CN103030597B - 肾脏型谷氨酰胺酶抑制剂及其制备方法和用途 - Google Patents
肾脏型谷氨酰胺酶抑制剂及其制备方法和用途 Download PDFInfo
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- CN103030597B CN103030597B CN201110304914.3A CN201110304914A CN103030597B CN 103030597 B CN103030597 B CN 103030597B CN 201110304914 A CN201110304914 A CN 201110304914A CN 103030597 B CN103030597 B CN 103030597B
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- compound
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- glutamine
- kidney type
- acid
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- VLCDJXYOZFLDTR-UHFFFAOYSA-N CC(C)(CC1=C2C(c(cc3)ccc3SC)Nc3c1c(cccc1)c1cc3)CC2=O Chemical compound CC(C)(CC1=C2C(c(cc3)ccc3SC)Nc3c1c(cccc1)c1cc3)CC2=O VLCDJXYOZFLDTR-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
Description
Claims (11)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110304914.3A CN103030597B (zh) | 2011-09-30 | 2011-09-30 | 肾脏型谷氨酰胺酶抑制剂及其制备方法和用途 |
PCT/CN2012/001346 WO2013044596A1 (zh) | 2011-09-30 | 2012-09-29 | 肾脏型谷氨酰胺酶抑制剂及其制备方法和用途 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201110304914.3A CN103030597B (zh) | 2011-09-30 | 2011-09-30 | 肾脏型谷氨酰胺酶抑制剂及其制备方法和用途 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN103030597A CN103030597A (zh) | 2013-04-10 |
CN103030597B true CN103030597B (zh) | 2014-10-01 |
Family
ID=47994210
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CN201110304914.3A Active CN103030597B (zh) | 2011-09-30 | 2011-09-30 | 肾脏型谷氨酰胺酶抑制剂及其制备方法和用途 |
Country Status (2)
Country | Link |
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CN (1) | CN103030597B (zh) |
WO (1) | WO2013044596A1 (zh) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8604016B2 (en) | 2011-11-21 | 2013-12-10 | Calithera Biosciences Inc. | Heterocyclic inhibitors of glutaminase |
JP6783663B2 (ja) | 2014-01-06 | 2020-11-11 | ライゼン・ファーマシューティカルズ・エスアー | 新規グルタミナーゼ阻害剤 |
JP6798890B2 (ja) * | 2014-06-13 | 2020-12-09 | キャリセラ バイオサイエンシーズ, インコーポレイテッド | グルタミナーゼ阻害剤との併用療法 |
BR112017002403A2 (pt) | 2014-08-07 | 2017-12-05 | Calithera Biosciences Inc | formas de cristais de inibidores de glutaminase |
WO2016054388A1 (en) | 2014-10-03 | 2016-04-07 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Glutaminase inhibitors |
WO2016160980A1 (en) * | 2015-03-30 | 2016-10-06 | Calithera Biosciences, Inc. | Methods of administering glutaminase inhibitors |
JP6944377B2 (ja) | 2015-04-06 | 2021-10-06 | キャリセラ バイオサイエンシーズ, インコーポレイテッド | グルタミナーゼの阻害剤を用いる肺がんの処置 |
JP6971239B2 (ja) | 2015-10-05 | 2021-11-24 | キャリセラ バイオサイエンシーズ, インコーポレイテッド | グルタミナーゼ阻害剤とイムノオンコロジー薬剤との併用療法 |
CN109982703A (zh) | 2016-08-25 | 2019-07-05 | 卡利泰拉生物科技公司 | 用谷氨酰胺酶抑制剂的组合疗法 |
KR20190040302A (ko) | 2016-08-25 | 2019-04-17 | 칼리테라 바이오사이언시즈, 인코포레이티드 | 글루타미나제 억제제와의 병용 요법 |
AU2020241589A1 (en) * | 2019-03-18 | 2021-10-14 | Alteron Therapeutics, Inc. | Modulators of TDP-43 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003043582A2 (en) * | 2001-11-19 | 2003-05-30 | Iconix Pharmaceuticals, Inc. | Modulators of rho c activity |
WO2010111504A2 (en) * | 2009-03-25 | 2010-09-30 | Cornell University | Inhibition of glutaminase c |
-
2011
- 2011-09-30 CN CN201110304914.3A patent/CN103030597B/zh active Active
-
2012
- 2012-09-29 WO PCT/CN2012/001346 patent/WO2013044596A1/zh active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003043582A2 (en) * | 2001-11-19 | 2003-05-30 | Iconix Pharmaceuticals, Inc. | Modulators of rho c activity |
WO2010111504A2 (en) * | 2009-03-25 | 2010-09-30 | Cornell University | Inhibition of glutaminase c |
Non-Patent Citations (8)
Title |
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Condensation of 5,5-dimethyl-1,3-cyclohexanedione (dimedone) with azomethines;Kozlov, N. S.等;《Vestsi Akademii Navuk BSSR, Seryya Khimichnykh Navuk》;19681231(第1期);第67-72页 * |
Heterocyclic compounds prepared from diketones. XIV. Addition of dimedone to Schiff bases obtained from β-naphthylamine;Lielbriedis, I.等;《Latvijas PSR Zinatnu Akademijas Vestis, Kimijas Serija》;19691231(第2期);第197-199页 * |
K.N.Gusak等.Synthesisoffusedderivativesof4 7-phenanthroline by condensation of 6-aminoquinoline with aromatic aldehydes and dimedone.《Russian Journal of Organic Chemistry》.2001 |
Kozlov, N. G.等.Synthesis and spectral properties of new benzo[a]phenanthridine derivatives.《Khimiya Geterotsiklicheskikh Soedinenii》.1996,(第1期),第34-39页. |
Kozlov, N. S.等.Condensation of 5,5-dimethyl-1,3-cyclohexanedione (dimedone) with azomethines.《Vestsi Akademii Navuk BSSR, Seryya Khimichnykh Navuk》.1968,(第1期),第67-72页. |
Lielbriedis, I.等.Heterocyclic compounds prepared from diketones. XIV. Addition of dimedone to Schiff bases obtained from β-naphthylamine.《Latvijas PSR Zinatnu Akademijas Vestis, Kimijas Serija》.1969,(第2期),第197-199页. |
Synthesis and spectral properties of new benzo[a]phenanthridine derivatives;Kozlov, N. G.等;《Khimiya Geterotsiklicheskikh Soedinenii》;19961231(第1期);第35页图 * |
Synthesis of fused derivatives of 4,7-phenanthroline by condensation of 6-aminoquinoline with aromatic aldehydes and dimedone;K.N.Gusak等;《Russian Journal of Organic Chemistry》;20010531;第37卷(第10期);第1496页 * |
Also Published As
Publication number | Publication date |
---|---|
CN103030597A (zh) | 2013-04-10 |
WO2013044596A1 (zh) | 2013-04-04 |
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Effective date of registration: 20190102 Address after: 330031 Institute of Translational Medicine, Nanchang University, No. 1299 Xuefu Avenue, Honggutan New District, Nanchang City, Jiangxi Province Patentee after: Wang Jianbin Address before: Room 108, High-tech Pioneer Park, No. 2 High-tech Road, Nanchang High-tech Zone, Jiangxi Province Patentee before: WANG JIANBIN |
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