EA201791095A1 - Способ лечения рака - Google Patents
Способ лечения ракаInfo
- Publication number
- EA201791095A1 EA201791095A1 EA201791095A EA201791095A EA201791095A1 EA 201791095 A1 EA201791095 A1 EA 201791095A1 EA 201791095 A EA201791095 A EA 201791095A EA 201791095 A EA201791095 A EA 201791095A EA 201791095 A1 EA201791095 A1 EA 201791095A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- treatment method
- cancer treatment
- inhibitor
- ezh2
- methods
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 101000882127 Homo sapiens Histone-lysine N-methyltransferase EZH2 Proteins 0.000 abstract 2
- 239000003112 inhibitor Substances 0.000 abstract 2
- 102100038970 Histone-lysine N-methyltransferase EZH2 Human genes 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
- A61K9/2846—Poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2893—Tablet coating processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Abstract
Изобретение относится к фармацевтическим композициям, содержащим ингибитор(ы) гистонметилтрансферазы EZH2 человека, и способам терапии рака с применением ингибитора(ов) EZH2.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462080985P | 2014-11-17 | 2014-11-17 | |
US201562166572P | 2015-05-26 | 2015-05-26 | |
US201562251903P | 2015-11-06 | 2015-11-06 | |
PCT/US2015/061194 WO2016081523A1 (en) | 2014-11-17 | 2015-11-17 | Method for treating cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
EA201791095A1 true EA201791095A1 (ru) | 2017-10-31 |
Family
ID=56014476
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EA201791095A EA201791095A1 (ru) | 2014-11-17 | 2015-11-17 | Способ лечения рака |
Country Status (21)
Country | Link |
---|---|
US (2) | US10786511B2 (ru) |
EP (2) | EP4272742A1 (ru) |
JP (3) | JP6829684B2 (ru) |
KR (3) | KR102644844B1 (ru) |
CN (2) | CN107249591B (ru) |
AU (3) | AU2015350108B2 (ru) |
BR (1) | BR112017010166A2 (ru) |
CA (1) | CA2967664A1 (ru) |
DK (1) | DK3220916T3 (ru) |
EA (1) | EA201791095A1 (ru) |
ES (1) | ES2947819T3 (ru) |
FI (1) | FI3220916T3 (ru) |
HU (1) | HUE062159T2 (ru) |
IL (3) | IL296080B2 (ru) |
LT (1) | LT3220916T (ru) |
MX (2) | MX2017006089A (ru) |
PL (1) | PL3220916T3 (ru) |
PT (1) | PT3220916T (ru) |
SG (1) | SG11201703806XA (ru) |
SI (1) | SI3220916T1 (ru) |
WO (1) | WO2016081523A1 (ru) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL282741B2 (en) | 2013-12-06 | 2024-01-01 | Epizyme Inc | Tazematostat in combination with an acceptable treatment factor for use in the treatment of cancer |
MX2021007651A (es) | 2014-06-17 | 2021-08-11 | Epizyme Inc | Inhibidores de ezh2 para tratar linfomas. |
AU2015350108B2 (en) | 2014-11-17 | 2021-04-08 | Eisai R&D Management Co., Ltd. | Method for treating cancer |
EA201792304A1 (ru) | 2015-04-20 | 2018-03-30 | Эпизайм, Инк. | Комбинированная терапия для лечения рака |
CN107635965A (zh) | 2015-06-10 | 2018-01-26 | Epizyme股份有限公司 | 用于治疗淋巴瘤的ezh2抑制剂 |
US10493076B2 (en) | 2015-08-24 | 2019-12-03 | Epizyme, Inc. | Method for treating cancer |
AU2017211331A1 (en) | 2016-01-29 | 2018-06-07 | Epizyme, Inc. | Combination therapy for treating cancer |
WO2017210395A1 (en) | 2016-06-01 | 2017-12-07 | Epizyme, Inc. | Use of ezh2 inhibitors for treating cancer |
WO2017218953A1 (en) | 2016-06-17 | 2017-12-21 | Epizyme, Inc. | Ezh2 inhibitors for treating cancer |
US11311524B2 (en) | 2017-01-19 | 2022-04-26 | Daiichi Sankyo Company, Limited | Pharmaceutical composition used for treatment of HTLV-1-associated myelopathy |
WO2018183885A1 (en) | 2017-03-31 | 2018-10-04 | Epizyme, Inc. | Combination therapy for treating cancer |
JP2020522687A (ja) | 2017-06-02 | 2020-07-30 | エピザイム,インコーポレイティド | 癌を処置するためのezh2阻害剤の使用 |
JP7399079B2 (ja) | 2017-09-05 | 2023-12-15 | エピザイム,インコーポレイティド | 癌を処置するための併用療法 |
BR112022012258A2 (pt) * | 2019-12-20 | 2022-08-30 | Epizyme Inc | Sal cristalino de bromidreto de um inibidor de ezh2, sua preparação e composição farmacêutica útil para o tratamento de câncer |
JP2022167451A (ja) | 2021-04-23 | 2022-11-04 | 日立Astemo株式会社 | 情報処理装置、情報処理方法、プログラムおよび記憶媒体 |
WO2023159124A2 (en) * | 2022-02-17 | 2023-08-24 | Memorial Sloan-Kettering Cancer Center | Methods for overcoming tazemetostat-resistance in cancer patients |
WO2023209591A1 (en) | 2022-04-27 | 2023-11-02 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate with ezh1 and/or ezh2 inhibitor |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6248363B1 (en) * | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
US7229774B2 (en) | 2001-08-02 | 2007-06-12 | Regents Of The University Of Michigan | Expression profile of prostate cancer |
US20070026064A1 (en) * | 2005-07-29 | 2007-02-01 | Yoder Steven L | Pharmaceutical dosage forms having watermark-type identification and authentication inditia |
US20100278921A1 (en) * | 2009-04-30 | 2010-11-04 | Fischer Cristina M | Solid oral formulation of abt-263 |
US9175331B2 (en) | 2010-09-10 | 2015-11-03 | Epizyme, Inc. | Inhibitors of human EZH2, and methods of use thereof |
EP2614369B1 (en) | 2010-09-10 | 2016-02-03 | Epizyme, Inc. | Method for determining the suitability of inhibitors of human ezh2 in treatment |
EP2663283B1 (en) * | 2011-01-14 | 2017-05-10 | Bristol-Myers Squibb Company | High drug load tablet formulation of brivanib alaninate |
EP3323820B1 (en) | 2011-02-28 | 2023-05-10 | Epizyme, Inc. | Substituted 6,5-fused bicyclic heteroaryl compounds |
TW201733984A (zh) | 2011-04-13 | 2017-10-01 | 雅酶股份有限公司 | 經取代之苯化合物 |
JO3438B1 (ar) | 2011-04-13 | 2019-10-20 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
EP3536314A1 (en) * | 2012-03-12 | 2019-09-11 | Epizyme, Inc. | Inhibitors of human ezh2, and methods of use thereof |
IL289300B2 (en) * | 2012-04-13 | 2024-05-01 | Epizyme Inc | Combined treatment for cancer |
BR112014025508B1 (pt) * | 2012-04-13 | 2020-11-17 | Eisai R&D Management Co., Ltd. | forma de sal de um inibidor de histona metiltransferase ezh2 humana |
HUE046790T2 (hu) * | 2012-10-15 | 2020-03-30 | Epizyme Inc | A rák kezelésének módszerei |
MY180311A (en) | 2012-10-15 | 2020-11-28 | Epizyme Inc | Substituted benzene compounds |
EP2934531A4 (en) * | 2012-12-19 | 2016-06-15 | Glaxosmithkline Llc | COMBINATION |
EP2935264B1 (en) | 2012-12-21 | 2017-10-18 | Epizyme, Inc. | 1,4-pyridone bicyclic heteroaryl compounds |
CA2894216A1 (en) | 2012-12-21 | 2014-06-26 | Epizyme, Inc. | 1,4-pyridone compounds |
EP2970306A4 (en) | 2013-03-15 | 2016-08-03 | Epizyme Inc | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS CONDENSED IN 6.5 |
WO2014172044A1 (en) | 2013-03-15 | 2014-10-23 | Epizyme, Inc. | Substituted benzene compounds |
US10150764B2 (en) | 2013-07-19 | 2018-12-11 | Epizyme, Inc. | Substituted benzene compounds |
EP4324525A3 (en) * | 2013-10-16 | 2024-07-17 | Epizyme, Inc. | Hydrochloride salt form for ezh2 inhibition |
JP2016533364A (ja) | 2013-10-18 | 2016-10-27 | エピザイム,インコーポレイティド | 癌を処置する方法 |
IL282741B2 (en) | 2013-12-06 | 2024-01-01 | Epizyme Inc | Tazematostat in combination with an acceptable treatment factor for use in the treatment of cancer |
MX2021007651A (es) * | 2014-06-17 | 2021-08-11 | Epizyme Inc | Inhibidores de ezh2 para tratar linfomas. |
WO2015200650A1 (en) | 2014-06-25 | 2015-12-30 | Epizyme, Inc. | Substituted benzene and 6,5-fused bicyclic heteroaryl compounds |
CA2963149A1 (en) | 2014-10-16 | 2016-04-21 | Epizyme, Inc. | Method for treating cancer |
AU2015350108B2 (en) | 2014-11-17 | 2021-04-08 | Eisai R&D Management Co., Ltd. | Method for treating cancer |
CN107635965A (zh) * | 2015-06-10 | 2018-01-26 | Epizyme股份有限公司 | 用于治疗淋巴瘤的ezh2抑制剂 |
WO2017218953A1 (en) * | 2016-06-17 | 2017-12-21 | Epizyme, Inc. | Ezh2 inhibitors for treating cancer |
-
2015
- 2015-11-17 AU AU2015350108A patent/AU2015350108B2/en active Active
- 2015-11-17 EP EP23168326.9A patent/EP4272742A1/en active Pending
- 2015-11-17 ES ES15860676T patent/ES2947819T3/es active Active
- 2015-11-17 KR KR1020217040314A patent/KR102644844B1/ko active IP Right Grant
- 2015-11-17 PT PT158606764T patent/PT3220916T/pt unknown
- 2015-11-17 HU HUE15860676A patent/HUE062159T2/hu unknown
- 2015-11-17 FI FIEP15860676.4T patent/FI3220916T3/fi active
- 2015-11-17 EP EP15860676.4A patent/EP3220916B1/en active Active
- 2015-11-17 EA EA201791095A patent/EA201791095A1/ru unknown
- 2015-11-17 US US15/527,375 patent/US10786511B2/en active Active
- 2015-11-17 SG SG11201703806XA patent/SG11201703806XA/en unknown
- 2015-11-17 CN CN201580063476.2A patent/CN107249591B/zh active Active
- 2015-11-17 WO PCT/US2015/061194 patent/WO2016081523A1/en active Application Filing
- 2015-11-17 CA CA2967664A patent/CA2967664A1/en active Pending
- 2015-11-17 DK DK15860676.4T patent/DK3220916T3/da active
- 2015-11-17 CN CN202310518396.8A patent/CN116650500A/zh active Pending
- 2015-11-17 KR KR1020247007271A patent/KR20240035908A/ko not_active Application Discontinuation
- 2015-11-17 JP JP2017526088A patent/JP6829684B2/ja active Active
- 2015-11-17 SI SI201531949T patent/SI3220916T1/sl unknown
- 2015-11-17 MX MX2017006089A patent/MX2017006089A/es unknown
- 2015-11-17 PL PL15860676.4T patent/PL3220916T3/pl unknown
- 2015-11-17 KR KR1020177016377A patent/KR102338802B1/ko active IP Right Grant
- 2015-11-17 BR BR112017010166A patent/BR112017010166A2/pt not_active Application Discontinuation
- 2015-11-17 LT LTEPPCT/US2015/061194T patent/LT3220916T/lt unknown
- 2015-11-17 IL IL296080A patent/IL296080B2/en unknown
-
2017
- 2017-05-09 IL IL252182A patent/IL252182B2/en unknown
- 2017-05-09 MX MX2021006734A patent/MX2021006734A/es unknown
-
2020
- 2020-08-20 US US16/998,144 patent/US20210060030A1/en active Pending
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2021
- 2021-01-22 JP JP2021008382A patent/JP2021073241A/ja active Pending
- 2021-07-06 AU AU2021204706A patent/AU2021204706B2/en active Active
-
2023
- 2023-02-24 JP JP2023027585A patent/JP7485810B2/ja active Active
- 2023-07-04 IL IL304252A patent/IL304252A/en unknown
-
2024
- 2024-02-22 AU AU2024201171A patent/AU2024201171A1/en active Pending
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