SG11201703806XA - Method for treating cancer - Google Patents

Method for treating cancer

Info

Publication number
SG11201703806XA
SG11201703806XA SG11201703806XA SG11201703806XA SG11201703806XA SG 11201703806X A SG11201703806X A SG 11201703806XA SG 11201703806X A SG11201703806X A SG 11201703806XA SG 11201703806X A SG11201703806X A SG 11201703806XA SG 11201703806X A SG11201703806X A SG 11201703806XA
Authority
SG
Singapore
Prior art keywords
treating cancer
cancer
treating
Prior art date
Application number
SG11201703806XA
Inventor
Heike Keilhack
Brett Truitt
Yuta Suzuki
Tsukasa Murase
Futoshi Shikata
Original Assignee
Epizyme Inc
Eisai R&D Man Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Epizyme Inc, Eisai R&D Man Co Ltd filed Critical Epizyme Inc
Publication of SG11201703806XA publication Critical patent/SG11201703806XA/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/53751,4-Oxazines, e.g. morpholine
    • A61K31/53771,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2013Organic compounds, e.g. phospholipids, fats
    • A61K9/2018Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2072Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2095Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/284Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846Poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2893Tablet coating processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
SG11201703806XA 2014-11-17 2015-11-17 Method for treating cancer SG11201703806XA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201462080985P 2014-11-17 2014-11-17
US201562166572P 2015-05-26 2015-05-26
US201562251903P 2015-11-06 2015-11-06
PCT/US2015/061194 WO2016081523A1 (en) 2014-11-17 2015-11-17 Method for treating cancer

Publications (1)

Publication Number Publication Date
SG11201703806XA true SG11201703806XA (en) 2017-06-29

Family

ID=56014476

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11201703806XA SG11201703806XA (en) 2014-11-17 2015-11-17 Method for treating cancer

Country Status (22)

Country Link
US (2) US10786511B2 (en)
EP (2) EP3220916B1 (en)
JP (3) JP6829684B2 (en)
KR (3) KR102338802B1 (en)
CN (2) CN116650500A (en)
AU (3) AU2015350108B2 (en)
BR (1) BR112017010166A2 (en)
CA (1) CA2967664A1 (en)
DK (1) DK3220916T3 (en)
EA (1) EA201791095A1 (en)
ES (1) ES2947819T3 (en)
FI (1) FI3220916T3 (en)
HU (1) HUE062159T2 (en)
IL (3) IL296080B2 (en)
LT (1) LT3220916T (en)
MX (2) MX2017006089A (en)
NZ (1) NZ731696A (en)
PL (1) PL3220916T3 (en)
PT (1) PT3220916T (en)
SG (1) SG11201703806XA (en)
SI (1) SI3220916T1 (en)
WO (1) WO2016081523A1 (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2863996T3 (en) 2013-12-06 2021-10-13 Epizyme Inc Combination therapy for cancer treatment
CN106999498B (en) 2014-06-17 2021-06-08 Epizyme股份有限公司 EZH2 inhibitors for the treatment of lymphoma
EP3285773A4 (en) 2015-04-20 2019-04-10 Epizyme, Inc. Combination therapy for treating cancer
EP3307713A4 (en) 2015-06-10 2019-01-23 Epizyme, Inc. Ezh2 inhibitors for treating lymphoma
WO2017035234A1 (en) 2015-08-24 2017-03-02 Epizyme, Inc. Method for treating cancer
CA3011186A1 (en) 2016-01-29 2017-08-03 Epizyme, Inc. Combination therapy for treating cancer
CA3025933A1 (en) 2016-06-01 2017-12-07 Epizyme, Inc. Use of ezh2 inhibitors for treating cancer
MA45406A (en) 2016-06-17 2019-04-24 Epizyme Inc EZH2 INHIBITORS TO TREAT CANCER
WO2018135556A1 (en) 2017-01-19 2018-07-26 第一三共株式会社 Pharmaceutical composition used for treatment of htlv-1-associated myelopathy
US11642346B2 (en) 2017-03-31 2023-05-09 Epizyme, Inc. Combination therapy for treating cancer
US11602529B2 (en) 2017-06-02 2023-03-14 Epizyme, Inc. Use of EZH2 inhibitors for treating cancer
JP7399079B2 (en) 2017-09-05 2023-12-15 エピザイム,インコーポレイティド Combination therapy to treat cancer
JP2022167451A (en) 2021-04-23 2022-11-04 日立Astemo株式会社 Information processing apparatus, information processing method, program, and storage medium
WO2023159124A2 (en) * 2022-02-17 2023-08-24 Memorial Sloan-Kettering Cancer Center Methods for overcoming tazemetostat-resistance in cancer patients
WO2023209591A1 (en) 2022-04-27 2023-11-02 Daiichi Sankyo Company, Limited Combination of antibody-drug conjugate with ezh1 and/or ezh2 inhibitor

Family Cites Families (29)

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Publication number Priority date Publication date Assignee Title
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US7229774B2 (en) 2001-08-02 2007-06-12 Regents Of The University Of Michigan Expression profile of prostate cancer
US20070026064A1 (en) * 2005-07-29 2007-02-01 Yoder Steven L Pharmaceutical dosage forms having watermark-type identification and authentication inditia
US20100278921A1 (en) * 2009-04-30 2010-11-04 Fischer Cristina M Solid oral formulation of abt-263
US9175331B2 (en) 2010-09-10 2015-11-03 Epizyme, Inc. Inhibitors of human EZH2, and methods of use thereof
RU2618475C2 (en) 2010-09-10 2017-05-03 Эпизайм, Инк. Human ezh2 inhibitors and methods of application thereof
EP2663283B1 (en) * 2011-01-14 2017-05-10 Bristol-Myers Squibb Company High drug load tablet formulation of brivanib alaninate
WO2012118812A2 (en) 2011-02-28 2012-09-07 Epizyme, Inc. Substituted 6,5-fused bicyclic heteroaryl compounds
JO3438B1 (en) * 2011-04-13 2019-10-20 Epizyme Inc Aryl- or heteroaryl-substituted benzene compounds
TWI598336B (en) 2011-04-13 2017-09-11 雅酶股份有限公司 Substituted benzene compounds
ES2718900T3 (en) 2012-03-12 2019-07-05 Epizyme Inc Human EZH2 inhibitors and methods of use thereof
SG11201406468YA (en) * 2012-04-13 2015-01-29 Epizyme Inc Salt form of a human hi stone methyltransf erase ezh2 inhibitor
KR20230004871A (en) * 2012-04-13 2023-01-06 에피자임, 인코포레이티드 Combination therapy for treating cancer
NZ706836A (en) * 2012-10-15 2019-02-22 Epizyme Inc Methods of treating cancer
PE20150887A1 (en) 2012-10-15 2015-06-04 Epizyme Inc SUBSTITUTE BENZENE COMPOUNDS
EP2934531A4 (en) * 2012-12-19 2016-06-15 Glaxosmithkline Llc Combination
WO2014100665A1 (en) 2012-12-21 2014-06-26 Epizyme, Inc. 1,4-pyridone bicyclic heteroaryl compounds
US20150344427A1 (en) 2012-12-21 2015-12-03 Epizyme, Inc. 1,4-pyridone compounds
US9776996B2 (en) 2013-03-15 2017-10-03 Epizyme, Inc. Substituted 6,5-fused bicyclic heteroaryl compounds
AU2014254392B2 (en) 2013-03-15 2018-05-24 Epizyme, Inc. Substituted benzene compounds
US10150764B2 (en) 2013-07-19 2018-12-11 Epizyme, Inc. Substituted benzene compounds
AU2014337300B2 (en) 2013-10-16 2019-01-03 Eisai R&D Management Co., Ltd. Hydrochloride salt form for EZH2 inhibition
JP2016533364A (en) 2013-10-18 2016-10-27 エピザイム,インコーポレイティド How to treat cancer
ES2863996T3 (en) 2013-12-06 2021-10-13 Epizyme Inc Combination therapy for cancer treatment
CN106999498B (en) * 2014-06-17 2021-06-08 Epizyme股份有限公司 EZH2 inhibitors for the treatment of lymphoma
WO2015200650A1 (en) 2014-06-25 2015-12-30 Epizyme, Inc. Substituted benzene and 6,5-fused bicyclic heteroaryl compounds
MX2017004969A (en) 2014-10-16 2017-07-19 Epizyme Inc Method for treating cancer.
EP3307713A4 (en) * 2015-06-10 2019-01-23 Epizyme, Inc. Ezh2 inhibitors for treating lymphoma
MA45406A (en) * 2016-06-17 2019-04-24 Epizyme Inc EZH2 INHIBITORS TO TREAT CANCER

Also Published As

Publication number Publication date
IL252182A0 (en) 2017-07-31
WO2016081523A1 (en) 2016-05-26
PL3220916T3 (en) 2023-08-14
KR20170103768A (en) 2017-09-13
JP6829684B2 (en) 2021-02-10
MX2021006734A (en) 2021-07-02
US20170360797A1 (en) 2017-12-21
CN107249591A (en) 2017-10-13
NZ731696A (en) 2024-03-22
CA2967664A1 (en) 2016-05-26
KR20210156840A (en) 2021-12-27
JP2021073241A (en) 2021-05-13
EP4272742A1 (en) 2023-11-08
IL252182B2 (en) 2023-02-01
KR20240035908A (en) 2024-03-18
US20210060030A1 (en) 2021-03-04
EP3220916A4 (en) 2018-07-11
KR102338802B1 (en) 2021-12-14
AU2021204706B2 (en) 2023-11-23
MX2017006089A (en) 2017-12-11
PT3220916T (en) 2023-06-26
SI3220916T1 (en) 2023-09-29
IL296080B2 (en) 2023-12-01
DK3220916T3 (en) 2023-06-26
IL252182B (en) 2022-10-01
IL304252A (en) 2023-09-01
AU2024201171A1 (en) 2024-03-14
AU2015350108A1 (en) 2017-05-25
EA201791095A1 (en) 2017-10-31
EP3220916A1 (en) 2017-09-27
KR102644844B1 (en) 2024-03-07
HUE062159T2 (en) 2023-10-28
FI3220916T3 (en) 2023-06-19
IL296080A (en) 2022-11-01
BR112017010166A2 (en) 2018-02-14
IL296080B1 (en) 2023-08-01
US10786511B2 (en) 2020-09-29
AU2015350108B2 (en) 2021-04-08
JP2023062189A (en) 2023-05-02
ES2947819T3 (en) 2023-08-21
AU2021204706A1 (en) 2021-07-29
CN107249591B (en) 2024-01-30
LT3220916T (en) 2023-07-25
JP2017537899A (en) 2017-12-21
CN116650500A (en) 2023-08-29
EP3220916B1 (en) 2023-04-19

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