EA201691135A1 - Новые ингибиторы глутаминазы - Google Patents

Новые ингибиторы глутаминазы

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Publication number
EA201691135A1
EA201691135A1 EA201691135A EA201691135A EA201691135A1 EA 201691135 A1 EA201691135 A1 EA 201691135A1 EA 201691135 A EA201691135 A EA 201691135A EA 201691135 A EA201691135 A EA 201691135A EA 201691135 A1 EA201691135 A1 EA 201691135A1
Authority
EA
Eurasian Patent Office
Prior art keywords
new
glutaminase inhibitors
methods
glutaminase
inhibitors
Prior art date
Application number
EA201691135A
Other languages
English (en)
Other versions
EA033163B1 (ru
Inventor
Прашант Кашинат Бхавар
Сваруп Кумар Венката Сатья Ваккаланка
Срикант Висванадха
Мерикапуди Гаятри Сваруп
Говиндараджулу Бабу
Original Assignee
Ризен Фармасьютикалз Са
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52478027&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA201691135(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ризен Фармасьютикалз Са filed Critical Ризен Фармасьютикалз Са
Publication of EA201691135A1 publication Critical patent/EA201691135A1/ru
Publication of EA033163B1 publication Critical patent/EA033163B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract

В настоящем изобретении предложены соединения формулы (I)-(III) в качестве ингибиторов глутаминазы, способы их получения, содержащие их фармацевтические композиции, а также способы лечения, предотвращения и/или ослабления заболеваний или нарушений, в которых задействован глутамин.
EA201691135A 2014-01-06 2015-01-05 Ингибиторы глутаминазы EA033163B1 (ru)

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IN39CH2014 2014-01-06
IN2639CH2014 2014-05-29
IN2647CH2014 2014-05-29
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IN3525CH2014 2014-07-18
IN3612CH2014 2014-07-24
IN3613CH2014 2014-07-24
IN5438CH2014 2014-10-31
PCT/IB2015/050076 WO2015101958A2 (en) 2014-01-06 2015-01-05 Novel inhibitors of glutaminase

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