CN103030597A - 肾脏型谷氨酰胺酶抑制剂及其制备方法和用途 - Google Patents
肾脏型谷氨酰胺酶抑制剂及其制备方法和用途 Download PDFInfo
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- CN103030597A CN103030597A CN2011103049143A CN201110304914A CN103030597A CN 103030597 A CN103030597 A CN 103030597A CN 2011103049143 A CN2011103049143 A CN 2011103049143A CN 201110304914 A CN201110304914 A CN 201110304914A CN 103030597 A CN103030597 A CN 103030597A
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- 0 CC(c1c(C=C=C)c(N)c(*)c(P)c1*)C(C(CC(C)(C)C1)=C)=C1c1c(C)ccc2c1cccn2 Chemical compound CC(c1c(C=C=C)c(N)c(*)c(P)c1*)C(C(CC(C)(C)C1)=C)=C1c1c(C)ccc2c1cccn2 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/18—Ring systems of four or more rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
Description
Claims (17)
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
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CN201110304914.3A CN103030597B (zh) | 2011-09-30 | 2011-09-30 | 肾脏型谷氨酰胺酶抑制剂及其制备方法和用途 |
PCT/CN2012/001346 WO2013044596A1 (zh) | 2011-09-30 | 2012-09-29 | 肾脏型谷氨酰胺酶抑制剂及其制备方法和用途 |
Applications Claiming Priority (1)
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CN201110304914.3A CN103030597B (zh) | 2011-09-30 | 2011-09-30 | 肾脏型谷氨酰胺酶抑制剂及其制备方法和用途 |
Publications (2)
Publication Number | Publication Date |
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CN103030597A true CN103030597A (zh) | 2013-04-10 |
CN103030597B CN103030597B (zh) | 2014-10-01 |
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CN201110304914.3A Active CN103030597B (zh) | 2011-09-30 | 2011-09-30 | 肾脏型谷氨酰胺酶抑制剂及其制备方法和用途 |
Country Status (2)
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CN (1) | CN103030597B (zh) |
WO (1) | WO2013044596A1 (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107027291A (zh) * | 2014-06-13 | 2017-08-08 | 卡利泰拉生物科技公司 | 用谷氨酰胺酶抑制剂的组合疗法 |
CN107921031A (zh) * | 2015-03-30 | 2018-04-17 | 卡利泰拉生物科技公司 | 给予谷氨酰胺酶抑制剂的方法 |
US10245254B2 (en) | 2014-10-03 | 2019-04-02 | University of Pittsburgh—of the Commonwealth System of Higher Education | Glutaminase inhibitors |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8604016B2 (en) | 2011-11-21 | 2013-12-10 | Calithera Biosciences Inc. | Heterocyclic inhibitors of glutaminase |
EP3092236B1 (en) | 2014-01-06 | 2020-08-26 | Rhizen Pharmaceuticals S.A. | Novel glutaminase inhibitors |
AU2015300825B2 (en) | 2014-08-07 | 2019-10-10 | Calithera Biosciences, Inc. | Crystal forms of glutaminase inhibitors |
SG11201708153XA (en) * | 2015-04-06 | 2017-11-29 | Calithera Biosciences Inc | Treatment of lung cancer with inhibitors of glutaminase |
CN108601767A (zh) | 2015-10-05 | 2018-09-28 | 卡利泰拉生物科技公司 | 用谷氨酰胺酶抑制剂和免疫肿瘤学药剂的组合疗法 |
EP3503893A4 (en) | 2016-08-25 | 2020-04-29 | Calithera Biosciences, Inc. | COMBINATION THERAPY WITH GLUTAMINE INHIBITORS |
SG11201901389XA (en) | 2016-08-25 | 2019-03-28 | Calithera Biosciences Inc | Combination therapy with glutaminase inhibitors |
JP2022526465A (ja) * | 2019-03-18 | 2022-05-24 | アルテロン・セラピューティクス・インコーポレイテッド | Tdp-43のモジュレーター |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003043582A2 (en) * | 2001-11-19 | 2003-05-30 | Iconix Pharmaceuticals, Inc. | Modulators of rho c activity |
WO2010111504A2 (en) * | 2009-03-25 | 2010-09-30 | Cornell University | Inhibition of glutaminase c |
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2011
- 2011-09-30 CN CN201110304914.3A patent/CN103030597B/zh active Active
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2012
- 2012-09-29 WO PCT/CN2012/001346 patent/WO2013044596A1/zh active Application Filing
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003043582A2 (en) * | 2001-11-19 | 2003-05-30 | Iconix Pharmaceuticals, Inc. | Modulators of rho c activity |
WO2010111504A2 (en) * | 2009-03-25 | 2010-09-30 | Cornell University | Inhibition of glutaminase c |
Non-Patent Citations (4)
Title |
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K.N.GUSAK等: "Synthesis of fused derivatives of 4,7-phenanthroline by condensation of 6-aminoquinoline with aromatic aldehydes and dimedone", 《RUSSIAN JOURNAL OF ORGANIC CHEMISTRY》, vol. 37, no. 10, 31 May 2001 (2001-05-31), pages 1496 * |
KOZLOV, N. G.等: "Synthesis and spectral properties of new benzo[a]phenanthridine derivatives", 《KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII》, no. 1, 31 December 1996 (1996-12-31), pages 34 - 39 * |
KOZLOV, N. S.等: "Condensation of 5,5-dimethyl-1,3-cyclohexanedione (dimedone) with azomethines", 《VESTSI AKADEMII NAVUK BSSR, SERYYA KHIMICHNYKH NAVUK》, no. 1, 31 December 1968 (1968-12-31), pages 67 - 72 * |
LIELBRIEDIS, I.等: "Heterocyclic compounds prepared from diketones. XIV. Addition of dimedone to Schiff bases obtained from β-naphthylamine", 《LATVIJAS PSR ZINATNU AKADEMIJAS VESTIS, KIMIJAS SERIJA》, no. 2, 31 December 1969 (1969-12-31), pages 197 - 199 * |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107027291A (zh) * | 2014-06-13 | 2017-08-08 | 卡利泰拉生物科技公司 | 用谷氨酰胺酶抑制剂的组合疗法 |
CN107027291B (zh) * | 2014-06-13 | 2020-10-30 | 卡利泰拉生物科技公司 | 用谷氨酰胺酶抑制剂的组合疗法 |
US10245254B2 (en) | 2014-10-03 | 2019-04-02 | University of Pittsburgh—of the Commonwealth System of Higher Education | Glutaminase inhibitors |
US11013724B2 (en) | 2014-10-03 | 2021-05-25 | University of Pittsburgh—of the Commonwealth System of Higher Education | Glutaminase inhibitors |
CN107921031A (zh) * | 2015-03-30 | 2018-04-17 | 卡利泰拉生物科技公司 | 给予谷氨酰胺酶抑制剂的方法 |
Also Published As
Publication number | Publication date |
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WO2013044596A1 (zh) | 2013-04-04 |
CN103030597B (zh) | 2014-10-01 |
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Effective date of registration: 20190102 Address after: 330031 Institute of Translational Medicine, Nanchang University, No. 1299 Xuefu Avenue, Honggutan New District, Nanchang City, Jiangxi Province Patentee after: Wang Jianbin Address before: Room 108, High-tech Pioneer Park, No. 2 High-tech Road, Nanchang High-tech Zone, Jiangxi Province Patentee before: WANG JIANBIN |