891727A EA035515B1 (ru) | 2016-02-04 | 2017-02-03 | Композиции на основе дейтерированного домперидона и способы терапии расстройств |
Country Status (10)
Country | Link |
---|---|
US (2) | US10266516B2 (ru) |
EP (2) | EP3411031A4 (ru) |
JP (3) | JP7296185B2 (ru) |
KR (2) | KR20180104662A (ru) |
CN (4) | CN113995755A (ru) |
AU (2) | AU2017213852B2 (ru) |
BR (2) | BR112018016032B1 (ru) |
CA (2) | CA3013123A1 (ru) |
EA (2) | EA035515B1 (ru) |
WO (2) | WO2017136617A1 (ru) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3288556A4 (en) | 2015-04-29 | 2018-09-19 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
WO2017136617A1 (en) * | 2016-02-04 | 2017-08-10 | Cinrx Pharma, Llc | Deuterated domperidone compositions and methods for therapy of disorders |
US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
US11364226B2 (en) | 2017-06-30 | 2022-06-21 | Cinrx Pharma, Llc | Deuterated domperidone compositions, methods, and preparation |
AU2019290231A1 (en) * | 2018-06-21 | 2020-12-17 | Dermavant Sciences GmbH | Topical formulations of DGAT1 inhibitors and their methods of use |
KR20210082480A (ko) * | 2018-10-25 | 2021-07-05 | 신돔 파마, 인크. | 돔페리돈을 함유하는 제제 |
AU2019366993B2 (en) * | 2018-10-25 | 2024-02-15 | Cindome Pharma, Inc. | Formulations containing deuterated domperidone |
US20220307004A1 (en) * | 2021-03-29 | 2022-09-29 | The Government Of The United States Of America, As Represented By The Secretary Of The Navy | Multi-Enzyme Nanoparticle-Assisted Stable Isotope Incorporation Into Small Molecules by Channeling |
WO2023205368A1 (en) * | 2022-04-20 | 2023-10-26 | Cindome Pharma, Inc. | Deuterated domperidone for treating gastroparesis |
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US4066772A (en) | 1975-07-21 | 1978-01-03 | Janssen Pharmaceutica N.V. | 1,3-Dihydro-1-[3-(1-piperidinyl)propyl]-2H-benzimidazol-2-ones and related compounds |
NZ181256A (en) * | 1975-07-21 | 1978-04-28 | Janssen Pharmaceutica Nv | 1-(w-benzazol-11-ylalkyl)-piperidine derivatives and pharmaceutical compositions containing certain of these derivatives |
TW466119B (en) * | 1994-02-28 | 2001-12-01 | Janssen Pharmaceutica Nv | Film coated tablet of paracetamol and domperidone |
FR2725986B1 (fr) * | 1994-10-21 | 1996-11-29 | Adir | Nouveaux derives de piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US5773031A (en) | 1996-02-27 | 1998-06-30 | L. Perrigo Company | Acetaminophen sustained-release formulation |
US20140163060A1 (en) | 2001-10-12 | 2014-06-12 | Monosol Rx, Llc | Films and Drug Delivery Systems Made Therefrom |
US20130220526A1 (en) | 2001-10-12 | 2013-08-29 | Monosol Rx, Llc | Films and Drug Delivery Systems Made Therefrom |
US20140271788A1 (en) | 2013-03-15 | 2014-09-18 | Monosol Rx, Llc | Sublingual and buccal film compositions |
US20140070440A1 (en) | 2001-10-12 | 2014-03-13 | Monosol Rx, Llc | Films and Drug Delivery Systems Made Therefrom |
US20160206639A9 (en) | 2001-10-12 | 2016-07-21 | Monosol Rx, Llc | Films and Drug Delivery Systems Made Therefrom |
ITMI20020514A1 (it) | 2002-03-12 | 2003-09-12 | Jagotec Ag | Sistema terapeutico per il rilascio controllato di uno o piu' principi attivi |
US9101540B2 (en) | 2002-04-12 | 2015-08-11 | Alkermes Pharma Ireland Limited | Nanoparticulate megestrol formulations |
HUE031650T2 (en) | 2002-10-01 | 2017-07-28 | Banner Life Sciences Llc | Enterosolvent preparation for soft capsule wall production |
US7387793B2 (en) | 2003-11-14 | 2008-06-17 | Eurand, Inc. | Modified release dosage forms of skeletal muscle relaxants |
JP6091041B2 (ja) | 2004-12-31 | 2017-03-08 | イシューティカ ピーティーワイ リミテッド | ナノ粒子組成物及びその合成方法 |
ITMI20050477A1 (it) | 2005-03-23 | 2006-09-24 | Bouty S P A | Cerotto transdermico |
CN100386323C (zh) * | 2006-02-27 | 2008-05-07 | 南京长澳医药科技有限公司 | 马来酸多潘立酮的合成方法 |
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NZ599069A (en) | 2006-06-30 | 2013-10-25 | Iceutica Pty Ltd | Methods for the Preparation of Biologically Active Compounds in Nanoparticulate Form |
WO2008134540A1 (en) | 2007-04-26 | 2008-11-06 | Aronchick Craig A | Compositions and methods for transmucosal delivery of domperidone |
JP5345620B2 (ja) | 2007-08-15 | 2013-11-20 | マクニール−ピーピーシー・インコーポレーテツド | 即時放出及び徐放型イブプロフェンの投与法 |
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WO2009146310A1 (en) | 2008-05-28 | 2009-12-03 | Concert Pharmaceuticals Inc. | Deuterated tizanidine |
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DK2421513T3 (en) | 2009-04-24 | 2018-03-26 | Iceutica Pty Ltd | UNKNOWN FORMULATION WITH INDOMETHACIN |
MX344838B (es) | 2009-04-24 | 2017-01-09 | Iceutica Pty Ltd | Metodo para la produccion de polvos de nanoparticulas y microparticulas comerciales. |
MX344222B (es) | 2009-04-24 | 2016-12-07 | Iceutica Pty Ltd | Una formulacion novedosa de naproxeno. |
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US20140017299A1 (en) | 2011-08-18 | 2014-01-16 | Monosol Rx, Llc | Steroid hormone delivery systems and methods of preparing the same |
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US20150197525A1 (en) | 2012-06-15 | 2015-07-16 | Concert Pharmaceuticals, Inc. | Deuterated derivatives of ruxolitinib |
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US20140019395A1 (en) | 2012-07-12 | 2014-01-16 | Craig Charles Bauer | Method and application of Fear, Love and Methodology as protocols within and of a programming group, as a means of creating an artificial individual, software system or other independent entity capable of independent self directive creation of choice and/or self directive creation of purpose within a virtual and/or any environment |
EP2968334A4 (en) | 2013-03-14 | 2016-08-03 | Deuterx Llc | 3- (SUBSTITIERTES-4-OXO-quinazolin-3 (4H) -yl) -3-deutero-PIPERIDINE-2,6-DIONE DERIVATIVES |
US20140271787A1 (en) | 2013-03-15 | 2014-09-18 | Monosol Rx, Llc | Continuous single layer film structure including discrete domains |
US20140272220A1 (en) | 2013-03-15 | 2014-09-18 | Monosol Rx, Llc | Reduction in stress cracking of films |
EP2969227B1 (en) | 2013-03-15 | 2019-05-08 | Iceutica Inc. | Abiraterone acetate formulation |
WO2017136617A1 (en) | 2016-02-04 | 2017-08-10 | Cinrx Pharma, Llc | Deuterated domperidone compositions and methods for therapy of disorders |
-
2017
- 2017-02-03 WO PCT/US2017/016334 patent/WO2017136617A1/en active Application Filing
- 2017-02-03 CA CA3013123A patent/CA3013123A1/en active Pending
- 2017-02-03 BR BR112018016032-6A patent/BR112018016032B1/pt active IP Right Grant
- 2017-02-03 CN CN202111078948.5A patent/CN113995755A/zh active Pending
- 2017-02-03 EA EA201891727A patent/EA035515B1/ru not_active IP Right Cessation
- 2017-02-03 CN CN201780008640.9A patent/CN108697700B/zh active Active
- 2017-02-03 AU AU2017213852A patent/AU2017213852B2/en active Active
- 2017-02-03 KR KR1020187023566A patent/KR20180104662A/ko not_active Application Discontinuation
- 2017-02-03 JP JP2018535888A patent/JP7296185B2/ja active Active
- 2017-02-03 EP EP17748198.3A patent/EP3411031A4/en active Pending
- 2017-06-30 US US15/639,431 patent/US10266516B2/en active Active
-
2018
- 2018-06-28 JP JP2019571517A patent/JP2020534246A/ja active Pending
- 2018-06-28 AU AU2018290905A patent/AU2018290905B2/en active Active
- 2018-06-28 CN CN202310648870.9A patent/CN116712432A/zh active Pending
- 2018-06-28 EP EP18743261.2A patent/EP3644995A1/en active Pending
- 2018-06-28 EA EA202090183A patent/EA202090183A1/ru unknown
- 2018-06-28 KR KR1020207002879A patent/KR20200044790A/ko active IP Right Grant
- 2018-06-28 CA CA3055777A patent/CA3055777A1/en active Pending
- 2018-06-28 BR BR112019028185A patent/BR112019028185A8/pt unknown
- 2018-06-28 WO PCT/US2018/039928 patent/WO2019006078A1/en unknown
- 2018-06-28 CN CN201880043378.6A patent/CN111093653B/zh active Active
-
2019
- 2019-04-16 US US16/385,599 patent/US10590110B2/en active Active
-
2022
- 2022-12-22 JP JP2022205876A patent/JP2023052045A/ja active Pending
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