EA201992137A1 - ПИРИМИДОПИРИМИДИНОНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗЫ Wee-1 - Google Patents

ПИРИМИДОПИРИМИДИНОНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗЫ Wee-1

Info

Publication number
EA201992137A1
EA201992137A1 EA201992137A EA201992137A EA201992137A1 EA 201992137 A1 EA201992137 A1 EA 201992137A1 EA 201992137 A EA201992137 A EA 201992137A EA 201992137 A EA201992137 A EA 201992137A EA 201992137 A1 EA201992137 A1 EA 201992137A1
Authority
EA
Eurasian Patent Office
Prior art keywords
wee
pyrimidopyrimidinones
kinase inhibitors
compound
methods
Prior art date
Application number
EA201992137A
Other languages
English (en)
Inventor
Питер Хьюитт
Франк Буркамп
Эндрю Уилкинсон
Юг Миэль
Колин О'Доуд
Original Assignee
Олмак Дискавери Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Олмак Дискавери Лимитед filed Critical Олмак Дискавери Лимитед
Publication of EA201992137A1 publication Critical patent/EA201992137A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

Данное изобретение относится к соединению, которое применяют в качестве ингибитора активности Wee-1 киназы. Данное изобретение также относится к фармацевтическим композициям, содержащим это соединение, к способам применения этого соединения в лечении рака и способам лечения рака.
EA201992137A 2017-03-10 2018-03-12 ПИРИМИДОПИРИМИДИНОНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗЫ Wee-1 EA201992137A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1703881.1A GB201703881D0 (en) 2017-03-10 2017-03-10 Pharmaceutical compounds
PCT/GB2018/050620 WO2018162932A1 (en) 2017-03-10 2018-03-12 Pyrimidopyrimidinones useful as wee-1 kinase inhibitors

Publications (1)

Publication Number Publication Date
EA201992137A1 true EA201992137A1 (ru) 2020-02-05

Family

ID=58605309

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201992137A EA201992137A1 (ru) 2017-03-10 2018-03-12 ПИРИМИДОПИРИМИДИНОНЫ В КАЧЕСТВЕ ИНГИБИТОРОВ КИНАЗЫ Wee-1

Country Status (30)

Country Link
US (2) US11208413B2 (ru)
EP (1) EP3592745B1 (ru)
JP (1) JP7244430B2 (ru)
KR (1) KR102605546B1 (ru)
CN (1) CN110603256B (ru)
AU (1) AU2018231671B2 (ru)
BR (1) BR112019018753A2 (ru)
CA (1) CA3055874A1 (ru)
CL (1) CL2019002557A1 (ru)
CY (1) CY1124613T1 (ru)
DK (1) DK3592745T3 (ru)
EA (1) EA201992137A1 (ru)
ES (1) ES2895365T3 (ru)
GB (1) GB201703881D0 (ru)
HR (1) HRP20211652T1 (ru)
HU (1) HUE056220T2 (ru)
IL (1) IL269063B (ru)
LT (1) LT3592745T (ru)
MA (1) MA47736B1 (ru)
MX (1) MX2019010554A (ru)
MY (1) MY195580A (ru)
PH (1) PH12019502049A1 (ru)
PL (1) PL3592745T3 (ru)
PT (1) PT3592745T (ru)
RS (1) RS62464B1 (ru)
SA (1) SA519410093B1 (ru)
SG (1) SG11201908114UA (ru)
SI (1) SI3592745T1 (ru)
UA (1) UA125093C2 (ru)
WO (1) WO2018162932A1 (ru)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3078945A1 (en) 2017-10-09 2019-04-18 Nuvation Bo Inc. Heterocyclic compounds and uses thereof
US11299493B2 (en) 2017-10-09 2022-04-12 Nuvation Bio Inc. Heterocyclic compounds and uses thereof
BR112021019703A2 (pt) 2019-04-09 2021-12-14 Nuvation Bio Inc Compostos heterocíclicos e usos dos mesmos
EP3952878A4 (en) * 2019-04-09 2023-01-04 Nuvation Bio Inc. HETEROCYCLIC COMPOUNDS AND USES THEREOF
EP3952879A4 (en) * 2019-04-09 2023-01-04 Nuvation Bio Inc. HETEROCYCLIC COMPOUNDS AND USES THEREOF
WO2023083194A1 (zh) * 2021-11-09 2023-05-19 杭州格博生物医药有限公司 Wee1蛋白激酶降解剂及其用途
WO2023170065A1 (en) * 2022-03-07 2023-09-14 Debiopharm International S.A. Methods of treating small cell lung cancer
WO2023217201A2 (zh) * 2022-05-10 2023-11-16 杭州德睿智药科技有限公司 作为Wee1抑制剂的新型嘧啶并杂环类新化合物及其应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7196090B2 (en) 2002-07-25 2007-03-27 Warner-Lambert Company Kinase inhibitors
PE20080695A1 (es) * 2006-04-27 2008-06-28 Banyu Pharma Co Ltd Derivados de dihidropirazolopirimidinona como inhibidores de quinasa weel
EP2376494A4 (en) 2008-12-12 2012-07-11 Msd Kk DIHYDROPYRIMIDOPIRYMIDINE DERIVATIVES
EP2817308B1 (en) 2012-02-23 2016-09-07 AbbVie Inc. Pyridopyrimidinone inhibitors of kinases
GB201306610D0 (en) * 2013-04-11 2013-05-29 Almac Discovery Ltd Pharmaceutical compounds
GB201322602D0 (en) * 2013-12-19 2014-02-05 Almac Discovery Ltd Pharmaceutical compounds

Also Published As

Publication number Publication date
CN110603256A (zh) 2019-12-20
PH12019502049A1 (en) 2020-06-29
AU2018231671A1 (en) 2019-09-26
SA519410093B1 (ar) 2022-07-16
CA3055874A1 (en) 2018-09-13
US20220194947A1 (en) 2022-06-23
MY195580A (en) 2023-02-02
SI3592745T1 (sl) 2021-12-31
MA47736B1 (fr) 2021-10-29
WO2018162932A1 (en) 2018-09-13
GB201703881D0 (en) 2017-04-26
KR20190128673A (ko) 2019-11-18
CY1124613T1 (el) 2022-07-22
CN110603256B (zh) 2022-10-28
HRP20211652T1 (hr) 2022-02-04
JP7244430B2 (ja) 2023-03-22
LT3592745T (lt) 2021-11-10
PL3592745T3 (pl) 2022-01-03
IL269063A (en) 2019-11-28
UA125093C2 (uk) 2022-01-05
SG11201908114UA (en) 2019-10-30
US11208413B2 (en) 2021-12-28
DK3592745T3 (da) 2021-10-18
KR102605546B1 (ko) 2023-11-22
AU2018231671B2 (en) 2022-03-24
US20210128560A1 (en) 2021-05-06
IL269063B (en) 2022-04-01
PT3592745T (pt) 2021-10-20
RS62464B1 (sr) 2021-11-30
EP3592745B1 (en) 2021-07-28
BR112019018753A2 (pt) 2020-04-07
CL2019002557A1 (es) 2019-12-27
EP3592745A1 (en) 2020-01-15
JP2020510040A (ja) 2020-04-02
ES2895365T3 (es) 2022-02-21
MA47736A (fr) 2021-04-21
MX2019010554A (es) 2019-12-16
HUE056220T2 (hu) 2022-02-28

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