AU2001236720A1 - Compositions useful as inhibitors of erk - Google Patents

Compositions useful as inhibitors of erk

Info

Publication number
AU2001236720A1
AU2001236720A1 AU2001236720A AU3672001A AU2001236720A1 AU 2001236720 A1 AU2001236720 A1 AU 2001236720A1 AU 2001236720 A AU2001236720 A AU 2001236720A AU 3672001 A AU3672001 A AU 3672001A AU 2001236720 A1 AU2001236720 A1 AU 2001236720A1
Authority
AU
Australia
Prior art keywords
erk
inhibitors
compositions useful
compositions
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2001236720A
Inventor
Xiaoling Xie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
Original Assignee
Vertex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of AU2001236720A1 publication Critical patent/AU2001236720A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
AU2001236720A 2000-02-05 2001-02-05 Compositions useful as inhibitors of erk Abandoned AU2001236720A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18050200P 2000-02-05 2000-02-05
US60180502 2000-02-05
US19195900P 2000-03-24 2000-03-24
US60191959 2000-03-24
PCT/US2001/003904 WO2001056557A2 (en) 2000-02-05 2001-02-05 Compositions useful as inhibitors of erk

Publications (1)

Publication Number Publication Date
AU2001236720A1 true AU2001236720A1 (en) 2001-08-14

Family

ID=26876382

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2001236720A Abandoned AU2001236720A1 (en) 2000-02-05 2001-02-05 Compositions useful as inhibitors of erk

Country Status (5)

Country Link
US (2) US6849267B2 (en)
EP (1) EP1207864A2 (en)
AU (1) AU2001236720A1 (en)
CA (1) CA2369502A1 (en)
WO (1) WO2001056557A2 (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6436915B1 (en) 2000-04-07 2002-08-20 Kinetek Pharmaceuticals, Inc. Pyrazole compounds
ES2269458T3 (en) 2000-09-15 2007-04-01 Vertex Pharmaceuticals Incorporated ISOXAZOLES AND ITS USE AS INHIBITORS OF THE ERK.
JP2005519878A (en) 2001-11-30 2005-07-07 キネテク ファーマシューティカルズ，インコーポレーテッド Hydrazonopyrazole derivatives and their use as therapeutic agents
US20040175384A1 (en) * 2003-12-12 2004-09-09 Mohapatra Shyam S. Protein kinase C as a target for the treatment of respiratory syncytial virus
AU2004264440B2 (en) * 2003-08-15 2008-10-23 Vertex Pharmaceuticals Incorporated Pyrrole compositions useful as inhibitors of c-Met
EP1677747A1 (en) * 2003-10-31 2006-07-12 The Procter & Gamble Company Method of providing a blended composition
US8592368B2 (en) * 2003-12-19 2013-11-26 University Of South Florida JAK/STAT inhibitors and MAPK/ERK inhibitors for RSV infection
SE526596C2 (en) 2004-01-13 2005-10-11 Vaelinge Innovation Ab Floating floor with mechanical locking system that allows movement between the floorboards
TW200639163A (en) * 2005-02-04 2006-11-16 Genentech Inc RAF inhibitor compounds and methods
US8546404B2 (en) 2005-12-13 2013-10-01 Merck Sharp & Dohme Compounds that are ERK inhibitors
MX2008010635A (en) 2006-02-16 2008-10-28 Schering Corp Pyrrolidine derivatives as erk inhibitors.
UY30892A1 (en) 2007-02-07 2008-09-02 Smithkline Beckman Corp AKT ACTIVITY INHIBITORS
CA2687715A1 (en) * 2007-05-09 2008-11-20 Traffick Therapeutics Inc. Screening assay to identify correctors of protein trafficking defects
JP5276676B2 (en) 2008-02-21 2013-08-28 メルク・シャープ・アンド・ドーム・コーポレーション Compounds that are ERK inhibitors
KR101341876B1 (en) * 2008-09-05 2013-12-20 셀진 아빌로믹스 리서치, 인코포레이티드 Algorithm for designing irreversible inhibitors
EP2478361A4 (en) 2009-09-16 2014-05-21 Celgene Avilomics Res Inc Protein kinase conjugates and inhibitors
RU2012132473A (en) 2009-12-30 2014-02-10 Селджин Авиломикс,Инк LIGAND-DIRECTED COVALENT PROTEIN MODIFICATION
KR101151715B1 (en) * 2010-01-21 2012-06-15 중앙대학교 산학협력단 Method for Diagnosis of Prostatitis and Kit for the Same
KR20130113430A (en) 2010-08-05 2013-10-15 케이스 웨스턴 리저브 유니버시티 Inhibitors of erk for developmental disorders of neuronal connectivity
EP2714037B1 (en) 2011-05-25 2016-07-13 Université Paris Descartes Erk inhibitors for use in treating spinal muscular atrophy
WO2013109142A1 (en) 2012-01-16 2013-07-25 Stichting Het Nederlands Kanker Instituut Combined pdk and mapk/erk pathway inhibition in neoplasia
WO2015041534A1 (en) 2013-09-20 2015-03-26 Stichting Het Nederlands Kanker Instituut P90rsk in combination with raf/erk/mek
WO2015041533A1 (en) 2013-09-20 2015-03-26 Stichting Het Nederlands Kanker Instituut Rock in combination with mapk-pathway
WO2015156674A2 (en) 2014-04-10 2015-10-15 Stichting Het Nederlands Kanker Instituut Method for treating cancer
WO2015178770A1 (en) 2014-05-19 2015-11-26 Stichting Het Nederlands Kanker Instituut Compositions for cancer treatment
WO2017058007A1 (en) 2015-10-01 2017-04-06 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Histone deacetylase inhibitors for the use in the treatment of drug resistant melanoma
WO2017099591A1 (en) 2015-12-07 2017-06-15 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Treatment of inhibitor resistant braf-mutant cancers
WO2017204626A1 (en) 2016-05-24 2017-11-30 Stichting Het Nederlands Kanker Instituut-Antoni van Leeuwenhoek Ziekenhuis Combination therapy - combined map2k4/map3k1 and mek/erk inhibition
WO2020192750A1 (en) 2019-03-28 2020-10-01 江苏恒瑞医药股份有限公司 Thienoheterocyclic derivative, preparation method therefor and medical use thereof
EP3950690A4 (en) 2019-03-29 2022-12-07 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Pyrroloheterocyclic derivative, preparation method therefor, and application thereof in medicine
EP3978498A1 (en) 2019-05-24 2022-04-06 Jiangsu Hengrui Medicine Co., Ltd. Substituted fused bicyclic derivative, preparation method therefor, and application thereof in medicines
TW202221001A (en) 2020-09-29 2022-06-01 大陸商江蘇恒瑞醫藥股份有限公司 Crystal form of pyrrolo heterocyclic derivatives and preparation method thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9608435D0 (en) * 1996-04-24 1996-06-26 Celltech Therapeutics Ltd Chemical compounds
EP1019394A1 (en) * 1997-05-22 2000-07-19 G.D. Searle & Co. PYRAZOLE DERIVATIVES AS p38 KINASE INHIBITORS
RU2249591C2 (en) * 1997-05-22 2005-04-10 Дж.Д. Серл Энд Ко. 3-(5)-heteroaryl-substituted pyrazoles as kinase p38 inhibitors
GB9716557D0 (en) * 1997-08-06 1997-10-08 Glaxo Group Ltd Benzylidene-1,3-dihydro-indol-2-one derivatives having anti-cancer activity
GB9718913D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Substituted oxindole derivatives
GB9721437D0 (en) * 1997-10-10 1997-12-10 Glaxo Group Ltd Heteroaromatic compounds and their use in medicine
AU782878B2 (en) * 2000-02-05 2005-09-08 Vertex Pharmaceuticals Incorporated Pyrazole compositions useful as inhibitors of erk
US6962936B2 (en) * 2001-04-27 2005-11-08 Vertex Pharmaceuticals Incorporated Triazole-derived kinase inhibitors and uses thereof

Also Published As

Publication number Publication date
US6849267B2 (en) 2005-02-01
WO2001056557A2 (en) 2001-08-09
CA2369502A1 (en) 2001-08-09
US20040048861A1 (en) 2004-03-11
EP1207864A2 (en) 2002-05-29
US6994868B2 (en) 2006-02-07
WO2001056557A3 (en) 2002-04-04
US20030049820A1 (en) 2003-03-13

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