LT3220916T - Vėžio gydymo n-((4,6-dimetil-2-okso-1,2-dihidropiridin-3-il)metil)-5- (etil(tetrahidro-2h-piran-4-il)amino)-4-metil-4’-(morfolinometil)-[1,1’- bifenil]-3-karboksamidu būdas - Google Patents

Vėžio gydymo n-((4,6-dimetil-2-okso-1,2-dihidropiridin-3-il)metil)-5- (etil(tetrahidro-2h-piran-4-il)amino)-4-metil-4’-(morfolinometil)-[1,1’- bifenil]-3-karboksamidu būdas

Info

Publication number
LT3220916T
LT3220916T LTEPPCT/US2015/061194T LT15061194T LT3220916T LT 3220916 T LT3220916 T LT 3220916T LT 15061194 T LT15061194 T LT 15061194T LT 3220916 T LT3220916 T LT 3220916T
Authority
LT
Lithuania
Prior art keywords
methyl
dihydropyridin
morpholinomethyl
pyran
carboxamide
Prior art date
Application number
LTEPPCT/US2015/061194T
Other languages
English (en)
Inventor
Heike KEILHACK
Brett TRUITT
Yuta Suzuki
Tsukasa Murase
Futoshi SHIKATA
Original Assignee
Epizyme, Inc.
Eisai R&D Management Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epizyme, Inc., Eisai R&D Management Co., Ltd. filed Critical Epizyme, Inc.
Publication of LT3220916T publication Critical patent/LT3220916T/lt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893—Tablet coating processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
LTEPPCT/US2015/061194T 2014-11-17 2015-11-17 Vėžio gydymo n-((4,6-dimetil-2-okso-1,2-dihidropiridin-3-il)metil)-5- (etil(tetrahidro-2h-piran-4-il)amino)-4-metil-4’-(morfolinometil)-[1,1’- bifenil]-3-karboksamidu būdas LT3220916T (lt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462080985P 2014-11-17 2014-11-17
US201562166572P 2015-05-26 2015-05-26
US201562251903P 2015-11-06 2015-11-06
PCT/US2015/061194 WO2016081523A1 (en) 2014-11-17 2015-11-17 Method for treating cancer

Publications (1)

Publication Number Publication Date
LT3220916T true LT3220916T (lt) 2023-07-25

Family

ID=56014476

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEPPCT/US2015/061194T LT3220916T (lt) 2014-11-17 2015-11-17 Vėžio gydymo n-((4,6-dimetil-2-okso-1,2-dihidropiridin-3-il)metil)-5- (etil(tetrahidro-2h-piran-4-il)amino)-4-metil-4’-(morfolinometil)-[1,1’- bifenil]-3-karboksamidu būdas

Country Status (22)

Country Link
US (2) US10786511B2 (lt)
EP (2) EP3220916B1 (lt)
JP (3) JP6829684B2 (lt)
KR (3) KR102338802B1 (lt)
CN (2) CN107249591B (lt)
AU (3) AU2015350108B2 (lt)
BR (1) BR112017010166A2 (lt)
CA (1) CA2967664A1 (lt)
DK (1) DK3220916T3 (lt)
EA (1) EA201791095A1 (lt)
ES (1) ES2947819T3 (lt)
FI (1) FI3220916T3 (lt)
HU (1) HUE062159T2 (lt)
IL (3) IL296080B2 (lt)
LT (1) LT3220916T (lt)
MX (2) MX2017006089A (lt)
NZ (1) NZ731696A (lt)
PL (1) PL3220916T3 (lt)
PT (1) PT3220916T (lt)
SG (1) SG11201703806XA (lt)
SI (1) SI3220916T1 (lt)
WO (1) WO2016081523A1 (lt)

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SG10201811128RA (en) 2014-06-17 2019-01-30 Epizyme Inc Ezh2 inhibitors for treating lymphoma
CA2967664A1 (en) 2014-11-17 2016-05-26 Epizyme, Inc. Pharmaceutical formulations comprising inhibitors of human histone methyltransferase ezh2
AU2016252546A1 (en) 2015-04-20 2017-11-02 Epizyme, Inc. Combination therapy for treating cancer
US20180311251A1 (en) 2015-06-10 2018-11-01 Epizyme, Inc. Ezh2 inhibitors for treating lymphoma
AU2016312514A1 (en) 2015-08-24 2018-03-15 Epizyme, Inc. Method for treating cancer
AU2017211331A1 (en) 2016-01-29 2018-06-07 Epizyme, Inc. Combination therapy for treating cancer
US11786533B2 (en) 2016-06-01 2023-10-17 Epizyme, Inc. Use of EZH2 inhibitors for treating cancer
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TW201831181A (zh) 2017-01-19 2018-09-01 日商第一三共股份有限公司 用以用於治療ｈｔｌｖ－１相關脊髓病之醫藥組成物
US11642346B2 (en) 2017-03-31 2023-05-09 Epizyme, Inc. Combination therapy for treating cancer
JP2020522687A (ja) 2017-06-02 2020-07-30 エピザイム，インコーポレイティド 癌を処置するためのｅｚｈ２阻害剤の使用
CN111093660A (zh) 2017-09-05 2020-05-01 Epizyme股份有限公司 用于治疗癌症的组合疗法
AU2020408395A1 (en) * 2019-12-20 2022-07-07 Epizyme, Inc. Crystalline hydrobromide salt of a EZH2 inhibitor, its preparation and pharmaceutical composition useful for the treatment of cancer
JP2022167451A (ja) 2021-04-23 2022-11-04 日立Astemo株式会社 情報処理装置、情報処理方法、プログラムおよび記憶媒体
WO2023159124A2 (en) * 2022-02-17 2023-08-24 Memorial Sloan-Kettering Cancer Center Methods for overcoming tazemetostat-resistance in cancer patients
TW202400140A (zh) 2022-04-27 2024-01-01 日商第一三共股份有限公司 抗體-藥物結合物與ezh1及/或ezh2抑制劑之組合

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Also Published As

Publication number Publication date
KR102338802B1 (ko) 2021-12-14
CN107249591A (zh) 2017-10-13
ES2947819T3 (es) 2023-08-21
EA201791095A1 (ru) 2017-10-31
WO2016081523A1 (en) 2016-05-26
PL3220916T3 (pl) 2023-08-14
SI3220916T1 (sl) 2023-09-29
AU2021204706A1 (en) 2021-07-29
DK3220916T3 (da) 2023-06-26
EP4272742A1 (en) 2023-11-08
BR112017010166A2 (pt) 2018-02-14
US10786511B2 (en) 2020-09-29
IL296080A (en) 2022-11-01
CN107249591B (zh) 2024-01-30
SG11201703806XA (en) 2017-06-29
IL252182A0 (en) 2017-07-31
IL252182B2 (en) 2023-02-01
KR20210156840A (ko) 2021-12-27
JP2021073241A (ja) 2021-05-13
IL296080B1 (en) 2023-08-01
AU2015350108A1 (en) 2017-05-25
AU2021204706B2 (en) 2023-11-23
PT3220916T (pt) 2023-06-26
IL252182B (en) 2022-10-01
FI3220916T3 (fi) 2023-06-19
KR102644844B1 (ko) 2024-03-07
MX2017006089A (es) 2017-12-11
NZ731696A (en) 2024-03-22
MX2021006734A (es) 2021-07-02
JP2017537899A (ja) 2017-12-21
HUE062159T2 (hu) 2023-10-28
IL296080B2 (en) 2023-12-01
JP2023062189A (ja) 2023-05-02
KR20240035908A (ko) 2024-03-18
CN116650500A (zh) 2023-08-29
US20210060030A1 (en) 2021-03-04
IL304252A (en) 2023-09-01
CA2967664A1 (en) 2016-05-26
EP3220916B1 (en) 2023-04-19
JP7485810B2 (ja) 2024-05-16
EP3220916A1 (en) 2017-09-27
AU2024201171A1 (en) 2024-03-14
US20170360797A1 (en) 2017-12-21
EP3220916A4 (en) 2018-07-11
AU2015350108B2 (en) 2021-04-08
JP6829684B2 (ja) 2021-02-10
KR20170103768A (ko) 2017-09-13

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