EA202091186A1 - ИНГИБИТОРЫ KRas G12C - Google Patents

ИНГИБИТОРЫ KRas G12C

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Publication number
EA202091186A1
EA202091186A1 EA202091186A EA202091186A EA202091186A1 EA 202091186 A1 EA202091186 A1 EA 202091186A1 EA 202091186 A EA202091186 A EA 202091186A EA 202091186 A EA202091186 A EA 202091186A EA 202091186 A1 EA202091186 A1 EA 202091186A1
Authority
EA
Eurasian Patent Office
Prior art keywords
kras
inhibitors
compounds
relates
inhibit
Prior art date
Application number
EA202091186A
Other languages
English (en)
Inventor
Джеймс Ф. Блейк
Лоренс Е. Берджесс
Марк Джозеф Чикарелли
Джеймс Гейл Кристенсен
Адам Кук
Джэй Брэдфорд Фелл
Джон П. Фишер
Мэтью Арнольд Маркс
Македонио Дж. Мехия
Павел Савеченков
Гай П.А. Вайгерс
Кристофер Рональд Смит
Марта Е. Родригес
Original Assignee
Мирати Терапьютикс, Инк.
Эррэй Биофарма Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мирати Терапьютикс, Инк., Эррэй Биофарма Инк. filed Critical Мирати Терапьютикс, Инк.
Publication of EA202091186A1 publication Critical patent/EA202091186A1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems

Abstract

Данное изобретение относится к соединениям, которые ингибируют KRas G12C. В частности, данное изобретение относится к соединениям, которые необратимо ингибируют активность KRas G12C, к фармацевтическим композициям, содержащим соединения, и способам их применения.
EA202091186A 2017-11-15 2018-11-14 ИНГИБИТОРЫ KRas G12C EA202091186A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762586775P 2017-11-15 2017-11-15
PCT/US2018/061060 WO2019099524A1 (en) 2017-11-15 2018-11-14 Kras g12c inhibitors

Publications (1)

Publication Number Publication Date
EA202091186A1 true EA202091186A1 (ru) 2020-10-01

Family

ID=66431793

Family Applications (1)

Application Number Title Priority Date Filing Date
EA202091186A EA202091186A1 (ru) 2017-11-15 2018-11-14 ИНГИБИТОРЫ KRas G12C

Country Status (28)

Country Link
US (4) US10689377B2 (ru)
EP (2) EP3710439B1 (ru)
JP (2) JP7322019B2 (ru)
KR (1) KR20200100632A (ru)
AU (1) AU2018369759B2 (ru)
BR (1) BR112020009818A2 (ru)
CA (1) CA3082579A1 (ru)
CL (1) CL2020001271A1 (ru)
CO (1) CO2020007244A2 (ru)
DK (1) DK3710439T3 (ru)
EA (1) EA202091186A1 (ru)
ES (1) ES2944547T3 (ru)
FI (1) FI3710439T3 (ru)
HR (1) HRP20230377T1 (ru)
HU (1) HUE061599T2 (ru)
IL (1) IL274601B2 (ru)
LT (1) LT3710439T (ru)
MX (1) MX2020005063A (ru)
PH (1) PH12020550622A1 (ru)
PL (1) PL3710439T3 (ru)
PT (1) PT3710439T (ru)
RS (1) RS64182B1 (ru)
SG (1) SG11202004427TA (ru)
SI (1) SI3710439T1 (ru)
TW (1) TWI809005B (ru)
UA (1) UA125802C2 (ru)
WO (2) WO2019099524A1 (ru)
ZA (1) ZA202002105B (ru)

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