MX2012007684A - Modificacion covalente ligando dirigida de proteina. - Google Patents

Modificacion covalente ligando dirigida de proteina.

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Publication number
MX2012007684A
MX2012007684A MX2012007684A MX2012007684A MX2012007684A MX 2012007684 A MX2012007684 A MX 2012007684A MX 2012007684 A MX2012007684 A MX 2012007684A MX 2012007684 A MX2012007684 A MX 2012007684A MX 2012007684 A MX2012007684 A MX 2012007684A
Authority
MX
Mexico
Prior art keywords
ligand
covalent modification
protein
directed covalent
directed
Prior art date
Application number
MX2012007684A
Other languages
English (en)
Inventor
Deqiang Niu
Juswinder Singh
Lixin Qiao
Russell C Petter
Zhendong Zhu
Charles F Jewell
Kwangho Lee
Aravind Prasad Medikonda
Original Assignee
Avila Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avila Therapeutics Inc filed Critical Avila Therapeutics Inc
Publication of MX2012007684A publication Critical patent/MX2012007684A/es

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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
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    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11001—Non-specific serine/threonine protein kinase (2.7.11.1), i.e. casein kinase or checkpoint kinase
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    • C12Y304/21—Serine endopeptidases (3.4.21)
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    • C12Y603/02—Acid—amino-acid ligases (peptide synthases)(6.3.2)
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Abstract

La presente invención se relaciona con inhibidores de enzima. De manera más especial, la presente invención se relaciona a modificación covalente dirigida a ligando de proteínas; método del mismo diseño; formulación farmacéutica de la misma; y método de uso.
MX2012007684A 2009-12-30 2010-12-30 Modificacion covalente ligando dirigida de proteina. MX2012007684A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33504309P 2009-12-30 2009-12-30
PCT/US2010/062473 WO2011082285A1 (en) 2009-12-30 2010-12-30 Ligand-directed covalent modification of protein

Publications (1)

Publication Number Publication Date
MX2012007684A true MX2012007684A (es) 2012-10-05

Family

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Application Number Title Priority Date Filing Date
MX2012007684A MX2012007684A (es) 2009-12-30 2010-12-30 Modificacion covalente ligando dirigida de proteina.

Country Status (13)

Country Link
US (2) US20110269244A1 (es)
EP (1) EP2519664A4 (es)
JP (2) JP2013516422A (es)
KR (1) KR20130067487A (es)
CN (1) CN102812167A (es)
AU (2) AU2010339456A1 (es)
BR (1) BR112012015721A2 (es)
CA (1) CA2785738A1 (es)
MX (1) MX2012007684A (es)
RU (1) RU2012132473A (es)
SG (1) SG181965A1 (es)
TW (1) TW201134825A (es)
WO (1) WO2011082285A1 (es)

Families Citing this family (92)

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Publication number Priority date Publication date Assignee Title
CA2711957C (en) 2007-10-11 2019-03-19 The Regents Of The University Of California Use of inhibitors of n-acylethanolamine-hydrolyzing acid amidase as anti-inflamatory medicaments
WO2009143389A1 (en) 2008-05-21 2009-11-26 Ariad Pharmaceuticals, Inc. Phosphorous derivatives as kinase inhibitors
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
BRPI0918970A2 (pt) * 2008-09-05 2019-09-24 Avila Therapeutics Inc algoritmo para projeto de inibidores irreversíveis
WO2011034907A2 (en) 2009-09-16 2011-03-24 Avila Therapeutics, Inc. Protein kinase conjugates and inhibitors
TW201134825A (en) 2009-12-30 2011-10-16 Avila Therapeutics Inc Ligand-directed covalent modification of protein
EA201391626A1 (ru) 2011-05-04 2014-03-31 Ариад Фармасьютикалз, Инк. Соединения для ингибирования клеточной пролиферации в egfr-стимулированных типах рака
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EP2519664A1 (en) 2012-11-07
CN102812167A (zh) 2012-12-05
AU2016244281A1 (en) 2016-11-03
JP2013516422A (ja) 2013-05-13
US20110269244A1 (en) 2011-11-03
CA2785738A1 (en) 2011-07-07
TW201134825A (en) 2011-10-16
SG181965A1 (en) 2012-08-30
BR112012015721A2 (pt) 2017-09-26
RU2012132473A (ru) 2014-02-10
JP2016195596A (ja) 2016-11-24
AU2010339456A1 (en) 2012-07-05
WO2011082285A1 (en) 2011-07-07
US11542492B2 (en) 2023-01-03

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