FR2104783A1 - 2,5-disubstd 2-amino-1,3,4-thiadiazoles-from 4-substd 1-acylthiosemic - virustatics - Google Patents

2,5-disubstd 2-amino-1,3,4-thiadiazoles-from 4-substd 1-acylthiosemic - virustatics

Info

Publication number
FR2104783A1
FR2104783A1 FR7111316A FR7111316A FR2104783A1 FR 2104783 A1 FR2104783 A1 FR 2104783A1 FR 7111316 A FR7111316 A FR 7111316A FR 7111316 A FR7111316 A FR 7111316A FR 2104783 A1 FR2104783 A1 FR 2104783A1
Authority
FR
France
Prior art keywords
substd
acylthiosemic
disubstd
virustatics
thiadiazoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR7111316A
Other languages
French (fr)
Other versions
FR2104783B1 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Berlin Chemie AG
Original Assignee
Berlin Chemie AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Berlin Chemie AG filed Critical Berlin Chemie AG
Publication of FR2104783A1 publication Critical patent/FR2104783A1/en
Application granted granted Critical
Publication of FR2104783B1 publication Critical patent/FR2104783B1/fr
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C07D285/135—Nitrogen atoms

Abstract

Cpds. of general formula (I): (where R1 = adamantyl, phenyl, 2-hydroxyphenyl, pyridyl-(4)- or benzyl; R2 = phenyl, cyclohexyl, n-butyl, 4-chlorophenyl or allyl) are prepd. by cyclisation of 1-acyl-4-alkyl-thiosemicarbazides with dehydrating agents, pref. phosphoroxychloride or conc. H2SO4. Using the same process 4-substd. alkylene-alpha,omega-dicarbonyl-bisthiosemicarbazides may be cyclised to form cpds. of general formula (II): (where R1 = methylene or ethylene; R2 is as defined).
FR7111316A 1970-07-14 1971-03-31 2,5-disubstd 2-amino-1,3,4-thiadiazoles-from 4-substd 1-acylthiosemic - virustatics Granted FR2104783A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DD14880270 1970-07-14

Publications (2)

Publication Number Publication Date
FR2104783A1 true FR2104783A1 (en) 1972-04-21
FR2104783B1 FR2104783B1 (en) 1975-04-18

Family

ID=5482716

Family Applications (1)

Application Number Title Priority Date Filing Date
FR7111316A Granted FR2104783A1 (en) 1970-07-14 1971-03-31 2,5-disubstd 2-amino-1,3,4-thiadiazoles-from 4-substd 1-acylthiosemic - virustatics

Country Status (4)

Country Link
CH (1) CH546254A (en)
DE (1) DE2126261A1 (en)
FR (1) FR2104783A1 (en)
SU (1) SU455108A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0061434A1 (en) * 1981-03-18 1982-09-29 Società Italo-Britannica L. Manetti - H. Roberts & C. Derivatives of 2-amino-5-(o-sulphamidophenyl)-1,3,4-thiadiazole as antiviral agents and a process for the preparation thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2934700A1 (en) * 2014-01-06 2015-07-09 Rhizen Pharmaceuticals Sa Glutaminase inhibitors

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0061434A1 (en) * 1981-03-18 1982-09-29 Società Italo-Britannica L. Manetti - H. Roberts & C. Derivatives of 2-amino-5-(o-sulphamidophenyl)-1,3,4-thiadiazole as antiviral agents and a process for the preparation thereof

Also Published As

Publication number Publication date
CH546254A (en) 1974-02-28
SU455108A1 (en) 1974-12-30
FR2104783B1 (en) 1975-04-18
DE2126261A1 (en) 1972-01-20

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Legal Events

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ST Notification of lapse