BR112016015706A8 - composto, uso do mesmo e composição farmacêutica - Google Patents

composto, uso do mesmo e composição farmacêutica Download PDF

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Publication number
BR112016015706A8
BR112016015706A8 BR112016015706A BR112016015706A BR112016015706A8 BR 112016015706 A8 BR112016015706 A8 BR 112016015706A8 BR 112016015706 A BR112016015706 A BR 112016015706A BR 112016015706 A BR112016015706 A BR 112016015706A BR 112016015706 A8 BR112016015706 A8 BR 112016015706A8
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BR
Brazil
Prior art keywords
compound
pharmaceutical composition
methods
treating
iii
Prior art date
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BR112016015706A
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English (en)
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BR112016015706A2 (pt
Inventor
Babu Govindarajulu
Gayatri Swaroop Merikapudi
Kashinath Bhavar Prashant
Viswanadha Srikant
Kumar Venkata Satya Vakkalanka Swaroop
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Rhizen Pharmaceuticals S A
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Application filed by Rhizen Pharmaceuticals S A filed Critical Rhizen Pharmaceuticals S A
Publication of BR112016015706A2 publication Critical patent/BR112016015706A2/pt
Publication of BR112016015706A8 publication Critical patent/BR112016015706A8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/433—Thidiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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Abstract

a presente divulgação fornece compostos de fórmula (i) a (iii) como inibidores da glutaminase, métodos para a sua preparação, composições farmacêuticas contendo os mesmos e métodos de tratamento, prevenção e/ou melhoramento de doenças ou distúrbios que envolvem a glutamina.
BR112016015706A 2014-01-06 2015-01-05 composto, uso do mesmo e composição farmacêutica BR112016015706A8 (pt)

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IN36CH2014 2014-01-06
IN39CH2014 2014-01-06
IN2647CH2014 2014-05-29
IN2639CH2014 2014-05-29
IN2783CH2014 2014-06-06
IN3525CH2014 2014-07-18
IN3613CH2014 2014-07-24
IN3612CH2014 2014-07-24
IN5438CH2014 2014-10-31
PCT/IB2015/050075 WO2015101957A2 (en) 2014-01-06 2015-01-05 Novel glutaminase inhibitors

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