EA201791992A1 - Ингибиторы грелин-o-ацилтрансферазы - Google Patents

Ингибиторы грелин-o-ацилтрансферазы

Info

Publication number
EA201791992A1
EA201791992A1 EA201791992A EA201791992A EA201791992A1 EA 201791992 A1 EA201791992 A1 EA 201791992A1 EA 201791992 A EA201791992 A EA 201791992A EA 201791992 A EA201791992 A EA 201791992A EA 201791992 A1 EA201791992 A1 EA 201791992A1
Authority
EA
Eurasian Patent Office
Prior art keywords
grelin
acyltransferase inhibitors
inhibitors
acyltransferase
salts
Prior art date
Application number
EA201791992A
Other languages
English (en)
Inventor
Кристофер Стэнли Галка
Эрик Джеймс Хембр
Николас Аллан Хонигшмидт
Мария Анджелес Мартинез-Грау
Джема Руано Плаза
Алмудена Рубио
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA201791992A1 publication Critical patent/EA201791992A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Epidemiology (AREA)

Abstract

В данном изобретении представлены новые ингибиторы GOAT и их соли, а также их фармацевтические композиции.
EA201791992A 2015-04-15 2016-04-13 Ингибиторы грелин-o-ацилтрансферазы EA201791992A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP15382180 2015-04-15
PCT/US2016/027177 WO2016168222A1 (en) 2015-04-15 2016-04-13 Ghrelin o-acyl transferase inhibitors

Publications (1)

Publication Number Publication Date
EA201791992A1 true EA201791992A1 (ru) 2018-03-30

Family

ID=52991669

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201791992A EA201791992A1 (ru) 2015-04-15 2016-04-13 Ингибиторы грелин-o-ацилтрансферазы

Country Status (16)

Country Link
US (1) US10093651B2 (ru)
EP (1) EP3283473B1 (ru)
JP (1) JP6458168B2 (ru)
KR (1) KR20170123693A (ru)
CN (1) CN107428723B (ru)
AR (1) AR104672A1 (ru)
AU (1) AU2016247901A1 (ru)
BR (1) BR112017017835A2 (ru)
CA (1) CA2976636A1 (ru)
EA (1) EA201791992A1 (ru)
ES (1) ES2715763T3 (ru)
IL (1) IL253969A0 (ru)
MX (1) MX2017013073A (ru)
TW (1) TWI589574B (ru)
WO (1) WO2016168222A1 (ru)
ZA (1) ZA201705675B (ru)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2874587T3 (es) 2016-08-05 2021-11-05 Boehringer Ingelheim Int Derivados de oxadiazolopiridina para su uso como inhibidores de la grelina O-aciltransferasa (GOAT)
CN111630055B (zh) 2018-02-02 2023-07-14 勃林格殷格翰国际有限公司 用作饥饿素o-酰基转移酶(goat)抑制剂的吡唑取代的和吲唑取代的噁二唑并吡啶衍生物
EP3746451B1 (en) 2018-02-02 2023-07-12 Boehringer Ingelheim International GmbH Benzyl-, (pyridin-3-yl)methyl- or (pyridin-4-yl)methyl-substituted oxadiazolopyridine derivatives as ghrelin o-acyl transferase (goat) inhibitors
CR20200331A (es) 2018-02-02 2020-09-03 Boehringer Ingelheim Int Derivados de oxadiazolopirisdina sustituidos con heterociclilo para usar como inhibidores de ghrelin o-aciltrasferasa (goat)
MA51774A (fr) 2018-02-02 2021-05-12 Boehringer Ingelheim Int Dérivés de triazolopyrimidine destinés à être utilisés en tant qu'inhibiteurs de la ghréline o-acyltransférase (goat)
CN108610337A (zh) * 2018-05-30 2018-10-02 王丽萍 一种苯并[b]噻吩类化合物及其在肥胖和糖尿病中的应用
EP4153599B1 (en) 2020-05-22 2024-03-13 Boehringer Ingelheim International GmbH Process for manufacturing alkyl 7-amino-5-methyl-[1,2,5]oxadiazolo[3,4-b]pyridine-carboxylate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1670827A2 (en) 2003-09-05 2006-06-21 Eli Lilly And Company Anti-ghrelin antibodies
US20050070712A1 (en) * 2003-09-26 2005-03-31 Christi Kosogof Pyrimidine derivatives as ghrelin receptor modulators
WO2006019577A1 (en) 2004-07-14 2006-02-23 Eli Lilly And Company Anti-ghrelin antibodies
US20090060920A1 (en) 2004-11-15 2009-03-05 Eli Lilly And Company Desacyl ghrelin antibodies and therapeutic uses thereof
US7479271B2 (en) 2005-02-23 2009-01-20 Eli Lilly And Company Humanized anti-ghrelin antibodies
WO2013125732A1 (en) * 2012-02-24 2013-08-29 Takeda Pharmaceutical Company Limited Aromatic ring compound
UA118034C2 (uk) * 2013-11-14 2018-11-12 Елі Ліллі Енд Компані Заміщений піперидилетилпіримідин як інгібітор грелін-o-ацилтрансферази

Also Published As

Publication number Publication date
JP6458168B2 (ja) 2019-01-23
BR112017017835A2 (pt) 2018-04-10
AU2016247901A1 (en) 2017-09-14
CA2976636A1 (en) 2016-10-20
TW201704225A (zh) 2017-02-01
IL253969A0 (en) 2017-10-31
WO2016168222A1 (en) 2016-10-20
US20180086732A1 (en) 2018-03-29
ES2715763T3 (es) 2019-06-06
EP3283473A1 (en) 2018-02-21
TWI589574B (zh) 2017-07-01
US10093651B2 (en) 2018-10-09
CN107428723B (zh) 2020-05-05
AR104672A1 (es) 2017-08-09
ZA201705675B (en) 2019-07-31
EP3283473B1 (en) 2019-01-02
JP2018511630A (ja) 2018-04-26
MX2017013073A (es) 2017-12-04
CN107428723A (zh) 2017-12-01
KR20170123693A (ko) 2017-11-08

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